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Validated All-in-One™ qPCR Primer for HNRNPL(NM_001533.3) Search again
Product ID:
HQP130568
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HNRPL, P/OKcl.14, hnRNP-L
Gene Description:
heterogeneous nuclear ribonucleoprotein L
Target Gene Accession:
NM_001533.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes.
Gene References into function
- AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter
- HnRNP L may be involved in the regulation of many other genes containing CA repeats or A/C-rich enhancers.
- hnRNP L plays roles in enhancing stability, polyadenylation, and nucleocytoplasmic export; it does so by directly recruiting to intronless pre-mRNA processing enhancer (PPE) element-containing RNAs cofactors normally recruited to intron-containing RNAs.
- 11 target genes of hnRNP L were describes.
- This study determined that hnRNP L interacts specifically with the hnRNP D/AUF1 in the yeast two-hybrid system.
- hnRNP L is an essential component of CaMKIV-regulated alternative splicing through CA repeats, with its phosphorylation likely playing a critical role.
- These results strongly demonstrate the functional requirement of cellular hnRNP L for the HCV internal ribosome entry site activity.