|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for MUC1(NM_002456.5) Search again
Product ID:
HQP102651
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM
Gene Description:
mucin 1, cell surface associated
Target Gene Accession:
NM_002456.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
|
|
| A | B |
|
Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
|
Summary
This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity.
Gene References into function
- MUC1 immunoreactivity correlates with malignant transformation in the colorectum
- marker for discriminating hepatocellular carcinoma from other carcinomas
- Tyrosine kinase c-Src constitutes a bridge between cystic fibrosis transmembrane regulator channel failure and MUC1 overexpression in cystic fibrosis
- The present results demonstrate that MUC1 associates with protein kinase Cdelta (PKCdelta).
- expression may be very useful predictor of surgical outcome in mass-forming intrahepatic cholangiocarcinoma
- 2 new DHS are in the MUC1 promoter at -750 bp and -250 bp from the transcriptional start site. They are seen in human cell lines and a transgene. The -250 DHS is undetectable in cell lines from colon adenoma to carcinoma with reduced MUC1 expression.
- Endogenous MUC1 from T47D and MCF-7 cell supernatants revealed almost identical O-glycosylation profiles compared with the respective recombinant probes, indicating that the fusion proteins reflected the authentic O-glycan profiles of the cells
- Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cells
- biosynthesis in breast cancer cell is altered by factors affecting cell proliferation
- Non-glycosylated tandem repeats of MUC1 facilitate attachment of breast tumor cells to normal human lung tissue and immobilized extracellular matrix proteins (ECM) in vitro and have a potential role in metastasis.
- Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis.
- MUC1 is regulated by ZEB1 in epithelial cells
- Constitutive and inducible expression of MUC1 in human T cells
- CD227 is expressed on human and murine activated dendritic cells
- shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM 17.
- The invasive behavior of breast cell lines may depend on different expression patterns of the MUCI gene determined by a genetic polymorphism.
- its cDNA used to vaccinate mice to suppress the development of lung metastases
- MUC1/beta-catenin interaction occurs in both primary and metastatic tumors, but is dramatically increased in metastatic lesions. Addition of MUC1-cytoplasmic domain peptides to breast cancer cell lines increases their invasive capability.
- MUC5AC, MUC1 and heparan sulfate proteoglycans cooperated in the formation of a biological inhibitory complex towards the function of E-cadherin in colonic neoplasms
- MUC1 may contribute to the anti-adhesive character of the tubal surface, inhibiting ectopic implantation.
- FUT1 catalyses the addition of alpha-1,2-fucose to MUC1 and MUC5AC apomucins
- results confirm that there is downregulation of MUC1 mucin expression in cancer culture cells treated with selective estrogen receptor modulators
- MUC1 expression was inhibited by NGF treatment in breast cancer tumor cell lines, suggesting that its expression can be regulated by signals resulting from the homodimerization of Erb-B2.
- It was also observed that the mucins from colon carcinoma patients had MUC1-type mucins that carried both sialyl-Lewis a and x epitopes and CD43-type sialyl-Lewis a mucins with only low levels of sialyl-Lewis x epitopes.
- Regulates intracellular oxidant levels and the apoptotic response to oxidative stress in cancer cells
- A correlation has been found between EMA expression and prognosis in renal cell carcinoma patients who underwent nephrectomy.
- conformational features that contribute to acceptor substrate specificity
- findings demonstrate that MUC1 functions in cross talk between ErbB2 and Wnt pathways by acting as a shuttle for heregulin/neuregulin-1-induced nucleolar targeting of gamma-catenin
- These findings provide the first evidence that MUC1 induces cellular transformation.
- MUC1 and Met can be detected in the axillary fluids of patients with breast cancer; the expression of both tumor markers in the axillary drainage is strongly associated with unfavorable tumor features and can be used as a prognostic factor
- MUC1 splice variant expression is different in pure DCIS compared to DCIS with adjacent invasive cancer
- increased synthesis may be a key element in the host response to infection with oral pathogens
- All salivary gland tumors expressed MUC1.
