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Validated All-in-One™ qPCR Primer for APOBEC1(NM_001644.5) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs.
Gene References into function
- Demonstrates the presence of a 36-aa peptide (isoform 2) derived from this gene in adult small intestinal villi using immunocytochemical analysis.
- C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme
- expression of two proteins essential for apolipoprotein B mRNA editing from a single gene through alternative splicing
- determination of multifunctional cycle and suppression of nonsense-mediated decay
- apobec-1 complementation factor has a role in regulating nucleocytoplasmic import and shuttling
- apobec-1-mediated apoB mRNA editing is regulated by BAG-4
- Expression of Apobec1 in HepG2 cells resulted in apoB mRNA editing, leading to decreased apoB100 abundance (to 6% of control) and the appearance of apoB48.
- APOBEC3G is not a nucleo-cytoplasmic shuttling protein like APOBEC-1 and activation-induced cytidine deaminase
- No evidence of association of APOBEC1 and PPARG with gallstone susceptibility was detected.