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Validated All-in-One™ qPCR Primer for ADRB3(NM_000025.3) Search again
Product ID:
HQP149374
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BETA3AR
Gene Description:
adrenoceptor beta 3
Target Gene Accession:
NM_000025.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins.
Gene References into function
- lipid mobilizing factor induces lipolysis through binding to a beta3-adrenoceptor
- the cAMP response of W64R-beta3AR can be enhanced under the particular condition that adenylyl cyclase type III was coexpressed
- obese postmenopausal women who carry the Trp64Arg variant in the beta(3)-adrenoceptor had similar changes in body composition and energy expenditure to noncarriers of the variant in response to prolonged caloric restriction
- polymorphism found to be associated with exercise-mediated improvement in glucose tolerance and leptin resistance in healthy Japanese men
- The frequency of Trp64Arg mutation of beta(3)-AR gene was higher in the male subjects with MS than those with simple obesity and non-obese controls
- genetic variants in the gene appear not to have a major role as modifier genes in familial combined hyperlipidemia
- findings suggest that the Trp64Arg variant in the beta3-adrenergic receptor gene may be associated with reducing LDL particle size, probably due to insulin resistance
- beta3-adrenergic receptors play a role in proliferation and migration of cultured human retinal endothelial cells.
- results suggest that the Arginine-64 beta(3)-adrenoceptor allele contributes significantly to the genetic variability in both resting metabolic rate and thermic effect of feeding
- Amino acid substistution is not associated with insulin resistance phenotype.
- Arg64/arg64 beta(3)-AR polymorphism may contribute to increased triglycerides and very low-density lipoprotein cholesterol in rheumatoid arthritis patients, independently of chloroquine treatment.
- b3-AR 64Arg polymorphisms have a protective effect against metabolic disorders in obese families from southern Poland.
- ADRB3 polymorphism is not associated with a risk of endometrial neoplasms.
- genotypes of aldehyde dehydrogenase 2 and beta3-adrenergic receptor were strongly associated with elevated alanine aminotransferase level which increased with the accumulation of components of metabolic syndrome
- The Trp(64)Arg mutation of ADRB3 has little or no influence on either body weight or body mass index in the general Japanese population.
- altitude-related lifestyle of a population has had little influence on the frequency of Trp64Arg polymorphism and obesity in Bolivian natives
- beta3-AR genotype does not appear to be associated with any maximal or submaximal exercise CV hemodynamic responses in postmenopausal women.
- the Trp64Arg variant of the beta3-adrenergic receptor gene may have a role in the central adiposity gain in a metabolic syndrome
- beta(3) adrenergic receptor (ADRB3) R64 allele was associated with increased body weight and body mass index in men but not in women
- polymorphic in metabolic syndrome phenotype in brazil
- The Trp64Arg polymorphism of the beta(3)-receptor does not predispose to preeclampsia, and it is it not associated with obesity and carbohydrate intolerance in a population of young pregnant women.
- hetero-oligomerization between beta(2)AR and beta(3)AR forms a beta-adrenergic signaling unit that possesses unique functional properties
- body fat response to exercise training in older adults is associated with the combined effects of the Glu12/Glu9 alpha2b-adrenergic receptor, Trp64Arg beta3-adrenergic receptor, and Gln27Glu beta2-adrenergic receptor gene variants
- Beta3-adrenoceptors are expressed in the endothelium of human coronary resistance arteries and mediate adrenergic vasodilatation through both NO and vessel hyperpolarization.
- the ADRB3 Trp64Arg variant is not related to the development of gestational diabetes mellitus and has no effect on obesity during pregnancy in a Taiwanese population
- the ADRB2 Arg(16)-Gly genotype influences total cholesterol and LDL-C levels in an age-specific manner, that it may interact with beta(3)-adrenergic receptor Trp(64)-Arg genotypes
- results suggest that the combination of cholecystokinin 1 receptor (CCK1R) and the beta3-adrenergic receptor (beta3-AR) polymorphisms is a contributing factor for midlife weight gain in men
- Polymorphisms in beta3-adrenergic receptor is associated with Type 2 Diabetes Mellitus
- the Trp64Arg beta3-AR gene polymorphism may contribute to insulin resistance associated with reduced fetal growth.
- The beta(3)-AR Trp64Arg polymorphism might have an impact on the mechanisms involved in leptin release from adipose tissue.
- beta3-adrenoceptor (beta3-AR) stimulation regulates the activity of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.
- predominant role for beta(3)-AR in the regulation of human myometrium contractility, especially at the end of pregnancy
- study does not confirm the influence of Trp64Arg mutation in heterozygous carriers on insulin resistance
- the Arg allele of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene may contribute to the susceptibility to endometrial cancer among obese/overweight individuals
- Both newly detected TSC C1784T and ADRB3 T727C are gene polymorphisms susceptible to the antihypertensive effect of thiazides in patients with essential hypertension
- evidence for an interaction between the beta1- and beta2-adrenergic receptors was observed in men for longitudinal change in body mass index and women showed suggestive evidence for an interaction between
- beta3-adrenergic receptor Trp64Arg polymorphism is linked to BP elevation
- beta3 adrenoceptor activation exerts inhibitory effect on human fibroblast DNA synthesis as a result of the activation of nitric oxide-cyclic GMP pathway and the inhibition of adenylate cyclase activity.
- results suggest no association between Trp64Arg polymorphism of the beta3-AR gene and the incidence of overweight and type 2 diabetes mellitus in Polish population
- A variant in ADRB3 influences diabetes risk in an Mexican American family and supports a role for alterations of the beta3-adrenergic receptor in the pathogenesis of type 2 diabetes.
