|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for MAOA(NM_000240.3) Search again
Product ID:
HQP102107
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BRNRS, MAO-A
Gene Description:
monoamine oxidase A
Target Gene Accession:
NM_000240.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
|
|
| A | B |
|
Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
|
Summary
This gene encodes monoamine oxidase A, an enzyme that degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the mitochondrial outer membrane. The gene is adjacent to a related gene on the opposite strand of chromosome X. Mutation in this gene results in monoamine oxidase deficiency, or Brunner syndrome. [provided by RefSeq].
Gene References into function
- Substrates but not inhibitors alter the redox potentials of monoamine oxidases.
- Evidence for positive selection and population structure at the human MAO-A gene.
- Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling
- study did not support the involvement of 5-HTTLPR, TPH, MAO-A, or DRD4 polymorphisms in mood disorders
- possible association between the prophylactic efficacy of lithium in mood disorders and the following gene variants: catechol-O-methyltransferase (COMT) G158A, monoamine oxydase A (MAO-A) 30-bp repeat, G-protein beta 3-subunit (Gbeta3) C825T
- possible influence of monoamine oxydase A (MAO-A), catechol-O-methyltransferase (COMT), serotonin receptor 2A (5-HT2A), dopamine receptor D2 (DRD2), and dopamine receptor D4 (DRD4) gene variants on timing of recurrence in mood disorders
- No association exists between genetic variation at the MAOA locus and alcoholism in Chinese Han males in Taiwan.
- a role for the MAO A promoter-region polymorphism in conferring risk for attention deficit hyperactivity disorder
- Role of genotype in the cycle of violence in maltreated children: Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems
- MAO-A promoter polymorphism is associated with Moclobemide response in depressed patients.
- Single nucleotide polymorphism in smokers
- spectrum and redox properties are altered by inhibitors
- Case control analysis of the VNTR showed an association with a subgroup of children with comorbid conduct problems.
- These findings suggest that the three-repeat allele of the MAOAuVNTR 30-bp polymorphism is not associated with impulsive and aggressive personality traits.
- Investigation of possible ssociation of a T941G single nucleotide polymorphism with generalized anxiety disorder, panic disorder, or major depression showed an association with gneralized anxiety disorder only.
- Comparison of male alcoholics to male normal controls for the frequencies of two-loci and three-loci haplotypes was statistically significant
- MAO-A polymorphisms are associated with smoking behaviour
- Mao-A gene promoter allele was found in panic disorder.
- genotyped 16 subjects for the DRD4 and MAOA genes who had been scanned during the Attention Network Test
- study shows that the monoamine oxidase A structure is "more flexible" than that of monoamine oxidase B and that clorgyline and pargyline inactivation increase structural stability of both enzymes
- There was a weak association of MAOA in neuroticism only in males. The er was no significant interaction between COMT and MAOA.
- In a study of 129 Chinese Han males neither antisocial alcoholism nor antisocial personality disorder is found to be associated with genetic variants of the MAO-A gene.
- This study showed that the genetic polymorphism of MAOA-VNTR might affect the incidence of nausea induced by SSRIs.
- Functional MAOA-uVNTR alleles may act as a genetic modifier of the severity of autism in males.
- It is proposed that the FAD binding site in MAO A is quite similar to that in MAO B. Structural information in this review is used to explain previous studies on flavin analog incorporation into either MAO B or into MAO A.
- polymorphism is associated with aggression in children
- association between the monoamine oxidase A (MAO-A) gene and obesity.
- lower expression of the MAOA variable number tandem repeat polymorphism is related to a history of early abuse and may sensitize males, but not females, to the effects of early abuse experiences on impulsive traits in adulthood
- There was no evidence of epistatic interaction between MAOA, MOAB, and COMT genes on Overt aggression scale scores.
- our results do not confirm the hypothesis that there is a simple correlation between single gene polymorphisms in monoamine oxidase A and personality traits measurement
- These data suggest that the EcoRV and uVNTR polymorphisms may be involved in the pathogenesis of major depression and associated with insomnia in depressed patients.
- evidence in support of interaction between the MAOA and serotonin transporter (SERT) genes in 114 anorexia nervosa nuclear families (patient with AN plus biological parents)
- monoamine oxidase A has a stable tyrosyl radical
- MAOA gene variation may modulate the expression of some clinical aspects of severe mood disorders.
- High-activity MAOA promoter gene polymorphisms, as in aging, are a risk factor for telomeric shortening.
- This study findings further support the notion that allelic variation of MAOA activity contributes modestly to the balance of hyper- (impulsive-aggressive) and hyporeactive (anxious-depressive) traits.
- Monoamine oxidase A polymorphism could play a role in susceptibility to alcoholism, which may differ across sexes.
- This study findings suggest that the MAOA-uVNTR may be involved in the pathogenesis of major depressive disorder and the antidepressant therapeutic mechanisms in Chinese population, and that there may be a gender effect in this association.
- present study strongly supports the notion that carrying the 3-repeat allele of the MAO-A-gene promoter increases the risk of male adolescent criminal behavior, when interacting with psychosocial factors.
