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Validated All-in-One™ qPCR Primer for NGFR(NM_002507.3) Search again
Product ID:
HQP102902
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR
Gene Description:
nerve growth factor receptor
Target Gene Accession:
NM_002507.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq].
Gene References into function
- Nerve growth factor regulates dopamine D(2) receptor expression in prolactinoma cell lines via p75(NGFR)-mediated activation of nuclear factor-kappaB
- results indicate that neurons expressing p75(NTR), mostly if expressing also proinflammatory cytokine receptors, might be preferential targets of the cytotoxic action of Abeta in Alzheimer's disease (p75 neurotrophin receptor)
- Rabies virus glycoprotein (RVG) is a trimeric ligand for the N-terminal cysteine-rich domain of this protein
- P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG (myelin-associated glycoprotein) and OMgp
- p75(NTR) may be involved in the formation of tangles in the Alzheimer process.
- tumor necrosis factor receptor-associated death domain protein (TRADD) interacts with p75(NTR) upon nerve growth factor (NGF) stimulation in breast cancer cells
- p75(NTR) tumor suppressor induces caspase-mediated apoptosis in bladder tumor cells
- Data describe the identification of a variant of the beta catalytic subunit of cyclic AMP-dependent protein kinase (PKACbeta) as a p75 neurotrophin receptor(NTR)-interacting protein, which phosphorylates p75(NTR) at Ser304.
- p75 neurotrophin receptor (p75NTR) expression is induced by osmotic swelling via nitric oxide
- p75(NTR) has a role in differentiation of human esophageal keratinocyte stem cells
- gamma-secretase-mediated p75NTR proteolysis plays a role in the formation/disassembly of the p75-TrkA receptor complex by regulating the availability of the p75 TM domain that is required for this interaction
- Using yeast two-hybrid systems, RanBPM was identified as a binding partner of p75(NTR).
- The p75(NTR)-mediated trophic support profoundly affects competitive melanoma-cell survival when the tumor cell microenvironment becomes growth limiting.
- p75NTR activation has diverse effects on neuroblastomas.
- p75-NGFR expression is observed in fetuses from 15 weeks of gestation in the borderline between pars intermedia and the neurohypophysis.
- Data show that sustained activation of p38(MAPK) is essential for the death cascade following exposure of Ewing's sarcoma tumor cells to bFGF and provide evidence that activation of p38(MAPK) results in an up-regulation of the death receptor p75(NTR).
- c-Cbl-dependent ubiquitination of p75NTR involved in the regulation of p75NTR signalling.
- expression of NGF and its receptors, TrkA and p75NTR, in hepatocellular carcinomas (HCC); NGF and its receptors are thought to have a role in cellular interactions involving HCC cells, hepatic stellate cells, arterial cells and nerve cells in HCC tissues
- pro-NGF purified from AD human brains can induce apoptosis in neuronal cell cultures through its interaction with the p75NTR receptor
- In rat, p75 neurotrophin receptor cleavage by alpha-secretase and gamma-secretase requires specific receptor domains.
- This review focuses on p75NTR as a facilitator of Trk receptor tyrosine kinase-mediated neuronal survival and as a regulator of neuronal cell death--opposing roles dictated by distinct partnering molecules.
- signaling pathway in which Abeta peptide binds to p75NTR and activates p38 and JNK in a DD-dependent manner, followed by NF-kappaB translocation and p53 activation cause neuron death
- trimeric oligomerization state of Rabies virus G protein is required for binding with p75NTR
- p75(NTR) and Fas receptors could share common signalling pathways.
- p75(NTR) retarded cell cycle progression by induced accumulation of cells in G0/G1 and a reduction in the S phase of the cell cycle.
- Loss of p75 neurotrophin receptor expression accompanies malignant progression to human and murine retinoblastoma
- In dermis of atopic dermatitis (AD), the intensity of p75 NGFr-IR nerves was stronger in areas of increased numbers of NGF-IR cells. Nerve growth factor and its receptors may contribute to the neurohyperplasia of AD.
- Elevated p75NGFR expression is associated with a favorable prognosis in human pancreatic cancer.
