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Validated All-in-One™ qPCR Primer for INO80(NM_017553.3) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
INOC1 is the human homolog of S. cerevisiae Ino80, the catalytic ATPase subunit of the INO80 chromatin remodeling complex (Shen et al., 2000 [PubMed 10952318]; Bakshi et al., 2004 [PubMed 15207721]). INOC1 defines a subfamily of SWI2/SNF2 chromatin remodeling proteins; see SMARCA (MIM 600014) for background information.[supplied by OMIM].
Gene References into function
- Identifies INOC1 gene product as a SNF2-like helicase associated with human INO80 chromatin remodeling complex (hINO80). hINO80 includes orthologs of 8 subunits of the yeast INO80 complex, as well as additional, metazoan-specific proteins.
- report the cloning, expression, and functional activity of the domains from hINO80 gene both in terms of the DNA dependent ATPase as well as DNA binding activity
- Methods for purification and assay of the INO80 chromatin remodeling complexes are described.
- Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters
- Ino80 has a crucial role in stabilizing a stalled replisome to ensure proper restart of DNA replication
- INO80 is an important new player in DNA replication to help safeguard the integrity of the genome
- In the nucleus Uch37 is also associated with the human Ino80 chromatin-remodeling complex (hINO80).