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Validated All-in-One™ qPCR Primer for IL6(NM_000600.4) Search again
Product ID:
HQP101037
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6
Gene Description:
interleukin 6
Target Gene Accession:
NM_000600.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
Gene References into function
- IL-6 stimulates proliferation of rat pituitary tumor cells in culture, inhibits secretion of prolactin and growth hormone and induces tyrosine phosphorylation of STAT3 in the cells.
- Individuals genetically predisposed to produce high levels of IL-6 during aging are disadvantaged for longevity.
- Data demonstrate that exercise activates transcription of the IL-6 gene in working skeletal muscle, a response that is dramatically enhanced when glycogen levels are low.
- Interleukin-6 stimulates thyrotropin receptor expression in human orbital preadipocyte fibroblasts from patients with Graves' ophthalmopathy
- Interleukin (IL)-6 protein concentrations are increased approximately 18-fold in clinically localized prostate cancers when compared to normal prostate tissue.
- Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells.
- Levels of IL-6 were significantly higher in patients with dyslipidemia as compared with the healthy controls
- Interleukin-6, tumor necrosis factor alpha and interferon gamma serum levels in patients with anorexia nervosa.
- Pancreatic periacinar myofibroblasts secrete a large amount of IL-6 in response to proinflammatory cytokines IL-17, IL-1 beta, and TNF-alpha.
- detection in pericardial fluid in coronary pathologies
- Function and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligands
- Expression of Interleukin-6 (IL-6) and IL-6 receptor mRNA in human bone samples from pre- and postmenopausal women.
- biosynthesis induced by tnf-alpha or interleukin 1 beta in human fibroblast-like synoviocytes increases with cell passage
- Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6
- Il-6 and oncostatin M act synergistically to promote growth in a new human myeloma cell line.
- Certoparin but not UFH led to a dose-dependent increase in IL-6 from non-stimulated PBMC.
- NADH significantly stimulated the dose-dependent release of IL-6 from peripheral blood leukocytes.The biological relevance of these data is discussed in the context of the recent use of NADH for the treatment of several neurodegenerative disorders.
- Increased plasma levels of interleukin-6 and interleukin-8 are observed in beta-thalassaemia major patients and may be relevant in the pathophysiology of beta-thalassaemia
- In dengue shock syndrome pts, IL-6 was significantly associated with both activation markers of coagulation (F1+2; p < 0.03) and fibrinolysis (PAPc; p = 0.002). IL6 is involved in the onset and regulation of hemostasis
- IL-6 a key cytokine in in vitro and in vivo response of Sertoli cells to external gamma irradiation
- Cancer cachexia is mediated in part by the induction of IL-6-like cytokines from the spleen.
- secretion induced by combined effects of protein kinase C and ERK activation with TFF-papetide and TNF-alpha
- Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts.
- The -597 G-->A and -174 G-->C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenism.
- polymorphism -174G/C does not contribute substantially to hyperlipidaemia and Type II diabetes mellitus in Japanese men
- results suggest that IL-6 is a mediator of the effects of Crohn's serum on in vitro mineralization and may be a contributing factor to the osteopenia associated with Crohn's disease
- TNF-alpha induced IL-6 gene expression in airway smooth muscle (ASM) cells via a nuclear factor (NF)-kappaB-dependent pathway
- Fas engagement increases expression of interleukin-6 in human glioma cells.
- process of cervical dilatation during parturition at term is associated with an increased expression of interleukin-1 beta, interleukin-6 and interleukin-8 mRNA in the lower uterine segment
- Reproductive hormone-induced, STAT3-mediated interleukin 6 action in normal and malignant human ovarian surface epithelial cells.
- Secretion levels of sIL-2R, IL-6, IL-8, IL-10, and TNF-alpha, but not IL-4 and IL-12, are elevated in activated T-cells in large granular lymphocytic leukemia associated with autoimmune disorders.
- the effects of high glucose in concert with AGII on IL-6 production in human mesangial cells and the modulation by blocking AGII
- determine the cellular contents and concentrations of interleukin 6 (IL-6), interleukin 8 (IL-8) and tumour necrosis factor alpha (TNF-alpha) in fluids of patients with spermatocele or epididymal cyst
- expressed in multiple sclerosis brain lesions
- findings suggest that the IL-6prom G allele which may affect plasma IL-6 concentration might be a risk factor for sporadic AD in Japanese
- high concentrations of IL-6 in the mid-secretory phase, the putative implantation window, and a further increase in the late secretory phase, the premenstrual period, support a role of IL-6 in the regulation of endometrial functions
- IL-6 has a role in contributing directly to paclitaxel and doxorubicin resistance in U-2OS through a non-MDR-1 pathway.
- secretion from acute myelogenous leukemia blasts was up-regulated by leptin
- IL-6 induced activation of full-length LCAT promoter activity. A minimal IL-6 response element mapped within the distal promoter and was sufficient to mediate the IL-6 response
- These results suggest that polymorphism of the IL-6 gene may be a useful marker for reduced bone mineral density.
- VEGF and IL-6 were both independent prognostic factors for overall survival of aggressive lymphoma
- Interleukin-6 production is induced in smooth muscle cells by monocyte chemoattractant protein-1 via differential activation of nuclear factor-kappa B.
- The role of interleukin-6 in the development of functionally defective dendritic cells in multiple myeloma.IL-6 inhibited the colony growth of CD34(+)DC progenitors and switched the commitment of CD34(+) cells from DCs to monocytic cells.
- IL-6 is produced by human adipocytes and is a potential marker of adipocyte differentiation; it is a hormonally regulated cytokine, suppressed by glucocorticoids, and stimulated by catecholamines and insulin in physiological concentrations
- identification of the positive role of IL-6 in the secretolytin release from monocytes in vitro
- Glutamine decreases rhis and interleukin-8 but not nitric oxide and prostaglandins e(2) production by human gut in-vitro.
- Endotoxin-stimulated production is increased in short-term cultures of whole blood from healthy term neonates.
- Impaired glucose tolerance is associated with increased serum concentrations.
- The loss of response to IL-6 is an important step in the process of adrenal tumorigenesis. IL-6 stimulates cortisol secretion from adrenal cells. IL-6 mRNA is upregulated in adrenal adenomas from Cushing syndrome patients.
- Simvastatin reduces expression of the proinflammatory cytokine interleukin-6 in circulating monocytes from hypercholesterolemic patients.
- role of p38 map kinase, NF-kappaB, and protein kinase c in IL-6 mRNA expression by human peripheral blood leukocytes, monocytes, and neutrophils in response to Anaplasma phagocytophila
- Acanthamoeba castellanii by release of ADP and other metabolites lead to human monocytic cell death through apoptosis and stimulate the secretion of IL-6
- IL-6 gene region may contribute to susceptibility to HTLV-I associated myelopathy
- Inheritance of the G/G genotype of both IL-1B and IL-6 was a particularly strong predictor for the development of recurrent aphthous stomatitis.
- IL-7 may function to regulate the milieu of the microenvironment by modulating IL-6 secretion by the IL-7R-expressing stromal elements
- regulation of synthesis by isoflavones during osteoblast cell differentiation via an estrogen-receptor-dependent pathway
- These results suggest that hepatocyte growth factor and interleukin-6 upregulate each other's receptors, and thus cooperatively enhance tissue invasion.
- Normal and SV40 transfected human peritoneal mesothelial cells produce IL-6 and IL-8: implication for gynaecological disease.
- activation of the hIL-6 gene by HHV-8/KSHV. role of hIL-6 in the development of Kaposi sarcoma.
- activation of the ERK pathway is involved in the induction of IL-6 mRNA stabilization by IL-17 plus TNF-alpha.
- the IL-6 G(-174)C polymorphism is not associated with the risk of CAD or MI and does not contribute to cardiovascular risk stratification.
- The endogenous levels of TPO, IL-6 and IL-8 are elevated in the thrombocytopenic patients with AML and MDS.
- an independent predictor of mortality in patients starting dialysis treatment
- Hepatocyte growth factor as cardiovascular hormone: role of HGF in the pathogenesis of cardiovascular disease. Review.
- IL-6 levels were not correlated with seminal parameters. IL-6 and TNF-alpha may be involved in male fertility.
- IL-6 in combination with its recombinant receptor enhances the expression of receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin in neonatal mouse calvarial bone cultures, while decreasing RANK expression.
- Interleukin-10 activates the transcription factor C/EBP and the interleukin-6 gene promoter in human intestinal epithelial cells.
