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Validated All-in-One™ qPCR Primer for NFKB1(NM_003998.3) Search again
Product ID:
HQP102886
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1, NF-kappaB, NF-kappabeta, NFKB-p105, NFKB-p50, NFkappaB
Gene Description:
nuclear factor kappa B subunit 1
Target Gene Accession:
NM_003998.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions.
Gene References into function
- This lithium-induced up-regulation of NF-kappa B and MAP kinase activation was associated with an enhancement of interleukin-8 mRNA accumulation as well as an increase in interleukin-8 protein release.
- CD14-dependent activation of NF-kappaB by filarial parasitic sheath proteins
- The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex.
- Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophages.
- Incontinentia pigmenti: the first single gene disorder due to disrupted NF-kappa B function
- NFKB-p50 is a binding protein in the negative regulatory element of the epsilon-globin gene.
- NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105
- IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA
- NF-KB could be considered as a coordinating element in the body's response to stress, infection, or inflammation, and it may be a good therapeutic target.
- Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors
- results suggest that NFkappaB is involved in the IL-1beta-induced COX-2 expression in the mesenchymal cells of human amnion
- NF-kappaB activates Bcl-2 expression in t(14;18) lymphoma cells.
- NF-kappaB-dependent MnSOD expression protects adenocarcinoma cells from TNF-alpha-induced apoptosis.
- Inhibitors in the NFkappaB cascade comprise prime candidate genes predisposing to multiple sclerosis
- Differential activation of nuclear factor-kappa B by monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in smooth muscle cells.
- MUC2 upregulated by PMA Phorbol 12-myristate 13-acetate includes a role for NF-kB
- activation induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes (Nuclear factor-kappaB)
- Low intracellular zinc impairs the translocation of activated NF-kappa B to the nuclei in human neuroblastoma IMR-32 cells.
- NO can influence cell death by modulating NF-kappaB activity with the sites of inhibition being cell type-specific.
- the role NF-kappaB plays in TNFalpha- or lipopolysaccharides (LPS)- induced chemokine secretion by human monocyte-derived macrophages was examined
- mechanisms that underlie CD40-mediated activation of NF-kappaB in airway epithelial cells
- NF-kappaB is a major and essential factor in regulating the expression of cytokine and plays a fundamental role in the pathogenesis of ulcerative colitis UC.
- Induction of IkappaB: atrial natriuretic peptide as a regulator of the NF-kappaB pathway
- Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.
- Mitogen-activated protein kinases and nuclear factor-kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages.
- Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.
- NF-kappaB seems important in modulating of immunoregulatory genes relevant in critical illnesses.
- Depletion of intracellular GTP results in nuclear factor-kappaB activation and intercellular adhesion molecule-1 expression in human endothelial cells.
- APC inhibited both the binding of NF-kB to target sites and the degradation of I kappa B alpha, and inhibited both the binding of activator protein-1 (AP-1) to target sites and the activation of mitogen-activated protein kinase pathways.
- characterized activity in S-type neuroblastoma cells and determined its role in their survival
- inhibition of its transcriptional activity by protein kinase A
- These results point to the negative regulation of osteoblast differentiation by NFkappaB, with implications in the pathogenesis and progression of osteosarcomas.
- Mutation of this protein's promoter binding site (-45 bp) impaired the ability of ITGB3BP to downregulate the urokinase-type plasminogen activator receptor promoter activity.
- NF-kappaB can be a central regulator of chemokine gene expression in BFT-stimulated intestinal epithelial cells and may be an important regulator of neutrophil migration.
- NFkB, I-kBalpha and I-kB kinase are present in platelets; upon platelet activation, the NF-kappaB/I-kappaBalpha complex is dissociated by phosphorylation of I-kB and proteolysis.
- Bovine serum albumin induced an increase in the expression of this protein in human kidney proximal tubule cells in culture.
- Cytokines trigger this transcriptional factor to be expressed in human stomach neoplasm cells cultivated in vitro.
- nf-kappa B activity plays role in apoptosis of hepatocellular carcinoma
- These data suggest that the subcellular location of I(kappa)B(alpha) is a critical determinant in ionizing radiation-induced nuclear factor-kappaB activation.
- NFkappaB response to anti-beta(2)GP1 antibodies is indirect, and is an essential intermediate in the activation of endothelial cells by anti-beta(2)GP1 antibodies
- NF-kappaB may play a key regulatory role in skeletal muscle wasting associated with cachexia
- found in mitochondria; regulates mitochondrial gene expression
- Protease causes direct cleavage of p65 NF-kappaB in N-terminal region by PR3 and in C-terminal region by HNE, resulting in diminished transcriptional activity by NF-kappaB (diminished levels of TNF-alpha-induced IL-8 message in presence of PR3 or HNE).
- NF-kappa B is upregulated and proinflammatory cytokine IL-6 activated in patients with ureteropelvic junction obstruction who failed endopyelotomy.
- Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway
- a key role for NF-kappaB in EPO gene regulation in response to hypoxia
- NFkappaB is a focal point for the convergence of MDA-mediated signaling events leading to HIF-1 induction
- adhesion of Streptococcus pyogenes to human respiratory epithelial cells stimulates NF-kappaB nuclear translocation, however, bacterial internalization is required for a sustained nuclear translocation of this transcriptional factor
- In PC-3/vector cells when exposed to IR caused an induction of NFk-B activity; however, DX down-regulated this activity.
- Didox regulates radiation tolerance by inhibiting NF-kappa B activation following irradiation.
- NFkappaB signaling can suppress the angiogenic potential and metastasis of pancreatic cancer
- Akt1 may be an important regulator of TRAIL sensitivity in HL60 cells through the activation of NF-kappaB and up-regulation of cFLIP(L) synthesis
- retinoblastoma protein has the ability to stimulate cyclin D1 transcription by activation of the NF-kappaB transcription factor
- NF-kappa B has a role in the regulation of the NK-1R gene and the increase in expression of the NK-1R gene in responsive cells
- acute hyperglycemia-mediated mononuclear cell activation is dependent on activation of ras, p42/p44 mitogen-activated protein kinase phosphorylation, and subsequent NF-kappaB activation
- Adenosine selectively suppresses TNF-induced NF-kappaB activation, which may contribute to its role in suppression of inflammation and of the immune system.
- data suggest that NO may play a major role in the regulation of IkappaBalpha levels in aortic endothelial cells and that the application of low shear flow increases NF-kappaB activity by attenuating NO generation and thus IkappaBalpha levels
- Hematopoietic CD34+ cells secreted IL-15 that, through autocrine/paracrine loop distinct signal pathways, activated NF-kB in bone marrow and cord blood progenitors, and activated STAT3 and STAT5 in peripheral G-CSF-mobilized and BM progenitors only.
- functional studies demonstrated GMCSF-dependent activation of IkappaB kinase activity in endothelial cells, degradation of IkappaB, and activation of NF-kappaB
- Peripheral blood mononuclear cells from B-CLL patients have a constitutive high NF-kappaB activity, which is modulated by cytokines TGF-beta, IL-4, and IL-1.
- NF-kappa B is activated by ASC protein
- oxidized high-density lipoprotein activates NF-kappa B via binding to oxidized low-density lipoprotein receptor-1 on the cell surface, followed by enhancement of intracellular reactive oxygen species production in endothelial cells
- p105 functions as a physiological partner and inhibitor of Tpl2
- NF-kappa B induced proinflammatory & antiapoptotic genes in epithelial and mesenchymal cells of human skin. In keratinocytes, not fibroblasts, it induced p21(CIP1). GIF levls increased by NF-kappa B in both, but inhibited growth only in keratinocytes.
- Circumvention of Ras-induced growth arrest by blockade of NFKB1 function by expression of IkBalpha frees the oncogenic functions of Ras and results in invasive carcinoma resembling squamous cell carcinoma.
- results suggest that tumor necrosis factor receptor-associated factor 1(TRAF1) exerts regulatory effects on receptor-induced nuclear factor-kappaB activation by targeting inhibitor of kappab kinase complex
- H2O2 induces NF-kappaB activation, not through serine phosphorylation or degradation of IkappaBalpha, but through Syk-mediated tyrosine phosphorylation of IkappaBalpha
- Melanogenic inhibitors downregulate NFKB activation in keratinocytes.
- CD40L expression by BCG-activated CD4(+) T cells is regulated via the PKC pathway and by NF-kappaB DNA binding activity
- NF-kappaB is involved in the formation of epiretinal membranes after proliferative diabetic retinopathy, especially for the development of vascular endothelial cell component.
- results show for the first time that NF-kappa B is activated in the inflamed mucosa of celiac patients and suggest that it may represent a molecular target for the modulation of inflammatory response in celiac disease
- transcriptional activation of the interleukin-8 promoter by bradykinin involves the prostanoid-independent activation of nuclear factor-kappaB, and prostanoid-dependent activation of activating protein-1 and nuclear factor-interleukin-6
- Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer.
- first report that osteopontin induces nuclear factor kappaB activity and urokinase secretion by activating phosphatidylinositol 3'-kinase/Akt protein/Ikappab kinase-mediated signaling pathways
- NF-kappaB involvedin COX-2 induction in colorectal tumors
- nuclear factor kappa b is inactivated by nitric oxide and regulated by c-myc
- NF-kappa B activity is modulated by exchange of dimers.
- HIF-1alpha and NF-kappaB have roles in transcriptional regulation of hypoxic conditions on mast cells
- Primary CML blasts showed constitutive p65/RelA NF-kappaB/Rel DNA binding activity
- The effects of PrP(106-126) on DCs were elicited through a receptor complex distinct from that used by human monocytes, suggesting an involvement of DCs in prion disease pathogenesis.
- Common polymorphisms in this protein are associated with increased risk of colorectal cancer.
- Nuclear factor-kappaB has a role in mediating angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8
- activation of NF-kappaB mediates the induction of the CD83 promoter by LMP1 of Epstein Barr virus in B cells
- NF-kappaB is involved in the Ara-C sensitivity of leukemic blast progenitors but may exert opposite dual functions, namely protection from and induction of apoptosis, under different conditions.
- role for NF-kappaB in the co-ordinate induction of COX-2, mPGES and in the corresponding release of PGE2 by IL-1beta
- overexpression of HER-2/neu gene could induce NF-kappaB activity in human breast cancer cells
- molecular cross-talk between glycogen synthase kinase-3 beta (GSK-3 beta) and the p105 precursor of the NF-kappa B p50 subunit
- NF-kappaB activation is linked to monocytic, but not granulocytic differentiation, and is lineage-dependent, while ERK or STAT3 activation is not lineage-dependent
- induction of the MMP-13 gene by TNF-alpha is mediated by ERK, p38, and JNK MAP kinases as well as AP-1 and NF-kappaB transcription factors
- NF-kappaB is activated by Fas and may contribute to hepatocellular carcinoma cell survival or proliferation
- NF-kappaB has a role in cancer formation [neoplasms]
- NF-kappaB is the key molecule involved in alpha-MSH-mediated cell death and this may help to regulate mast cell-mediated inflammation
- NF-kappaB activation may play a role in protecting gastric epithelial cells from H. pylori-induced apoptosis by upregulating endogenous inducible nitric oxide synthase.
- okadonic acid induces sustained activation of nfkappab in neutrophils
- the DNA binding ability of NF-kappaB p50 subunit is regulated through phosphorylation of residue Ser337
- NF-kappaB pathway provides little protective role for human keratinocytes against UV-induced apoptosis
- oxidative stress-dependent MMP-9 induction in brain capillary endothelial cells was accompanied by a significant increase in the NF-kappaB localized in the nuclei
- NF-B inhibition attenuates the increased expression of ICAM-1 observed after exposure to CO2, confirming that upregulation of ICAM-1 is mediated via the NF-B pathway.
- NF-kappaB-dependent gene expression is regulated by PARP-1 acting synergistically with p300
- p21WAF1/CIP1, pRB, Bax and NF-kappaB have roles in induction of growth arrest and apoptosis by resveratrol in tumor cell lines
- the activation of NF-kappaB by H.8/Lip in HEK cells was enhanced upon coexpression of TLR1 AND TLR2, but not TLR6
- Estrogen receptors (+), estradiol-independent MCF-7 tumor cells derived from estradiol-dependent MCF-7 cells contain elevated basal NF-kappaB activity and elevated expression of the transcriptional coactivator Bcl-3 compared with the parental MCF-7 line.