- In breast cancer patients, MUC1 was detected both in tissue specimens as well as free in serum samples; furthermore, MUC1 can also circulate complexed with IgG and IgM antibodies; accurate measurements should include free and complexed forms.
- First simultaneous kinetic description of O-glycosylation events by human recombinant UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase I at all putative O-glycosylation sites within human mucin MUC1 containing 5 tandem repeats.
- MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation.
- MUC1 synthesized in the airway cell line showed low levels of sialylation but carried a range of oligo-N-acetyllactosamine structures not seen in the colon carcinoma cell line.
- MUC1 integrates T cell receptor signaling with the beta-catenin pathway
- MUC1 attenuates the apoptotic response to DNA damage and that this oncoprotein confers resistance to genotoxic anticancer agents
- MUC1 mRNA expression was identified for twenty-six lymph nodes (15.7%), in eighteen patients (42%) who were diagnosed as having nodal micrometastasis.
- Mucin 1 and adenomatous polyposis coli co-immunoprecipitate in breast cancer cells.
- T-cell lines generated using the agonist epitope were able to lyse HLA-A2 human tumor cells expressing MUC-1.
- MUC1 and beta-catenin have a role in progression and invasiveness of colorectal carcinomas
- TNFalpha-stimulated MUC1 shedding occurs independently of increased de novo protein synthesis and TNFalpha-induced increase in MUC1 gene expression is mediated through the kappaB site in the MUC1 promoter
- VNTR polymorphism of the MUC1 gene was not associated with female infertility. Other regulatory molecules and signals may interact with the MUC1 gene variations, favouring endometrial receptivity and embryo attachment.
- Data show that MUC1 mucin expressed on the surface of cells can initiate a calcium-based oscillatory signal on contact with intercellular adhesion molecule (ICAM)-1-transfected cells.
- tumor-derived MUC-1 profoundly affects the cytokine repertoire of monocyte-derived DC and switch them into IL-10(high)IL-12(low) regulatory APCs with a limited capacity to trigger protective Th1 responses
- MUC1 regulates the FOXO3a signaling pathway in a survival response to oxidative stress.
- Grb2 plays a significant role in the endocytosis of MUC1
- Cytokeratin 7 and epithelial membrane antigen are essentially negative in yolk sac tumors but are diffusely positive in clear cell carcinomas and endometriod adenocarcinomas making them useful markers for differentiating YSTs from both CCCs and EACs.
- overexpression of MUC1 in pancreatic cancer is a useful target
- polymorphism in the MUC1 tandem repeat influences the expression of tumor-associated carbohydrate antigens in gastric cancer cells and may therefore allow the identification of subgroups of patients that develop more aggressive tumors expressing T antige
- analysis of a novel MUC1 protein isoform MUC1/ZD, which is generated by an alternative splicing event that both deletes the tandem-repeat array and leads to a C-terminal reading frameshift
- IL-7 up-regulates MUC1 (CD227) on CD4+, CD8+, CD25+, CD69+, naive CD45RA+, and memory CD45RO+ T cells. IL-7, but not IL-2 or IL-4, markedly induces MUC1 expression on CD3+ T cells.
- MUC1 regulates p53-responsive genes and thereby cell fate in the genotoxic stress response
- The Muc1 Mucin is a large membrane-tethered glycoprotein that shows differential expression in many adenocarcinomas, where it contributes to their invasive and metastatic properties.
- MUC1 expression is related to tumor progression and worse prognosis in mucoepidermoid carcinomas of the salivary glands.
- evidence for a strong Th1 Cells polarization and cross-priming of MUC1-specific CD8+ T cells
- The altered dendritic cell differentiation and antigen presentation function induced by soluble sialylated tumor-associated mucin may represent a mechanism by which epithelial tumors can escape immunosurveillance.
- Results suggest that the large MUC1 allele is associated with susceptibility to lung adenocarcinoma and poor prognosis.
