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Validated All-in-One™ qPCR Primer for NR4A2(NM_006186.3) Search again
Product ID:
HQP103046
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HZF-3, IDLDP, NOT, NURR1, RNR1, TINUR
Gene Description:
nuclear receptor subfamily 4 group A member 2
Target Gene Accession:
NM_006186.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression.
Gene References into function
- The result suggests that the c.-469delG and possibly other variants of the NR4A2 gene may be of relevance to the complex factors involved in the pathogenesis of schizophrenia.
- may contribute to susceptibility to alcoholism.
- NURR1 induction by proinflammatory mediators represents a point of convergence of at least two distinct signaling pathways, suggesting an important common role for this transcription factor in mediating multiple inflammatory signals.
- A homozygous polymorphism has been found in intron 6 of Nurr1 gene, which was significantly higher in Parkinson's subjects compared to control.
- Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers
- Mutations in NR4A2 associated with familial Parkinson disease
- Nurr1, NGFI-B and NOR-1 mRNA are expressed constitutively in various human neural and non-neural cell lines, and their levels are up-regulated in human neurons by activation of protein kinase A or protein kinase C pathway.
- Data do not support the notion that the NR4A2 gene plays a major role in risk for schizophrenia among Japanese individuals.
- Nurr1 may play a direct role for specification of DA neurotransmitter identity by activating TH gene transcription in a cell context-dependent manner
- The common heterozygous NI6P is associated with an increased risk of Parkinson disease and an association of borderline significance was found for the homozygous NI6P and diffuse Lewy body disease.
- crystal structure of the orphan receptor Nurr1 at 2.2 A resolution; structure-activity relationship
- NURR1 promoter polymorphisms were studied in Parkinson's disease (PD), schizophrenia (SZ), and personality traits and found unlikely to be involved in conferring susceptibility for SZ or PD.
- Point mutations in exon 1 are not major cause of familial Parkinson disease
- NURR1 is a nuclear receptor which can assume an active conformation in the absence of a ligand agonist.
- The genes identified here are novel candidates as key early mediators of VEGF-induced endothelial functions.
- Nurr1 activates the OPN promoter directly in osteoblastic cells and may have a role in the regulation of bone homeostasis
- NR4A2 (A NEWLY DISCOVERED MUTANT GENE)IS A MEMBER OF A NUCLEAR RECEPTOR SUPERFAMILY REQUIRED FOR THE DIFFERENTIATION AND MAINTENANCE OF NIGRAL DOPAMINERGIC NEURONS. LOCATION 2Q22-23(P.81)
- To evaluate the role of NR4A2 in PD, exon 1 was analyzed in 108 families with apparent autosomal dominant PD. None of the previously described mutations were found by sequence analysis of the 481 bp fragment of exon 1; no new sequence variants were found
- Polymorphic variant within intron 6 of the Nurr1 gene was reported to be associated with familial Parkinson disease.
- search for all known mutations in 176 Caucasian Portuguese and 82 Caucasian Brazilian subjects with lifetime diagnosis of schizophrenia failed to identify any of the described mutations in patients or controls
- Expression of Nurr1 and NGFI-B plays an important role in human adrenal cortex and its neoplasms, including possible regulation of steroidogenesis.
- Virtually all striatal cells that stain for tyrosine hydroxylase also express Nurr1, confirming the existence of dopaminergic neurons intrinsic to the human striatum.
- Causal relationship between the rapid decline of aromatase mRNA and induction of orphan nuclear receptors NURR1 and NGFI-B expression, which concomitantly occur upon LH surge at the later stages of ovarian follicular development.
- down-regulation of NR4A2 as well as NR4A1 promoted intrinsic apoptosis
- NR4A nuclear receptors NR4A1, NR4A2, NR4A3 are potential transcriptional mediators of inflammatory signals in activated macrophages
- NR4A2 can stimulate progression of colorectal cancer downstream from cyclooxygenase 2-derived PGE2.
- In Parkinsons, Nurr1 was decreased in nigral neurons containing alpha-synuclein-immunoreactive inclusions. In Alzheimer's, Nurr1 was decreased in neurons containing neurofibrillary tangles. In PSP, Nurr1 was also decreased.
- Nurr1 and Pitx3 cooperatively promote terminal maturation to the midbrain dopamine neuron phenotype in murine and human ES cell cultures.
- Nur77, Nurr1, and NOR-1 are expressed in human atherosclerotic lesion macrophages and reduce human macrophage lipid loading and inflammatory responses, providing further evidence for a protective role of these factors in atherogenesis.
- Insights into the mechanisms of transcription via the Nurr1 LBD identifies an alternative co-activator-binding surface that is unique to the NR4A family of NRs.
- Nurr1 has a protective function in cartilage homeostasis by selectively repressing matrix metalloproteinase gene expression during inflammation.
- This study examines whether BDNF V66M (c.196 G --> A) or NR4A2 IVS6 +18insG polymorphism is associated with the risk of Taiwanese Parkinson's disease and the age of onset using a case-control study.
- These results suggest that the suppression of aromatase activity and its transcription level by MEHP exposure to NCI-H295R cells was regulated through the rapid and transient expression of Nur77 gene.
- aberrant expression and distribution of NURR1 in psoriasis
- Nurr1 phosphorylation by ERK2 may play a role in regulating the TH expression.
- These data describe regulatory convergence between Nurr1 and beta-catenin, providing a mechanism by which Nurr1 could be regulated by Wnt signaling.
- Significant alteration of mRNA expression of Nurr1, a transcription factor that regulates dopamine transporter expression, is confined to the paranigral nucleus.
- Rat and mouse species-dependent differences of Nurr1 and Ngn2 actions in dopamine neuron differentiation.
- These data identify the NR4A receptor family as potential mediators of an MC1R-coordinated DNA damage response to ultraviolet rays exposure in melanocytic cells.
- decreased expression of Nurr1, which has been found in Parkinson's disease patients with Nurr1 mutations, was shown to transcriptionally increase alpha-synuclein expression
- The induction of nur77 expression by n-butylenephthalide as pharmaceuticals on hepatocellular carcinoma cell therapy is reported.
- NURR1 gene expression were associated with significantly increased risk for PD in women, in patients 60 years old or older, and in patients of Caucasian origin.
- association between the polymorphisms of [c.-2922(C)2-3 and IVS6+ 18insG] in the NURR1 gene and Parkinson's disease (PD) in a Han population from Sichuan province
- the orphan nuclear receptor Nurr1 has a role in inhibiting bladder cancer growth