- Review. We review the evidence for the involvement of IL-6 in the pathophysiology of autoimmune diseases and chronic inflammatory proliferative diseases (CIPD) and discuss the possible molecular mechanisms of its involvement
- role in human herpesvirus-8 replication
- antagonism by a homodimeric form of recombinant interleukin-6
- human IL6 expression mediates elements of the systemic inflammatory response in pancreatic tumor cell lines
- IL-6 expression is modulated by hormone replacement therapy in postmenopausal women
- Interleukin-6 down-regulates TFF expression in human stomach neoplasm cells cultivated in vitro.
- results strongly suggest that the IL-6-induced tyrosine-phosphorylation and activation of STAT3 were suppressed by overexpression of the nuclear isoform of TC-PTP in 293T cells
- Rta expression during lytic reactivation of HHV-8 would lead to expression of some cellular genes, including IL-6, whereas activation of NF-kappa B could inhibit some responses to transcription activator, Rta
- results indicate that mouse IL-19 may play some important roles in inflammatory responses because it up-regulates IL-6 and TNF-alpha and induces apoptosis [IL-19]
- Carriers of the -174C-allele (genotype GC/CC) had an inferior three-year graft survival (71/104 = 68.3%; P = 0.0059) with a 3.7-fold increased relative risk of graft loss compared to carriers of the -174GG-genotype (48/54 = 88.9%).
- Human bone marrow-derived mesenchymal cells do not differentiate into the osteogenic lineage until Gp130 is activated by soluble IL-6 receptors and IL-6.
- IL-6 production induced by hydrostatic pressure stresses was dependent on the PKC signaling pathway.
- results suggest that tumor necrosis factor-alpha and interleukin-6 are involved in endotoxin-induced anorexia in humans
- Release of IL-6 from oncostatin M-stimulated peritoneal mesothelial cells is dose- and time-dependent and contributes to the control of leukocyte recruitment by the soluble IL-6 receptor.
- IFN-gamma shifts monocyte differentiation to macrophages rather than DCs through autocrine M-CSF and IL-6 production.
- Inhibition of p38 MAPK inhibits IL-6 and VEGF secretion in bone marrow stromal cells triggered by adherence of multiple myeloma cells.
- cystatins SA1 and SA2 adhere to human fibroblasts and that the event results in tyrosine phosphorylation and upregulation of the release of IL-6 mediated enhancement of NF-kappa B activity.
- results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes
- growth mechanism of human myeloma cells by interleukin-6
- a multifunctional cytokine which causes contrasting effects in prostate cancer cells; may have an important role in progression of prostate cancer towards resistance to endocrine therapy [review]
- in basal cell carcinoma cells, the upregulation of the anti-apoptotic Mcl-1 protein by interleukin-6 is mainly through the Janus tyrosine kinase/phosphotidyl inositol 3-kinase/Akt, but not the STAT3 pathway.
- soluble proteins of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-6 receptor subunit gp80 (sIL-6R gp80), as markers of multiple sclerosis
- The presence of high-expression polymorphisms at position -174 of the IL-6 gene significantly increases the risk for bronchiolitis obliterans syndrome development after lung transplantation.
- IL6 regulates growth-related gene espression in murine myeloma cells
- levels in children with acute and chronic idiopathic thrombocytopenic purpura and their relationship with mega-dose methylprednisolone therapy
- IL-18 is a promising candidate for the enhanced secretion of IL-6 by human neutrophils.
- The IL-6 -174G>C polymorphism combined with IL-6 plasma levels may chronically predispose an individual to develop atherosclerosis.
- role in inducing N-ras and K-ras in myeloma cells
- An examination of quantitative gene expression of this protein in the renal artery wall of chronically rejected human renal allografts.
- IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation(review)
- IL-6 may be linked to the regulation of glucose homeostasis during exercise. The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor.
- The interleukin-6 promoter polymorphism -174 G/C does not contribute significantly to overall disease susceptibility but does predispose the carrier to distinct endometriosis with chocolate cysts
- Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma
- describe two functional polymorphisms in the IL-6 gene regulatory region associated with IL-6 activity in postmenopausal women both systemically (C-reactive protein) and locally in bone
- The promoter polymorphism of this gene affects energy expenditure and insulin sensitivity.
- only in a subset of both benign and malignant thyroid nodules the interleukin-6/interleukin-6 receptor signal could be induced by the CD30 ligand/CD30
- data demonstrated that Hsp90 may function as a stabilizer of an IL-6-mediated signal-transducing molecule, STAT3, by directly interacting with STAT3
- IL-6 mediates insulin resistance with SOCS-3 in the liver
- in men, the IL6 -174G/C polymorphism is associated with some indices of body composition and parameters of glucose and insulin homeostasis
- Although known to alter IL-6 expression, the IL-6 polymorphism investigated was not associated with idiopathic recurrent miscarriage and alterations in IL-6 serum levels in a Middle-European Caucasian population.
- Recombinant human IL-6 induces from peripheral blood mononuclear cells the formation of osteoclastic cells, which are positive for tartrate-resistant acid phosphatase, vitronectin receptor, and calcitonin receptor and capable of lacunar resorption.
- IL-6 secreted during an aseptic inflammatory state, such as sustaining head trauma with SIADH, is quantitatively correlated to AVP, indicating that this cytokine is directly and/or indirectly involved in the pathogenesis of SIADH.
- found that the G/C polymorphism in the IL6 promoter region is associated with development of type-2 diabetes mellitus in Native Americans and Caucasians; Pima Indians have a higher frequency of the GG genotype than Caucasians
- Inhibition of IL-6+IL-6 soluble receptor-stimulated aromatase activity by the IL-6 antagonist, Sant 7, in breast tissue-derived fibroblasts
- Bradykinin induces IL-6 production in human airway smooth muscle cells.
- combined elevation of interleukin-1beta and interleukin-6, rather than the isolated elevation of interleukin-6 alone, independently increases the risk of type 2 diabetes
- IL-6 and GM-CSF may be involved in the autoimmune mechanism of non-segmental vitiligo.
- STAT3 activation induced by IL-6 in primary human macrophages is affected differentially compared to STAT3 activation by IL-10, by mechanisms that suppress the Jak1/STAT3 pathway, despite the ability of the two cytokines to signal via similar pathways.
- We conclude that IL-6 may promote cervical tumorigenesis by activating VEGF-mediated angiogenesis via a STAT3 pathway.
- Interleukin-6 levels were elevated 5-fold in preeclamptic plasma. Human umbilical vein endothelial cell interleukin-6 production was increased 25% by preeclamptic plasma. plasma.
- Synergistic effect of -174 G/C polymorphism of the interleukin-6 gene promoter and a polymorphism of the intercellular adhesion molecule-1 gene in Italian patients with history of ischemic stroke.
- The significant correlation of IL-6 and fructose levels indicates that the seminal vesicles take part in the production of seminal IL-6.
- lack of role in expression of Mcl-1 in multiple myeloma
- This study provides further evidence that IL-6, leptin, and adiponectin are associated with impaired fibrinolysis in overweight hypertensive humans.
- data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of C-reactive protein and interleukin-6
- the thermotolerant effect of IL-6 is independent of the heat shock response
- IL-6 release from human adipocytes is stimulated in the autocrine/paracrine system by IL-1beta
- IL-6 precludes the negative effects induced by IL-3 on cord blood CD34+ cell expansion and telomerase activity.
- interleukin-6 stimulates mast cell adhesion to extracellular matrix and thus allows for the accumulation of the cells at tissue sites by enhancing integrin expression
- MTmRNA is high in lymphocytes from elderly people coupled with high IL-6, low zinc ion bioavailability, decreased NK cell activity and impaired capacity of PARP-1 in base excision DNA-repair.
- reduction in the frequency of GG homozygotes in the octo/nonagenarian age group and a higher serum IL-6 level associated with CC homozygotes with reciprocal changes for the anti-inflammatory cytokine IL-10.
- higher IL6 promoter activity may confer risk to type 1 diabetes mellitus in very young females
- IL-8 increased by 30% after weight loss. IL-8 and IL-6 correlated with measures of insulin resistance, and changes in IL-6 but not IL-8 were correlated with improvement in insulin sensitivity after weight loss.
- parallel expression with cyclooxygenase-2, interleukin-1beta, and NF-kappaB in colorectal cancer
- Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer.