- important component of the active site structure of hMAO A is the loop conformation of residues 210-216, which differs from that of hMAO B and rat MAO A
- The present results do not support the hypothesis that MAO-A gene polymorphism is related to certain personality traits in females.
- found a significant association between two MAOA gene haplotypes and reduced trbc-MAO activity, but no association with depressed state.
- a specific genetic variation of MAOA involving serotonergic catabolism can modulate BOLD response associated with human impulsivity
- there is an important association between MAOA polymorphisms and smoking status, suggesting a possible role of MAOA gene variants in nicotine dependence.
- The hypothesis that gene variants could influence temperamental traits in mood disorders patients was tested. The long MAO-A allele was associated with decreased persistence scores among females.
- Results confirmed previous reports showing an association of the low activity 3-repeat allele of MAOA-uVNTR polymorphism with substance dependence and impulsive/antisocial behaviors.
- The monoamine oxidase A promoter region variable number tandem repeat polymorphism affects novelty seeking and reward dependence in healthy study participants.
- monoamine oxidase A activation of glucocorticoids and androgens is regulated differently by R1 and Sp1
- In alcohol-dependent heavily smoking men there is evidence for a MAO-A gene-associated effect on the quantity that is smoked as reflected by the daily number of cigarettes consumed.
- MAOA may be involved in the regulation of body mass index in controls and in alcoholic criminals.
- Meta-analysis demonstrated that across studies, the association between maltreatment and mental health problems is significantly stronger in the group of males with the genotype conferring low vs high MAOA activity.
- Genotypes associated with high levels of MAOA activity buffered abused and neglected whites from increased risk of becoming violent and/or antisocial in later life. This protective effect was not found for non-white abused and neglected individuals.
- demonstrates the functions of MAO A and its repressor R1(RAM2/CDCA7L/JPO2) in apoptotic signaling pathways
- results show that the MAO-A gene has mono-allelic expression in skin fibroblasts; this could have important implications for understanding traits that display gender differences
- Therefore, allelic mRNA expression is affected by genetic and epigenetic events, both with the potential to modulate biogenic amine tone in the CNS.
- the association of MAOA genetic variation with a large set of quantitative behavioural traits in normal individuals
- family-based association study gives mild but further support of the involvement of MAOA variants in bipolar disorder
- Findings from this general population sample could not confirm the hypothesis that MAOA moderates the relationship between adolescent maltreatment and adolescent or adult antisocial behavior.
- There is a a strong association between endometrial receptivity and MAO-A expression in the endometrial epithelium, suggesting an important role for this enzyme in normal implantation.
- These findings do not support a major role for common 5-hydroxytryptamine transporter, TPH1, and monoamine oxidase A polymorphisms in contributing to susceptibility to premenstrual dysphoric disorder.
- The lack of an association between the high and low MAO A genotype and brain MAO A activity suggests that this polymorphism by itself does not contribute to differences in brain MAO A activity in healthy adult male subjects.
- Promoter polymorphism is observed in mental retardation, such as Down syndrome.
- Time course of response and antidepressant efficacy of mirtazapine, but not paroxetine, seem to be influenced in a clinically relevant manner by this allelic variation within the MAOA gene, at least in female patients.
- study reports the learning process of decision-making in suicide attempters to be modulated by four serotonergic gene polymorphisms, 5HTTLPR, TPH1 A218C, MAOA u-VNTR, and TPH2 rs1118997
- alleles of MAOA have been shown to confer functional variation in stress (Review)
- Our study indicates that MAO catalytic activity is involved in apoptotic signalling in response to serum withdrawal in neuronal cells.
- monoamine oxidase expression during in vitro differentiation of human preadipocytes and in adipose and stroma-vascular fractions of human fat depots
- Our results show that the MAO-A gene has mono-allelic expression in these cells. This could have important implications for understanding traits that display gender differences.
- monoamine oxidase A gene may play an important role in the etiological development of the borderline personality disorder by means of various polymorphisms.
- The current study examined the association between adolescent outcome of attention-deficit/hyperactivity disorder and MAO gene polymorphisms.
- plausible explanations for previous Inconsistencies in studies of the relationship between testosterone and MAOA genotype and male human aggression.
- Study showed evidence of interactions between MAOA and MD susceptibility in baseline ACTH measures indicating a role for these genotypes in stable-state endocrine regulation.
- The monoamine oxidase-A gene may modify the association between the dopamine D2 receptor gene and alcohol dependence and anxiety, depression or both phenotype.
- Our data implicate a neural circuit for variation in human personality under genetic(MAOA) control.
- Individuals with less active MAOA-uVNTR alleles may be at increased risk for depressive symptoms and poor sleep
- MAOA seems to moderate the impact of childhood trauma on adult psychopathology in female subjects in the same way as previously shown among male subjects.
- The MAO-A genes may be involved in aggressive schizophrenic patients.
- No association between MAOA gene and schizophrenia is found in Chinese Han population, but CT genotype is likely to be a susceptible factor of male schizophrenia.
- Our data suggest that the MAOA-VNTR affects the activity and gene expression of MAOA in the brain of AD patients, and is involved in the changes of monoamine metabolism.