- Progesterone-dependent regulation of MUC1 appears to be an important factor in determining endometrial receptivity
- The human mucin MUC1 is expressed both as a transmembrane heterodimeric protein complex that recycles via the trans-Golgi network (TGN) and as a secreted isoform.
- The MUC1 SEA module is a self-cleaving domain.
- MUC1 attracts immature dendritic cells in vivo in cancer patients through chemotaxis and subverts their type 1 helper T cell immunostimulatory function important for tumor rejection
- glycopeptide-specific helper T-cell clones are a prerequisite for strong and long-lasting immune responses to MUC1-positive tumours.
- Expression and localization of MUC1 proteins in primary liver carcinomas may act as prognostic markers.
- HNE stimulation of mucin release by human airway epithelial cells involves intracellular activation of PKC, specifically the delta isoform.
- Lack of MUC1 polymorphism in breast cancer is significantly related to neoplasm aggressiveness, especially lymphatic vessel invasion and lymph node metastasis.
- MUC1 is delivered to mitochondria by a mechanism involving activation of the ErbB receptor-->c-Src pathway and transport by the molecular chaperone HSP70/HSP90 complex
- MUC1, MUC5B and MUC8, but not MUC2 or MUC5AC, are up-regulated in endometrial adenocarcinomas
- Eighty-six patients (43%) had elevated CA 125 levels and 35 (17.5%) had elevated CA 15.3 levels at diagnosis
- Analysis of the ability of human milk to inhibit the attachment of rNV VLPs (recombinant NV-like particles) to their carbohydrate ligands and to characterize potential inhibitors found in milk is presented.
- Immunity and tumor protection in mice transgenic for human MUC.1, a glycoprotein expressed in the majority of epithelial tumors in humans, were induced by vaccination with B lymphocytes genetically programmed to activate MUC.1-specific CD4 T cells.
- pro-proliferative and anti-apoptotic effects of KL-6 on lung fibroblasts; findings suggest a novel pathophysiological role for KL-6 in idiopathic pulmonary fibrosis, as it stimulates fibrotic processes in the alveolar space
- ICAM-1 can influence the migration of cells that express endogenous or transfected MUC1.
- MUC1 568 A to G polymorphism may be of interest for diagnostic purposes because our study delivered in vivo evidence that it contributes to interindividual variations in KL-6 levels.
- Decrease of mucin contained in saliva may be important in further evolution or progression of squamous cell carcinoma oral cavity
- SEA domain of the human MUC1 transmembrane mucin undergoes a novel type of autoproteolysis, which is catalyzed by conformational stress and the conserved serine hydroxyl
- using RT-PCR for the detection of c-Met or MUC1 mRNA may be a promising tool for the early detection of micro-metastatic circulating tumor cells in gastric carcinoma patients
- MUC1 binds directly to the ERalpha DNA binding domain and stabilizes ERalpha by blocking its ubiquitination and degradation.
- Overexpresssed in the progression and lymphatic metastasis of prostate cancer.
- Reversed apical pattern of MUC1 expression is associated with invasive micropapillary carcinoma of the breast
- MUC1/Muc1 suppresses pulmonary innate immunity and speculate its anti-inflammatory activity may play an important modulatory role during microbial infection
- A marked difference is seen between the N-glycans on membrane-bound and secreted forms of the MUC1 native molecule.
- Expression of the tumor-associated Ag mucin-1 (MUC1) was detected using Monoclonal Antibody defining different MUC1 glycoforms.
- CA 15-3 expression increases in patients with advancing metastatic breast cancer
- results support the hypothesis that MUC1 contributes significantly to growth and metastasis, and that down-regulation of MUC1 protein expression decreases the metastatic potential of pancreatic adenocarcinoma
- MUC1 carries selectin ligands throughout the secretory phase of the menstrual cycle, including the mid-secretory (receptive) phase
- Progesterone receptor isoforms A and B differentially regulate MUC1 expression in uterine epithelial cells.