- combination of low insulin-like growth factor-I and high interleukin-6 levels confers a high risk for progressive disability and death in older women
- in healthy adults, age-related alterations in nocturnal wake time and daytime sleepiness are associated with elevations of both plasma interleukin-6 and cortisol concentrations, but REM sleep decline with age is associated with cortisol increases
- A disease-modifying effect of IL-6 C allele could not be demonstrated in multiple sclerosis patients of German Caucasian descent.
- Giant cell arteritis patients with ischemic complications have lower tissue expression and circulating levels of IL-6 than patients with no ischemic events; IL-6 effects on vascular wall components may be protective
- intestinal epithelial and smooth muscle cells demonstrate the ability to release significant amounts of IL-6.Human intestinal parenchymal cells, influenced by paracrine mediators might contribute to the systemic inflammatory response by producing IL-6.
- might also be valuable biochemical marker in the evaluation of oocyte maturation
- there appeared to be no significant associations between IL6 promoter variants and disease outcome in chronic hepatitis B
- The level of IL-6 secretion in the gastric cancer cell lines correlated with the level of soluble IL-6R secretion, and was significantly higher (< approximately 100 pg/ml) than the level of IL-6 secretion in the colorectal cancer cell lines.
- There is a positive association of IL6 promoter variant with bone mineral density in pre-menopausal women.
- we found no significant association between the -174 G/C interleukin-6 polymorphism and the occurrence or the clinical features of migraine
- High levels of interleukin 6 is associated with hormone-refractory metastatic breast cancer
- IL-6 derived from blood during breakdown of blood-retinal barrier and produced by retinal pigment epithelial(RPE) cells and hematogenous soluble interleukin-6 receptor cause RPE proliferation.
- Elevated serum interleukin-6 correlates with the increased serum butyrate level in patients with nasopharyngeal carcinoma
- exercise results in an increase in IL-6 gene expression in adipose tissue in response to exercise, an effect that is significantly blunted by ingestion of carbohydrate
- IL-6 is found to be significantly higher in the cerebrospinal fluid of the "delayed-responders" than the "poor-responders" subtype of schizophrenics and the controls.
- Data show that angiogenin isolated from cow milk induces the production of cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha in human leukocytes.
- Presence of a common G/C polymorphism at position was the best predictor of disease-free survival in ovarian cancer. It influences the biological phenotype of ovarian cancer because it is associated with early stage and improved DFS and overall survival.
- Data suggest that interleukin-6 activation of gp130 promoted cell division in fibroblasts from patients with idiopathic pulmonary fibrosis (IPF), while IL-11 was mitogenic in both normal and IPF cells.
- Promoter polymorphism in this gene predicts the conversion from impaired glucose tolerance to type 2 diabetes.
- a structural model, derived from 3.65 A resolution crystallographic data of the complex between IL-6, the extracellular binding domains of IL-6R, and the extracellular activation and binding domains of gp130 is presented
- involvement of IL-6 in the pathogenesis of liver diseases and suggest a protective role of IL-6/gp130-dependent pathways in nonparenchymal liver cells during fibrosis progression in chronic liver diseases
- systemic antibody responses against Salmonella typhimurium LPS are largely effected by IL-6 and, moreover, the amount and the cellular location of recombinantly expressed IL-6 appears to be crucial for enhancement of immune responses.
- Hyperketonemia increases IL-6 levels in the blood of type 1 diabetic patients.
- Common polymorphisms in this protein are associated with increased risk of colorectal cancer.
- mechanism through which chronic stressors may accelerate risk of a host of age-related diseases by prematurely aging the immune response
- IL-6 and osteocalcin genes are susceptibility loci for reduced bone mineral density in postmenopausal women
- Serum concentrations of IL-6, sgp130, and sIL-6R were measured in stroke patients and controls. The data demonstrate genetic variation in the expression of IL-6 in stroke
- association between the IL-6 promoter polymorphism -174G/C and high blood pressure and LVH in hemodialysis patients, especially those with diabetes
- Higher cytosol IL6 levels were found in the walls of ruptured aneurysms than in the asymptomatic aneurysms.
- data demonstrate that the hepatosplanchnic viscera remove interleukin-6 from the circulation; this removal may constitute a mechanism limiting the negative chronic metabolic action of chronically elevated circulating IL-6
- study suggests that muscle-derived interleukin-6 has a central role in exercise-induced leukocyte trafficking
- trend for augmented exercise-induced IL6 release in type 2 diabetics; results also suggest that neither type 2 diabetic nor healthy skeletal muscle releases IL6 at rest,indicating that other organs contribute to elevated basal IL6 in type 2 diabetics
- serum and cyst fluid levels of interleukin (IL)-6, IL-8 and tumour necrosis factor-alpha (TNF-alpha) were evaluated in women with endometriomas and compared with those in women with benign or malignant ovarian tumours.
- adipose tissue mRNA of tumor necrosis factor-alpha, interleukin-6, and interleukin-8 was increased in HIV-associated lipodystrophy syndrome subjects
- IL-6 may function as a direct hepatic mitogen in vivo
- IL-6 has a role in growth inhibition of human myeloma cells induced by HMG-CoA reductase inhibitor
- IL-6 response elements have roles in transactivating Stat3 on fibrinogen promoters with additional transcription factors during acute phase response
- mechanism for the secretion of IL-6 from endothelial cells in response to uni-axial continuous stretch
- upregulation of TLR-4 via IL-6 can increase the responsiveness of mononuclear phagocytes
- A high serum level of IL-6 is significantly associated with a high serum level of CEA in preoperative colorectal cancer patients.
- Two polymorphic regions of the interleukin-6 (IL-6) gene were investigated in patients with Alzheimer's disease and non-demented controls. The -174 C allele in the promoter region of IL-6 gene was over-represented in AD patients.
- Spinal administration of recombinant human IL-6 to rats following spinal nerve ligation demonstrates inhibitory effects on C-fiber activity and suggests that IL-6 is a potential modulator of neuropathic pain.
- up-regulated to a greater extent in patients with influenza-associated encephalopathy than in those without neurologic complications
- both 5'-AMP-activated protein kinase and interleukin-6 are independent sensors of a low muscle glycogen concentration during exercise
- A continuous rise of IL-6 and a transient elevation of IL-10 during liver cancer surgery.
- IL-6 can play an important role in insulin resistance
- Skeletal muscle fibers are the dominant cell source of exercise-induced release of IL-6.
- Activation of the NF-kappa B pathway by IL-6 is required for the induction of ICAM-1 expression in model intestinal epithelial cells.
- IL-6 expression in UVB-irradiated human keratinocytes via cyclic AMP/protein kinase A pathway and a possible reduction of deleterious inflammatory effects of cytokine following by using pharmacological agents.
- Regulation of most IL-6 target genes in a multiple myeloma cell line required the activation of Stat3, underscoring its central role for IL-6 signal transduction.
- GNAS1 mutated stromal cells produce IL-6 at a basal magnitude and rate that are significantly higher than in the cognate wild-type cells
- potential direct involvement of CRP and IL-6 in atherogenesis.
- results indicate that leptin does not play a role in the pathogenesis of anorexia in children with failure to thrive but interleukin 6 may be an important factor
- The (-174)GG-genotype of the IL-6 gene is associated with severe stroke in young patients with acute cerebrovascular events.
- Skeletal muscle IL-6 production is regulated by an autocrine mechanism at the transcriptional level.
- The IL-6 -174 GG genotype is associated with the development of septicemia in preterm infants. Variation in the IL-6 gene seems to influence the defense against bacterial pathogens in the very preterm infant.
- DHT down-regulates NF-kappaB mediated IL-6 expression by human TCC lines in response to BCG. This effect depends on a functional androgen receptor signaling pathway and it can be blocked by the inhibition of androgen/androgen receptor binding.
- the human pituitary cell line HP75 synthesizes IL-6 mRNA and expresses and secretes IL-6
- IL-6 secreted by Mycobacterium tuberculosis-infected macrophages inhibits the responses of uninfected macrophages to interferon-gamma.
- During Rhinovirus upper respiratory tract infection, significant increases in mean levels of nasal interleukin 6 (IL-6) (P = .01) were observed in symptomatic but not asymptomatic subjects
- Intratumoral IL-6, which is differently regulated by various factors, might contribute to excessive grwoth hormone production in the majority of somatotroph adenomas.
- Cyclooxygenase 2 gene polymorphism is associated with squamous cell carcinoma.