- PKCalpha acts upstream of PKC-theta to activate I Kappa B Kinase and NF-kappaB in T-lymphocytes.
- NF-kappa B and AP-1 are required for basal MAT2A expression in HepG2 cells and mediate the increase in MAT2A expression in response to TNF-alpha
- NFkappaB activation is regulated by p56lck in the presence of hypoxia-reoxygenation
- NFkB controls the PLC-delta1 promoter and mediates the expression of PLC-delta due to Abeta42
- Ku antigen interacts with RBP-Jkappa and NF-kappaB p50 may act as a positive regulator of p50 expression in gastric cancer AGS cells.
- Specific alterations in NF-kappaB1 expression coupled with detection of numerous CD68-immunoreactive macrophages suggests activation of proinflammatory cytokine signaling pathways in the tuberous sclerosis complex brain that may culminate in cell death.
- IkappaBalpha was markedly degraded at 1 h, and NF-kappaB-DNA-binding activity markedly increased 2 h after beta(2) integrin aggregation, which activated IkappaB kinase activity at 1 h.
- Increase in IL-8 is independent of nuclear factor kappaB activation and is associated with an increase in c-Jun N-terminal kinase and activator protein-1 activity.
- NF-kappaB may regulate the transcription of one or more antiapoptotic proteins that may regulate cell survival during mitotic cell cycle arrest
- PP2Cbeta down-regulates cytokine-induced NF-kappaB activation by altering IKK activity.
- STAT3/NF-kappaB p65 cross-talk activated by IL-1 via TRAF6.
- NFKB has a role in CXCL16 signaling that induces cell-cell adhesion and aortic smooth muscle cell proliferation
- NFkappaB inhibition is sufficient to induce apoptosis in human tumor cells
- Divergent C-terminal transactivation domains of NF-kappa B proteins are critical determinants of their oncogenic potential in lymphocytes.
- recent findings show the activity of NF-kappaB as a critical regulator of apoptosis in the immune, hepatic, epidermal and nervous systems, on the mechanisms through which it operates and on its role in tissue development, homoeostasis and cancer.
- Caspases have an essential role in epigallocatechin gallate-mediated inhibition of NF-kappa-B and induction of apoptosis.
- interleukin-12 p40 transcription and NF-kappaB activation are inhibited by nitric oxide in macrophages and dendritic cells
- an autocrine mechanism accounts for the constitutive activation of NF-kappaB in metastatic human pancreatic cancer cells
- Novel androgen receptor/NF-kappaB mediated mechanism for VCAM-1 expression and monocyte adhesion operating in male endothelial cells that may represent an important unrecognized mechanism for the male predisposition to atherosclerosis.
- NF-kappaB activity has also been demonstrated in primary prostate cancer tissue samples and suggested to have prognostic importance for a subset of primary tumors (review).
- CF1101 inhibits human colon carcinoma growth in mice via modulation of NF-Kappa-B.
- NFKB has a role in resistance to TGF-beta-mediated suppression of IL-4 signaling
- Virtually all TNF-alpha-inducible genes were dependent on I kappa B kinase 2 (IKK2)/NF-kappa B activation, whereas a minor number was additionally modulated by p38; genes suppressed by IKK2/NF-kappa B were newly identified
- These results suggest that NF-kappaB is involved in the formation of both glial and vascular endothelial cell components, and that these two cell types might have functional interactions
- the TRIF-induced IFN-stimulated response element and NF-kappaB activation and apoptosis pathways are uncoupled
- Nuclear localization/activation of NF-kappaB is up-regulated in prostate cancer lymph node metastasis. Such up-regulation of NF-kappaB activity is observed in the tumor cells as well as in the surrounding lymphocytes.
- Rel/NF-kappaB factors could take part in the occurrence of senescence by generating an oxidative stress.
- Epstein Barr virus LMP1 drives bfl-1 promoter activity through interactions with components of the tumor necrosis factor receptor (TNFR)/CD40 signaling pathway; evidence presented that this process is NF-kappa B dependent
- Both active and non-active forms of NF-kappaB are increased in hepatitis B virus-associated hepatocellular carcinoma. Variant hepatitis B virus X protein is major cause of enhancement of NF-kappaB activity.
- identified a 5' distal TNFalpha-responsive enhancer of the PAI-1 gene located 15 kb upstream of the transcription start site containing a conserved NFkappaB-binding site that mediates the response to TNFalpha.
- Her-2/NEU oncogene is essential for the regulation of VEGF-C in ovarian carcinoma; p38 MAPK and NF-kappa B are critically involved in the transcriptional activation of the VEGF-C gene by Her-2/NEU.
- Overexpression of EAR1 upregulated expression of IL6 and COX2, and increased transactivation by NFKB and nuclear translocation of p65 in A7r5 VSMCs. The expression of EAR1 was upregulated by RORalpha1 but that upregulation was attenuated by EAR1 itself
- NFkappaB is differentially expressed in melanocytes of normal skin, benign intradermal naevus and human metastatic melanoma biopsies
- NF-kappaB activation and IL-1beta secretion are induced by cryopyrin with an increased ability to interact with ASC
- Reactive oxygen species regulate immune signaling through TLR4 mediated NF-kappa B activation
- NFKB has a role in XIAP upregulation that is involved in Cyr61-induced resistance to apoptosis in breast cancer
- NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling
- NF-kappa-B induced by cytotoxic stimuli (e.g., UV-C, daunorubicin or doxorubicin) is am active repressor of antiapoptotic gene expression. These effects are mediated by the RelA (p65) NF-kappa B subunit.
- nuclear factor-kappaB has a role in mitogen-activated protein kinase-induced estrogen receptor-alpha down-regulation in breast cancer cells
- detection of NF-kappa B activation in stimulated normal peripheral blood lymphocytes
- nuclear factor-kappa B and I kappa B alpha proteins have roles in development of prostatic adenocarcinomas
- NF-kappaB activation is induced by p53 by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
- Human Cytomegalovirus-mediated NF-kappaB activation, through the dysregulation of the IKK complex, plays a primary role in the initiation of the HCMV gene cascade in fibroblasts and may provide new targets for therapeutic intervention.
- induction of noncanonical NF-kappaB signaling may involve the rescue of NIK from TRAF3-mediated negative regulation
- NF-kappaB and nucleophosmin have roles in inducing the human SOD2 gene
- NF-kappaB and NF-kappaB-regulated gene expressions induced by carcinogens and inflammatory stimuli are inhibited by SCH 66336
- Altered NF-kappaB signaling is associated with impaired stimulation of an upstream IKK activator
- NF-kappaB plays an essential role in activation of wild-type p53 tumor suppressor to initiate proapoptotic signaling in response to overgeneration of superoxide.
- Ang II stimulates IL-6 and IL-8 production and release from human adipocytes by a NF-kappaB-dependent pathway. Ang II increases p50/p65 heterodimer translocation to the nucleus in adipocytes.
- Disruption of the actin cytoskeleton results in NFKB1 activation and inflammatory mediator production in cultured intestinal epithelial cells.
- TIMP2 promotes growth of A549 lung cells, accompanied by increase in NF-kappaB activity and downregulation of IkappaBalpha and beta proteins and later increases in Bcl-3, IkappaB, and cyclin D1 proteins.
- optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105
- I kappa B-NF kappa B participates on ERK2-mediated survival mechanisms
- Culture of B-CLL cells with fibroblasts sustained Akt and NF-kappaB activities, which was dependent on PI3K. Spontaneous apoptosis was associated with the loss of Akt and NF-kappaB activities. Constitutive activity of the PI3K pathway prevented apoptosi
- Data report the construction of two chimeric proteins comprising the DNA-binding domain of nuclear factor of activated T-cells c (NFATc) and the dimerisation domain of NF-kappaB-p50.
- These observations demonstrate that the two NF-kappaB binding sites are essential for phorbol myristate acetate-induced leukotactin-1 (Lkn-1)/CCL15 expression in human monocytes.
- UV light regulates early phase NFkappaB activation by means of an endoplasmic reticulum-stress-induced translational inhibition pathway
- Ikappa kinase gamma-NFkappaB binds to CARMA1 and CARMA3 in B and T lymphocytes
- granule pools of Zn may be distinct from those regulating activation of procaspase-3 and NF-kappaB.
- in early inflammatory arthritis, expression of NF-kappa B1 in synovial tissue was highest at sites most likely to be associated with joint erosion.
- KSHV vFLIP K13 is required for the growth and proliferation of lymphoma cells and alternative NF-kappa B pathway plays a key role in this process.
- NADPH oxidase has a role in Cox-2 inhibition through ROS and GSH/GSSG reduction, and NF-kappaB suppression
- Acute fatiguing exercise appears to decrease NF-kappaB activity in muscle under a variety of conditions.
- NF-kappaB dysregulation and uPA overexpression have roles in a more aggressive tumor behavior in hepatocellular carcinoma, and IKKbeta plays a critical role in the HBx-activated NF-kappaB signaling pathway
- silencing ELKS expression by RNA interference blocked induced expression of NF-kappaB target genes
- NF-kappaB has a role in inducing CYLD
- Data demonstrate a master regulatory role of IkappaB kinase (IKK)/NF-kappaB signaling for immediate-early gene induction after lipopolysaccharide engagement in precursor B cells.
- the activation of NF-kappaB pathway in human endothelial cells mediates the TNFalpha effects on arginine transport
- TRIF-induced ISRE and NF-kappaB activation are inhibited by PIASy
- inhibition of NFkappaB activation, indirectly by preventing IKK activation or directly by inhibiting NFkappaB nuclear translocation, prevents the detrimental effects of palmitate on the metabolic actions of insulin in L6 myotubes
- CD80 driven by NF-kappaB is regulated by the enzymatic actions of caspases, which allows monocytes to participate in massive T-cell activation
- Transcriptional activation of NF-kappa B can contribute to the pathomechanism of the disease-specific lesion of the neurons in the substantia nigra in Parkinson disease.
- NFKB activation and IL-8 secretion in human bronchial epithelial cells are induced by Protein kinase Cdelta-mediated lysophosphatidic acid
- A strong upregulation of MCP-1 and RANTES was observed in all the cases, mainly in tubular cells, and there was a strong correlation between the expression of these chemokines and NF-kappaB activation in the same cells.
- AIP1 is a novel transducer in TNF-induced TRAF2-dependent activation of ASK1 that mediates a balance between JNK versus NF-kappaB signaling
- Data describe a possible mechanism by which NF-kappa B regulates the expression of c-Fos and AP-1 by controlling the expression of Elk-1.
- one specific nucleotide determines cofactor specificity for NF-kappaB dimers
- NF-kappaB and pp38 mitogen-activated protein kinase have roles in endoplasmic reticulum stress-stimulated expression of cyclooxygenase 2
- Data show that TAB2 and TAB3 are receptors that bind preferentially to polyubiquitin chains through a highly conserved zinc finger (ZnF) domain, and activate NF-kappa B and IKK.
- FasL induces NF-kappaB activation and IL-8 production by a novel mechanism, distinct from that of TNF-alpha
- SNARK is an NF-kappaB-regulated anti-apoptotic gene that contributes to the tumor-promoting activity of CD95 in apoptosis-resistant tumor cells
- pancreatic elastase induced proinflammatory effects are mediated by TLR4 and NF-kappaB in human myeloid cells
- The phosphorylation of multiple transcription factors by kinases leads to the formation of transcription factor complexes and differential transactivation from a subset of NF-kappaB sites.
- activity blocked by uropathogenic E coli in urothelial cells
- role of nuclear factor-kappaB (NF-kappaB) during the induction of IL-6 by IL-1beta in human trophoblast cells
- there is a novel association between TRAF2 and TRAF3 that is mediated by unique portions of each protein and that specifically regulates activation of NF-kappaB, but not AP-1
- demonstrated that TRAIL mediates the recruitment of PI-3K/Akt and NF-B/IB pathways in leukaemic cells, namely Jurkat T cells
- The NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an effective immune response but is also involved in the regulation of cell proliferation, development, and apoptosis.
