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Validated All-in-One™ qPCR Primer for DDC(NM_001082971.2) Search again
Product ID:
HQP147286
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
AADC
Gene Description:
dopa decarboxylase
Target Gene Accession:
NM_001082971.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Gene References into function
- gene promoter directs transgene expression to the adult floor plate and aminergic nuclei induced by the isthmus.
- findings suggest that the DDC gene is unlikely to play a major role in the development of autism in our data set
- Results do not support an involvement of the 1-bp or 4-bp deletion within the DDC gene in the etiology of affective disorders.
- DDC might confer susceptibility to bipolar affective disorder predominantly when paternally transmitted
- This enzyme is cloned from and expressed in placenta.
- We report three siblings who showed the clinical phenotype to be caused by aromatic L-amino acid decarboxylase deficiency. Molecular characterization showed a homozygous point mutation (c.387 G-->A) in exon 3.
- Polymorphisms studied do not play a major role in paranoid schizophrenia pathogenesis in the population investigated.
- dopamine decarboxylase mRNA in neuroblastoma patients could be a potential marker for minimal residual disease
- Detection of a new alternative splicing event within the coding region of the human dopa decarboxylase (DDC) mRNA, suggests that the single copy human DDC gene undergoes complex processing leading to the formation of multiple mRNA isoforms.
- Single nucleotide polymorphisms in the dopa decarboxylase gene is associated with nicotine dependence
- Immunohistochemical detection of DOPA decarboxylase shows diffuse staining of Langerhans islets in congenital hyperinsulinism.
- association of alleles and haplotypes at the DOPA decarboxylase (DDC) locus with the DSM-IV diagnosis of nicotine dependence
- Association of the DOPA decarboxylase (DDC) gene on chromosome 7p11 with measures of nicotine dependence.
- Autoantibodies to the COOH-terminal region induce a significant inhibition of enzymatic activity.
- Expands clinical spectrum of AADC deficiency and contributes to the knowledge of the genotype and phenotype correlation for the DDC gene.
- study does not support the involvement of tyrosine hydroxylase gene variants as major contributors to suicide, whereas dopa decarboxylase variants could mediate some features related to suicide and be involved in violent suicidal behavior
- analysis of Ddc redefines the imprinted Grb10 domain on mouse proximal chromosome 11 and identifies Ddc_exon1a as the first example of a heart-specific imprinted gene
- These data reveal the potential of DDC expression, at the mRNA level, as a novel biomarker in prostate cancer.
- Hhigh expression of DDC both in peripheral blood and bone marrow corresponds to metastatic neuroblastoma at diagnosis, residual disease, and poor outcome.
- The expression of enzymatically active DDC in human leukocytes could indicate a cross-talk between the nervous and the immune systems and raises new questions about the regulatory role of DDC in immune responses.