- MIF, TNF-alpha and IL-6 may participate in pathological process of chronic hepatitis B and cirrhosis. IL-6 may play important role in ascites formation. Serum MIF, TNF-alpha and IL-6 appear to reflect severity of tissue injury in hepatitis B.
- Some levels, such as interleukin-6 and interleukin-8, may fluctuate during normal pregnancy. These spontaneous variations during pregnancy must be taken into account when mucosal immunologic responses to lower genital tract infection are being studied.
- Microvessel endothelium of fetal placental vasculature produces both interleukin-6 and interleukin-8 in umbilical placental vascular disease. May play key role in interaction of endothelial cells of placenta villi with neighboring cells.
- Increased serum levels of interleukin-6 in malnourished patients with colorectal cancer
- Results suggests that IL-6 may be a reliable marker of disease outcome in studies based on novel approaches aiming at modifying age- and cancer-related biologic mechanisms.
- IL-6 induced vascular endothelial growth factor 165 expression is enhanced by glucose via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling
- IL6 G-174C promoter polymorphism was associated with fat-free mass in men but not in women.
- Endogenous production of IL-6 appears to protect fetal liver-derived mast cells (MC)and those of the lung MC(T) phenotype from human recombinant IL-4-mediated apoptosis, because neutralization of IL-6 renders these mast cells sensitive.
- IGF-1, IGFBP-2 levels were related to IL levels, disease activity and anatomical distribution, consistent with active inflammation modifying the IGF-IGFBP system, possibly relevant to disturbance of growth.
- Garlic supplementation increases resting tissue blood flow and this may be mediated by increases in serum IL-6.
- IL-6 plays a critical role in the synergistic induction of human SAA gene when stimulated with proinflammatory cytokines
- Although IL-6 levels were elevated in diabetic groups with and without diabetic nephropathy in comparison with the control, no significant difference was found between patient groups
- Among Japanese women, those carrying the -634G allele of the IL-6 gene might have a decreased risk of recurrent pregnancy loss.
- Unglycosylated humanhIL-6 is as potent as glycosylated hIL-6 in stimulating B cell proliferation.
- Pim1 and Etk are required for IL6-induced activation of androgen receptor-mediated transcription in prostate cancer.
- IL-6 directly modulated monocyte adhesion to endothelial cells.
- These data suggest that moderate wine intake may acutely increase plasma levels of IL-6 in men with coronary artery disease.
- IL-10 and IL-6 induce decorin mRNA transcription, but additional signals from the extracellular matrix are necessary for its translation.
- In the blister fluid a significant difference (median +/- interquartile range, Wilcoxon signed-ranks test P < 0.05) was found between the involved and uninvolved extremity in IL-6 [53.5 (17.3-225) versus 6.2 (2-20.3) pg/ml]
- -572 G/C polymorphism may be one of the protective factors associated with lower susceptibility to chronic periodontitis
- IL-6 expression may be modulated by the composition of circulating free fatty acids
- This is the first demonstration that IL-6, secreted by macrophages, can induce a STAT3-mediated IL-10 production by colon tumor cells.
- In prostatectomy patients, preoperative plasma levels of TGF-beta(1) and IL-6 are associated with metastases to regional lymph nodes and disease progression.
- Elevated il 6 levels in Barrett esophagus may contribute to the development of apoptosis resistance, thereby placing this epithelium at higher risk of developing malignancy.
- data suggest that interleukin-6 may be a paracrine regulator of adipose tissue
- results support the findings of a pathologic role for IL-6 in the neuroinflammatory response as related with the pathogenesis of neuronal degeneration
- CC (low secreting) genotype was associated with a decreased risk of young adult Hodgkin lymphoma relative to the GG (high secreting) genotype
- Obese patients with body mass index greater than or equal to 28 kg/m(2) carrying CC genotype showed more than 5-fold increased risk of developing type 2 diabetes mellitus compared with remaining genotypes and might profit most from weight reduction.
- mRNA abundance of IL-6 and IL-8 appears to be influenced by glycogen availability in the contracting muscle.
- circulating IL-6 is markedly elevated at rest and during prolonged moderate-intensity exercise when lipolysis is suppressed.
- In end-stage renal disease on long-term hemodialysis, single nucleotide polymorphisms in promoter of IL-6, TNF-alpha, and IL-10 show strong association with indices of comorbidity and function, and biological and nutritional markers.
- In a Con A-induced model of murine liver injury, recombinant human IL-6 suppresses the cytotoxicity of natural killer (NK)T cells and prevents hepatitis via targeting CD4+ T cells in a STAT3-dependent way.
- IL-6 trans signaling differentially controls neutrophil-activating CXC chemokine expression.
- IL-6 is released from ruptured vulnerable atherosclerotic plaque, and regional activation of macrophages is involved in occlusive process of coronary artery in acute myocardial infarction.
- may participate in the pathogenesis of temporomandibular disorders and induce osseous changes in the condyle
- concetration in children with acute lymphoblbastic leukemia after chemotherapy
- evidence that the multifunctional cytokine, IL-6, may induce VEGF expression which increases angiogenesis in gastric carcinogenesis
- interleukin-6 promoter is activated by a dominant negative mutant of c-Jun
- IL-6 and sIL-6R may contribute to the pathogenesis of endometriosis-associated infertility
- IVIG inhibits NF-kappaB activation induced by TNF-alpha in cultured endothelial cells of coronary arteries, thereby possibly modulating IL-6 production and E-selectin expression
- The -174C allele is associated with higher BMI in type 2 diabetes, but not amongst healthy subjects.
- In conclusion, fasting glucose and the extent to which glucose tolerance changes with exercise training may be influenced by the IL-6 -174 gene polymorphism.
- In conclusion, epinephrine acutely increases IL-6 mRNA levels in subcutaneous adipose tissue as well as circulating IL-6 levels in healthy men.
- These women were more likely to present with a body mass index >27 kg/m(2), elevated total T serum levels, and a pathological oral glucose tolerance test result.
- Data do not support a pathogenic role in Alzheimer's disease for the C-174G polymorphism in the promoter of IL-6, which influences expression in vitro.
- The effects of low concentrations of extracellular ATP on cytosolic Ca(2+), membrane potential, and transcription of IL-6 were studied in macrophages.
- We believe that H. pylori-related cytokine activation becomes concentrated on gastric mucosa and this pathogen-induced local inflammatory cascade does not cause changes in circulatory levels of these cytokines.
- IL-6 and IL-8 levels in all amniotic fluids and in all supernatants
- IL-6 may influence glucose homeostasis during exercise. Potential new insights into factors that mediate glucose production and disposal and implicates IL-6 in the so-called "work factor."
- No difference in serum level of normal and hemodialysis or peritoneal dialysis patients.
- Blocking effect of IL-6 in humans may improve lupus by interacting with the autoinflammatory process both systemically and locally. (REVIEW)
- Expreeeion of interleukin-6 in human osteoblast-like cells is suppressed by arginine-vasopressin.
- high concentrations of leptin (100 nM) and/or PRL significantly (p<0.05) reduce the inhibitory effect of IL-6 (10 and 100 ng/ml) and TNF-alpha (10 and 100 ng/ml) on beta-casein gene expression in HC11 cells transfected with pbetacCAT
- PIV-4 infection enhances epithelial IL-8 and IL-6 production by transcriptional and posttranscriptional mechanisms
- Polymorphism in the IL-6 gene was associated with the severity of appendicitis and its outcome after appendectomy.
- data reveal an important role for MgcRacGAP in STAT3 activation, and demonstrate that MgcRacGAP regulates IL-6-induced cellular differentiation in which STAT3 plays a pivotal role
- study concluded that individuals homozygous for G allele on the interleukin-6 gene have higher values in some parameters associated with obesity
- Ryanodine receptor 1 enhances the production of the inflammatory cytokine IL-6, which may in turn affect signaling pathways responsible for the trophic status of muscle fibers.
- ICAM-1, VCAM-1, E-selectin and interleukin-6 expression are enhanced by glucose and regulated by poly(ADP-ribose) polymerase in human umbilical endothelial cells
- The magnitude of exercise-induced IL-6 mRNA expression in contracting human skeletal muscle was markedly reduced by 10 weeks of training.
- interleukin-1beta regulates interleukin-6-induced suppressor of cytokine signaling 3 expression
- Our results indicate that TGF-beta(1) gene Arg(25)-->Pro, TNF alpha gene G-308A and IL-6 gene G-174C polymorphisms are not risk factors or markers of progression in focal segmental glomerulosclerosis
- IL6 has a unique role in the progression of PCa.