- atypical MUC1 bearing the noncluster form of Tn antigen is implicated in aggressive growth of primary breast cancer cells, particularly in lymphatic metastasis
- MUC1 causes varying changes in genetic transcription, cell proliferation, apoptosis,and invasion in 2 different breast cancer cell lines
- mucin and MUC1 have roles in progression of hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer
- MUC1 sequesters c-Abl in the cytoplasm and thereby inhibits apoptosis in the response to genotoxic anticancer agents.
- Disruption of MUC1-C-terminal subunitmight represent a novel immunotherapeutic approach for the treatment of ovarian cancer(review).
- Serum measurement has the potential to serve as a noninvasive diagnostic test for the detection of bronchiolitis obliterans syndrome in lung transplantation.
- data indicate that MUC1 expression is a potent regulator of erbB1 receptor stability upon activation and may promote transformation through the inhibition of erbB1 degradation
- The study demonstrates that the GSTA region of the MUC1 tandem repeat contains a highly immunodominant epitope when presented with immature short O-glycans.
- Poorly differentiated tumors are inversely correlated with tumor and serum MUC1 detection.
- GATA3 is probably a mediator for the transcriptional upregulation of MUC1 expression in some breast cancers.
- Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion
- MUC1 attenuates HIF-1alpha activation in a survival response to hypoxic stress
- The present studies show that MUC1 associates with FGFR3.
- The overexpression and membrane delocalization of MUC1 is associated with a worse prognosis and a shorter survival in breast, colon, kidney, prostate or gastro-intestinal cancers. [REVIEW]
- To validate the occurrence of MGL-MUC1 interactions in situ, we studied the binding of MGL to MUC1 in primary colon carcinoma tissue. Isolation of MUC1 out of colon carcinoma tissue showed strong binding activity to MGL.
- MUC1 peptide immunogenicity depends on context of the epitope and not sequence alone
- Expressions of membrane (MUC1) and secreted (MUC5AC, MUC6) mucins are frequently modified in reactive gastropathy.
- Histiocytoid features of invasive lobular carcinoma is immunopositive for MUC1.
- Interaction of MUC1 with CTNNB modulates cyclin D1 in H. pylori-induced stomach neoplasms.
- Upregulation of MUC1 is associated with disease progression to adenocarcinoma of the esophagus
- A novel classification of MUC1 expression pattern (HP, LP, and D) was correlated with tumor differentiation and postoperative survival in NSCLC, especially in lung adenocarcinoma.
- Short mucin 1 alleles are associated with low-virulece H pylori strains infection.
- Review discusses the role of MUC1 overexpression in the progression of prostate cancer, and targeting MUC1 to control micrometastases and hormone refractory disease.
- Results suggest that MUC1 inhibits cell proliferation through a beta-catenin/LEF-1/cyclin D1/c-Myc pathway.
- Circulating TARC/CCL17 and KL-6 are useful measurements for discriminating acute eosinophilic pneumonia from other causes of acute lung injury.
- TNF-alpha induces MUC1 gene transcription through a TNFR1 --> MEK1/2 --> ERK1 --> Sp1 pathway.
- Results suggest that there is no effect of the polymorphic MUC-1 sequence on the implantation failure. However, the data do not exclude MUC-1 relevance during embryo implantation.
- This study shows that MUC1, MUC4, and MUC16 are regulated differently by dexamethasone in human corneal epithelial cells.
- EMA was not expressed in the germinative cells of sebaceoma, but was expressed strongly in approximately 50% of mature sebocytes; expression of EMA was uncommon in basal cell carcinoma and was confined to keratotic or squamoid areas
- Up-regulation of MUC1 by inflammatory mediators such as neutrophil elastase and TNF-alpha suggests a crucial role for MUC1 in the control of excessive inflammation during airway bacterial infection.
- bacterium affects the soluble form of MUC 1 mucin, thus suggesting a likely role of this mucin in the course of H. pylori infection
- IL-10(-/-) mice, crossed to human MUC1-transgenic mice, develop MUC1(+) IBD characterized by an earlier age of onset, higher inflammation scores, and a much higher incidence and number of colon cancers
- In stepwise multivariate analysis MUC1 negativity was an independent predictor of both relapse-free survival and overall survival.
