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Validated All-in-One™ qPCR Primer for INHBA(NM_002192.3) Search again
Product ID:
HQP101112
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
EDF, FRP
Gene Description:
inhibin subunit beta A
Target Gene Accession:
NM_002192.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Gene References into function
- distribution in gestational tissues across human pregnancy and during labour
- Activin was secreted by both endometrial adenocarcinoma cell lines. Activin showed a weak, but significant, mitogenic effect on HEC-50 cells without modifications in Bax and Bcl-2. Activin is a regulator of endometrial cancer cell growth.
- Activin A is potently induced in the bone marrow and may play a role in the suppression of inflammatory or immune processes.
- Activin A promotes human endometrial stromal cell decidualization in vitro.
- Seminal inhibin B levels were higher in normal men than in men after vasectomy and in men with azoospermia.
- synthesis by the endosalpinx
- Activin A induces cardiac ankyrin repeat protein (CARP) in cultured intimal smooth muscle cells in a dose-dependent way.
- data suggest that the increased placental expression of inhibin subunit mRNAs is part of the mechanism leading to increased serum activin A and inhibin A levels
- Results quantify the relative expression of inhibin alpha, inhibin/activin beta(A), beta(B), beta(C), follistatin, activin receptors and beta-glycan genes in placental tissue of term pre-eclamptic patients.
- Activin-A modulates ActRI mRNA levels in human trophoblast cells.
- Proportions of precursor inhibin B and alpha-subunit forms in the circulation are unchanged in men with spermatogenic disorders indicating there is no alteration of the Sertoli cell inhibin secretory pattern.
- Serum inhibin B is an effective marker of follicular development in infertile women undergoing induction of superovulation, and may represent a further marker for ovarian follicular capacity.
- activin promoted ovine preantral follicle & oocyte growth in vitro, but did not accelerate follicle differentiation; these results support a paracrine role for activin A during early oocyte & follicular development
- Peripheral blood monoCYTES and endothelium, activated by TNFalpha, could be extraplacental sources of activin A in preeclampsia. May have role in mechanisms underlying endothelium dysfunction.
- DLX1 blocks multiple signals from TGF-beta superfamily cytokines such as activin A, TGF-beta1, and BMP-4, including differentiation of a hematopoietic cell line by activin A
- Data indicate that activin A and activin receptors IIA and IIB may be involved in the regulation of germ cell proliferation in the human ovary during the period leading up to primordial follicle formation.
- Activin A markedly increased gene expression of mediators involved in infarction healing and myocardial remodeling in neonatal rat cardiomyocytes.
- the smad pathway and the tumor suppressor menin are key regulators of activin effects on PRL and Pit-1 expression, as well as on cell growth inhibition
- Testosterone secretion is impaired in infants with Klinefelter syndrome.
- Activin A increased the expression of VEGF receptors in cultured sinusoidal endothelial cells.
- activin signaling via type II receptors requires a specific sequence for ALK4 binding
- activin A is a novel stimulus of vascular endothelial growth factor gene expression in hepatocellular carcinoma
- Mutations in INHbetaB and INHbetaA genes are not associated with ovarian failure.
- may be an anabolic factor in cartilage
- Women with POF showed low levels of inhibin A and inhibin B, but not of activin A, whereas the levels of pro-alphaC were significantly higher than in postmenopausal women
- review article of gene expression of inhibin beta A in normal breast carcinoma, fibroadenoma, and normal mammary tissue
- enhanced activin A expression suppresses proliferation and colony formation of human neuroblastoma cell
- activin A inhibits adipogenesis via affecting the transcriptional factor cascade upstream of PPARgamma expression
- Activin A and inhibin A may be used as markers to predict pregnancies that are likely to miscarry.
- Activation of TAK1 (and probably p38-MAPK), but not Smad3, is necessary for triggering induction of oFSHbeta by activin.
- Hyperplastic tissue labelled more intensely than endometrium for the presence of INH-betaA and -betaB.