- cFLIP(L) is not only a central antiapoptotic modulator of TRAIL-mediated apoptosis but also an inhibitor of TRAIL-induced NF-kappaB activation and subsequent proinflammatory target gene expression
- association of nuclear factor-kappaB and NFAT with its enhancer region is dependent on activation of the HIV-1 clade E long terminal repeat, which is inhibited by T-cell activation
- Fibrinogen exposure resulted in increase in NF-kappaB activation and up-regulation of expression of MCP-1 and of IL-8, a response linked to the p50, p65 and c-Rel components of NF-kappaB
- Transglutaminase 2 induces nuclear factor-kappaB activation via a novel pathway
- NF-kappaB protects lung epithelial cells from hyperoxia-induced nonapoptotic cell death.
- G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor requires c-Src, protein kinase C, and ERK signaling
- Blunting postprandial hyperglycemia in type 2 diabetes reduces meal-dependent NF-kappa B activation.
- TRAIL effects on mitochondrial NF-kappaB-DNA binding
- activated by Neisseria gonorrhoeae PorB IB and required for upregulation of host apoptotic factors in urethral epithelium
- CD95 requires different signalling thresholds for induction of apoptosis and activation of NF-kappaB
- role in differential regulation of eotaxin-1 and eotaxin-3 mRNA and protein expression in bronchial epithelial cells
- Results describe the lipopolysaccharide-induced NFkappaB activation in activated hepatic stellate cells from different human donors.
- glucocorticoid-mediated inhibition of NF-(kappa)B is an important mechanism in the antiproliferative response to glucocorticoids
- In PBMC, SEA was able to induce nuclear translocation of NF-kappaB from cytosol to nucleus, where NF-kappaB DNA-binding activity was increased, with increased levels of cytokines secreted into the supernatant
- In the present study, we have shown that actin cytoskeleton disruption induced NF-kappaB activation in myelomonocytic cells.
- a signal-specific transcriptional repression appears to selectively inhibit stimuli that transiently activate p65-p50 complexes
- intranuclear presence of NF-kappaB in monocytes from patients with multiple injuries significantly increased on admission (88 +/- 37) and 6 h after trauma (59 +/- 28) compared with the baseline level
- differentially regulated by GRR488Q mutant versus the wild-type GR after 2 h of treatment seem mainly to be involved in control of transcription and cell growth.
- NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages
- IKK-beta/NF-kappa B transcription pathway is a key regulator of IL-6, IL-8, and TNF-alpha release from adipose tissue and skeletal muscle
- Tax promotes cellular proliferation through activation of the NF-kappaB pathway while inhibiting the cell-cycle checkpoint and apoptotic function of the tumor suppressor gene p53 [review]
- paclitaxel transiently induces NFkappaB activity via the phosphatidylinositol 3-kinase/Akt cascade
- Cross-talk between the SOCS-3/interferon and the IL-1beta pathways of signalling in pancreatic beta cells.
- IL-8-induced NF-kappaB activation proceeds through a TRAF2-independent but TRAF6-dependent pathway, followed by recruitment of IRAK and activation of IKK
- Activation of nuclear factor-kappaB is critical for PF4-induced E-selectin expression, and LRP is the cell surface receptor mediating this effect
- TNF-alpha and IL-1beta are secreted with macrophage-released signals that affect NF-kappaB translocation and endothelial cell activation
- hTid-1 represses the activity of NF-kappaB through physical and functional interactions with the IKK complex and IkappaB
- activation of the NF-kappaB pathway by LMP-1 is required for the activation of CCL5 expression
- The blockage of TLR-4 activation by EGCG resulted in inactivation of extracellular signal response kinase 1/2 and of nuclear factor-kappaB, the downstream molecules of TLR-4 signaling induced by H. pylori
- Ciglitazone induces NF-Kappa B transcriptional activity in colon cancer cells.
- IkappaB-zeta harbors latent transcriptional activation activity which is expressed upon interaction with the NF-kappaB p50 subunit
- Nuclear factor-kappaB nuclear localization is associated with recurrence in prostate cancer
- The NF-kappaB activation was detected in the postive refence.
- the Galphai2 gene promoter is transcriptionally activated through nuclear factor-kappaB and antioxidant response elements
- repressor nuclear factor-kappaB p50/p50 binding to DNA depends on phosphorylation of Ser337 by the protein kinase A catalytic subunit
- NF-kappaB, ERK, and GADD45beta are able to coordinate in a loop-like signaling network to defend cells against the cytotoxicity induced by ionizing radiation
- Data suggest a deficiency of NF-kappaB signaling pathway and a role of IKKbeta, at least in part, for increased sensitivity of lymphocytes from aged humans to TNF-alpha-induced apoptosis.
- required for Tax protein induction of TRail expression in HTLV-1 infected T-cell lines and adult T cell leukemia cells
- NF-kappaB appears crucial in ICAM-1 induction, but p38 activation itself is not sufficient to confer HO-1 expression and may not be involved in HO-1 and ICAM-1 induction in human tumor cells
- acrolein can suppress inflammatory processes in the airways by inhibiting epithelial IL-8 production through direct or indirect inhibitory effects on NFkappaB activation
- Curcumin acts as a free radical scavenger to induce glutathione biosynthesis and inhibit NF-kappaB activation and interleukin-8 release in alveolar epithelial cells
- the G(i)-Ras-Raf-NF-kappaB signaling cascade is responsible for LPA-induced uPA up-regulation in ovarian cancer cells
- evidence that HPV-VLP signal dendritic cells through a pathway involving proteoglycan receptors, TLR4 and NF-kappaB
- Together, these results suggest that TPA-induced TLR2 expression in U937 cells may be at least in part mediated through activation of PKC and ERKs as well as NF-kappaB transcription factor, and that cross-talk between PKC or ERKs and NF-kappaB may exist.
- p50 binds to the N-terminal and p65 to the C-terminal NLS binding site of importin alpha3
- IL-4 > PI3K/Akt > NF-(kappa)B signaling pathways, which activate abdrogen receptor signaling, play an important role during the development of androgen independent prostate cancer cells.
- CPAP functions as a coactivator of NF-kappaB-mediated transcription
- Bcl-2 and NF-kappaB are downregulated through a caspase-independent mechanism during Resveratrol-induced apoptosis in human breast cancer cells
- TNF-alpha signals primarily through the p38, JNK, MAP kinase, and IKK pathways resulting in the activation of the transcription factors AP-1 and NF-kappa B
- caspase-8 plays an important role in the ASC-mediated NF-kappaB activation and IL-8 production, which actually induces physiologically relevant gene expression
- Our results suggest that concomitant infection with KSHV/HHV8 may stimulate HIV-1 LTR via vFLIP K13-induced classical NF-kappaB pathway which cooperates with HIV-1 Tat protein.
- Shear stress inhibited the smooth muscle cell coculture-induced NF-kappaB activation in endothelial cells and monocytic THP-1 cell adhesion to ECs.
- cFLIP/CFLAR is an essential NF-kappa B-dependent antiapoptotic gene in the tumor necrosis factor alpha-regulated pathway in epidermal keratinocytes
- specific genomic targets downstream of the nuclear factor-kappaB transcription factor mediate tumor necrosis factor signaling
- Dimethylsulfoxide induced upregulation of PTEN in HL-60 leukemia cells is blocked by an inibior of NF-kappa-b.
- Mitochondrial ROS production is a physiologically relevant component of the TNF signal-transduction pathway during apoptosis, and a novel functional role for mitochondrial ROS as a temporal regulator of NF-kappaB activation and antiapoptotic signalling.
- downregulation of Hsp72 leads to severe suppression of the major survival pathways, ERK and NF-kappaB, which may be responsible for enhanced sensitivity of prostate carcinoma cells to a variety of anticancer treatments
- S1P inhibits male germ cell apoptosis independently of its receptors, possibly by inhibiting the transcription factor NF-kappaB and Akt phosphorylation
- NF-kappaB activation in pulmonary leukocytes may be involved in the lung inflammatory process in infants with hyaline membrane disease
- caspase-8 deficiency specifically abolishes activation of NF-kappaB after stimulation in T, B & NK cells; recruitment of the IKKalpha, beta complex, its activation & the nuclear translocation of NF-kappaB require activity of full-length caspase-8
- NAG-1 expression is up-regulated by TPA in LNCaP cells through a PKC-dependent pathway involving the activation of NF-kappa B
- NF-kappaB and interferon regulatory factor, the two major transcription factors activated by virus infection, were essential for the induction of two sets of genes by Sendai virus
- PDK1 plays a critical role by nucleating the TCR-induced NF-kappaB activation pathway in T cells
- fMLP-induced activation of NF-kappaB utilizes a signaling pathway requiring activity of PKCepsilon, a signaling component downstream of RhoA in cytokine gene transcription stimulated by a chemoattractant
- gene transactivation by the transcription factor NF-kappaB is subject to the regulation of a dynamic balance between the coactivators and corepressors in the IkappaB alpha promoter
- Proliferative inhibition of breast cancer cells by Velcade is associated with blocking phosphorylated-NF-kappaB function by upregulation of nuclear I-kappaB.
- previously undescribed kappaB site in the t-PA gene promoter that influences t-PA expression in neuronal cells
- DLBCL subtypes had a robust NFKB target gene signature that partially overlapped that of MLBCL. In this series of MLBCLs and DLBCLs, NFKB activation was not associated with amplification of the cREL locus, suggesting alternative pathogenetic mechanisms.
- Elevated CD30 expression is considered one of the causes of constitutive NF-kappaB activation in adult T-cell Leukemia (ATL) cells, and may be involved in ATL development.
- hepatopoietin association with thioredoxin constitutes a redox signal transduction in activation of AP-1/NF-kappaB
- the constitutive activation and the protein expression of NF-kappaB are different in gastric cancer cell lines
- Phosphorylated NF-kappaB, overexpressed in high-grade dysplasia and squamous cell carcinoma of the tonsil, is associated with worse prognosis in terms of high recurrence and poor survival, respectively.
- NF-kappaB activity is enhanced by a PI3K signal mediated by Cbl-b and Rho
- Nfkb 1 expression was reduced in the majority of Emu-Myc lymphomas and was also suppressed in human Burkitt lymphoma, and it believed Nfkb1 is dispensable for myc-induced lymphomagenesis
- In conclusion, this study has demonstrated for the first time that sodium lactate and LPS exert synergistic effect on MMP and cytokine expression through NF-kappaB and MAPK pathways.
- chlorogenic acid stimulates Nrf2, inhibits activator protein-1, NF-kappaB, and MAPKs and induces phase 2 detoxifying enzyme activity
- NIBP is a NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation
- Activation of transcription factor nuclear factor (NF)-kappaB, which controls transcription of various pro-inflammatory cytokine genes, has been shown to play a critical role in the pathogenesis of inflammatory bowel disease.
- NF-kappa B diferentially regulates DR5 expression involving histone deacetylase 1.
- Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappa B activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP dcownregulation, and c-Jun N-terminal Kinase 1 activation.
- Helicobacter pylori CagA activates and potentiates NFKB and proinflammatory responses
- There is enhanced G2/M arrest by NFKB1-dependent p21waf1/cip1 induction.
- Our results suggest that MUC6 transcription is regulated by NFkappaB and Sp family members.
- Constitutive NF-kappaB activity in the human Burkitt lymphoma Daudi cells is maintained by a mechanism independent of IkappaB-alpha degradation.
- Moreover, supershift experiments indicated that these elements are recognized by the NF-kappaB p50/p65 heterodimer.
- Activation of both NF-kappaB and AP-1 may be required for ICH-1L/S-induced apoptosis in hepatocellular carcinoma(HCC), but not for Fas/FasL-mediated apoptosis. NF-kappaB and AP-1 may play important roles in pathogenesis of human HCC.
- IL-4 regulates TNFalpha-induced IL-8 expression at a transcriptional level and this mechanism involves STAT6 and NF-kappaB transcription factors
- Taken together, IFN-alpha-induced activations of NF-kappaB and COX-2 were inhibited by the addition of curcumin in A549 cells.
- Dexamethasonereduces the expression of inflammatory cytokines and other proteins in a synovial sarcoma cell line by infhibiting NF-kappaB. synovial sarcoma
- We find that while hKSR-2 blocks MEKK3 activation, it has little to no effect on other members of the MAP3K family, including MEKK4, TAK1, and Ras-Raf, suggesting that its effects are selective.
- The pro-inflammatory nature of hResistin was further evident from the ability of this protein to induce the nuclear translocation of NF-kappaB transcription factor as seen from electrophoretic mobility shift assays.