- MUC1, TF and galectin might have important roles in endometrial pathogenesis and malignant transformation
- Four patterns of MUC1 expression are recognized in DCIS that suggest a relationship to functional differentiation.
- Typical cystitis glandularis expresses MUC1.
- glycosylation variants of MUC1 were expressed in the fetal respiratory tracts as early as 13 weeks of gestation, and its expression persisted even after lung maturation
- 69% of the thalassaemic patients had abnormal levels of Carbohydrate antigen 15.3(CA 15.3)
- both the MUC1-N and MUC1-C subunits evolved from secreted gel-forming mucins and that the MUC1-CD oncogenic function emerged by diversification after evolution from MUC5B
- MUC1 expression was significantly reduced in the fallopian tubes of women with ectopic pregnancy.
- MUC1 in serum of ovarian and breast cancer patients inhibits huHMFG-1 dependent cell-mediated cytotoxicity
- PIASy has a role in down-regulation of MUC1 expression
- MUC-1 is an independent prognostic marker for prostate cancer death.
- MUC1 may affect cancer cell migration by increasing E-cadherin/beta-catenin complex formation and restoring E-cadherin membrane localization
- Measurement of CA 15-3 serum values in conjunction with sHER2 and CA 15-3 can increase sensitivity in metastasis detection.
- These findings indicate that MUC1 and galectin-3 function as part of a miR-322-dependent regulatory loop.
- The results indicated that IL-4-treated LS174T cells are able to produce mucins with a higher degree of O-glycosylation than untreated counterparts.
- A high correlation between MUC1 and cyclin D1 implies MUC1 involvement in the Wnt cascade functioning in a large subset of human papillary thyroid carcinoma and papillary microcarcinoma
- We found MUC1 expressed in male germ cell line and within the ejaculated sperm, but its presence in mature sperm does not seem to be related to male fertility.
- The present study failed to demonstrate any association between serum levels of MMPs, VEGF and CA 15.3 (antigen product from MUC1 gene) and well-known clinicopathological characteristics of breast carcinoma
- These results support the hypothesis that the adhesive interactions between MUC1 and MAG are of biological significance in pancreatic cancer perineural invasion.
- If MUC1 is detected in regional lymph nodes from patients with esophageal cancer. MUC1 does not appear to be expressed in normal lymph nodes.
- MUC1 is important for physiological activation of IKKbeta and that overexpression of MUC1, as found in human cancers, confers sustained induction of the IKKbeta-NF-kappaB p65 pathway.
- PKC delta plays an important role in mucin secretion by airway epithelium via regulation of MARCKS phosphorylation.
- LL-37 can directly stimulate mucus synthesis through activation of MUC1 and MUC2 expression and MAP kinase pathway in human colonic cells.
- To clarify the localization of KL-6 and epithelial membrane antigen (EMA) in human lungs, immune reactions to antibodies to these factors were examined in detail at light and electron microscopic levels.
- MUC1 stabilizes Bcr-Abl and contributes to pathogenesis of chronic myelogenous leukemia cells by promoting self renewal and the MUC1 cytoplasmic domain.
- The PAM4-reactive MUC1 epitope was not detected in normal pancreas but was expressed in invasive pancreatic adenocarcinomas, including early stage 1 disease
- Bile acids induce MUC1 mucin overexpression in human esophageal adenocarcinoma cells and tissues by activating its transcription through a process involving phosphatidylinositol 3-kinase.
- CA 15-3 levels might have a role in the response to EGFR inhibitors in patients with bronchioloalveolar carcinoma
- Genetic polymorphisms in the glycosylation process of MUC1 may be novel risk factors for ovarian cancer.
- SEA domain autoproteolysis accelerated by conformational strain.
- SEA domain autoproteolysis accelerated by conformational strain: mechanistic aspects.
- MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of the MUC1 VNTR domain.