- Increases in intracellular Ca2+ availability could contribute to a MAO-A-mediated mechanism with a role in Alzheimer's disease-related oxidative stress.
- MAO-A, through its production of reactive oxygen species as a by-product of its catalytic activity on the mitochondrial surface, is recruited by the cell to enhance apoptotic signalling.
- Monoamine oxidase A variant influences antidepressant treatment response in female patients with Major Depression.
- This study may suggest a role of the COMT Val158Met polymorphism in smoking behavior in Japanese individuals.
- Analyzed the genotype distributions and allele frequencies for the MAO-A and MAO-B polymorphism of the MAO gene among the patients with fibromyalgia syndrome.
- no significant evidence of association with the two schizophrenia susceptibility polymorphisms monoamine oxidase A gene .
- There were no relationship between MAOA-uVNTR polymorphisms and novelty-seeking personality traits in Korean females.
- Heightened depressive symptoms were found only among extensively maltreated youth with low MAOA activity.
- findings support the hypothesis that the MAO-A variable number of tandem repeat polymorphism in the promoter region may be associated with anger-related personality traits in Korean women
- 5-HT2A and MAOA genes, regulating activity of serotonin, influence on subjective time flow.
- study does not support previous reports of an interaction between monoamine oxidase A genotype and childhood adversity for antisocial behavior in males.
- Polymorphisms of genes MAO-A and COMT were described in relation to their expression altered activity; influence on cognitive functions, affective and anxiety disorders, learning disabilities, aggressive behaviour, eating disorders or gender differences.
- Functional polymorphism leads to variable expression or change of MAO activity and exerts an impact on the onset of mental disorders, such as: schizophrenia, affective disorders, forms of alcohol dependence, and personality and behavioural disorders.
- Contribution of the MAOA gene, parenting style and their interactions to variation in the risk for early onset behavior disorders and liability to substance use disorders.
- These data suggest that the structural properties of the active site cavities in rat MAOs are significantly different from the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs.
- Trends were observed for interactions between the DRD4 gene and, among males, the MAOA gene and ADHD symptoms to predict smoking risk.
- The association analysis shows that men with a 2 repeat report a level of serious delinquency and violent delinquency in adolescence and young adulthood; the results for women are similar, but weaker
- Higher total cholesterol (p<0.03), LDL/HDL ratio (p<0.01), triglycerides (p<0.02), and VLDL (p<0.02) were associated with low activity MAOA-uVNTR alleles.
- SLC6A4 and MAOA genes are implicated in dopamine and serotonin regulation on energy balance.
- monoamine oxidase A prevents basal epithelial cells from differentiating into secretory cells.
- Article discusses the low-expressing allele of the MAOA u-VNTR in information processing within a circuit composed of amygdala, rostral cingulate and medial prefrontal cortex, and provides a model for gene-environment interactions in impulsive aggression
- Our data reveal pronounced MAO-A genotype-related functional changes in specific prefrontal region (VLPFC) subserving spatial working memory.
- The study suggest gender-specific contribution of the more active MAO-A VNTR variant to an increased vulnerability for complicated grief as a potential intermediate phenotype of major depression.
- association between the MAOA "low activity" allele and larger brain volumes for regions of the cortex in children with autism
- Role of genes TPH2, 5-HTT, and MAOA regulating the serotonin metabolic pathway in the brain stain in the etiopathogenesis of the sudden infant death syndrome was studied.
- MAOA-uVNTR polymorphism can affect activation of limbic regions, elicited by negative emotional stimuli.
- flexibility of loop 108-118, facilitated by anchoring the enzyme into the membrane, is essential for controlling substrate access to the active s
- In boys hemizygosity for the short MAO-A hemizygosity for the short MAO-A Variable Number of Tandem Repeats(VNTR) allele is s associated with disruptive behavior allele is associated with disruptive behavior.
- Data show that MAOA promoter polymorphisms uVNTR and EcoRV are not associated with bipolar disorder or any of its subtypes, in either the frequencies of alleles or genotypes.
- Methylation of the monoamine oxidase A promoter may play a significant role in common psychiatric illness in women, but not men.
- Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression.
- our data nevertheless argue against a major genetic role of MAO-A polymorphism in frontotemporal dementia.
- 5-HT2C receptor and MAOA interaction analysis showed no association among this intergenic haplotype combination and suicidal behaviour in bipolar disorder.
- genetic variation in the MAOA gene may affect the course of major depression by disrupting cortico-limbic connectivity
- Children with the 4- versus 3-repeat allele had significantly (p < 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety.
- Data show that individuals carrying the MAO A-high activity variant show substantial relative grey matter decreases in the bilateral orbitofrontal cortex.
- Differential association between MAOA, ADHD and neuropsychological functioning in boys and girls is reported.
- Sex factor effects are described for MAOA in genetic association with ADHD.
- Higher-activity MAO-A genotypes in women, but not in men, are associated with greater 5-HT1A receptor binding potential in numerous brainstem and forebrain regions.
- Females bearing the MAOA genotype 3/4 are at increased risk of depression relative to either 3/3 or 4/4 homozygote.