- When cultured with the mesonephros, Wolffian ducts formed ectopic buds in response to GDNF; inhibition of GDNF-induced budding by activin A led to inhibition of cell proliferation, & decrease of both Pax2 expression and PI3- & MAP kinase phosphorylation
- Activin has autocrine roles in tumor growth of ovarian clear cell adenocarcinoma cells.
- Activin A has opposite effects on glucagon and arx gene expression in alpha-cells compared with beta-cells, a finding that may have relevance during pancreatic endocrine lineage specification and physiological function of the adult islets
- Phosphatidylinositol 3-kinase antagonizes the ability of human embryonic stem cells to differentiate in response to transforming growth factor beta family members such as Activin A
- FGF-2 and activin A enhance their signals each other in bovine aortic endothelial cells, and endogenous activin A is critical for FGF-2-induced capillary formation.
- Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells
- Serum AMH and inhibin B are significantly lower in the men with nonobstructive azoospermia compared to the controls.
- Activin-A is an excellent candidate for an effector molecule in human luteolysis whose paracrine action is inhibited during maternal recognition of pregnancy
- Ovarian follicle size did influence rates of local hormone production.
- Overexpression of Activin a causes cancer cell aggressiveness in esophageal squamous cell carcinoma
- bFGF does not directly act on p38 nor on the mRNA expression levels of activin receptors but inhibit activin A activation of p38 upstream of p38 in K562 cells.
- A peptide corresponding to the N-terminal region of human follicle-stimulating hormone (FSH)-binding inhibitor (FSHBI/ovarian follicular fluid peptide) shows FSHBI inhibitory activity in rat ovarian granulosa cell cultures.
- Activin A is potentially an anticatabolic molecule in articular cartilage
- Inhibin/activin BA subunit, follistatin, and activin receptor proteins and mRNAs are present in the human fetal palate.
- new hypoxia-inducible and SOX9-regulated genes, Gdf10 and Chm-I. In addition, Mig6 and InhbA were induced by hypoxia, predominantly via HIF-2alpha
- Cripto facilitates Nodal signaling and inhibits activin signaling by forming receptor complexes with these ligands that are structurally and functionally similar.
- These findings establish an immune-regulatory role for activin-A in dendritic cells, highlighting the potential of antagonizing activin-A signaling in vivo to enhance vaccine immunogenicity.
- The effects of activin on germ cells are indirect and include mediation by the kit ligand/c-Kit pathway, rather than being an autocrine germ cell effect.
- analysis of the production and function of activin A in human dendritic cells
- These results reveal a key role of GLI2 in activation of the activin/BMP antagonist FST in response to hedgehog (HH) signaling.
- A dual role of activin A in regulating immunoglobulin production of B cells.
- Activin A increases invasiveness of endometrial cells in an in vitro model of human peritoneum.
- Concentration of anti-Mullerian hormone and inhibin-B in relation to steroids and age in follicular fluid from small antral human follicles.
- Women with polycystic ovary syndrome have high serum concentration of total inhibin but not of inhibin A or inhibin B.
- Activin A may mediate ovarian oncogenesis by activating Akt and repressing GSK to stimulate cellular proliferation.
- ActA interferes with selected aspects of DC maturation & may help prevent activation of allogenic T-cells by the embryo. This may promote the generation of tolerance-inducing DCs.
- Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin.
- activin A may modulate the expression of MMP-7 via AP-1
- synergistic effect of Wnt3a and ActivinA on hESCs differentiation into hepatic-like cells
- analysis of the structure of the FSTL3.activin A complex
- The serum activin A level increased in acute myocardial infarction positively correlated with peak creatine kinase and CK-MB levels which are measures of infarction size.
- Data suggest that activin A can down-regulate inflammatory mediator production and phagocytosis of LPS-activated macrophages via suppressing CD14 expression, and may influence the presentation of exogenous antigens via inhibiting MHC II expression.
- activin-beta(C) is an antagonist of activin A
- Activin B is a key mediator of VHL/HIF-induced transformation in renal cell carcinomas.