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Validated All-in-One™ qPCR Primer for ITGA6(NM_001079818.2) Search again
Product ID:
HQP101152
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD49f, ITGA6A, ITGA6B, JEB6, VLA-6
Gene Description:
integrin subunit alpha 6
Target Gene Accession:
NM_001079818.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Gene References into function
- Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling
- Reduction in integrin alpha6beta4 is related to changes seen during immortalization and malignant progression
- The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits.
- These results demonstrate that integrin-dependent cell to extracellular matrix adhesion reinforces E-cadherin-dependent cell-cell adhesion in Caco-2 cells.
- Production of the alpha(6p) variant from alpha(6) integrin may involve a post-translational processing event at the cell surface.
- Human prostate tumors display on their cell surface the alpha6beta1 and/or alpha3beta1 integrins
- Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation (Integrin alpha6beta4)
- role in mediating pro-angiogenic activity of CYR61
- Data suggest that the stability of the interaction between alpha6beta4 and laminin-5 is influenced by the clustering of alpha6beta4 through the deposition of laminin-5 underneath the cells.
- Results suggest that alpha6beta4 integrin-mediated interactions of astrocytes with beta(ig)-h3 transduce intracellular signals through the focal adhesion proteins, which may regulate certain aspects of astrocyte response to brain injury.
- integrin alpha 6 beta 1 binds to CCN1
- alpha6beta1 integrins have roles as thrombospondin receptors in microvascular and large vessel endothelial cells
- Data show that macrophage stimulating protein (MSP) and its receptor (Ron) induce phosphorylation of both Ron and alpha6beta4 integrin, and result in activation of alpha3beta1 integrin.
- In pancreatic cancer, IL-1alpha enhanced alpha(6)beta(1)-integrin expression, probably via increased IL-1RI levels.
- compartmentalization in lipid rafts is necessary to couple the alpha6beta4 integrin to a palmitoylated src family kinases and promote EGF-dependent mitogenesis.
- Data demonstrate that alpha6beta4 integrin mediates pancreatic epithelial cell adhesion to Netrin-1, whereas recruitment of alpha6beta4 and alpha3beta1 regulate the migration of putative pancreatic progenitors on Netrin-1.
- ligand-binding specificities of integrin alpha3beta1 and alpha6beta1
- Results indicate that alpha6-containing integrin expression can be a significant marker of malignancy in intraductal papillary-mucinous tumors (IPMTs).
- alpha(6)beta(4) has a generic influence on the invasion of carcinoma cells that is not specific to Met
- Results suggest that bacterial heat shock protein 60 may promote epithelial cell migration through activation of epidermal growth factor receptor and mitogen-activated protein kinases, and inhibition of alpha6beta4 integrin expression.
- cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin
- CD82 attenuates integrin alpha6 signaling during a cellular morphogenic process
- alpha6beta4 can augment cell-cell adhesion and slow down haptotaxis over laminin-5
- Enhanced expression of Integrin alpha6 is associated with liver metastases from gastrointestinal tumours
- adhesion to laminin-1 through alpha6-integrin represents a protective mechanism for melanocytes to withstand UVB damage
- alpha6beta4 integrin potentiates autotaxin expression through the upregulation and activation of NFAT1.
- alpha3, alpha5, and alpha6 beta1 integrins are expressed in ductal cells at 8 weeks, before glucagon- and insulin-immunoreactive cells bud off in fetal pancrea.
- the signals induced by integrin alpha6beta1 modulate at the level of PI3K and Cdc42 activity to allow platelets to actively form filopodia
- alpha6beta4 integrin is mobilized and activated durign carcinoma progression [review]
- Data show that alpha6 and alpha3 integrin subunits interact with laminin 5 to increase expression of E-cadherin, and suggest that phosphoinositide 3-kinase (PI 3-kinase) activation plays a key role in this cross-talk.
- A peptide is identified within the extracellular domain of integrin alpha 6 molecule, to which antibodies in the sera from patients with oral pemphigoid (OP) bind, and which may play an important role in the pathogenesis of OP.
