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Validated All-in-One™ qPCR Primer for NPY(NM_000905.3) Search again
Product ID:
HQP102936
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
PYY4
Gene Description:
neuropeptide Y
Target Gene Accession:
NM_000905.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Gene References into function
- Aging of human microvascular endothelial cells in vitro led to a loss of their mitogenic responses to NPY accompanied by a lack of NPY receptor mRNAs
- Circulating NPY in fulminant hepatic failure does not seem to reflect cerebral blood flow.
- NPY regulates the CRH system of the human hypothalamus and some of the effects of NPY on metabolic, autonomic, and endocrine functions may be mediated through CRH
- Autonomic neuropathy is associated with impaired pancreatic polypeptide and this peptide responses to insulin-induced hypoglycaemia in Type I diabetic patients.
- a study of ligand-receptor interactions (review)
- Neuropeptide Y Pro7 frequencies in the control populations were similar to the alcoholics, in Finns and Swedes, yielding no association with neuropeptide Y Pro7 frequency, in contrast with the Yale study.
- NPY affects the cortical sequelae of hunger and satiety regulation as reflected by cortical DC-potentials in man.
- Leu7Pro polymorphism of the NPY gene associates with alterations in FFA metabolism but does not have an impact on insulin sensitivity, insulin secretion, or glucose metabolism
- hypothalamic neuropeptide Y in the phenotypic expression of hyperphagia in the fa/fa pups during the second postnatal week
- Proline 7 substitution in signal peptide of the NPY is associated with enhanced endothelial-dependent vasodilation.
- genetically determined changes in NPY levels lead to widespread consequences in the control of sympathoadrenal, metabolic, and hormonal balance in healthy subjects.
- a novel polymorphism in the promoter region of the neuropeptide Y gene is associated with schizophrenia in humans.
- Analysis of a repressor region in the neuropeptide Y gene that binds Oct-1 and Pbx-1 in neurons.
- Leu7Pro polymorphism may contribute to the genetic susceptibility to diabetic nephropathy and coronary disease in type 1 diabetic patients
- Proportional comparison of NPY neurons in four compartments, upper cortical layers, lower cortical layers, subcortical white matter and deep white matter, demonstrated differential distribution between schizophrenic brains and controls.
- Aging women is have increased NPY gene expression. Functional relationship between NPY and POMC neurons demonstrated in other species also exists in human. Increase in NPY mRNA in older women may be due to factors other than ovarian failure of menopause.
- NPY participates in sympathetically mediated cutaneous vasoconstriction in humans during whole body cooling.
- the NPY T1128C polymorphism is an independent predictor for myocardial infarction and stroke in a Swedish hypertensive population.
- The leucine 7/proline 7 polymorphism in the NPY signal gene may favorably affect femoral neck bone mineral density in postmenopausal women.
- Our data support the hypothesis of epistatic interaction between ADRB2 and NPY in regulation of LDL levels in hypertensive subjects.
- Number and size of neuropeptide Y positive cells were greater at birth and reached maximal values of 100-400 cells per 1 mm2 and 2-5 microm in diameter, respectively.
- results corroborate the involvement of neuropeptide Y in sexual maturation and its role in delayed puberty
- Results indicate that the neuropeptide Y signaling system is implicated in body weight regulation and suggest a new and unexpected functional role of a signal peptide.
- choroid contains abundant NPY and TH nerve fibers related to chroroidal vascular structures
- Kidney transplantation does not normalize plasma NPY posttransplant. Transplanted kidney with good excretory functions and immunosupressive therapy are not essential factors involved in maintence of elevated NPY plasma level early posttransplant.
- the Leu7Pro polymorphism of preproNPY is related to decreased level of basal sympathetic activity, decreased insulin secretion, and delayed ghrelin suppression during oral glucose tolerance test
- The T1128C polymorphism of the NPY gene is population specific and extremely low in a Chinese population.
- human umbilical-vein endothelial cells produce, store and respond to NPY, suggesting an autocrine regulatory role for NPY in the endothelium
- study provides the evidence that Leu7Pro polymorphism in the neuropeptide Y (NPY) gene is associated with impaired glucose tolerance (IGT) and type 2 diabetes in Swedish men
- NPY polymorphisms might influence cholesterol metabolism, but might not act as major risk factor in Alzheimer's disease
- orexin A, NPY, leptin play an important role in the regulation of energy metabolism in humans; in obesity the activity of these peptides is disturbed.
- Altered neuroregulation of the neuropeptides (leptin and NPY) secretion may contribute persistent amenorrhea after weight gain in anorectic patients with low initial body mass index
- Y1 receptor activation by neuropeptide Y regulates the growth of prostate cancer cells
- This review discusses the dual role of NPY as modulator of sympathetic co-transmission; it facilitates vascular smooth muscle reactivity and modulates the presynaptic release of adenosine triphosphate (ATP) and noradrenaline.
