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Validated All-in-One™ qPCR Primer for TK1(NM_003258.5) Search again
Product ID:
HQP130517
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
TK2
Gene Description:
thymidine kinase 1
Target Gene Accession:
NM_003258.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- TK1 gene expression together with TS, TP and DPD gene expression may play important roles in influencing the malignant behavior of epithelial ovarian cancer.
- Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer
- Long-term treatment of H9 human lymphoid cells in the presence of dideoxycytidine down-regulated TK1 gene expression and reduced the expression and activity of TK in resistant cells.
- the enzymatic function at the G2/M phase of TK1 depends on its quaternary structure
- activation of the APC/C-Cdh1 complex during mitotic exit controls timing of TK1 destruction
- Activity of thymidine kinase, thymidine phosphorylase and thymidilate synthase in human cancer xenografts to investigate the contribution of these enzymes to the sensitivity of TAS-102.
- The importance of valine 106 for the structure and function of TK1.
- activation of TK1 may be critical to modulate the radiation-induced cell death and cell cycle progression in irradiated K562 cells.
- analysis and comparison of human and mycoplasmic thymidine kinase 1
- crystal structure of thymidine kinase 1
- TK1 expression is apparently a reliable marker in patients with non-small cell lung cancer.
- an increased expression of mRNA, specific for TK1, deoxycytidine kinase, and thymidine phosphorylase, may be involved in carcinogenic processes in the human thyroid
- an increase in activity of dCK, TK1 and 2 might be involved in an adaptive response of cultured human squamous lung carcinoma cells to radiation by facilitation of DNA repair
- analysis of the role of C-terminal 20, 40, and 44 amino acids of TK1 in in vitro stability, oligomerization, and enzyme kinetics
- thymidine is not only a substrate of TK1 but also acts as its expression regulator by modulating its proteolytic control during mitotic exit, conferring a feed-forward regulation of dTTP formation
- The structures of hTK1 and of the Thermotoga maritima thymidine kinase (TmTK) in complex with the bisubstrate inhibitor TP4A, is reported.
- Clinical-grade preparation of regulatory T-cells encoding the TK1 suicide gene as a safety gene is reported.
- TK1 concentration was found to have a pivotal effect on catalytic efficiency