- PMP22 forms a complex with alpha6beta4 integrin in cultured colonic adenocarcinoma cells.
- IL-1alpha can induce selective upregulation of alpha6beta1-integrin and uPA/uPAR in pancreatic cancer cells and these changes may modulate the aggressive functions of pancreatic cancer.
- EWI proteins EWI-2 and EWI-F, alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 organization
- Both integrin alpha3beta1- and alpha6beta4-dependent cell adhesion to laminin-5 were also impaired in CD151-silenced cells.
- Acquisition of multiple antitumor drugs was accompanied by a drastically reduced expression of alpha6beta1 in the adenocarcinoma cells.
- Ln-5 is an important regulator of ADPKD cell proliferation and cystogenesis; Ln-5 gamma(2) chain and Ln-5-alpha(6)beta(4) integrin interaction both contribute to these phenotypic changes
- in natural HPV infection, proliferating keratinocytes expressing alpha6 integrin at the site of epithelial wounding might be targeted by virions adsorbed transiently to LN5 secreted by migrating keratinocytes
- The role of PTHrP in breast cancer growth and metastasis may be mediated via upregulation of integrin alpha6beta4 expression and Akt activation, with consequent inactivation of GSK-3.
- The role of integrin alpha6beta4 in keratinocyte migration via laminin-332 matrix organization is reported.[integrin alpha6beta4; laminin-332]
- alpha6 integrin might play a role in vascular endothelial growth factor (VEGF)-induced angiogenesis.
- These data taken together suggest that the uPA-mediated cell surface cleavage of the alpha6 integrin extracellular domain is involved in tumor cell invasion and migration on laminin.
- Keratinocytes expressing elevated levels of alpha6 integrin expanded over 200-fold during the 33-week in vivo study.
- Integrin-mediated adhesion via alpha3beta1, but not alpha6beta4 integrin, supports cell survival through EGFR by signaling downstream to Erk.
- Laminin repressed transcription, directed by the alpha6 gene promoter, by altering the nuclear levels of Sp1 and Sp3
- alpha-6 integrin is required for the growth and survival of breast cancer cells
- VEGFR2 up-regulation had no effect on VEGF-induced cell proliferation, but significantly enhanced endothelial progenitor cells migration and pseudotubes formation dependent on integrin alpha(6) subunit overexpression.
- These results indicate that the alpha(6)(bri)/CD71(dim) subpopulation enriched corneal epithelial stem cells.
- the alpha6beta4 integrin strongly influence Akt phosphorylation through ErbB-3 protein regulation
- Subepicardial localization of CD117-positive cells and expression of laminin-1 and alpha(6) integrin subunits may all correspond to the activation of regeneration involving an epithelial-mesenchymal transition in adult heart
- CD151-alpha(6) integrin complexes play a functional role in basal-like mammary tumor progression.
- LPS or peritoneal dialysis effluent stimulated the adherence of T cells to mesothelial cells, a process mediated by the integrins alpha6beta1 and alpha4beta1
- Extracellular Cyr61 interacts with alpha(5), alpha(6), and beta(1) integrins
- PODXL(hi)/CD49f(hi) MSCs were less prone to produce lethal pulmonary emboli
- Tumor cells within the bone expressing the integrin mutation prevented cancer induced spontaneous flinching, tactile allodynia, and movement evoked pain.
- Integrin alpha6beta4 plays an essential role in axonal regeneration and subsequent myelination.
- results identify Y1494 as a major regulatory site for signaling from the alpha6beta4 integrin to promote tumor development and progression
- Integrin alpha6beta4 and NET1 coexpression is independently associated with the development of distant metastasis in breast cancer.
- Curcumin inhibits breast cancer cell motility and invasion by directly inhibiting the function of alpha(6)beta(4) integrin, and suggest that curcumin can serve as an effective therapeutic agent in tumors that overexpress alpha(6)beta(4).