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Validated All-in-One™ qPCR Primer for TSPY1(NM_003308.4) Search again
Product ID:
HQP110877
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CT78, DYS14, TSPY, pJA923
Gene Description:
testis specific protein Y-linked 1
Target Gene Accession:
NM_003308.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- TSPY has been proposed as the gene for the gonadoblastoma locus on the Y chromosome (GBY), and postulated to play certain role in gonadoblastoma, testicular and prostate cancers.
- As a candidate gene for the gonadoblastoma locus on the Y chromosome (GBY), it has been demonstrated to be expressed at high levels in tumor germ cells of this types of tumors and testicular seminomas.
- A transgenic mouse line, TgTSPY9, harboring a complete structural human TSPY gene was generated and the human TSPY gene integrated into the mouse genome follows the human expression pattern.
- Variant forms of TSPY transcripts are detected in human testis and prostate normal and cancer samples. They encode slightly polymorphic proteins harboring the SET/NAP conserved domain.
- A daughter who carried the der Y had the clinical features of Prader-Willi syndrome while a son who carries the der 15 has mild developmental delay and hypogonadism.
- Nested PCR revealed the testis specific protein 1-Y-linked (TSPY) gene in two women with Mayer-Rokitansky-Kuster-Hauser syndrome
- the TSPYL gene in SIDDT affected individuals contained a homozygous frameshift mutation resulting in truncation of translation at codon 169. Truncation leads to loss of a peptide domain with strong homology to the nucleosome assembly protein family.
- TSPY has been used as a marker for identifying germ cells at risk for neoplastic transformation in gonadoblastoma and testicular germ cell tumors.
- TSPY promoter is capable of directing a reporter gene expression in male and female germ cells and neurons of transgenic mice.
- testis-specific expression of human TSPY is mediated by Sox proteins
- phosphorylation of the (T300) residue is dependent on CK2 and is a necessary and functional prerequisite for TSPY's transport into the nucleus
- TSPY is expressed in germ cell tumors in the brains of male patients.
- The most prominent observation on prostate cancer specimens was a deletion at Yp11.2 containing the TSPY tandem gene array. Out of 36 primary prostate tumors analyzed, 16 (44.4%) samples exhibited loss of TSPY gene copies.
- Ectopic TSPY expression potentiates cell proliferation by mediating a rapid G2/M transition of the cell cycle and promotes tumor growth in nude mice
- TSPY up-regulates pro-growth genes and down-regulates cell cycle inhibitors and apoptotic factors, revealed by microarray analysis.
- data, taken together, have provided important insights on the probable functions of TSPY in cell cycle progression, cell proliferation, and tumorigenesis
- rat Tspy may play critical roles as a histone chaperone during maturation of the elongating spermatids in the rat testis
- The earliest Y signal DYS14 was at 14 days post conceeption.
- possible effect of the copy number of TSPY genes on spermatogenesis
- TSPY, in combination with other markers, could be an important marker for diagnosis and subclassification of testicular germ cell tumors (TGCTs) and support its role in the pathogenesis of both gonadoblastoma and TGCTs.
- Patients with complete Sertoli cell-only syndrome (SCOS) did not exhibit TSPY gene expression.
- TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities.
- TSPY could exert its oncogenic function(s) by interacting with eEF1As and stimulating gene expression via its enhancements in protein synthesis and gene transcription