- The ADRB3 gene does not seem to exert an important role in excessive fat accumulation in Brazilians of European descent.
- Finds that the Trp64Arg polymorphism in the beta3-AR gene does not represent an independent risk factor for coronary artery disease in Arabs but may be used as a predictor of coronary artery disease when other risk factors are present.
- ADRB3 gene polymorphisms do not associate with obesity.
- Trp64Arg polymorphism of the beta-3 adrenergic receptor may be independently associated with hyperuricemia in males.
- The wild-type allele of the ADRB3 missense change was associated with measures of obesity in our sample of African-American women
- ADRB3 polymorphism was significantly related to insulin resistance only in male subjects; moreover, increased BMI was related to age in obese subjects with the ADRB3 polymorphism.
- no relationship between ADRB3 polymorphism and metabolic syndrome in Shiga, Japan
- The findings demonstrate that the Arg64 allele of the beta3-adrenoceptor polymorphisms relates to weight gain-induced BP elevation accompanying high plasma norepinephrine in obese men.
- beta3-AR Trp64Arg and beta2-AR Gln27Glu genetic polymorphisms are associated with obesity in Chinese male hypertensive patients
- The Trp64Arg variation in the beta-3 adrenergic receptor has no relationship to the degree or incidence of childhood obesity.
- Results describe the effects of polymorphisms in the genes encoding microsome triglycerides transfer protein (MTP) and beta3-adrenergic receptor (beta3-AR) on lipid and glucose metabolism.
- Polymorphisms within the Beta-3 Adrenergic Receptor gene are associated with insulin resistance and obesity.
- the arginine 64 allele of the beta(3)-adrenergic receptor gene does not increase the risk of obstructive sleep apnoea syndrome, but is associated with the development of obesity in those patients who suffer obstructive sleep apnoea syndrome
- demonstration of expression of beta(3)-AR in the enteric nervous system
- The ADRB3 Trp64Arg polymorphism is associated with gallstone disease.
- Trp64Arg polymorphism of (beta3-adrenergic receptor) ADRB3 is related to obesity in postmenopausal and has no influence on oxidative stress intensification after standardized physical effort.
- These data show that the presence of the Arg64 allele at the beta3-adenoceptor gene locus is related to increase in leptin level in this population, but is not related to body mass index.
- ADRB3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis.
- Polymorphism of the beta-3 adrenergic receptor plays a role in the genetic predisposition to increased small dense low-density lipoprotein.
- beta3-AR are upregulated during sepsis in the human myocardium and by cytokines in murine cardiomyocytes, where they mediate an increased negative inotropic response to beta3 agonists.
- Our study in combination with a meta-analysis of previous reports do not provide support for a role of missense mutation replacing tryptophan with arginine at codon 64 (Trp64Arg) at the human ADRB3 gene in CHD risk.
- The Trp64Arg polymorphism of beta3-adrenergic receptor was not associated with obesity. However, the Arg-allele was associated with a slightly increased risk of type 2 diabetes
- There was no significant difference in the genotype frequency of the beta3-AR p.W64R and the LEP c.-2548G>A polymorphisms, between lean and obese subjects.
- These results confirm the presence of beta1-, beta2-, and beta3-adrenoceptors in human urinary bladder urothelium; they suggest that urothelial beta-adrenoceptors induce the release of a urothelium-derived factor muscle
- Trp64Arg polymorphism of the beta(3)-adrenergic receptor gene is not related to metabolic syndrome in postmenopausal Polish women but seems to be associated with decreased high density lipoprotein-cholesterol levels
- The presence of the Glu27 polymorphisms of the ADRB2 genes are not directly related to indices of the metabolic syndrome in blach South African women.
- Trp64Arg polymorphism of beta3-adrenergic receptor is not associated with obesity
- the genotypes of beta(3)-AR Trp64Arg polymorphism might be not associated with caffeine-induced increases in energy expenditure levels
- Findings suggested a role of the beta(3)-adrenergic receptor gene polymorphism in regulating lipid and lipoprotein metabolism.
- Aberrations in the beta-adrenoceptor signalling systems, rather than in the regulation of expression of these receptors may occur in preeclampsia
- In healthy pregnant women the relationship between Trp64Arg polymorphism of ADRB3 receptor and body gain has been suggested
- data suggest that the Trp64Arg ADRB3 genetic variant might be associated with BMI in East Asians, but not Europeans.
- The patients of the mutant group (Trp64/Arg64) had higher body mass index, weight, waist circumference, fat mass, waist-to-hip ratio, and C-reactive protein values than those of the wild-type group
- beta3-ARs are positively coupled to L-type Ca2+ channels and contractility in human atrial tissues through a cAMP-dependent pathway
- bladder relaxation in man is mediated exclusively via beta(3)-AR.
- Upregulation of beta3-adrenergic receptor mRNA is associated with colon cancer.
- presence of the Trp64Arg variant of the beta(3)-adrenergic receptor gene may not play a major role as a hindrance to weight reduction.
- Data show that presurgical morbidly obese patients with a mutant beta3 adrenoceptor gene have a poorer inflammatory profile, lipid profile and fat distribution than wild-type group.
- Four genetic variants, the 102T allele of HTR2A, the 825T allele of GNB3, the 23Cys allele of HTR2C, and the 64Arg/Arg genotype of ADRB3, were significantly associated with olanzapine-induced weight gain.