- Ater interaction with tracheal epithelial cells, Bordetella pertussis induces the secretion of interleukin-6. This is dependent on expression of adenylate cylcase/hemolysin by the bacteria.
- A polymorphism in the inflammatory cytokine IL6, but not polymorphisms in angiogenesis-related genes, was associated with intracranial hemorrhage presentation of brain arteriovenous malformation.
- Both IL-6 and LIF can be very efficiently induced by IL-1beta in articular chondrocytes in vitro, more so in osteosarthritis than in normal cells.
- Reduced carbohydrate intake that results in low intramuscular glycogen leads to phosphorylation of p38 MAPK at the nucleus. This event is associated with IL-6 gene transcription during contraction.
- The concentration of IL-6 was enhanced by IL-1beta in human trophoblast cells in a dose-dependent fashion
- areca nut induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells is regulated by MEK/ERK activation
- IL-6 plays an important role in the inflammatory reaction that occurs in the interface between the craniopharyngioma and the brain parenchyma
- RANKL treatment induced a significant increase of IL-6 secretion by both bone marrow stromal & endothelial cells.
- Acute IL-6 treatment increased fatty acid turnover
- We conclude that upper extremity, low-intensity exercise results in a substantial increase in IL-6 in the interstitium of the stabilizing trapezius muscle, whereas no change is seen for plasma IL-6.
- IL-6 and IL-10 polymorphisms act synergistically, with a fivefold decreased risk of AD being found in subjects who concomitantly carry the (-174) IL-6 C/C and the (-1,082) IL-10 A/A genotypes.
- gene polymorphisms of cytokines playing a major regulatory role in the inflammatory response do not affect life expectancy in the Sardinian population.
- frail older adults have both decreased LPS-induced proliferation and increased IL-6 production by peripheral blood mononuclear cells
- variation of the gene that may increase IL-6 synthesis is associated with disabling brain injury but not cognitive development despite association with worse early critical care indices
- Amniotic fluid interleukin-6 is increased in patients with cervical incompetence
- expression upregulated in oral mucosa cells by Candida albicans and Streptococcus salivarius
- Both -174G and -598G alleles were significantly associated with type 2 diabetes
- secreted in cultured osteoblasts from uremia patients.
- G-174C polymorphism of the IL-6 gene does not contribute to the development and severity of GO.
- The double heterozygote AGCG of both IL-6 promoter polymorphisms was associated with cutaneous T-cell lymphoma
- The additive concentration of cytokines in diabetes and CVD (cardiovascular disease)suggests a common inflammatory state in both diabetes and CVD.
- the human nucleotide excision repair gene, hHR23B, is epigenetically silenced in interleukin-6-responsive multiple myeloma KAS-6/1 cells
- Palmitate, but not linoleate, induced a significant increase in IL-6 mRNA expression in coronary artery endothelial cells.
- IKK-beta/NF-kappa B transcription pathway is a key regulator of IL-6, IL-8, and TNF-alpha release from adipose tissue and skeletal muscle
- Interleukin-6 is an important independent mediator of elevated C-reactive protein concentrations in patients with non-small-cell lung cancer.
- extracellular ATP-induced IL-6 synthesis occurs through P2Y receptors and mobilization of Ca(2+) from internal stores in human osteoblastic cells
- inhibition of protein tyrosine phosphatase by vanadate promotes hematopoietic differentiation activity of IL-6 through modulating multiple signalings, particularly actin filament polymerization
- regulated by human cytomegalovirus (HCMV) at the posttranscriptional level.
- The CC genotype of the IL-6 -174G>C polymorphism may be associated with a protective effect against retinal artery occlusion
- IL-6 gene polymorphism may be a predisposing genetic factor that contributes to racial and ethnic differences in breast cancer prognosis.
- GSK3 and PKB/Akt have roles in the integrin-mediated regulation of PTHrP, IL-6 and IL-8 in pancreatic cancer
- heat shock-induced expression of MMP-1 and MMP-3 is mediated via an IL-6-dependent autocrine mechanism
- The IL-6-mediated bFGF upregulation is through activation of JAK/STAT3 and PI3-Kinase/Akt pathways.
- IL-6 release from monocytes under hyperglycemia appears to be mediated via upregulation of PKC, through p38 map kinase and NF-kappaB
- induced and expressed in human alveolar epithelial cells by Legionella pneumophila after invasion.
- Cellular and subcellular expression of TNF-alpha, IL-1alpha and IL-6 in hepatocytes inx chronic hepatitis C.
- Single-nucleotide polymorphisms and composite genotypes or haplotypes of the IL6 promoter may be associated with several features of the metabolic syndrome in Caucasians.
- IL-6 increases trafficking of TGF-beta1 receptors to non-lipid raft-associated pools resulting in augmented TGF-beta1 Smad signaling
- IL-6 is associated with sleep quality and certain individual characteristics such as race, gender, and age modify that relationship.
- Spliced form of IL-6 mRNA detected in renal cell carcinoma encodes for a truncated IL-6 with IL-6 antagonist properties.
- These data demonstrate that TNF-alpha rather than IL-6 stimulates an increase in PAI-1 mRNA in the subcutaneous adipose tissue, suggesting that TNF-alpha may be involved in the pathogenesis of related metabolic disorders.
- IL6 is upregulated in DDIT3- and FUS-DDIT3-expressing fibrosarcoma cell lines.
- Interleukin 6 (IL-6) specifically enhances brain-derived neurotrophic factor secretion in monocytes and provides evidence that IL-6 represents a specific link between monocyte infiltration and neuronal changes in inflammatory diseases.
- Oncostatin M stimulates proliferation of prostate cacner 22Rv1 cells, in part through activation of the phosphatidylinositol 3-kinase (PI 3-K) signaling pathway.
- IL-6 increases hepatic PAI-1 expression mediated by the -232- to -210-bp region of the promoter containing a C/EBPdelta binding site.
- predominant presence of high-producing IL-6 alleles together with low-producing IL-10 and IFN-gamma alleles in G6PD-deficient individuals with ancestry from malaria-endemic regions
- It is shown for the first time that genetic alterations in the inflammatory mediator IL6 associate with intervertebral disc disease-related sciatica.
- the HNF-3 site in the fibrinogen beta promoter is important for IL6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism
- These data suggest that the increase in fatty acid utilization seen during exercise at moderate compared with low intensity is not mediated via alterations in plasma IL-6.
- The significant associations between VEGF and the levels of IL6 and IL1 alpha suggest an important role for these cytokines in the development of these tumours.
- hsCRP and IL-6 appear to be associated with small silent brain infarction, suggesting a role of inflammatory processes in cerebral small vessel disease
- Elderly patients with postoperative confusion had increased plasma IL-6 and cortisol concentrations. The interaction between IL-6 and cortisol after surgery is associated with developing postoperative confusion in the elderly patients.
- P38 MAPK activation is essential in the NECA-induced signalling cascade that leads to the increase in IL-6 synthesis in U373 MG cells.
- This proinflammatory cytokine may play important roles in the development of T cell imbalance, cardiovascular disease and wasting in the uremic milieu. (review)
- Quantitative RT-PCR analysis showed down-regulation by 3.86 and 1.9 for IL-6 and CXCR4 genes, respectively by recombinant erythropoetin
- Primary thyrocytes express P2YR and P2XR subtypes, coupled to increases in ([Ca(2+)](i)) and secretion of IL-6.
- These data support the hypothesis that pubertal changes may contribute to accelerated onset of type 1 diabetes in genetically susceptible females. This phenomenon may be orchestrated by the action of estrogen on the IL6 promoter.
- co-expression of IL-6 and its specific receptor (IL-6Ralpha) in keloid fibroblasts that points to the existence of an IL-6 autocrine loop in these cells
- IL-6 may reduce estrogen production via the MAPK signal pathway in human granulosa cells
- Positive association of IL-6 GG genotype with hypertension and elevated plasma PAI-1 in normotensive individuals in Chinese in Taiwan. IL-6 gene promoter G-174C polymorphism may affect regulation of PAI-1 and blood pressure through inflammatory mechanism
- IL-6 and OSM upregulate PAI-1 protein and mRNA in adipose tissue
- IL-17 particularly affects post-transcriptional regulation of IL-8 and IL-6 expression leading to enhanced IL-8 and IL-6 responses to secondary stimuli, and is only a weak proinflammatory stimulus by itself
- The presence of the C allele in the -174 position in the gene coding for IL-6 could play a role in the pathology of neonatal infection following IAI in the mother and probably is connected with decreased of immunological reaction.