- Tretinoin-induced activation of NF-kappa B in APL cells is not essential for granulocytic differentiation, but prolongs the life span of mature cells.
- T-oligos transcriptionally down-regulate COX-2 expression in human skin via activation and up-regulation of p53, at least in part by inhibiting NFkappaB transcriptional activation
- Galpha13-induced VASP phosphorylation that involves activation of RhoA and MEKK1, phosphorylation and degradation of IkappaB, release of PKA catalytic subunit from the complex with IkappaB and NF-kappaB, and subsequent phosphorylation of VASP
- p62 regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
- The data also suggest that combining siRNA/NF-kappaB with Velcade might achieve greater reduction in the growth of HNSCC in patients with constitutively activated NF-kappaB
- Ser15 phosphorylation is important in regulating the oncogenic function of mutant p53 apoptosis induction in the context of the NF-kappaB/IkappaB signaling pathway
- Our results using purified proteins indicate that p105 binding improves COT solubility and stability while down-regulating kinase activity, consistent with cellular data showing that p105 functions as an inhibitor of COT.
- Data show that, similar to H. pylori, low pH augments NF-kappaB nuclear binding in gastric epithelial cells and appears to be mediated through MEK1-dependent signaling pathways.
- (p52)2/Bcl-3P ternary complex, which is specifically induced in CD30-stimulated anaplastic large cell lymphoma, can modulate expression of apoptosis-related genes regulated by NF-kappaB.
- Regulation of basal and induced expression of C-reactive protein through an overlapping element for OCT-1 and NF-kappaB on the proximal promoter.
- Bcl-3, which is an inducer of nuclear (p50)2 and is associated with (p50)2 in anaplastic large-cell lymphomas and HRS cell lines, is abundantly expressed in anaplastic large-cell lymphomas and Hodgkin/Reed-Sternberg cells
- NF-kappaB and STAT3 are activated by proteolysis inducing factor in human Kupffer cells and monocytes
- NFkappaB-dependent cytokine production has a role in human adipocyte insulin resistance
- Our results demonstrate that radioresistance of Saos2 osteosarcoma cells is due to NFkappaB-mediated inhibition of JNK
- Expression of IKK-i can activate both NFkappaB and IRF3, leading to the production of several cytokines including interferon beta.
- Erbin is a regulator of Nod2-dependent NF-kappaB signaling with a role in inflammatory responses
- results indicate that 3-phosphoinositide-dependent protein kinase-1 is a critical regulator of cell survival by modulating the IkappaB kinase (IKK)/nuclear factor-kappaB pathway
- Patients with carotid atherosclerosis depict an overexpression of COX-2, mPGES-1 and EPs in blood mononuclear cells and plaque of patients with carotid atherosclerosis regulated by nuclear factor-kappaB
- NF-kappaB is constitutively activated in cutaneous T-cell lymphoma; down-regulation of NF-kappaB activation and induction of CTCL cell apoptosis in the presence of proteasome 26S inhibitors was evidenced
- STAT1, IRF1, and NF-kappaB activation and early myocyte apoptosis play a mechanistic role in septic myocardial depression and sepsis-induced organ dysfunction
- induction and continued secretion of CHI3L1 in chondrocytes require sustained activation of NF-kappaB
- We provide evidence that STAT3 plays an essential role in cytokine-driven SAA expression, although the human SAA gene shows no typical STAT3 response element
- Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages
- IkappaB kinase and IkappaBalpha have NF-kappaB-dependent as well as NF-kappaB-independent pathways of HAS1 activation
- TAK1 is recruited to the TNF-R1 complex via RIP and likely cooperates with MEKK3 to activate NF-kappaB in TNF-alpha signaling
- found two different subgroups of PTCL based on the expression of NF-kappaB pathway genes
- LMP1 utilizes two distinct pathways to activate NF-kappaB: a major one through CTAR2/TRAF6/TAK1/IKKbeta (canonical pathway) and a minor one through CTAR1/TRAF3/NIK/IKKalpha (noncanonical pathway)
- The activation of p50 and p65 by tumor necrosis factor alpha suppresses the expression of the alpha1C subunit of Cav1.2 channels in human colonic circular smooth muscle cells
- Smad4 plays the role in the transcriptional activation of NF-kappaB.
- activated by the LTR from Moloney murine and feline leukemia viruses (Mo-MuLV and FeLV) via TLR3 dependent pathway
- Induction of apoptosis was paralleled by reduction of nuclear NF-kappaB.
- Two unrelated transcription factors, Ci and NF-kappaB, use the same mechanism to undergo partial degradation by the proteasome in vivo.
- role for NF-kappaB in the regulation of the later class of viral genes and virus replication.
- the virus-inducible, NF-kappaB-dependent activation of A20 functions as a negative regulator of RIG-I-mediated induction of the antiviral state
- beta-arrestin2 is identified as a phosphorylation-regulated suppressor of UV induced NF-kappaB activation
- TNF-alpha and IFN-gamma regulate gene transcription mediated by NF-kappaB-Stat1 interactions
- NF-kappaB p50-HDAC1 complexes constitutively bind the latent HIV LTR and induce histone deacetylation and repressive changes in chromatin structure of the HIV LTR, changes that impair recruitment of RNA polymerase II and transcriptional initiation.
- Together, these studies demonstrate a novel signal transduction pathway involving p38MAPK-NF-kappaB-PTEN in IL-18-mediated HCMEC death, and identify IL-18 as potential therapeutic target to inhibit or reduce myocardial inflammation and injury.
- suppression or activation of NFkappaB by HPK1 determines sensitivity to activation-induced cell death
- Transcription of the CCL15 gene is regulated by AP-1 and NF-kappaB through MEK and JNK MAPK pathways in monocytoid cells.
- Oral squamous cell carcinoma with lymph node metastasis or advanced stage had significantly higher frequency of NFKB1 ins allele.
- In addition, the identified mutations will help understanding at the molecular level how NF-kappaB is activated in response to cell stimulation.
- Molecular pathways upstream and downstream of NF-kappaB in neurons are being elucidated and may provide novel targets for therapeutic intervention in various neurological disorders.
- Herpes simplex virus disrupts NF-kappaB regulation by blocking its recruitment on the IkappaBalpha promoter
- Recent studies indicate that coreceptor pathways influence the threshold activities of many signalling mediators and thus act on multiple layers of the NF-kappaB pathway.
- Therefore, in this review, we will try to summarize the current knowledge of distinct DNA damage-induced NF-kappaB signalling pathways.
- This review will discuss the different functions of NF-kappaB, the pathways that modulate NF-kappaB subunit activity and its ability, under some circumstances, to behave as a tumor suppressor.
- CARD6 is a regulator of NF-kappaB activation that modulates the functions of RICK protein
- NF-kappaB plays a key role in the resistance of lung cancer cells to TNF and TRAIL
- TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB
- We discuss recent insights into this specific signal transduction cascade(the cascade leading to NF-kappaB activation following engagement of the T-cell receptor by a foreign antigen), and the way it is controlled both spatially and temporally.
- No evidence of association was detected for those genetic markers in 270 Spanish T1D patients and 484 healthy ethnically matched controls. Therefore, it seems that this gene plays no major role in T1D predisposition.
- NF-kappa B signaling is induced by the oncoprotein Tio through direct interaction with TRAF6.
- persistent IL-1beta signaling causes sustained activation of NFkappaB in a promoter-specific manner in human glial cells, leading to prolonged induction of selective pro-inflammatory genes
- In order to appropriately move NF-kappaB inhibitors in the clinic, thorough approaches must be initiated to determine the molecular mechanisms that dictate the complexity of oncologic and therapeutic outcomes that are controlled by NF-kappaB.
- analysis of involvement of NF-kappaB regulated by capacitative Ca2+ entry in muscarinic receptor-mediated sAPPalpha release enhancement
- Siva-1 has a role, through its inhibitory effect on NF-kappaB activity, in TCR-mediated AICD with implications in peripheral tolerance, T-cell homeostasis and cancer
- NFKB and NFAT regulate BLyS expression via at least one NFKB and 2 NFAT BLYS promoter binding sites. Constitutive activation of NFKB and BLyS in NHL-B cells forms a positive feedback loop associated with lymphoma cell survival and proliferation
- Thus, NF-kappaB inhibitory molecules may be clinically useful, either as single therapeutic agents or in combination with classical chemotherapeutic agents, for the treatment of hematological malignancies.
- NF-kappaB, but not PI3K/Akt activation, is required for the Dex protective effect against TNF-alpha-mediated cell death, and correlates with lack of degradation of the anti-apoptotic protein c-IAP1.
- IkappaB-zeta functions as an additional regulator of NF-kappaB activity
- activated by P. gingivalis in primary human gingival epithelial cells (HGEC)
- Enhanced expression of NFkappaB1 mRNA in bone marrow CD34+ cells plays pivotal role in their abnormal responses to TNF-alpha and, thus, in the pathogenesis of rheumatoid arthritis.
- This review will focus on the role of nuclear factor kappaB (NF-kappaB) signaling in hematopoietic differentiation. We will also discuss several hematopoietic pathologies associated with deregulation of NF-kappaB and their potential therapies.
- This study provides the first genetic evidence that the ubiquitination of RIP is required for TNFalpha-induced NF-kappaB activation.
- Although a key factor in TRAF6-dependent activation of PI 3-kinase, ectopic expression of Src was insufficient for NF-kappaB activation and, in contrast to NF-kappaB, was not inhibited by IRAK2.
- TNF-alpha-induced CD38 expression involves NF-kappaB expression and its activation and dexamethasone inhibits CD38 expression through NF-kappaB-dependent and -independent mechanisms.
- GSK-3beta selectively regulates NFkappaB-mediated inflammatory gene expression of IL-1beta and TNF-alpha by controlling the flow of NFkappaB activity between transcription of inflammatory and survival genes
- Treatment with fenoldopam prevented activation of NF-kappaB DNA binding activity (p < 0.001) and attenuated 72 of 75 I/R-induced genes and 3 of 8 I/R-suppressed genes.
- the NF-kappaB activation pathway is suppressed by plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) in human tumor cells
- topoisomerase II inhibition and oxygen free radicals regulate NF-kappaB but are not required for the particular ability of NF-kappaB to repress rather than activate transcription
- In conclusion, CDM is a pleiotropic agent that not only inhibits the multiplication of DNA and RNA viruses by the same mechanism of action but also modulates the NF-kappaB signaling pathway.
- PI3K/AKT, MAPK/ERK and NFkappabeta signalling have roles in the maintenance of human embryonic stem cell pluripotency and viability
- SUMOylation and activation of ataxia-telangiectasia-mutated protein, PKCdelta, caspase-3, and nuclear factor kappaB signaling pathways modulate salivary adaptive responses to stress in cells exposed to either 1% O(2) or DFO.
- Here we describe a novel region, a Processing Inhibitory Domain-PID, that upon its removal, the molecule is processed in high efficiency, which requires ubiquitination on a single, though non-specific, lysine.
- The results of this study showed that there was the constitutively activated NF-kB signaling pathway in the ESCC cell lines.
- ABIN-1 physically links A20 to NEMO/IKKgamma and facilitates A20-mediated de-ubiquitination of NEMO/IKKgamma, thus resulting in inhibition of NF-kappaB
- LDAg translocation by Hepatitis b virus surface antigens correlates with ER stress and activation of NF-kappaB.
- protease-activated receptor-1 has a role in calcium influx, which activates a feed-forward mechanism of TRPC1 expression via nuclear factor-kappaB activation in endothelial cells
- Smooth muscle cells exposed to degraded collagen are protected against apoptosis by mechanism involving alpha(v)beta(3)-dependent NF-kappaB activation with consequent activation of inhibitor of apoptosis proteins. (Integrin alpha v beta 3)
- The NF-kappaB transcription factor pathway probably contributes to the phenotype of IBC and possibly offers new options for treatment of patients diagnosed with this aggressive form of breast cancer.
- Data demonstrate an important role of NF-kappaB-1 and -2 pathways in mediating resistance to apoptosis and distinctive antiapoptotic downstream target gene profiles responsible for this effect.
