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Validated All-in-One™ qPCR Primer for TAS1R3(NM_152228.3) Search again
Product ID:
HQP148813
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
T1R3
Gene Description:
taste 1 receptor member 3
Target Gene Accession:
NM_152228.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners.[supplied by OMIM].
Gene References into function
- sequence differences in T1R receptors within and between species (human and mouse) can significantly influence the selectivity and specificity of taste responses
- The mechanism of interaction of the sweet protein monellin with T1R2-T1R3 receptor.
- cysteine-rich region of T1R3 has a role in determining responses to intensely sweet proteins
- findings demonstrate the different functional roles of T1R3 and T1R2 and the presence of multiple ligand binding sites on the sweet taste receptor
- An immunohistochemistry study to determine whether and where T1R3 may be localized in the liver and pancreas.
- transmembrane domains of human T1R3 bind with lactisole to inhibit sweet taste
- water rinses remove the inhibitor from the heteromeric sweetener receptor TAS1R2-TAS1R3, which activates cells and results in the perception of strong sweetness from pure water
- Although T1R2-T1R3 is known to have multiple potential ligand-binding sites to receive a wide variety of sweeteners, the present study is apparently the first to identify the ATD of hT1R3 as a new sweetener-binding region.
- These results show that T1R2 and T1R3 receptors, in addition to their role in taste perception, may also have a role in intrahepatic cholangiocytes.
- Some of the amino acid positions crucial for activation of hTAS1R2+hTAS1R3 by neohesperidin dihydrochalcone are involved in the binding of allosteric modulators in other class C GPCRs
- Expressed in the sweet/umami gustatory pathways in taste receptor cells and trigeminal neural pathways in transgenic mice.