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Validated All-in-One™ qPCR Primer for CSF1(NM_172212.3) Search again
Product ID:
HQP148848
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CSF-1, MCSF, PG-M-CSF
Gene Description:
colony stimulating factor 1
Target Gene Accession:
NM_172212.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors.
Gene References into function
- Macrophage colony-stimulating factor and receptor activator NF-kappaB ligand fail to rescue osteoclast-poor human malignant infantile osteopetrosis in vitro.
- High M-CSF levels may correlate with cellular or organ damage in patients treated with peripheral blood stem cell transplantation for hematologic diseases.
- Opposite effects of different doses of MCSF on ERK phosphorylation and cell proliferation in macrophages.
- CSF-1 and its receptor are regulated by 1,25(OH)(2)D(3) and its analogue tacalcitol in human monocytes which parallels the inhibition of differentiation into dendritic cells without altering survival
- IFN-gamma shifts monocyte differentiation to macrophages rather than DCs through autocrine M-CSF and IL-6 production.
- in human tumor cells, HGF and M-CSF stimulate osteopontin production (which is subsequently used as a substrate for cell adhesion)
- Time-dependent folding events reveal that recombinant MCSF beta molecules pass through both monomeric and dimeric intermediate states, suggesting that the denatured and dimeric bond-reduced protein folds via multiple pathways.
- macrophage colony-stimulating factor increased platelet-activating factor acetylhydrolase secretion by decidual macrophages
- Results suggest that macrophage colony-stimulating factor may autoregulate functional cellular subpopulations of human endometrial stromal cells in an autocrine or a paracrine manner.
- findings directly support the conclusion that membrane-bound colony stimulating factor-1 is functionally active in bone in vivo
- Serum VEGF concentration was increased in arteriosclerosis obliterans (ASO) and thromboangitis obliterans, but increased concentration of M-CSF was seen only in ASO.
- CSF1 has a role in regulating macrophage activation [review]
- Monocytes promote angiogenesis via M-CSF-induced vascular endothelial growth factor production.
- sCSF-1 is a key determinant of bone cell activity in the corticoendosteal envelope
- increased levels of serum macrophage colony stimulating factor markedly precede the development of clinical manifestations of preeclampsia
- Increase in serum M-CSF levels precedes development of preeclampsia. Elevation of serum M-CSF supports M-CSF elevation in placenta. This elevation at 18 weeks of gestation may be related to placental hypoxia, considered cause of preeclampsia.
- findings of co-expression of KIT and/or FMS with their respective ligands implies these receptors might contribute to leukemogenesis in some patients with AML through autocrine, paracrine, or intracrine interactive stimulation.
- The serum M-CSF concentration could be of interest as a tumor marker in squamous cell carcinomas of the head and neck.
- red blood cells from diabetic patients induced an increase in MCSF and VCAM1 expression in HUVEC cells, mediated by AGE-RAGE interaction
- Expreeeion of macrophage colony-stimulating factor in human osteoblast-like cells is suppressed by arginine-vasopressin.
- results suggest that nuclear actin plays a role in regulating CSF-1 gene transcription, and this role does not depend on actin polymerization
- In vitro human osteoclastogenesis is dependent on M-CSF and the stimulatory effects of GM-CSF are mediated by M-CSF.
- Crystal structures of HLA-B*3501 in complex with 14-mer macrophage-colony stimulating factor peptide reveal that the antigenic peptide follows the general rules of major histocompatibility complex binding.
- The MGFS mRNA expression in these cell lines and recent studies have demonstrated that HCs can stimulate tumor progression.
- Interferon-gamma stimulates transcription of the CSF-1 gene through this sequence, which binds STAT1
- A significant serum tumor marker in head and neck squamous cell carcinoma.
- Serum M-CSF levels are markedly increased in Langerhans cell histiocytosis patients who, in addition to bone disease, also show skin or lymph node involvement.
- indicate novel roles of M-CSF in articular cartilage metabolism in collaboration with CTGF/CCN2, particularly during an inflammatory response
- The M-CSF gene was cloned into baculovirus transfer vector pVL1392 under the control of polyhedrin promoter and expressed in the Sf9 cells (Spodoptera frugiperda).
- Uncreased macrophage colony stimulating factor is associated with the process of atherosclerosis in hemodialysis patients
- M-CSF enhances tumor growth in mice by increasing endothelial progenitor cells and activating angiogenesis; the effects of M-CSF are largely based on the induction of systemic VEGF from skeletal muscles.
- catalase has a critical role in CSF-independent survival of human macrophages via regulation of the expression of BCL-2 and BCL-XL
- INI1/hSNF5/BAF47 functions in activation of the colony stimulating factor 1 (CSF1) promoter in HeLa cells.
