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Validated All-in-One™ qPCR Primer for ALDH2(NM_001204889.2) Search again
Product ID:
HQP149485
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ALDH-E2, ALDHI, ALDM
Gene Description:
aldehyde dehydrogenase 2 family member
Target Gene Accession:
NM_001204889.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. [provided by RefSeq].
Gene References into function
- a rapid, reliable and inexpensive method, mismatch amplification mutation assay (MAMA), for the determination of human ALDH2 usual and atypical alleles
- Individuals possessing more susceptible ALDH2 1-2/2-2 genotypes were more likely to reveal p53 overexpression.
- The degree of liver dysfunction in alcoholic liver disease with ALDH2*1/2*2 may be less pronounced than that with ALDH2*1/2*1.
- The frequencies of the mutant ALDH2*2 allele were significantly higher in patients with esophageal cancer (27.7%) than in healthy control subjects (7.3%; p< 0.0001; habitual alcohol drinkers).
- ALDH2 Lys/Lys genotype is a risk factor for myocardial infarction in Japanese men due to its influence on HDL cholesterol level.
- No causal relation between hypertension and the ALDH2 genotype per se, after excluding for some confounding factors, especially for alcohol drinking.
- Polymorphisms of alcohol-metabolizing enzymes: analyses of mutations on the CYP2E1, ADH2, ADH3 and ALDH2 genes in a Mexican-American population living in the Los Angeles area.
- Genotype is associated with type 1 diabetes mellitus.
- Maternal inheritance of diabetes is associated with inactive ALDH2 genotype in diabetics with renal failure.
- Alcohol-related red cell value changes associated with inactive ALDH2 in Japanese men suggest the importance of acetaldehyde's role in increasing MCV and the potential for using MCV as a marker for high-risk drinkers for esophageal cancer.
- genotypes of aldehyde dehydrogenase 2 and beta3-adrenergic receptor were strongly associated with elevated alanine aminotransferase level which increased with the accumulation of components of metabolic syndrome
- The human aldehyde dehydrogenase-2 promoter contains a retinoid response element which may contribute to regulation of the retinoic acid receptor.
- this study of haplotype frequency and linkage disequilibrium of ALDH2 illuminates the global evolutionary history of the ALDH2 gene
- The ALDH2 gene may interact with the dopamine D2 receptor (DRD2) gene in the development of anxiety-depressive alcohol dependence in the Taiwan Han Chinese population.
- ALDH2 gene is implicated in conduct disorders and alcohol dependence in Chinese, Korean and White American individuals
- These results indicate that mitochondrial aldehyde dehydrogenase 2 (ALDH2) functions as a protector against oxidative stress, and that ALDH2 deficiency is a risk factor for late-onset Alzheimer's disease.
- The accumulation of acetaldehyde due to ALDH2 inactivity is associated with alcoholic polyneuropathy.
- results suggest that ALDH2 catalyses the mitochondrial bioactivation of nitroglycerin by the formation of a reactive NO-related intermediate that activates soluble guanylate cyclase
- Meta-analysis using three diabetes population studies strongly confirmed the association between ALDH2 inactivity and maternal inheritance.
- analyis of aldehyde dehydrogenase 2 tissue distribution and its role in alcohol metabolism
- Smoking habit did increase the risk of pancreatic cancer, and this risk was further enhanced in subjects with inactive ALDH2 in a male population but not in a female population
- ALDH2 genotype is significantly associated with acetaldehyde-induced micronuclei and alcohol-induced facial flushing.
- Polymorphisms of the alcohol metabolism-related ALDH2 gene are significantly different in Korean patients with alcoholism and Korean control subjects without alcoholism.
- x-ray crystallographic structure of ALDH2*2
- Individuals with the variant alleles ALDH2*2 had a decreased risk of colorectal adenoma, suggesting that folate inhibits the growth of colorectal adenomas.
- None of the 40 subjects with inactive mitochondrial aldehyde dehydrogenase (ALDH2*2 allele) exhibited pancreatitis (P = 0.004).
- Findings indicate that the ALDH2 polymorphism may modify hepatocellular carcinoma risk among light to moderate drinkers.
- interaction between ALDH2 and ADH2 polymorphisms may have a role in colorectal cancer in Japan
- ALDH2*2 allele has been associated with lower rates of alcohol dependence.
- Results suggest that the Lys504 allele of mitochondrial aldehyde dehydrogenase-2 contributes to the lack of an efficacious clinical response to nitroglycerin in Chinese heart disease patients.
- Single Nucleotide Polymorphisms of aldehyde dehydrogenase-2 is associated with esophageal squamous cell carcinoma
- mtALDH overexpression attenuates hyperoxia-induced cell death in lung epithelial cells through reduction of reactive oxygen species, activation of ERK/MAPK, and PI3K-Akt cell survival signaling pathways
- Genetic variation in ALDH2 affects alcohol metabolism in Europeans. However, the data do not support the hypothesis that this leads to effects on alcohol sensitivity, consumption, or risk of dependence.
- possible interaction between the ALDH2 1510 G/A polymorphism and age in head and neck squamous cell carcinoma.