- This review summarizes the evidence implicating peripheral and central NPY in the development and/or maintenance of hypertension or stress-induced hypertension in humans, and points out the definitive proof of the role of NPY that is still lacking.
- This review defines NPY as an important sympathetic transmitter that clearly acts via intracerebral nerves as well to regulate local cerebral blood flow.
- This is a review of evidence in support of a potential role for NPY in heart failure progression and remodeling via actions on vascular and cardiomyocyte function exerted via multiple NPY receptors
- In this review, NPY is a mediator and a marker of chronic stress in humans, including extreme trauma and posttraumatic stress disorder
- This review underscores the need to understand how the functions of NPY are altered by the chronic neurodegenerative changes that occur in Alzheimer's, Parkinson's, and Huntington's disease.
- Neuropeptide Y levels were significantly higher in normal cycling athletes, suggesting possibility of protective role of neuropeptide Y in maintenance of menstrual cycle in highly trained athletes.
- higher concentrations of neuropeptide Y in constitutional delay of puberty(CDP) girls may be responsible for CDP and reduced levels of insulin growth factor-I(IGF-I)
- -485 T, a novel polymorphism in the promoter region of the neuropeptide Y gene, most likely confers resistance but not susceptibility to schizophrenia.
- NPY, via NPY Y5 and to a lesser extent via the Y1 receptors, exerts a stimulatory action on Ucn1 cells in the nonpreganglionic Edinger-Westphal nucleus.
- this is the first demonstration of a ghrelin-NPY interaction in humans, which may suggest a possible mediation of ghrelin action by NPY in humans
- PreproNPY Pro7 allele is associated with an increased risk for type II diabetes with a higher insulin resistance among Pro7 carriers whereas low ghrelin concentrations in Pro7 carriers are possibly a consequence of high insulin levels.
- Leu7Pro polymorphism in the signal peptide region of the human prepro-NPY is not a risk factor for exudative AMD.
- No impact of preproNPY genotype on mean NPY or hormone levels were detected in subjects with type 2 diabetes.
- Cocaine- and amphetamine-regulated transcript is expressed in NPY and agouti related protein neurons in the human hypothalamus.
- Significant frequencies of the Pro7 allele of NPY are found in the majority of Indian populations studied.
- neuropeptide Y has a role in prostate neoplasm growth through MAP kinase/ERK 1/2 activation [review]
- remarkable haplotypic association suggested that the interaction between the 2 common sequence polymorphisms in NPY contributed to a great amount of phenotypic variability of ischemic stroke
- The Leu7Pro polymorphism of neuropeptide Y confers susceptibility to development of diabetic neuropathy in Swedish female type I diabetes patients.
- Inverse relationships between neuropeptide Y (NPY) and biomarkers (bone and serum alkaline phosphatase) levels of bone turnover suggest that NPY may be implicated in low bone turnover in dialysis patients by a parathyroid-independent mechanism.
- obesity may be a pivotal factor in multiplying the disease risk associated with the Leu7Pro polymorphism in preproNPY
- NPY Pro7 substitution protects middle-aged men from coronary artery atherosclerosis and might decrease the risk of acute coronary events
- no significant relationship between the NPY gene nt 5671 C/T polymorphism and febrile seizure.
- NPY plasma level in patients with atopic dermatitis was significantly increased both during exacerbation and remission.
- There is no significant association with neuropeptide Y gene and alcoholism following analysis of haplotype or single nucleotide polymorphism.
- Lower NPY expression level is significantly associated with more aggressive clinical behavior of prostate cancer
- The Leu7Pro polymorphism may be associated with dietary response to LDL-C concentration in overweight boys with a family history of early-onset CVD.
- haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety
- The reduction in NPY in the anterior and posterior vaginal wall epithelium might be related to nerve damage or degeneration in patients with pelvic organ prolapse and stress urinary incontinence.
- This study revealed that the GHRH perikarya formed intimate associations with NPY fiber varicosities and juxtapositions were found in the infundibular nucleus/median eminence where NPY fiber varicosities often covered surface area of the GHRH neurons.
- Results show that oxytocin modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels.
- p.L7P polymorphism may be a strong independent risk factor for various metabolic and cardiovascular diseases (Review)
- NPY-mediated mitogenesis signals primarily via neuropeptide Y1 receptors activating Ca2+-dependent, growth-promoting pathways
- The neuropeptide Y (NPY) genotype is suggested to be involved in the individual differences in regulation of catecholamine secretion.
- NPY contributes to atherosclerosis pathogenesis.