- CA IX and GLUT 1 as well as VEGF and IL 6 have roles in response of in head and neck squamous cell carcinoma to radiotherapy +/- chemotherapy
- IL6 is one of the important factors in the pathogenesis of psoriasis.
- IL-6 may play a role in modulating the inflammatory cascade of chronic periodontitis.
- Zip14 expression is up-regulated through IL-6
- Retinoic acid inhibits CD40 plus IL-4 mediated IgE production through alterations of sCD23, sCD54 and IL-6 production
- under certain circumstances, acute, pulsatile release of IL-6 does not stimulate synthesis of CRP
- STAT3 signaling pathway is involved in IL-6-induced neuroendocrine(NE) differentiation and that p38 MAPK is associated with IL-6-stimulated growth regulation in NSCLC-NE cells.
- IL-6 can induce cell proliferation and neuroendocrine(NE) dedifferentiation but has little effect on chemosensitivity in IL-6 receptor-expressing NSCLC-NE cells.
- A crystal structure of the ligand-binding domains of gp130 in complex with human interleukin-6 (IL-6) and its a-receptor (IL-6Ralpha).
- Polymorphisms of IL-6 and TNF-alpha can be used to identify subgroups of patients with higher risk of unsuccessful outcome.
- That nucleated red blood cell (NRBC) counts were elevated in fetuses delivered for "nonreassuring fetal status" with normal plasma erythropoietin and elevated IL-6 implies that IL-6 may have unique, short-term role in elevating fetal NRBC counts.
- Results suggest that the interleukin 6-174G/C polymorphism is associated with plasma high-density lipoprotein cholesterol responses to exercise training.
- IL-6 is a mediator of sleepiness and its circadian pattern reflects the homeostatic drive for sleep
- different members of the TGF-beta superfamily may also contribute in the reproductive process by enhancing endometrial proimplantatory LIF secretion and reducing proinflammatory IL-6 release by endometrial endothelium
- The identification of IL-6 and IL-1beta as activators of LT-beta supports their involvement in LT-beta signaling in liver regeneration associated with chronic liver damage.
- results suggest that interleukin (IL)-6(-174) G/C polymorphism is associated with insulin resistance and increased adipose tissue IL6 gene expression, which can impair adiponectin production
- IL-6 produced by type I interferon(IFN) dendritic cells controls IFN-gamma production by regulating the suppressive effect of CD4+ CD25+ regulatory T cells.
- show that IL-6 together with FGF enhanced proliferation of a myeloma cell line, KMS-11 carrying t(4;14)(p16.3;q32)
- Both white and African Americans carriers of IL6(-237)C had increased risk of spontaneous preterm birth.
- IL-6 was significantly related with visceral adiposity in obese subjects.
- SNPs in the promoter region and intron 3 of the IL-6 gene might play a role in the blood pressure regulation and progression of atherosclerosis in the Japanese
- linkage between the -634C/G marker and bone phenotypes at the spine and the hip
- IL-6 may have a role in the genesis of neurologic impairment in children born prematurely
- Polymorphisms associated with control of gene expression and protein levels were not associated with occurrence of chronic idiopaathic leukemia in adults and were not responsible for the increased cytokines.
- Multiple logistic regression revealed a significant association between the appearance of nucleated RBCs in the blood and erythropoietin, IL-3, IL-6, and age.
- IL-6 and TNFalpha are involved in the production of HGF by endometrial stromal cells and may be involved in the growth of endometriosis by an autocrine mechanism
- Data demonstrate a strong association of the -1746>C polymorphism of the IL-6 gene with the aggressiveness and recurrence of prostate cancer
- investigation of the effect of the IL-6 receptor antagonist Sant7 on proliferative and anti-apoptotic signals in the IL-6-secreting LCL41 B lymphoid cells
- oxalate up-regulates the expression and secretion of IL-6 in renal epithelial cells
- We investigated the association of the IL-6 single nucleotide polymorphism (SNP) C-174G with type 2 diabetes in a case-control study of 704 elderly participants of the KORA Survey S4 (1999/2001).
- gene expression is inhibited by estrogen receptor by disrupting nuclear factor kappaB transactivation
- C-174G/G genotype of the IL-6 gene may contribute to variations in insulin sensitivity.
- common genetic variants of CRP (3'UTR 1846C/T) and IL-6 (-174G/C) are significantly associated with the risk of stroke after cardiac surgery and may have a role in inflammation in post-cardiac surgery stroke
- PAR2 activation stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells
- Data suggest that IL-6 --174G>C polymorphism is a clinical marker to identify a subgroup of elderly acute coronary syndrome male patients at higher risk of death.
- The present study demonstrated that the IL-6R gene expression levels in skeletal muscle are increased in response to acute exercise, a response that is very well conserved, being affected by neither training status nor intramuscular glycogen levels.
- Promoter variation in IL6 is associated with the risk for serious infection in children undergoing therapy for acute myeloid leukemia
- Globular adiponectin (gAd) is a powerful inducer of TNF-alpha and IL-6 secretion in primary human peripheral macrophages, in the THP-1 human macrophage cell line, and in primary mouse peritoneal macrophages.
- IL6 polymorphism was significantly associated with breast cancer.
- IL-6 was significantly overexpressed in pancreatic specimens and elevated in serum of cachectic patients and represents a prominent cachexia-associated factor in pancreatic cancer.
- Production of IL-6 and its soluble receptors by stimulated peripheral blood monocytes appears to be inversely correlated with serum cholesterol levels in hemodialysis patients.
- Data suggest that by inhibiting interleukin (IL)-6 production and lowering plasma IL-6 concentration, high-density lipoproteins may limit the pro-atherogenic effects of both acute and chronic inflammatory states.
- IL-6-174 G > C polymorphism affects insulin resistance in type 2 diabetes.
- p38 mitogen-activated protein kinases mediated substance P-induced IL-6 production
- review of roles for IL-6 in both the resolution of innate immunity and the development of acquired immune responses; the regulatory properties of the soluble IL-6 receptor and how its activity may affect chronic disease progression.
- two functional promoters regulate the transcriptional expression of PSGR in human prostate tissues, and PSGR is a new target for IL-6 transcriptional regulation
- the IL-6 -174 genotype mediates growth failure in children with Crohn's disease; those with the IL-6 GG genotype were more growth-retarded than those with the GC or CC genotypes
- IL-6 174G/C polymorphism may have a role in common carotid artery IMT
- IL-1beta, IL-6 and TNF-alpha are all significantly increased in hypoxic ischemic encephalopathy infants when compared to controls.
- The C allele is associated with higher postoperative IL-6 levels and a less favorable clinical outcome. The G-174C polymorphism is related to the outcome after coronary revascularization.
- Our results indicate that integration of adenoviral DNA and expression of E1A and E1B can either increase or decrease IL-8 production.
- Current study does not confirm previously reported associations between sepsis, cerebral injury and the IL-6-174-genotype in very low birth weight infants.
- role for IL-6 in the homeostatic modulation of aqueous humor outflow resistance
- IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.
- the 174 G/C promoter IL-6 polymorphism does not seem to be implicated in susceptibility to and clinical expression of giant cell arteritis
- no significant association between the IL-6 genotype and risk of coronary heart disease
- Only women carrying at least one mutant allele of both polymorphisms (tumour necrosis factor-alpha A and interleukin-6 C) have a significantly elevated mean systolic blood pressure and diastolic blood pressure at the end of pregnancy.
- IL-10, but not TNF-alpha, TNF-beta, or IL-6 polymorphisms are associated with lung cancer
- Cyclooxygenase-2-dependent activation of STAT3 by interleukin-6 has a role in non-small cell lung cancer
- Results suggest that the IL-6 genotype associated with intracranial hemorrhage modulates IL-6 expression in brain arteriovenous malformation tissue.
- acetylation-deacetylation reaction as a novel signaling mechanism controlling the IL-6-STAT3 pathway in the hepatic acute phase response
- findings suggest that IL-6 directly inhibits hepatocyte proliferation via a p21cip1-dependent mechanism and indirectly enhances hepatocyte proliferation via stimulating nonparenchymal cells to produce HGF
- IL-6 expression levels were higher in undifferentiated marrow stromal cells (MSCs) than in MSCs treated with osteogenic medium.