- estrogen receptor-beta/NFkappaB crosstalk mediates ICI 182,780-regulated gene expression in DU145 prostate cancer cells
- a common mediator of inflammation can lead to the induction of SSAT expression by activating the NFkappaB signaling pathway in non-small cell lung cancer cells
- Halofuginone inhibits activated peripheral blood T cell functions and proinflammatory cytokine production through inhibition of NF-kappaB activation and p38 MAPK phosphorylation.
- Factors that trigger an NF-kappaB response in hepatic cells inhibit the transcriptional activity of HNF-4-dependent promoters; this inhibition could be accounted for by a decrease in DNA binding and the down-regulation of HNF-4.[HNF-4]
- trichostatin A-induced cell death of Ki-Ras-transformed cells is enhanced by inhibition of NF-kappaB
- Transcription factor TAL1 binds to the promoter of the NFKB1 gene that encodes p50 and represses its transcription to set up this unique response in T-ALL cells.
- analysis of the NFKB1 protein polymorphism interactions with CARD15/NOD2, IKBL, and IL-1RN genes
- anti-inflammatory actions mediated by gliotoxin include HO-1 induction and the subsequent blockade of NF-kappaB-dependent signaling pathways in vitro and in vivo
- by controlling Piasy stability, Trim32 regulates UVB-induced keratinocyte apoptosis through induction of NFkappaB
- COX-2 is downregulated by PC-SPES via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells
- Cytoplasmic expression as well as nuclear translocation of NF-kappaB increased with progression of oral cancer
- TNF-alpha increases the stability of BMP-2 mRNA through the pentameric motifs via NF-kappaB
- IKK-i/IKKepsilon has a role in controlling proliferation of certain cancer cells through regulation of constitutive NF-kappaB activity
- Data show that the suppression of NF-kappaB activation by Entamoeba histolytica in intestinal epithelial cells is mediated by heat shock protein 27.
- inhibition of TNF-alpha-induced autophagy is a novel mechanism of the antiapoptotic function of NF-kappaB activation
- TNF-alpha impairs fibrinolytic capacity in vascular endothelial cells by a NF-kappaB and p38 MAPK-dependent suppression of t-PA
- the t(11, 18)(q21;q21) translocation creating the c-IAP2.MALT1 fusion protein activates NF-kappaB independently of TRAF1 AND TRAF2 and contributes to human malignancy in the absence of signaling adaptors that might otherwise regulate its activity
- the TAK1-JNK pathway is activated by osmotic stress, while blocking TAK1-mediated NF-kappaB activation; TAO2 regulates TAK1 pathways
- Although small interfering RNAs (siRNAs) against PIASy (protein inhibitor of activated STATy) inhibit NEMO sumoylation and NF-kappaB activation in response to genotoxic agents, overexpression of PIASy enhances these events.
- In 293T cells, Vaccinia Virus apparently utilizes its M2L protein to interfere with a step (s) that would otherwise enable ERK2 phosphorylation and the consequential activation of an NF-kappaBeta response.
- IKK/NF-kappaB signaling plays a dominant role in P. gingivalis LPS-induced early response gene expression
- These findings substantiate the hypothesis of transitory delayed inflammation, as suggested by the animal model, and suggest the possibility of using therapeutic approaches to target NF-kappaB transcription in the treatment of migraine.
- glucose intake induces an immediate increase in intranuclear NF-kappaB binding, a fall in IkappaBalpha, an increase in IKKalpha, IKKbeta, IKK activity, and messenger RNA expression of TNF-alpha in MNCs in healthy subjects.
- histone deacetylase inhibitors not only inhibit deacetylase activity but also stimulate active NF-kappaB transcription and cell survival through signaling pathways involving Akt and increased p300 acetyltransferase activity
- PKD(2) activation is a novel early event in the biological action of LPA and mediates LPA-stimulated IL-8 secretion in NCM460 cells through a NF-kappaB-dependent pathway.
- NF-kappaB p105may be an important marker for human melanoma progression and prognosis as well as a potentially selective therapeutic target.
- Basis for future studies potentially for new strategies to stem cell graft manipulation, by specific NF-kappaB pathway modulation on stem cells, prior to transplant.
- LMP1 elevated kappa light chain through activation of the NF-kappaB and AP-1 signaling pathways. The present study provided some hints of possible mechanisms by which human cancer cells of epithelial origin produced immunoglobulins.
- The results demonstrated statistically significant increased oral mucosal staining for NF-kappaB and COX-2 following cytotoxic chemotherapy and provide further support for the role of NF-kappaB and COX-2 in the pathogenesis of mucositis.
- Elafin inhibits the lipopolysaccharide-induced production of monocyte chemoattractant protein-1 in monocytes by inhibiting AP-1 and NF-kappaB activation.
- epithelial cells infected with Chlamydophila pneumoniae resist apoptosis dependent upon the activity of Nf-kappa B, cIAP-1 and cIAP-2
- there is a cross-talk between the NFkappaB and the STAT3 signaling systems, and HNSCC may result from the aberrant activity of a signaling network
- human osteoclastogenesis is induced by canine distemper virus through NF-kappaB and sequestosome 1/P62 activation
- CENTB1 selectively down-regulates NF-kappaB activation via NODs pathways, creating a "feedback" loop and suggesting a novel role of CENTB1 in innate immune responses to bacteria and inflammatory responses
- Human labor is associated with decreased expression of nuclear factor kappa B in the myometrium.
- autotaxin induces uPA expression via the Gi-PI3K-Akt-NF-kappaB signaling pathway that might be critical for autotaxin-induced tumor cell invasion and metastasis
- NF-kappaB activity and keratinocyte differentiation are regulated by the RIP4 protein, which has roles in cutaneous wound repair
- these results indicate that STAT-4 can be finely tuned along with DC maturation through NF-kappaB activation and that its induction may be involved in preparing the DC to be receptive to the cytokine environment present in lymphoid organs.
- identify a role for caspase-8 in monocytes undergoing macrophagic differentiation, that is, the enzyme activated in an atypical complex down-regulates NF-kappaB activity through RIP1 cleavage.
- The results of our studies indicate that TX 527 inhibits TNF-alpha mediated effects on PBMC and the activation of NF-kappaB and that its action is mediated by Vitamin D receptor (VDR), which is activated when the cells are stimulated with TX 527.
- results suggest that wogonin effectively suppresses TNF-alpha-induced HASMC migration through the selective inhibition of MMP-9.
- ozLDL inhibited NF-kappaB and IRAK-1-associated signaling which may impair immune function and promote apoptosis
- T lymphocytes from patients with active pulmonary tuberculosis (PTB) had significantly decreased expression of CD3zeta & absence of the p65/p50 heterodimer of NF- kappa B; findings provide a novel mechanism for the T cell dysfunction in patients with PTB
- DSCR1 attenuates NF-kappaB-mediated transcriptional activation by stabilizing its inhibitory protein, IkappaBalpha
- Together, these studies reveal that phosphorylation of the SIMPL protein plays a critical role in SIMPL regulation by affecting both SIMPL subcellular localization and the p65 coactivator function of SIMPL.
- TNF-alpha enhances the binding of p50 to the promoter/enhancer regions of the MnSOD gene, which primes neuronal cells to develop resistance against subsequent exposure to beta-amyloid and FeSO(4).
- ABIN-3 is a novel negative feedback regulator of LPS-induced NF-kappaB activation
- These findings suggested that expression of NF-kappaB has an important role in H. pylori gastritis.
- the nuclear factor-kappaB signaling pathway is inhibed by gamma-tocopherol through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis
- p53 to NF-kappaB signaling has a role in chemotherapy responsiveness of neuroblastoma
- Findings indicate that IL-1beta-induced Cox-2 expression in human myometrial smooth muscle cells is dependent on the action of atypical PKCs, through stimulation of the activity of NF-kappaB.
- PIDD autoproteolysis marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway
- Our findings demonstrated that the shear stress-induced MMP-9 expression involved integrins-p38 MAPK or ERK1/2-NF-kappaB signaling pathways.
- interleukin-6 induces Oct-1 gene expression, providing a biologically relevant means by which NF-kappaB-dependent gene expression can be selectively reverted by Oct-1 to quiescent levels
- Physiologically high concentrations of estradiol enhance NF-kappaB activity in T-lymphocytes.
- KGF/FGF-7 induces NF-kappaB activation and NF-kappaB plays an essential role in regulation of KGF/FGF-7-inducible gene expression and KGF/FGF-7-initiated cellular responses
- NF-kappaB is a key mediator of the invasive phenotypic changes induced by RRM2 overexpression.
- Unequal alterations in the levels of activated NF-kappaB subunits p50 and p65 might provide insights into the mechanisms of NF-kappaB action and anti-TNF-alpha therapy in AS.
- IL1 induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta
- Interaction of the activated NFkappaB pathway and C/EBP-epsilon may be important in selective activation of a subset of C/EBP-epsilon-responsive genes.
- two kappaB-binding sites were identified upstream from the start codon in the IL-20 gene
- VAP-1-mediated activation was rapid and dependent upon nuclear factor-kappaB.
- These results strongly suggest that DGKalpha is a novel positive regulator of NF-kappaB, which suppresses TNF-alpha-induced melanoma cell apoptosis.
- These findings reveal for the first time that TNF stimulation of adhesion molecules ICAM-1 and VCAM-1 in human endothelial cells occurs through the TNFR1 subtype and is mediated by the NF-kappaB pathway, but not the ERK, p38MAPK or JNK kinase pathways.
- Overexpression of a constitutively activated IGF-IR (CD8-IGF-IR) was sufficient to cause transformation of immortalized human mammary epithelial cells and growth in immunocompromised mice.
- These results suggest that in human tracheal smooth muscle cells, activation of p42/p44 MAPK, p38, and JNK pathways, at least in part, mediated through NF-kappaB, is essential for lipopolysaccharide-induced VCAM-1 gene expression.
- induction of TNF gene transcription by virus or LPS does not depend upon NF-kappaB binding to the proximal promoter; rather, a stimulus-specific post-induction mechanism involving NF-kappaB is involved in the maintenance of maximal TNF mRNA levels
- The role of HERG in the regulation of SP1, NF-kappaB and Nkx3.1 metabolism in neoplastic cells is reported.
- protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator is regulated by heptad repeats, which are targeted by HTLV-I tax
- NF-kappaB inhibition may contribute partially to cell cycle arrest and apoptosis induced by Notch1 activation in human cervical cancer cells.
- Genetic predisposition for type 1 diabetes with polymorphisms in NFKB1.
- Stretch-induced transcriptional elevation of genes assigned to the NF-kappaB.
- Study demonstrates correlation between over expression of NF-kappaB and COX-2 in early precancerous stages of development of oral cancer and sustained elevation down the tumorigenic pathway.
- These data suggested that APR3 might be functionally important in certain processes under which NFAT and/or NFkappaB are/is activated.
- 1alpha,25-(OH)2DHT(3) blocks TNF-induced monocytic tissue factor expression by inhibition of AP1 and NF-kappa B.
- HSV-1-gD-HveA interaction initiates a signal transduction pathway leading to NF-kappaB activation
- evidence provided for activation of the NF-kappaB system in intervertebral discs in vivo which correlates with accumulated oxidative stress & increases in age & disc degeneration; oxidative stress may lead to RAGE activation & NF-kappaB translocation
- NF-kappaB is involved in the repression of Tac1 at higher levels of SDF-1alpha in MCF12A. These results are relevant to dysfunction of Tac1 in breast cancer cells .
- Tax-induced NFkappaB activation does not involve K63 polyubiquitination-mediated
- There is an essential role of virus-induced IKK/NF-kappaB activity to trigger both viral IE gene expression and productive replication in quiescent cells.
- Understanding of the cross-talk between NF-kappaB and MAPKs signaling in CF lung epithelial cells may help in developing new therapeutics to reduce lung inflammation in patients with CF.
- IkappaB-zeta acts as an essential transcriptional activator by forming a complex with NF-kappaB on promoters harbouring the NF-kappaB- and C/EBP-binding sites.
- These results suggest that NF-kappaB and IKK signals via Ca(2+) influx and mitochondrial ROI play a role in the up-regulation of chemokine expression in eosinophils stimulated with H. pylori VacA.
- Inhibition of NFkappaB at G2-M diminished mitosis induced by constitutive activation of ERK5, providing a direct link between ERK5, NFkappaB, and regulation of G2-M progression.
- NF-kappa-B inhibition enhances CASP3 degradation of Akt1 and apoptosis in response to campothecin.