- Results suggest that ALDH2 polymorphisms play a pivotal role on esophageal cancer and that the effect of these polymorphisms was modified by the amount of alcohol consumed.
- ALDH2 genotype affects the genotoxic damage caused by acetaldehyde
- Genetic polymorphisms of ALDH2 is associated with oral and pharyngeal squamous cell carcinoma
- present study revealed that the ALDH2 *1/*1 genotype was significantly associated with the prevalence of multiple lacunar infarcts in Japanese men
- ALDH2 polymorphisms may play an important role in the pathogenesis of MI in elderly Korean men
- Asians carrying the acetaldehyde dehydrogenase 2*2 (ALDH2*2) allele have a significantly increased cancer risk when they consume alcohol.
- examined genetic polymorphisms in the alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 genes in 505 patients with histologically confirmed lung cancer and 256 noncancer controls to determine association with alcohol drinking
- The oxidative pathway of ethanol metabolism via ADH and ALDH does not play a role in pancreatic carcinogenesis.
- Aldehyde dehydrogenase 2 (ALDH2) genotype is associated with essential hypertension independently of alcohol consumption.
- This study suggests that the ALDH2*A allele status may correlate with variations in alcohol consumption patterns among Jews, independent of the effect of ADH1B genotype.
- small number of haplotypes suggests strong linkage disequilibrium across region; confirms global linkage disequilibrium around the ALDH2 locus; provides a baseline for research into the role of the ALDH2 locus in alcoholism in Indian populations
- ADH2 and ALDH2 genotypes are associated with esophageal cancer risk. ADH2 1 allele and ALDH2 2 allele carriers have a much higher risk of developing esophageal cancer, especially among alcohol drinkers.
- the acetaldehyde dehydrogenase 2 polymorphism causing a substitution of Glu > Lys(504) is not associated with coronary atherosclerosis severity in Han Chinese
- the interplay of the ADH1B and ALDH2 genotypes, in conjunction with a behaved drinking habit and a practiced drinking pattern, along with continued tobacco consumption, plays an important pathogenic role in modulating esophageal SCC risk
- These results suggested that the ALDH2 gene 1/2 polymorphism might be a risk factor for LOAD and dependent on APOE epsilon4 status in Chinese.
- Japanese women with aldehyde dehydrogenase 2*1/1 genotype had significantly lower fasting plasma glucose levels than those without this genotype.
- It was observed that ADH variants, ADH2*1 and ADH3*2, were associated with increased risk for oesophageal cancer, possibly due to the tolerance of the carriers of these alleles to alcohol consumption
- In human capacitance vessels, ALDH2 is a key enzyme in the biotransformation of the frequently used antianginal drug nitroglycerin.
- describes demographic, alcohol use, country of origin, family history of alcohol dependence, and ALDH2 and ADH1b variables to elucidate response to alcohol amont Chinese and Korean-American college students
- The impact of presumed ALDH2 polymorphisms on human olfactory tissue concentrations of inhaled acetaldehyde was negligible.
- There is an association between the genotypes at rs671 and gamma-glutamyltranspeptidase (gamma-GTP) levels.
- Alcohol consumption and polymorphisms in the CYP2E1, ADH1B and ALDH2 genes are important risk factors for esophageal squamous cell carcinoma in Chinese males living in Gansu Province, China.
- Variants of this alcohol-metabolizing enzyme appeared in the relation to alcoholic chronic pancreatitis
- ALDH2 polymorphisms had a significant interaction with heavy alcohol consumption in the development of hepatocellular carcinoma.
- analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 and ALDH2
- Genetic polymorphism of the gene is substantially involving in individual variation of susceptibility to alcohol dependence.
- The cardiovascular response to alcohol ingestion is influenced by ALDH2 genotype and drinking, assumed to be in moderation, puts a strain on the hearts for the ALDH2-deficient individuals (QT interval).
- There are differences in exposure of the upper aerodigestive tract to high salivary acetaldehyde concentrations according to the type of alcoholic beverage and ALDH2 genotype.
- These kinetic properties ensure that ALDHs, and particularly ALDH2, can complete the ADH-mediated detoxification.
- ALDH2 and ADH1B polymorphisms were associated with changes in blood catecholamine levels and cardiovascular measures after alcohol ingestion.
- Polymorphisms of the ADH2 and ALDH2 genes are significantly associated with colorectal cancer risk in Chinese males
- Calcitonin gene-related peptide is associated with the cardiovascular effect of glyceryl trinitrate through an ALDH2-dependent pathway.
- genetic variation in the ALDH2 gene can influence HDL-C levels, independent of alcohol consumption
- Tha ALDH2 5'-UTR G allele was associated with binge drinking in a Caucasian population sample
- ALDH2-catalyzed GTN reduction was partly inactivated by preincubation with GTN, suggesting that the inactivation of GTN reduction is also partly irreversible.
- genetic polymorphisms for NQO1, CYP2E1, and ALDH2 synergistically with cumulative smoking amounts and alcohol drinking levels interact in the carcinogenesis of lung cancer in Koreans.
- ALDH2 variation was not associated with flushing or alcohol consumption, but was weakly associated with Alcohol dependence.
- Current data lend support to a role of polymorphisms ADH1B and ALDH2 combined with alcohol consumption