- IL-6 action regulated by variance in the IL-6 gene contributes todevelopment of both type 1 and type 2 diabetes. (review)
- secretion of IL-6 during day 7 of culture (standardised by taking natural logarithms) was increased markedly by the addition of TNF-alpha
- GBF1 is recruited to the endogenous IRF-9 promoter, and interacts with C/EBP-beta, IL-1, and IL-6
- transforming growth factor, beta 1 and IL-6 might play pivotal but opposing roles in the host tumor interaction
- A marker of endothelial damage/injury in the activation of vascular and coagulation abnormalities in acute coronary syndromes.
- Results report changes in the transcriptome profile of HepG2 cells exposed to interleukin (IL)-6 alone, or IL-1beta and IL-6.
- Multivariate regression analyses showed that lower levels of plasma IL-6 were predicted by greater sleep efficiency
- A multiple case-control logistic regression associated carriage of il-6 with low CD4 T-cell counts
- CD30-L/CD30 and IL-6/IL-6R systems could play a major role in the pathogenesis of Graves'disease (GD), but the expression of CD30L/CD30 and IL-6/IL-6R in Hashimoto's thyroiditis (HT) suggests that Th2 mechanisms are involved in tissue damage.
- a strong induction of the pro-inflammatory cytokine, IL-6, in IL-1-exposed SW1353 cells was found
- Levels of IL-6 in severe cases of influenza-associated encephalopathy are significantly higher than those levels in mild cases, compared with IL-6 levels in patients with febrile convulsion and rotavirus-associated convulsion.
- Suramin inhibits TNF-alpha and IL-6 production through the suppression of NF-kappaB activity from macrophages
- Our present study suggests that serum IL-6 and IL-10 levels are related to fever, and the CSF IL-6 level, myoclonic jerks, in SSPE patients in PNG.
- interleukin-6 has a role in insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells
- ST2 negatively regulates LPS-induced IL-6 production via the inhibition of IkappaB degradation in THP-1 cells
- NEU3 activated by IL-6 exerts IL-6-mediated signaling, largely via the PI3K/Akt cascade, in a positive feedback manner and contributes to expression of a malignant phenotype in renal cell carcinoma
- Increased interleukin-6 is associated with staging of colorectal cancer
- Polymorphisms in the promoter region of the pro-inflammatory IL-6 gene may represent a marker for increased risk of breast carcinoma; genetic variations may also predict outcome.
- Elevated IL-6 level may have a protective effect against development of type 1 diabetes mellitus and may delay the destruction of pancreatic beta-cells.
- Mcl-1 is identified as a mediator of IL-6-induced tumor cell survival and shown to be transcriptionally regulated by IL-6 via a p38 MAPK dependent pathway.
- Patients with active myeloma induce quantitatively higher levels of stromal cell IL-6 production when compared with those with monoclonal gammopathy of undetermined significance.
- The IL-6 concentration increased markedly after 24 h in skin areas irradiated with a twofold minimal erythemal dose (MED) compared to areas challenged repeatedly with 0.3 MED.
- Findings indicate that IL-6 mRNA translation and degradation are affected by the distortion of the cytoskeleton in airway epithelial cells.
- These changes in circulating IL-6 were closely associated with a prooxidant state (R2 = 0.47), whereas muscle IL-6 mRNA correlated with an antioxidant state (R2 = 0.65).
- We conclude that IL-6 triggers VEGF-induced angiogenic activity through increasing VEGF release, up-regulates KDR expression and phosphorylation through activating ERK1/2 signaling, and stimulates MMP-9 overexpression.
- levels of interleukin-6 & tumor necrosis factor-alpha were significantly higher in patients with fatal Crimean-Congo hemorrhagic fever (CCHF)than nonfatal CCHF; findings demonstrate that proinflammatory cytokines play a major role in the mortality in CCH
- salivary levels seem not to play a role in recurrent aphthous ulcer disease
- there are tissue-specific differences in IL-6-receptor-gp130-coupled signaling which limit the extent of Stat3 activation and gammaFBG expression during lung inflammation
- IL-6 and IL-8 production by human articular chondrocytes is vitro are stimulated by histamine exposure, this being mediated bia the H1R pathway
- IL-6 and IL-8 are associated with postoperative surgical site infection, including pancreatic leakage after pancreaticoduodenectomy.
- The results suggest that both IL-6 and GH may play a role in the progression of both endometriosis and endometrial carcinoma.
- analysis of interleukin-6 response to elective total hip replacement surgery
- The IL-6 -174 G/C, IL-10 -1082 G/A and CD14 -260 C/T SNPs may alter risk for sepsis in ventilated VLBW infants
- An IL-6-CD44 feedback loop in macrophages may aggravate atherosclerosis development.
- circulating IL-6 may have a role in acute stroke
- there is no association between the common polymorphisms in IL6 gene and circulating IL-6 levels and the risk of type 2 diabetes
- During exercise, with and without carbohydrate ingestion, plasma IL-6 increased. The concentration of IL-6 in CSF did not change with exercise and was below the plasma levels.
- This is the first study to show that IL-6 promoter polymorphisms are associated with intracranial aneurysmal dise
- macrophages may be a major source of IL-6 in the gastric mucosa upon H. pylori infection. The IL-6 induction by H. pylori in these cells is a multifactorial process, which requires the uptake and presumably degradation of H. pylori bacteria.
- sIL-2R and IL-6, but not IL-2, IL-4, or IL-10, may have a role in preventing progression of aggressive non-Hodgkin's lymphoma
- data suggest that the IL-6 G-174 C polymorphism does not seem to play a role in breast cancer risk, although its role as a prognostic factor remains to be studied
- IL-6 and Stat3 binding induces BCL3
- The release of IL-6 from peripheral tissues may act as a signal for the inflammatory response and contribute to functional dysregulation in uremia.
- Interleukin 6 is an independent factor that is associated with C-reactive protein in Japanese type 2 diabetic patients.
- IL6 gene -572G allele may be a genetic susceptibility factor to MI attack of Chinese Hans population.
- Further analyses show that inhibitors of phosholipase D, Rho, and protein kinase C also inhibited the LPL-induced release of IL-6 and IL-8.
- IL-6 level in tumor cells is not a predictive marker for response to paclitaxel in women with metastatic breast cancer.
- Polymorphisms of IL-6 were not associated with outcomes in acute coronary disease patients.
- present study provides the epidemiological evidence that IL-6 is one of the main correlates of low HDL-C levels in older individuals
- Pre-B cell colony-enhancing factor (PBEF) is regulated via IL-6 trans-signaling and the IL-6-related cytokine OSM. PBEF is also actively expressed during arthritis.
- IL-6 is associated in a reciprocal manner with the two pathophysiological components of type 2 diabetes, insulin resistance and insulin secretion.
- IL-6 promoter polymorphism -174 is associated with new-onset diabetes after transplantation.
- The results suggest that IL-6 plays a role in the GH-->IGF-I response to intense exercise.
- Although there are still missing links to it, our results support the concept that high concentrations of glucocorticoids, met in critically ill patients, prevent TNF-alpha- and LPS-stimulated IL-6 secretion.
- TLR2, IL-6 and IL-1beta may have roles in inflammatory reactions in the course of Lyme disease
- IL-2 and IL-6 in saliva may have roles in development of burning mouth syndrome
- serum IL-1beta and TNF-alpha are increased, and IL-2 and IL-6 are decreased in newly diagnosed IDDM patients
- IL-8 and IL-6 may have roles in development of psoriasis
- induction of IL-6 secretion from T cells by thrombin, trypsin and tryptase is probably through the activation of Proteinase-activated receptors, suggesting that serine proteinases are involved in the regulation of immune response of the body.
- Carriers of the IL-6 appeared to have an increased risk of stroke in association with a febrile episode prior to strokes.
- Has direct effects upon endothelial cells, inhibiting endothelial nitric oxide synthase expression in part through Stat3.
- The selective increase in sIL-6R implicates an enhanced trans-signaling capacity whereby sleep distinctly widens the profile of IL-6 actions, enabling an integrated influence on brain and peripheral organs
- There are associations between sudden infant death syndrome and particular polymorphisms.
- Evidence suggests a direct role for IL-6 in muscle cell destruction and a possibility of muscle cell damage via an autocrine fashion.
- IL-; Gene Polymorphism confers susceptibility to PH in patients with COPD.
- PDTC downregulates IL-6-induced STAT3 activation by altering the stability of STAT3-Hsp90 complex
- IL-6 -634C/G and ICAM-1 469K/E polymorphisms synergistically affect the susceptibility for endometriosis in the Japanese population.