- Absence of CFTR at the cell membrane leads to an intrinsic NF-kappa B activity.
- GRx-dependent S-glutathionylation of p65-NFkappaB is most likely responsible for NAC-mediated NFkappaB inactivation and enhanced hypoxic apoptosis
- insertion/deletion polymorphism in the promoter of NFKB1 influences the severity but not the mortality of acute respiratory distress syndrome
- Regulation of autophagy by NF-Kappa-B and reactive oxygen species is reported.
- Here, we report that expression and consequent activation of TNK1 enables tumor necrosis factor alpha (TNFalpha)-induced apoptosis by selectively inhibiting TNFalpha-induced activation of nuclear factor-kappaB (NF-kappaB).
- The NF-kappa B pathway in airway epithelial cells is critical for generation of lung inflammation and injury in response to local and systemic stimuli.
- NF-kappaB inactivation has a role in autophagocytosis [review]
- Results showed that the viral nucleocapsid (N) protein activated IL-6 expression in a concentration-dependent manner; promoter analyses suggested that NF-kappaB binding element was required for IL-6 expression regulated by N protein.
- Polymorphisms in NF-kappaB1 and NF-kappaBIalpha genes is associated with melanoma
- Dimethylfumarate specifically inhibits MSK1 and 2 activations and subsequently inhibits NF-kappaB-induced gene-transcriptions, which are believed to be important in the pathogenesis of psoriasis
- CDP inhibits cytokine-induced NF-kappaB-regulated chemokine transcription in melanoma cells
- transcription factors p53, NF-kappaB, and AP-1 may be important determinants of the heterogeneous pattern of gene expression, whereas STAT3 and EGR1 may broadly enhance gene expression in head and neck squamous cell carcinomas
- theaflavins induce apoptosis in human prostate cancer cells through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways
- Upon induction of NF-kappaB, a subset of target genes is regulated differentially by either P-TEFb or DSIF.
- These findings demonstrate that phosphorylation of Bcl10 at S138 down-regulates Bcl10 protein levels and thus negatively regulates T-cell receptor-mediated NF-kappaB activation.
- ET-1 induces functionally active CD40 protein via NFKB1 in vascular smooth mucle cells.
- Rho inactivation allows the activity of Rac to become dominant leading to stimulation of the phosphoinositide 3-kinase/Akt/IkappaB kinase/nuclear factor-kappaB prosurvival pathway.
- These findings provide evidence for the involvement of the nuclear hormone receptors PPAR gamma and VDR in butyrate-mediated inhibition of inducible NF kappa B activation dependent on the stimulated signalling pathway.
- Reduced activation of NF-kappaB via impaired PI3K/Akt activation under increased TNF-alpha levels could result in increased apoptosis of vitiliginous keratinocytes.
- increased apoptosis by dual knockdown of p65 and p50 may prove advantageous in preventing invasiveness and destructiveness of hyperplastic synoviocytes
- Our results indicate that IL-6 expression is regulated through NF-kappaB transcription factor and stereoid-receptor signalling pathways in ARPE-19 cells.
- In diabetic patients, FPG-sensitive DNA strand breaks correlated positively with PARP gene expression, PARP activity and NFkappaB binding activity.
- These results indicate that expression of the gamma-fibrinogen gene is mainly controlled by the strength of late phase STAT3 activation, which in turn is negatively regulated by the extent of interleukin-1beta-mediated NF-kappaB activity.
- Nuclear factor-kappaB-related serum factors have roles in progression of advanced oropharyngeal carcinoma
- the NFKB pathway in ovarian cancer is targeted by curcumin, which inhibits tumor growth and angiogenesis
- NF-kappaB status significantly correlates with disease-free survival and overall survival for patients with esophageal adenocarcinoma undergoing surgery as primary therapy
- Nitric oxide induces apoptosis in cutaneous T-cell lymphoma by downregulating constitutive NF-kappAB.
- These results suggest that E1Blarge interacts with NF-kappaB to prevent transcription and down regulate proinflammatory cytokine IL-8 production.
- Leukemia patients showing parallel activation of the studied proteins trended to exhibit higher incidence of fatal outcome.
- The results show that Hcy activated both ERK(1/2)/p38MAPK pathway and NF-kappaB-DNA-binding activity.
- V. cholerae induces proinflammatory cytokine response in Int407 cells, which is mediated by NF-kappaB and is modulated, in part, by adherence or motility of this organism.
- U2-OS cells were used to study direct interactions between fluorescent fusion proteins of ERalpha and the NF-kappaB subunits p50 and p65.
- KSHV oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation
- Involved in autoimmune diseases, the NFkB1 genes do not seem involved in the IBD predisposition
- These observations raise the possibility that the GITRL-mediated inflammatory activation of macrophages is involved in the pathogenesis of inflammatory diseases.
- Inhibitor of apoptosis proteins, nuclear factor-kappa, Smac/DIABLO and apoptosis inducing factor were increased in colon cancer cells.
- These studies suggest that Notch inhibition can initiate aberrant mitosis by inducing NF-kappaB activity that inappropriately increases cyclin B1 resulting in cell death via mitotic catastrophe.
- IP6 reduces paclitaxel induced NF-kappaB activation and increases paclitaxel-mediated cell killing and apoptosis.
- Hyaluronan of intrinsic molecular weight suppresses LPS-stimulated production of proinflammatory cytokines via ICAM-1 through down-regulation of NF-kappaB and IkappaB
- NFkappaB activation mediated by loss of E-cadherin may represent an essential, even initial event in colorectal neoplasm metastasis
- results implicate NF-kappaB activation in the tumorigenesis and progression of ER-negative breast cancer
- High expression of RelA/p65 is correlated to an activation of the NF-kappaB pathway and indicates poor patient survival.
- Bortezomib reduced the levels of the p50 and p65 components of the canonical NF-kappaB pathway and reduced the level of p52 in the noncanonical NF-kappaB pathway, which is induced by EBV LMP1.
- Results indicate that gp120 induces COX-2 transcription through NF-kappaB activation in astrocytoma cells.
- a NGF/BEX2/NF-kappaB pathway is involved in regulating apoptosis in breast cancer cells and in modulating response to tamoxifen in primary tumors
- O(6)-methylguanine adducts formed by temozolomide lead to inhibition of NF-kappaB activity
- Beta2-integrins and acquired glycoprotein IIb/IIIa (GPIIb/IIIa) receptors cooperate in NF-kappaB activation of human neutrophils
- (-94)NFKB1 I/D promoter variation contributes to the modulation of vascular function and adaptability to exercise-induced flow shear stress, most likely due to differences in NFKB1 gene transactivity.
- atorvastatin reduces LPL and EL expression by reducing the activation of LXRalpha and NF-kappaB, respectively
- IL-17 is a potent inducer of CRP expression via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.
- Targeting autophagic regulation of NF-kappaB in HTLV-1 transformed cells by geldanamycin: implications for therapeutic interventions.
- FAF1 robustly suppresses NF-kappaB activation through the inhibition of IKK activation in combination with previously reported cytoplasmic retention of NF-kappaB p65
- NFKB1 -94ins/del ATTG polymorphism may be associated with susceptibility to and/or phenotype of Graves' disease.
- Up-regulation of nuclear factor kappaB is associated with multiple myeloma
- overview of structure, synthesis & function of the NF-kappaB subunit; NF-kappaB1 (p105 & p50). Diverse interactions of NF-kappaB1 with co-activators, co-repressors & other signaling networks that influence NF-kappaB1 gene expression are discussed[review]
- The inverse correlation between NF-kappaB activation and ER activation is due to EGFR and/or ErbB2 overexpression, resulting in NF-kappaB activation and ER downregulation.
- NFKB and NFKBI polymorphisms have roles in susceptibility of tumour and other diseases [review]
- Optineurin competitively antagonized NEMO's binding to polyUb receptor-interacting protein, and its overexpression inhibited TNFalpha-induced NF-kappaB activation.for its association with glaucoma.
- Adiponectin has proinflammatory properties in monocytic cells, and activates NF-kappaB.
- NFKB1 gene may be regarded as a potential marker for some types of endometrial cancer.
- there is synergism between REST and NFkappaB in the suppression of TAC1 in non-neuronal cells
- The proapoptotic effects of alpha-synuclein might be mediated at least in part by the impairment of NF-kappaB signaling pathway which involves GSK3beta.
- Costimulation by anti-CD3 and anti-CD28 antibodies could activate JNK, p38 MAPK and NF-kappaB. The upregulation of IL-25 receptors were differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB.
- NFKB1 promoter polymorphism is a useful marker for the identification of patients with superficial bladder cancer
- ROCK I cooperates with RhoB to activate NF-kappaB, and suppression of ROCK I activity by genetic or pharmacological inhibitors blocks NF-kappaB activation.
- NF-kB may play a crucial role in predicting the efficacy of cetuximab and irinotecan in advanced colorectal tumors.
- Inhibition of NF-kappaB activation was done with designed ankyrin repeat proteins targeting the ubiquitin-binding/oligomerization domain of NEMO.
- PPARgamma agonists have diverging and overlapping mechanisms blocking transactivation of transcription factors NF-kappaB and C/EBPbeta.
- NF-kappaB plays a central role in glioblastoma growth.
- A gene deletion mutation of the NFKB1 promoter was associated with increased susceptibility to sporadic colorectal cancers in the Swedish population, but not in the Swedish patients with a family history of colorectal cancer or in Chinese patients.
- NFkappaB signaling is suppressed by indomethacin, which enhances the cytotoxicity of recombinant human lymphotoxin alpha
- CDX2 inhibits transcription of Cox-2 by interfering with the binding of NF-kappaB on the NF-kappaB binding site.
- IRAK-2 plays a more central role than IRAK-1 in TLR signaling to NFkappaB through TRAF6 ubiquitination
- AKAP13 plays a role in TLR2-mediated NF-kappaB activation; GEF-containing scaffold proteins may confer specificity to innate immune responses downstream of TLRs
- O-GlcNAc modification might be required for nuclear translocation of the transcription factors NFkappaB and NFAT
- Alterations in expression of p50 homodimer/NF-kappaB regulated genes may contribute to neuroplastic adaptation underlying alcoholism.
- Results indicate a role for NF-kappaB activation and TNF-alpha in the activation of monocytes of patients with rheumatoid arthritis (RA), and suggest an important role of circulating monocytes in RA pathogenesis.
- rerview of NF-kappaB gene signatures and p53 mutations in head and neck squamous cell carcinoma [review]
- NF-kappaB promotes expression of a novel NF-kappaB-related gene signature and cell survival in HNSCC that weakly express TP53, a subset previously associated with inactivated wild-type TP53, greater resistance to chemoradiotherapy, and worse prognosis
- Tyrosine nitration of IKBA reveals a novel mechanism for NF-kappaB activation.
- by NF-kappaB activation, Tax elevates the level of the cellular p53 in human T-cells
- CYLD acts as a negative regulator for NF-kappaB-dependent inflammation in vivo, hence protecting the host against detrimental inflammatory response to NTHi infection
- The results of this study results support a role for NFkappaB in cytokine-induced prostaglandin E synthase expression in amnion mesenchymal cells in vitro.
- high molecular weight hyaluronan suppresses HBFN-f-activated NF-kappaB in rheumatoid arthritis chondrocytes
- Data show that the inhibition of NFkappaB by ER is mediated by CBP.
- Data show that pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by casein kinase 2.
- Expression of MDM2 in rhabdomyosarcoma cells transcriptionally repressed p65RelA and suppressed NFkappaB activity, resulting in a reduced growth rate and enhanced apoptosis.
- Collectively, our results reveal that Ubc13 is essential for Tax ubiquitination, its interaction with NEMO, and Tax-mediated NF-kappaB activation.
- nuclear factor kappaB pathway inhibition blocks myeloma cell growth and induces apoptosis in strong synergy with TRAIL
- 20-Hydroxyeicosatetraenoic acid (20-HETE) triggers NF-kappaB and MAPK/ERK activation, and both signaling pathways participate in the cellular mechanisms by which 20-HETE activates vascular endothelial cells.
- The reciprocal crosstalk between beta-catenin/Tcf pathway and NF-kappaB signaling in hMSCs is mediated through the regulation of lzts2 expression.
- Tumorigenic adenovirus type 12 E1A inhibits phosphorylation of NF-kappaB by PKAc, causing loss of DNA binding and transactivation.
