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Validated All-in-One™ qPCR Primer for BMP4(NM_001347916.1) Search again
Product ID:
HQP109818
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
Gene Description:
bone morphogenetic protein 4
Target Gene Accession:
NM_001347916.1(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
Gene References into function
- The expression signals of BMP-4 mRNA in malignant schwannoma were relatively lower than in benign lesions
- BMP4 reached criteria of suggestive evidence of linkage in candidate genes of ossification of the posterior longitudinal ligament of the spine.
- Bmp-4 only activates Dkk-1 when it concomitantly induces apoptosis. Implanted recombinant human Bmp-4 beads abolish Dkk-1 transcription in chick limb buds and mouse embryo cells.
- Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells.
- Dissection of promoter control modules that direct Bmp4 expression in the epithelium-derived components of hair follicles.
- directs Smad5 activation in human hematopoietic cells, resulting in significantly increased proliferation of erythroid progenitors and formation of glycophorin-A+ cells.
- Transgenic expression of human Bmp4 driven by the mouse Msx1 promoter in the Msx1(-/-) palatal mesenchyme rescued the cleft palate phenotype and neonatal lethality
- Data show that VEGF plays a role in bone formation elicited by bone morphogenetic protein 4, and can significantly enhance BMP4-elicited bone formation and regeneration.
- Mutations act together with other gene variants in unlinked loci as susceptibility factors in spina bifida.
- demonstrated that the enhancement of expression of mRNA of BMP-4 by phosphate depletion mediates alkaline phosphatase induction in cultured mouse marrow stromal cell line ST2
- BMP2 and BMP4 differently affect activin A induction of erythropoiesis
- trans-activation by GATA-4 and GATA-6
- evidence for the role of cytokines and BMP-4 in promoting hematopoietic differentiation of embryonic stem cells
- BMP4 is a mechanosensitive, inflammatory factor playing a critical role in early steps of atherogenesis in the lesion-prone areas.
- data demonstrate the existence and putative function of bone morphogenetic protein 4 signaling in normal ovarian surface epithelium and ovarian cancer cells
- Deletion mutants of BMP folding variants are a new form of BMP antagonists and act through competition with osteoinductive BMP for BMP receptor binding.
- BMP2 or 4 in pilomatricoma is responsible for induction of proalpha(1)(II) collagen mRNA in overlying epidermal cells resulting in deposition of type II collagen in dermo-epidermal junction.
- biglycan modulates BMP-4-induced signaling to control osteoblast differentiation
- results revealed a novel potent effect of PTH and vitamin D(3) plus BMPs in inducing bone development by human mesenchymal stem cells
- BMP4 produced in ECs by oscillatory shear sress stimulates ROS release from the nox1-dependent NADPH oxidase leading to inflammation, a critical early atherogenic step.
- BMP-4 increases the levels of osteopontin, BMP-2, alkaline phosphatase and core binding factor alpha 1 mRNAs in human periodontal (HPL) ligament cells.
- Antiproliferative and prodifferentiation effects of BMP4 were Smad1 dependent with JNK also contributing to differentiation.
- the role of BMP family members in the control of ovarian folliculogenesis
- A polymorphism found in the BMP4 gene, affecting amino acid sequence, is associated with hip bone density in postmenopausal women, presumably via regulation of anabolic effects on the skeleton.
- To analyze the expression of bone morphogenetic proteins (BMPs) in prostate and breast cancers with established metastasis in bone
- BMPs influence the formation of the osteolytic prostate cancer metastases, and treatment modalities that inhibit BMP activity may limit the progression of the lytic component of prostate cancer metastases.
- Retinoic acid induces both BMP-4 transcription and expression and its antiproliferative action in pituitary adenoma
- OAZ can alter the intensity and duration of the BMP4 stimulus through Smad6
- BMP-4 may play a role in the regulation of ocular angiogenesis associated with diabetic retinopathy (DR) by stimulating vascular endothelial growth factor release from retinal pigment epithelial cells
- BMP-4 is expressed in normal synovial tissue and was decreased in osteoarthritis and rheumatoid arthritis.
- Topical and differential expression of BMP-2/4 and BMP-7 mRNA and protein was found in bursa tissue.
- Recombinant human BMP4 infusion caused hypertension in mice in a vascular NADPH-oxidase-dependent manner. BMP4 is a novel mediator of endothelial dysfunction and hypertension.
- GREMLIN 1 was expressed in the stroma of human basal cell carcinoma (BCC) tumors but not in normal skin in vivo. Bone morphogenetic protein (BMP) 2 and 4 are expressed by BCC cells.
- BMP4 and Gremlin are regulators of myogenic progenitor proliferation.
- The finding that BMP-4 subverts the ability of mammary epithelial cells to form polarized lumen-containing structures and endows them with invasive properties supports the involvement of this cytokine in the progression of breast cancer.
- BMP4 is a key growth factor for maintenance of hematopoietic stem cells and contributes to the properties of stromal culture.