- Expressions of p75(NTR) and heparanase-1 correlated with each other in medulloblastoma.
- This review focuses on the interactions between Abeta and p75NTR in the context of the broader p75NTR signalling field, and offers alternative explanations for how p75NTR might contribute to the etiology of Alzheimer's disease.
- The p75NTR is necessary for survival and maintenance of esophageal squamous cell carcinoma (ESCC), providing us with a potential target for novel therapies.
- p75 is a potential marker of oral keratinocyte stem/progenitor cells and that some neurotrophin/p75 signaling affects cell growth and survival.
- We propose that TrkA and p75 likely communicate through convergence of downstream signaling pathways and/or shared adaptor molecules, rather than through direct extracellular interactions.
- Conserved elements were found in the 25 kb upstream sequences of the human p75NTR gene. Only 1 of these, a proximal region rich in Sp1 sites, responds to changes in hypo-osmolarity.
- The novel finding that a mutation may increase processing of p75NTR may have implications for the pathogenic outcome in Alzheimer's disease
- results do not support an association of the p75(NTR) S205L polymorphism with risk for childhood-onset mood disorder(COMD)or suicide attempt in COMD
- p75 neurotrophin receptor forms may have a role in type 2 diabetic patients
- p75NTR had the function of inhibiting the invasive and metastatic abilities of gastric cancer cells, which was mediated, at least partially, by down-regulation of uPA and MMP9 proteins and up-regulation of TIMP1 protein.
- trkA(NGFR) and p75(NTR) have roles with nerve growth factor in the healing process as a result of injury [review]
- p75NTR downstream signalling is altered by PS2 mutation or gamma-secretase inhibition in SHSY-5Y cel
- Significantly decreased p75 neurotrophin receptor expression is associated with gastric cancer
- Data show that functional cooperation between TrkA and p75(NTR) accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities.
- These results provide the first evidence for p75(NTR) as a major contributor to the highly invasive nature of malignant gliomas and identify a novel therapeutic target.
- Differential expression throughout the epithelium suggests a role in epithelial differentiation
- Nerve growth factor facilitates TLR4 signaling-induced maturation of human dendritic cells through LPS-up-regulated p75(NTR) via activation of p38 MAPK and NF-kappaB pathways
- in astrocytomas, Trk receptors (TrkA, TrkB, TrkC) expression, but not p75NTR may promote tumor growth independently of grade
- A high expression of p75NGFR was often seen with better function of the transplanted muscle.p75NGFR expression might be a contributing factor in successful axonal regeneration.
- p75(NTR) suppresses progression of human retinoblastoma and is a potential target for therapy.
- Basal keratinocytes in oral lichen planus showed no or only weak cytoplasmic staining but in normal oral mucosa there was a clear cell membrane staining
- Melanoma cells express the low-affinity (p75NTR) and the high-affinity tyrosine kinase NT receptors (Trk).
- A potential role of all neurotrophins, through their different receptors, in pituitary functions.
- CD271 serves as a receptor for the pro-forms of these neurotrophins and is differentiated from other members of the TNFR receptor family in that it binds pro and mature neurotrophins and affects the growth of the nervous system.
- we provided the evidence that p75NTR was a potential tumor suppressor
- Data show that NGFR expression changes during the years of greatest risk for the development of schizophrenia.
- The demonstration of an increased level of p75NTR gene transcription in lesional mast cells points to an induction of low-affinity neurotrophin receptor sensitivity of mast cells under states of allergic inflammation
- The combination of p75(NTR) expression and the pattern of invasion strongly increased precision in the identification of oral squamous carcinomas with poor disease-free survival.
- Intramuscular p75(NTR) gene delivery impairs neovascularization and blood flow recovery in a mouse model of limb ischemia.
- These data establish Sall2 as a link between p75 neurotrophin receptor and transcriptional events that regulate the growth and development of neuronal cells.
- In kidney disease, p75 plays a role in both survival & death of cells, depending on absence of ligand, cytoplasmic/ligand interaction and interaction with TrkA.