- These findings reveal a dynamic regulation of DSIF involving either E-box or NF-kappaB depending on the physiological circumstances.
- the ability of NF-kappaB to regulate the G1-phase expression of key proto-oncogenes is subject to regulation by the integrated activity of IkappaB kinase (IKK)alpha, IKKbeta, Akt and Chk1
- The Epstein-Barr virus LMP1-induced Bcl-3 expression is considered to be mediated by the transcription factor NF-kappaB
- Hemin activated Elk-1, SRF, and NF-kappaB and promoted their interaction with the Egr-1 promoter
- the potential use of R-Roscovitine as a bitargeted anticancer drug that functions by simultaneously causing p53 activation and NF-kappaB suppression.
- Resistance to Ara-c up-regulates NFKB activity.
- crude extract of D. farinae induces ICAM-1 expression in EoL-1 cells through signaling pathways involving both NF-kappaB and JNK
- These results indicate that MMP-9 inhibition induces apoptosis due to altered beta1-integrin expression in medulloblastoma and ERK activation plays an active role and functions upstream of NF-kappaB activation to initiate the apoptotic signal.
- Pellino isoforms may be the E3 ubiquitin ligases that mediate the IL-1-stimulated formation of K63-pUb-IRAK1 in cells, which may contribute to activation of IKKbeta and transcription factor NF-kappaB, as well as signalling pathways dependent on IRAK1/4
- In conclusion, ADAM-17 plays an important role in cancer invasion probably through CD44 cleavage.
- VEGF is expressed not only by reactive cells, but also by neoplastic cells, and NF-kappaB activation is uncommon in angioimmunoblastic lymphoma, as suggested by frequent exclusively cytoplasmic c-REL localization
- methylseleninic acid causes nuclear factor-kappaB inhibition and the rapid generation of other selenium species
- using bioluminescent detection of NF-kappaB activation in mouse lug adenocarcinoma cells, we found a negative impact of p65/RelA on non-small cell lung cancer metastasis
- demonstrated that HCCs almost universally overexpress Bcl-3 and preferentially express nuclear p52 and p50, with little evidence of p65 activation
- the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa is abolished by simvastatin, which induces apoptosis in human breast cancer cells in a NFkappaB-dependent manner
- NF-kappaB, c-FOS, p-c-JUN, EGF-R and COX-2 were expressed in stromal myofibroblasts surrounding colon adenocarcinomas in the majority of cases.
- Our data suggest a crucial role of Ki-Ras:Akt1 complex in NF-kappaB transcriptional activation and enhancement of cell survival.
- Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activation
- PKCzeta is involved in regulation of IL-1beta-induced NF-kappaB signaling in human osteoarthritis chondrocytes, which regulates downstream expression of ADAMTS-4 and NOS2 via NF-kappaB.
- Data suggest that the p38 MAP kinase and NF-kappaB signaling pathways play an important role in regulation of IL-23p19 expression on human microglia, and are thus potential therapeutic targets in the treatment of MS.
- These data provide the first evidence that IL-18 and FN stimulate each other's expression.
- TRAF6 is involved but with different mechanisms in MyD88-induced and IRAK-induced activation of NF-kappaB.
- we postulate that CAPN3 intervenes in the regulation of the expression of NF-kappaB-dependent survival genes to prevent apoptosis in skeletal muscle.
- These results demonstrate that HCV NS2 up-regulates IL-8 transcription through NF-kappaB.
- variations in NFKB1 appear to affect the risk for alcoholism, particularly contributing to an earlier onset of the disease
- Upregulation of NFkappaB pathway-related genes in DCs infected with the live RV vaccine strain results in protective activity of SPBNGAS-GAS.
- Nuclear expression of NF-kappaB was significantly more frequently observed in gastric cancer tissues than in nonmalignant gastric tissues.
- Altered mechanisms regulating NOD2 induction, NF-kappaB activation and cytokine production may contribute to dysregulate the innate immune response underlying pediatric CD.
- Id-1 regulates Bcl-2 and Bax expression through p53 and NF-kappaB in MCF-7 breast cancer cells
- High levels of TNFRI at the cell surface in patients with the C73R mutation hypersensitizes cells to stimulation by TNF, leading to increased NF-kappaB p65 subunit activation and an exaggerated proinflammatory response
- A netwk involving signal coactivation of NF-kappaB and STAT3, differentially modified by p53 inactivation or mutation, promotes altered BAX/BCL-XL expression and cell survival in HNSCC.
- the activation of NF-kappaB in human cancer cell lines and Min mice is inhibited by NO-donating aspirin
- Cezanne forms a novel negative feedback loop in pro-inflammatory signaling and that it suppresses NF-kappaB activation by targeting RIP1 signaling intermediaries for deubiquitination
- potential coordinative effects of Wnt, NF-kappaB and/or Stat3 activation on gastric cancer formation presumably by promoting the transcription of their common target genes.
- The NEMO shuttle may link genotoxic stress to the activation of the innate immunity system and cause premature aging via inflamm-aging process.
- Helicobacter pylori inhibits H,K-ATPase alpha gene expression by ERK1/2-mediated NF-kappaB p50 homodimer binding to the HKalpha promoter
- copine-I regulates the half-life of NF-kappaB transcriptional responses through a novel mechanism that involves endoproteolysis of the p65 protein
- p65 and p50 subunits of NF-kappaB can bind to alpha-actinin; the alpha-actinin-4 is important for the NF-kappaB nuclear translocation and its functions inside the nucleus.
- These results identify NLRX1 as a NLR that contributes to the link between reactive oxygen species generation at the mitochondria and innate immune responses.
- Data demonstrate increased expression of the p38-NF-kappaB axis elements and COX-2 in disintegrated fibrocartilage, suggesting a role of these molecules in the pathobiochemistry of MD and consequential rupture.
- Data suggest that the antioxidant effect exerted by TGF-1beta-stimulated hyaluronan production reduces NF-kB activation and apoptosis in human fibroblasts exposed to FeSo4 plus ascorbate.
- Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFkappaB transcription factors.
- CX(3)CL1 expression is regulated through the NF-kappaB pathway and that dexamethasone inhibits CX(3)CL1 expression through a glucocorticoid receptor-dependent (RU486 sensitive) mechanism
- TNF and possibly other inflammatory cytokines in the tumor-stroma matrix likely select for breast cancer cells that stably overexpress NF-kappaB, leading to greater cancer cell survival.
- These data indicate that the differential crosstalk between beta-catenin/Tcf and NF-kappaB pathway in various cancer cells resulted from the differences in the regulation of NF-kappaB-induced lzts2 expression.
- The NF-kappaB pathway appears to play a major role in IBC, possibly contributing to the unusual phenotype and aggressiveness of this form of breast cancer.
- Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan
- These results demonstrate that interruption of TNF-alpha-induced signaling pathways in human endometriotic epithelial cells results in decreased expression and secretion of biomarkers for inflammation.
- NF-kappaB has roles in control of mesenchymal genes critical for promoting and maintaining an invasive phenotype [review]
- The canonical IKK2/IkappaBalpha pathway of NF-kappaB activation mediates the up-regulation of RGS4 expression in response to IL-1beta.
- PGE(2)-EP4 signaling augments NF-kappaB1 p105 protein stability through EPRAP after proinflammatory stimulation, limiting macrophage activation.
- pH-dependent increase in CXCL8 mRNA is due to activation of ERK and p38 and NFKB pathways
- TAT-IkappaBalphaSR reduced NF-kappaB dependent transcription, Bcl-2 expression and promoted Jun-N-terminal kinase-dependent apoptosis in human and rat hepatic myofibroblasts.
- TLR2/TLR4 stimulation was associated with NF-kappaB p65 nuclear translocation and proinflammatory cytokine production (TNF-alpha and IL-6) in adipose tissue
- HHHV8 vFLIP suppresses the AP-1 pathway, which is essential for KSHV lytic replication, by activating the NF-kappaB pathway.
- These results indicate that bile acid performs a critical function in the regulation of the induction of inflammatory-related genes in gastric cells
- IkappaB kinase beta is a key molecule in signaling to the transcription factor NF-kappaB [review]
- Heat stress prohibits IkappaB kinase activity by sequestrating the IKK and NF-kappaB complexes in lipid rafts and by segregating the chaperone protein Hsp90, an essential cofactor for IKK, from the IKK complex.
- Dendritic cell priming by L. major infection results in the early activation of NF-kappaB transcription factors and the up-regulation and nuclear translocation of interferon regulatory factor 1 (IRF-1) and IRF-8.
- EBV uses its latent protein, LMP2A, to activate the NF-kappaB-survivin pathway to rescue EBV-infected epithelial cells from serum deprivation
- a TAB1:TAK1:IKK beta:NF-kappaB signaling axis forms aberrantly in breast cancer cells and, consequently, enables oncogenic signaling by TGF-beta
- AEG-1 might function as a coactivator for NF-kappaB, consequently augmenting expression of genes necessary for invasion of glioma cells
- The SAA-RAGE-stimulated NF-kappaB signaling pathway has an important role in the pathogenesis of rheumatoid arthritis.
- These results show that NFkappaB induces AKR1B1expression under high glucose conditions, and the pattern of expression differs between nephropaths and the uncomplicated subjects.
- a marginal association between the NFKB1-94 ins/delATTG WW genotype and the increased psoriasis vulgaris risk and the association was more evident in the subgroups of onset age 20, male patients and sporadic patients in Chinese.
- Data show that Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling.
- Data show that LepA, a novel secreted protease from Pseudomonas aeruginosa, activates NF-kappaB through protease-activated receptors.
- The genome-wide mRNA expression profile under the condition of short-term stimulation (4h) with IL-18 using the Affymetrix GeneChip((R)) Array System, was characterized.
- enhanced transcriptional activity of nuclear factor-kappa B (NF-kappaB) by Daintain
- The NF-kappaB is more expressed in NP than in control mucosa.It is important in NP because NF-kappaB can induce the transcription of cytokines, chemokines and adhesion molecules, which play an important role in the inflammatory process.
- NF-kappaB, IkappaB-alpha, IkappaB-beta mRNA decreased significantly after weight loss.
- Nerve growth factor induced the cyclin D1 promoter via Sp1, nuclear factor-kappaB, and cAMP-response element/activated transcription factor sites.
- Histone deacetylase inhibitors exert time-dependent effects on NF-kappaB but consistently suppress the expression of proinflammatory genes in myometrial cells.
- Bortezomib was equally effective against cells with high and low constitutive NF-kappaB signaling
- the induction of inflammatory genes by farnesol is mediated by the activation of the NF-kappaB pathway and involves MEK1/2-ERK1/2-MSK1-dependent phosphorylation of p65/RelA(Ser(276))
- Results suggest that ganoderic acids-A and -H mediate their biological effects through the inhibition of AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4 and the suppression of secretion of uPA, respectively.
- Results suggest that the parthenolide-induced apoptosis of A549 cells is due to the direct suppression of NF-kappaB activity in a p53- and hsp72-independent manner based on NF-kappaB signaling.
- PIM1 kinase plays a critical role in the STAT3 --> PIM1 --> NFkappaB stress response pathway
- Results suggest that phosphorylation of TRAF1 by PKN1 regulates the ratio of TRAF1 and TRAF2 in receptor-proximal heteromeric complexes, thereby determining the level of constitutive NF-kappaB and JNK signaling.
- The p50 subunit which generally forms heterodimers with p65 can form a p50/p50 homodimer instead of conventional p50/p65 heterodimer.
- Phorbol 12-myristate 13-acetate -induced NF-kappaB-dependent transcription is driven by novel PKC isoforms, particularly PKCdelta and epsilon.
- These data support the idea of an activator function of c-Jun that is executed by multiple mechanisms, including phosphorylation-dependent interaction with p65 NF-kappaB and HDAC3 at the level of chromatin.
- azacitidine has an effect on interleukin-6 signaling and nuclear factor-kappaB activation
- Betulinic acid suppresses constitutive and TNFalpha-induced NF-kappa-B activation and induces apoptosis in human prostate carcinoma PC-3 cells.
- activation and formation of TICAM-1 signalosomes with NF-kappaB and interferon regulatory factor-3 requires oligomerization induced at two different sites and RIP1 binding
- direct binding of NF-kappaB-p50 to the Wnt-1 promoter
- TLR-7 signaling stimulates apoptosis resistance, associated with enhanced iNOS expression (protein and mRNA) and NO release, notably through an NF-kappaB-dependent activation of the NO pathway.