- demonstrate for the first time that the near-ubiquitous MUC1 tumor Ag can be targeted using chimeric Ag receptors-grafted T cells
- Breast cancer cells express MUC1 and give rise to MUC1(+) tumors in vivo. MUC1 is hypoglycosylated and sialylated; characteristics of the tumor-specific form were expressed on cancer cells and recognized by tumor-specific T cells and antibodies.
- These findings suggest a novel MUC1-Src-CrkL-Rac1/Cdc42 signaling cascade following ICAM-1 ligation, through which MUC1 regulates cytoskeletal reorganization and directed cell motility during cell migration.
- analysis of the role of MUC1 in colorectal cancer [review editorial]
- Epigenetic changes of MUC1 may be of importance for diagnosis of carcinogenic risk and prediction of outcome for cancer patients.
- MUC1 expression in the human placenta is increased during placental development, and its overexpression suppresses trophoblast-like cell invasion in vitro.
- Evidence is presented that strongly supports a mechanism whereby dimerization of the extracellular domain of MUC1* activates the MAP kinase signaling cascade and stimulates cell growth.
- CA15.3 (soluble MUC1) levels were significantly higher in the serum of mesothelioma patients than in healthy controls but were not significantly different to levels in patients with benign asbestos-related disease.
- MUC-1 expression was found to be a prognostic factor for gastric carcinoma patients, albeit not independent of parameters of invasion.
- MUC1 was expressed more intensely in prostate intraepithelial neoplasia and malignant prostate glands than in benign glands.
- MUC1 activates the beta-catenin and NF-kappaB pathways in multiple myeloma cells and contributes to their growth and survival.
- Bladder cancer stem (initiating) cells might be among EMA(-) CD44v6(+) subset.
- Serum samples were investigated for carcinoembryonic antigen (CEA), CA125 and MUC1, alpha-foetoprotein, neuron-specific enolase and CA19.9.
- MUC1 mucin is present in several glycoforms on the maternal side of human placenta after term delivery
- Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression.(
- Common variants in MUC1 and the surrounding region are not associated with risk or prognosis of prostate cancer in Swedish men.
- Retroviral overexpression of Mucin1 in cord blood CD34+ cells resulted in elevated stem cell and progenitor frequencies.
- MUC1 is of importance to the physiologic regulation of caspase-8 activity and that overexpression of MUC1, as found in human malignancies, could contribute to constitutive inhibition of death receptor signaling pathways
- Significant enhancement in the development of pancreatic intraepithelial preneoplastic lesions and progression to adenocarcinoma is observed in PDA.MUC1 transgenic mice
- These results indicated that MUC1 intra-cellular trafficking occurs through a regulated process that was stimulated by direct EGFR and MUC1 interaction, mediated by clathrin coated pits that were dynamin dependent and regulated by Rab5.
- immunotoxin binding to the MUC1 alpha/beta junction mediates cell killing
- Stimulating the MUC1* receptor with either the cognate antibody or its ligand NM23 enabled hESC growth in a feeder cell-free system and produced pluripotent colonies that resisted spontaneous differentiation
- These mucin genes were up-regulated after exposure to low pH in vitro (p < 0.005). Pepsin inhibited this up-regulation (p <0.001).Reflux laryngitis is associated with down-regulation of mucin gene expression.
- Alternatively glycosylated MUC1 and MUC5AC could be of significant potential as effective tumor markers in gastric cancer diagnosis.
- the combined pattern of positive KL-6 expression and decreased membranous beta-catenin expression by colorectal carcinoma is a useful biomarker for distinguishing a subgroup of patients with a worse prognosis.
- Serum CA 15-3 was found to have a value in the early detection and monitoring of treatment of breast cancer in Ghana
- These data suggest that hypoxia enhances the expression of MUC1 through the transcriptional regulation by HIF-1alpha in a human lung epithelial cell line.
- both foetal and adult tissues of known genotype, there is clear evidence for the role of single-nucleotide polymorphism in controlling alternative splicing of the 5' exon 2 region of both full-length transcripts and those lacking the tandem repeat domain