- MCP-1 and M-CSF, critical for monocyte recruitment, activation, and differentiation, differentially regulate VEGF-A expression and may play an important role in monocyte/macrophage- mediated tumor angiogenesis
- Nurse-like cells are involved in rheumatoid arthritis-induced bone destruction by maintaining osteoclast precursors via production of M-CSF.
- Fusion with COL6A3 overexpresses CSF1, found in some but not all cells in tenosynovial giant-cell tumor and pigmented villonodular synovitis.
- at 35 and 38 weeks, the Macrophage colony-stimulating factor (M-CSF) levels were significantly higher in twin pregnancy than in singleton pregnancy
- three polymorphisms located in the colony stimulating factor 1 (CSF1) gene showed a positive association with aggressive periodontitis
- IL-10 may contribute to the inflammatory process by facilitating monocyte differentiation into TNF-alpha-responsive macrophages in the presence of M-CSF in rheumatoid arthritis.
- Different individual CSF-1 isoforms regulate the frequency of activated macrophages in the kidney during experimental unilateral ureteral obstruction.
- CSF1 is involved in regulating macrophage trafficking at the fetal-maternal interface
- These data do not support the hypothesis that genetic variability of CSF1 influences the risk for Alzheimer's disease (AD).
- significantly higher levels of macrophage-colony stimulating factor is associated with pancreatic cancer
- Significantly higher macrophage-colony stimulating factor level is associated with lymph node metastasis in colorectal cancer patients
- a combination of the Src family kinase, phosphatidylinositol 3-kinase/Akt, phospholipase C, and ERK pathways mediates macrophage proliferation in response to M-CSF
- macrophage colony-stimulating factor(M-CSF) contributes to the pathogenesis of pulmonary fibrosis in patients with IPF through the involvement of mononuclear phagocytes and CCL2 production.
- Increased and prolonged ERK activation led to M-CSF-mediated macrophage differentiation but not to proliferation.
- M-CSF modulates osteoclast-resorbing activity, but is not required for cell survival
- We have shown for the first time that a homeobox gene, HLX1, is a downstream effector gene of CSF-1, that HLX1 regulates placental cell proliferation and that CSF-1 acts, at least in part, through HLX1 to control cell proliferation.
- Monocytopoiesis is controlled by a circuitry involving sequentially miRNA 17-5p-20a-106a, AML1 and M-CSFR, whereby miRNA 17-5p-20a-106a function as a master gene complex interlinked with AML1 in a mutual negative feedback loop.
- M-CSF-driven generation of plasmacytoid dendritic cells and conventional dendritic cells in vitro and in vivo was independent of endogenous Flt-3 ligand
- Csf1 fusion with collagen type VI alpha-3 gene is associated with tenosynovial giant cell tumors.
- Human cardiac cells constitutively express M-CSF and its expression is up-regulated by TNF-alpha.
- CSF-1 and TPA use independent pathways to initiate RIPping, and that the intracellular domain is targeted for degradation through ubiquitination
- Differential constitutive and cytokine-modulated expression of Toll-like receptors in primary neutrophils, monocytes, and macrophages is reported.
- CSF-1 stimulates extracellular signal-regulated kinase 5 (ERK5) activation in macrophages.
- Peripheral blood mononuclear cells (PBMCs) from periodontitis patients do not need priming by M-CSF to become osteoclast-like cells, suggesting that PBMCs from periodontitis patients are present in the circulation in a different state of activity.
- Expression of M-CSF, CSF-1R and CD3 is a significant prognostic factor in primary prostatic cancers by predicting the development of metastases.
- nuclear c-Abl kinase can activate CSF-1 gene transcription by regulating AP-1 activity in the signaling events induced by L-selectin ligation.
- mM-CSF may be a critical linker between macrophages and malignant cells in the development of hematopoietic malignancies
- CCL23, M-CSF, TNFRSF9, TNF-alpha, and CXCL13 are predictive of rheumatoid arthritis disease activity and may be useful in the definition of disease subphenotypes and in the measurement of response to therapy in clinical studies.
- CSF1, EGFR, and CA IX have roles in increasing survival in early-stage squamous cell carcinoma of the lung
- GAPDH, a multifunctional protein, now adds regulation of mRNA stability to its repertoire.
- Report clinical use of colony-stimulating factor-1 in ovulation induction for poor responders.
- These results suggest that orthodontic tooth movement causes an increase in VEGF and M-CSF levels, which may induce bone remodeling via osteoclastic bone resorption.
- ability of M-CSF to recruit mononuclear phagocytes, increase VEGF levels, and enhance angiogenesis
- CSF-1 represents a further link between inflammation and cardiovascular disease.
- CRP up-regulates M-CSF release from human monocyte-derived macrophages and human aortic endothelial cells and increased macrophage proliferation.
- Calorimetric data indicate that M-CSF cannot dimerize FMS without receptor-receptor interactions mediated by FMS domains D4 and D5