- downstream signaling pathways that govern the production of IL-8 include NF-kappaB and p38 MAPK in retinal pigment epithelial cells
- Fn14-mediated NF-kappaB pathway activation has a role in in breast tumor invasion and metastasis
- The results suggest that the NF-kappaB is frequently activated in medullary thyroid carcinoma.
- Lithocholic acid down-regulation of NFKB1 activity through vitamin D receptor in colonic cancer cells is reported.
- NF-kappaB is necessary for CYBB and NCF1 gene expression and activation of the phagocyte NADPH oxidase normal and anhidrotic ectodermal dysplasia leukocytes.
- metapneumovirus small hydrophobic protein inhibits NF-kappaB transcriptional activity
- inhibiting the activity of NF-B potentiates cisplatin-induced apoptosis of A549 cells
- SMS2 (Sphingomyelin synthase 2) is a modulator of N-kappa-B (nuclear factor kappa-B) activation
- Data suggest that TLR2/NF-kappa B signaling, particularly on mTHP-1 cells, mediates IL-8 secretion associated with extracellular B. burgdorferi.
- These results suggest that STAP-2 acts as an endogenous negative regulator of Epstein-Barr virus LMP1-mediated signaling through TRAF3 and TRADD.
- These data shed new light on the significance of negative feedback regulation of NF-kappaB and identifies PP2A as the key regulator of this process.
- The regulation of human RON gene expression by nuclear factor-kappaB.
- Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products.
- bortezomib does not block nuclear activation of the noncanonical NF-kappaB or other prosurvival signal pathways, which may contribute to the heterogeneous responses observed in HNSCC
- Transfection of IkappaBalpha can inhibit NF-kappaB activity, thus inhibit cell invasion of A549, which may be through the down-regulation of MMP-2 and MMP-9 expressions.
- NF-kappaB, but not p38, is critical for TNF-alpha-induced expression of ICAM-1, VCAM-1 and E-selectin
- Study reports that stochastic and monoallelic expression of the IFN-B gene depends on interchromosomal associations with 3 identified distinct genetic loci that could mediate binding of the limiting transcription factor NF-kappaB to the IFN-B enhancer.
- Pregabalin and gabapentin decreased substance P-induced NF-kappaB activation in human neuroblastoma and rat glioma cells
- -94ins/del ATTG promoter polymorphism of NFKB1 may have functional consequences in BD, especially in patients with ocular involvement.
- Data show that the protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association.
- Lysophosphatidic acid might regulate VEGF-C and lymphatic marker expression in endothelial cells, which contributes to endothelial cell tube formation in vitro and in vivo, thus facilitating endothelial cell participation lymphangiogenesis.
- The protein encoded by the hybrid transcript lacks the putative kinase domain of RIP1, but potently stimulates NFkappaB, AP-1 and Ets-1 activity.
- that Adriamycin-induced NF-kappaB is a transcriptional activator that protects lung cancer cells against apoptosis
- the PI3K/Akt pathway is involved in MDR in lymphoma cell lines and PI3K/Akt inhibition correlates down-regulation of NF-kappaB activity and inhibition Pgp function.
- growth inhibition and apoptosis-inducing activity produced via interruption of the CD40-CD40 ligand interaction on Burkitt lymphoma cells was attributable to the suppression of NF-kappaB binding activity
- To test whether polymorphisms in IL-1, NF-KB, FAS, and FASL genes are associated with risk of silicosis
- the constitutively activated melanoma MAPK pathway stimulates activation of NF-kappaB hetero- and homodimers, which, in turn, drive iNOS expression and support melanoma tumorigenesis
- These results suggest that Flt3 inhibitors might exert an anti-neoplastic effect in high-risk myelodysplastic syndrome and acute myeloid leukemia through inhibition of NFkappaB.
- findings favor inhibitory role of high NO level on regulation of NFKB activation in normal & osteoarthritic chondrocytes, indicating NF-kappaB activity is regulated, by production of NO resulting from a process that determines availability of nNOS & iNOS
- These data reveal a novel "feed-forward" mechanism induced by NF-kappaB which ensures that acutely synthesized IRF-1 operates in concert with NF-kappaB to amplify the immunoproteasome and antigen-processing functions of CD40.
- Results indicate that ghrelin inhibits both basal and TNF-alpha-induced PAI-1 production via NF-kappaB pathway in HepG2 cells.
- C/EBPbeta was found to have an important role in epithelial cell ICAM-1 regulation, while the adjacent NF-kappaB sequence binds the RelA/p65 and NF-kappaB1/p50 members of the NF-kappaB family to induce ICAM-1 expression in response to H. influenzae.
- The state of activation of components of mTOR, Ras/Raf kinase/ERK, and nuclear factor (NF)-kappaB signal transduction pathways, as well as cell cycle protein analyte correlates in gastric adenocarcinoma cases, was examined.
- NFKB1-94ins/delATTG genotypes and allele frequencies not significantly different between Hungarian inflammatory bowel disease patients and controls
- These results show that a protein moiety of BmpA can induce cytokine responses in synovial cells via activation of the NF-kappaB and p38 MAP kinase pathways and thus, could potentially contribute to the genesis of Lyme arthritis.
- S100A6 is induced by tumor necrosis factor-alpha via an NF-kappaB-dependent mechanism, serving a role in homeostasis to limit tumor necrosis factor-alpha-induced apoptosis by regulating p53 phosphorylation
- GbetaL is involved in the negative regulation of TNFalpha-stimulated NF-kappaB signaling through a direct interaction with IKK.
- Through interaction with MEKK2, XIAP functions in an ubiquitin ligase dependent manner to evoke a second wave of NF-kappaB activation, resulting in the modulation of NF-kappaB target gene expression.
- Glycine-extended gastrin induced signalling involves a JAK2/PI3-kinase/Akt/NF-kappaB sequence leading to COX-2 transcription.
- aberrant gene regulation by NF-kappaB on T-cell transcriptome may have a role in relapse of multiple sclerosis
- ING4 may specifically regulate the activity of NF-kappaB molecules that are bound to target gene promoters.
- oxaliplatin increased the transcription and secretion of CXCL8, which potentiated NF-kappaB activation in prostate cancer cells, increasing the transcription and expression of NF-kappaB-regulated antiapoptotic genes of the Bcl-2 and IAP families
- ChIP and EMSA demonstrated that p50 binds to a kappaB site residing between -1753 and -1743 of the CRMP-1 promoter region.
- our results demonstrate the role of NF-kB as the mediator of bcl-xL-induced CXCL8 up-regulation in glioblastoma cells.
- During inflammatory conditions, TNF-alpha is a key regulator of SPAK expression.
- Buthionine sulfoximine activates a noncanonical, inhibitory NF-kappaB- and p65-independent NF-kappaB pathway via a multistep process leading to the up-regulation of Bcl-2
- glucosamine efficiently promotes cell death via inhibiting TGase 2-mediated NF-kappaB activation in drug-resistant breast cancer cells
- The current study demonstrates that CSE activates NF-kappaB and up-regulates Bcl-XL through NF-kB activation in HBECs, and that CSE induces cell death in cells lacking p65.
- HuR is a direct transcription target of NF-kappaB; its activation in gastric cancer cell lines depends on phosphatidylinositol 3-kinase/AKT signaling. HuR activation by this pathway has proliferative and antiapoptotic effects on gastric cancer cells.
- nuclear factor kappaB is inhibited through an AKT-independent pathway by liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts
- results suggest that NFKB1 haplotypes induce dysregulation of innate immune responses by altering NF-kappaB expression.
- GlcNAc6ST-1 transcription is coordinated with the NF-kappaB/GATA-3 axis, which is known to figure heavily in Th2 cell differentiation
- NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues
- These findings suggest that combined NFkappaB and STAT3 targeting can overcome apoptosis resistance of multiple myeloma cell lines.
- NF-kappaB p50 subunit mediates melanoma angiogenesis by specifically upregulating IL-6
- Chemokine induction in dendritic cells by CbpA and Ply may be important for their potential use in future pneumococcal vaccines.
- Hyperoxia combined with LPS induced a more prolonged duration of NF-kappaB activation.
- NFKB signal transduction is altered in premature rupture of fetal membranes
- Data show that an increase in JNK activation in the presence of NFkappaB inhibition significantly increased the expression of IGFBP6.
- NF-kappaB activation in diffuse large B-cell lymphoma is preferentially mediated through the classical pathway and a novel mechanism involving phosphorylation of p65.
- IPS-1 requires TRAF6 and MEKK1 to activate NF-kappaB and mitogen-activated protein kinases that are critical for the optimal induction of type I interferons
- SOCS-3 but not SOCS-1 mRNA levels increase in an RNA- and NF-kappaB-dependent but type I IFN-independent manner early in the viral replication cycle.
- Evidence is provided for the role of genetic variation in NFKB1, a downstream target of TNF signaling, with risk of NHL.
- These data demonstrate for the first time that LMX1B directly regulates transcription of a subset of NF-kappaB target genes in cooperation with nuclear p50/p65 NF-kappaB.
- a functional NFKB1 promoter polymorphism is associated with increased risk for nasopharyngeal carcinoma
- NGF induces Mac-2BP expression via the PI3K/Akt/NF-kappaB pathway.
- EGF induces uPAR expression via ERK-1/2, AP-1, and NF-kappaB signaling pathways and, in turn, stimulates cell invasiveness in human gastric cancer AGS cells
- review of role of the NFKB pathway in treatment outcome in diffuse large B-cell lymphoma
- These results indicate that treatment of nonpermissive TPC-1 cells with HMBA induces major immediate-early gene permissiveness by up-regulating NF-kappaB activity.
- GEF-H1 is a critical component of cellular defenses forming an intracellular sensing system with NOD1 for the detection of microbial effectors during cell invasion by pathogens.
- effect of fhaB on the NFKB pathway in human monocytes, macrophages,epithelial cells; nuclear translocation of RelA, degradation of cytosolic IkappaB alpha, activation of the NF-kappaB pathway.
- Therapeutic potentials of targeting different NF-kappaB dimers to limit cerebral ischemia-associated neurodegeneration.[REVIEW]
- decreased expression of the Hint1 gene through epigenetic silencing may play a role in enhancing the growth of a subset of human hepatoma by increasing the expression of genes controlled by the transcription factors beta-catenin, USF2, and NFkappaB.
- These results demonstrated that in A549 cells, activation of p50/p65 heterodimer through sequential activation of PKC alpha-JNK-NIK-IKK beta-NF-kappaB was required for IL-1 beta-induced uPA expression associated with migration of tumor cells.
- Brd4 as a novel coactivator of NF-kappaB through specifically binding to acetylated lysine-310 of RelA.
- These results suggest the anti-inflammatory activity of platonin is a result of reduced NF-kappaB activity due to inhibition of Akt and IKKbeta.
- analysis of TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL
- dectin-1 expressed on human dendritic cells activates not only the Syk-dependent canonical NF-kappaB subunits p65 and c-Rel, but also the noncanonical NF-kappaB subunit RelB.
- NF-kappaB repression and activation of AP-1 enhance apoptosis in prostate cancer cells
- Statistical analyses of more than 14,000 transfections identified ORF75 as a novel and confirmed K13 as a known human herpesvirus 8 activator of NF-kappaB.
- each Sp1 and NF-kappaB site differentially contributes to the regulation of HIV viral gene expression, and Sp1 sites functionally "dampen" transcriptional noise and thereby modulate the frequency and maintenance of this model of viral latency
- Targeting CREB or NF-kappaB using small-molecule inhibitors, such as KG-501, holds promise as a preventive and/or therapeutic approach for NSCLC.
- plays a crucial role in BMP-2 expression and acetylation of NF-kappaB p65 and p50 subunits by TSA treatment may activate the BMP-2 promoter.
- Expanded catalog of genetic loci implicated in psoriasis susceptibility.
- NF-kappaB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlates with immune tolerance
- cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation.
- NFKB1 could be a susceptible gene for gastric cancer and its functional polymorphism in promoter is associated with the risk of gastric cancer, particularly in aged patients.
- TLR4-mediated activation of HIV-LTR is largely governed by the nuclear factor-kappaB pathway.