- the BMP1 prodomain specifically binds and regulates signaling by BMP2 and BMP4
- strong BMP staining is seen in maturing chondrocytes, and thus may play a role in chondrocyte differentiation and/or apoptosis; BMP release by osteoclasts may promote osteoblastic differentiation at sites of bone remodeling
- A link between autocrine BMP4 signalling mediated through the Rho GTPase family may collectively contribute to aggressive ovarian cancer behavior.
- These results indicate that BMP-4 confers invasive phenotype during progression of colon cancer.
- Association with autosomal recessive DOOR syndrome not found.
- These data support a model in which TNF-alpha-induced RelA interacts with SP1 to bring about transcriptional repression of Bmp4 gene.
- treatment of normal human colonocytes with lambdaCGN activated the Wnt/beta-Catenin cascade and suppressed the expression and secretion of BMP4
- RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and that increased utilization of ActRIIA leads to generation of an enhanced BMP signal
- BMP4 induces epithelial-mesenchymal transition through MSX2 induction on pancreatic cancer cell line.
- Distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis.
- BMP pathway could play a role in the transformation of normal esophageal squamous cells into columnar cells.
- Expression of BMP-4 and BMP-7 and their receptors in human ovaries from fetuses as well as adults.
- BMP-4 can protect colon cancer cells from heat-induced apoptosis through enhancing the activation of ERK as well as inhibiting the activation of JNK.
- Expression analysis of additional genes, AKT1, NOG and its antagonist BMP4, which interact downstream to FGFR1, demonstrated expression differences between primary rhabdomyosarcoma tumors and normal skeletal muscles
- Endothelial cells coexpress BMP4 antagonists along with BMP4 to minimize the inflammatory response to oscillatory shear stress.
- interactive effect on serum ferritin level of rs235756 in BMP2 and a SNP in HJV, with a small additive effect of a SNP in BMP4
- ERK1/2 functions as an alternative pathway in BMP-4 signaling in human umbilical vein endothelial cells. Capillary sprouting induced by BMP-4 is dependent on ERK phosphorylation.
- SHED cells transmitted BMP signals through both the SMAD and p38 mitogen-activated protein kinase (MAPK) pathways and responded to BMP4 treatment by inducing BMP responsive genes
- A BMP4/growth differentiation factor 5 (GDF5) selective binding protein exists in human pulmonary artery smooth muscle cells.
- polymorphisms in the BMP2 and BMP4 genes, both members of the TGF-beta superfamily, contribute to the susceptibility to otosclerosis and further strengthen the results from the recently reported association of TGFB1 with this disease
- BMP-7 but not BMP-2 and BMP-4 prevents the loss of primitive hematopoietic progenitor cells cultured in SFM plus SF3.
- Mutations in BMP4,are infrequently found in patients with congenital cardiac septal defects
- Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways.
- neural precursor cell ultrasensitivity is evident at the population and single-cell levels based on Msx1 induction when exposed to Bmp4
- Defects in these proteins could affect kidney development at multiple stages, leading to the congenital anomalies observed in patients with renal hypodysplasia
- These results reveal a key role of GLI2 in activation of the activin/BMP antagonist FST in response to hedgehog (HH) signaling.
- BMP-2, BMP-4, and BMP-6 are endogenous ligands for Hemojuvelin in hepatoma-derived cell lines, and all 3 of these ligands are expressed in human liver
- the activity of BMP4 in EMT during development is recapitulated in adult airway epithelial cells and may contribute to inflammation and fibrosis in vivo
- Suggest that BMP-4 and calcium binding in MGP are independent but functionally intertwined processes and that the BMP binding is essential for prevention of vascular calcification.
- Demonstrate the impairment of BMP-4 signaling by glycosaminoglycans in multipotent stem cells in human Hurler syndrome.
- These results support a model in which the angular gradient in gap junction-mediated intercellular coupling in the lens, and thus proper lens function, is dependent on signaling between the FGF and BMP pathways.
- BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells
- Hypoxia-induced upregulation of CHL-1 alters the homeostatic balance between BMP-4 and VEGF to synergize with VEGF in driving retinal angiogenesis.
- the trophoblast induction effect of BMP4 correlates with and depends on the inhibition of Activin/Nodal signaling
- Wnt3a and Wnt5a have roles in inducing BMP-4 and 6 expression in prostate cancer osteoblast differentiation
- BMP4 plays an important role in the control of human megakaryopoiesis
- BMP signaling plays a role in the induction of an osteoblastic phenotype in human dermal fibroblasts in response to vitamin D(3) stimulation
- These results in the present study indicate that oversulfated chondroitin sulfate, which possesses 4,6-disulfates in N-acetyl-galactosamine, binds to BMP-4 and promotes osteoblast differentiation and subsequent mineralization.
- Genotypes of 184 patients with nonsyndromic cleft lip with or without cleft palate and 205 controls showed significant differences in the genotype and allele distribution of 538T/C polymorphisms of the BMP4 gene among the cases and controls.
- BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis.
- BMP2/4 were selectively expressed by endothelial colony-forming cells but not by early colonies in culture (CFU-Hill).