- Adiponectin-mediated induction of IL-6, CCL2 and CXCL8 is disturbed in monocytes from type I diabetes patients.
- Impaired glucose tolerance and type 2 diabetes, but not impaired fasting glucose are associated with elevated plasma IL-6 levels.
- These results indicate that AUF1 binds to the AU-rich element in vivo and promotes IL-6 mRNA degradation.
- Data show that the gene expression for interleukin-8, IL-10, and IL-1Ra, but not IL-6, is increased in blood leukocytes taken from athletes following 2 hours of intensive cycling and is not influenced by carbohydrate compared with placebo ingestion.
- The -174 IL-6 promoter polymorphism modifies the association of obesity with IR and diabetes risk in men.
- Medroxyprogesterone acetate and danazol appeared to have a decreased effect on the suppression of IL-6 liberated by ESCs in adenomyosis.
- A case of parotid myoepithelioma occurred in a patient affected by myasthenia gravis supports a possible IL-6 mediated relationship between myasthenia gravis and parotid myoepithelioma.
- Pro-inflammatory cytokines derived from surgical trauma may enhance tumor cell adhesion to microvascular endothelial cells and thus bring about more successful tumor cell implantation resulting in an increased risk of metastasis formation.
- The GC and CC genotypes of IL6 -174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%.
- An elevated preoperative C-reactive protein was associated with increased tumour stage, interleukin-6 and interleukin-10 concentrations.
- alpha-synuclein strongly stimulates human astrocytes as well as human U-373 MG astrocytoma cells to up-regulate both interleukin IL-6 and ICAM-1; mutated forms are more potent stimulators than wild-type
- mutual link between the post-coronary artery bypass grafting (CABG) major adverse cardiovascular events (MACE) incidence, the - 174G > C IL6 polymorphism and past acute infections history
- The -174G/C interleukin-6 promoter gene variant appears to modulate the response to phacoemulsification surgery and to influence the development of postoperative Cystoid Macular Oedema.
- Results indicate a direct regulatory effect of IL-6 genotypes in the determination of 60-kDa heat-shock protein autoantibody levels.
- The early induction of IP-10 and IL-2, as well as the subsequent over-production of IL-6 and lack of IL-10 production, probably contribute to the main immuno-pathological processes involved in lung injury in SARS.
- An association between the IL6 G-174C polymorphism and Australian SIDS infants was observed.
- TGF-beta1 activates IL-6 production, and the functional interaction between TGF-beta1 and IL-6 contributes to intrahepatic cholan-giocarcinoma (ICC) cell growth by TGF-beta1.
- Periodontal tissue destruction and local synthesis are associated with elevated serum levels in transplant recipients
- Our results demonstrate NFAT expression and activation in native human vessels and point out A-285222 as a powerful pharmacological blocker of NFAT signaling in the vasculature.
- haplotypes of IL6 (-660G/-635C/-236G) and IL10 (-6653C/-1116G) were significantly associated with HTLV-I infection in children independent of maternal provirus load and duration of breast-feeding
- analyzed the expression of Toll-like receptors 1 to 9 on myeloid dendritic cells generated from X-linked agammaglobulinemia patients and evaluated their response to activation by specific Toll-like receptor agonists
- Polymorphisms of TNF-alpha, IFN-gamma, TGF-beta1, IL-10 and IL-6 do not appear to influence the onset of broncholitis obliterans syndrome or graft survival in recipients.
- relationships of IL-6 with components of the IGF system in the placenta and newborn infant
- The biliary IL-6 and TNF-alpha levels were positively correlated with serum DBIL, TBA and gamma-GT levels in infantile hepatitis syndrome subjects.
- In heart transplant patients, high levels of serum IL6 were associated with low grade cellular rejection.
- Interleukin-6 single nucleotide polymorphism (SNP) IL6(-174) association with severe carotid artery disease is confirmed.
- There were no statistically significant differences in IL-6 and IL-8 gene polymorphisms between the SLE and control groups (chi-squared test, P=0.53, chi(2)=1.27 and P=0.44, chi(2)=1.62, respectively).
- IL-6 promoter genotypes may be associated with increased risk of plasma cell neoplasms
- Histamine stimulates IL-6 release from SW982 cells by binding to the H1 receptor and this is coupled to the PI/PKC signal transduction pathway.
- The association of this gene variant of IL-6 with the metabolic syndrome is intimately linked with obesity per se.
- This preliminary study is the first to suggest that the TGF-beta1 signal sequence (29T-->C) and IL-6 promoter (-597G-->A)|(-572G-->C) transitions are predictive for the time to onset of aseptic instability after total hip arthroplasty
- patients with a transient increase in IL-6 in response to IFN-beta showed a slow disease progression
- CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production.
- BRG1 is constitutively present at IL-6-responsive promoters and is required for STAT3 recruitment, downstream histone modifications, and IL-6-induced chromatin remodeling.
- aneurysms secrete IL-6 into the circulation
- Serum levels of IL-6 were increased in Down's syndrome (DS) children and adults, but not in older DS patients.
- interleukin-6 induces Oct-1 gene expression, providing a biologically relevant means by which NF-kappaB-dependent gene expression can be selectively reverted by Oct-1 to quiescent levels
- The hypothalamic-pituitary-adrenal (HPA) axis and the proinflammatory cytokines (and interleukin-6 [IL-6] in particular) are enmeshed in the response to somatic stress
- The maternal side of term placentas secreted significantly higher amounts of interleukin (IL)-6 compared with preterm placentas. Exposure to LPS significantly decreased IL-6 secretion from the maternal side in both term and preterm placentas.
- possibility that the IL-6 mediated androgen-independent proliferation of PC-3 and DU145 prostate cancer cells is regulated at least partly via SAPKs signaling pathway especially through p38MAPK activation.
- higher risk in ESRD patients with low IL-4 and high IL-6 producing genotypes
- CD14+ cells producing TNF-alpha, IL-6, IL-10, MCP-1, and IL-8 were significantly higher in peripheral blood than peritoneal fluid mononuclear cells of women with endometriosis.
- The -174IL-6 single-nucleotide polymorphism are associated with susceptibility to chronic periodontitis in the population studied.
- keratin-8 has a role in interleukin-6-induced barrier function alterations
- let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes
- The mucosa of esophagitis patients produced significantly greater amounts of IL-1beta and IL-6 compared with those of control patients
- SOCS-3 epigenetic silencing is responsible for sustained IL-6/STAT-3 signaling and enhanced Mcl-1 expression in cholangiocarcinoma
- IL6 down-regulated CD33, CD7, or CD56 expression in primary myeloma cells, as well as in Liu01 cells
- Recombinant human IL-6-treated neural Paju cells upregulate stanniocalcin-1 expression via MAP kinase signaling.
- no impact of -174 G/C of interleukin-6 promoter region polymorphism on the susceptibility to multiple myeloma
- the increased expression of IL-6 and IL-6 (-174) polymorphism are associated with periodontal disease severity in Brazilian individuals
- Intracytoplasmic sperm injection patients with serum progesterone above 0.9 ng/ml have elevated serum and intrafollicular concentrations of interleukin 6.
- IL-6 concentration seems to be a more specific marker of liver metastasis.
- IL-6 can directly influence cell proliferation and the invasion potential as the first step of tumor metastasis.
- BMP pathway regulates IL-6 in pulmonary tissues and conversely that IL-6 regulates the BMP pathway
- Single nucleotide polymorphism in IL-6 is associated with cardiovascular diseases
- The polymorphism of IL-6 may at least partially explain the genetic predisposition to an aggressive course of the disease with the development of terminal stage.
- Elevated IL-6 levels occur in connection with bacterial infections after kidney transplantation.
- Data showed that the frequencies of IL-6 (A nt565) and IL-6 (G nt565) alleles are more than 0.95.
- The transition of IL-6 from a paracrine growth inhibitor to an autocrine growth stimulator suggests that IL-6 plays an important role during prostate cancer progression, possibly androgen-independent progression.
- Increasing the protein levels of the signal transducer and activator of transcription 3 (Stat3) led to Stat3-androgen receptor (AR) complex formation in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) stimulation.
- CCL2 mediates fibroblast survival by inhibiting apoptosis through IL-6/STAT3 signaling
- Circulating IL-6 is linked to endothelial dysfunction independently of insulin sensitivity in apparently healthy men.
- higher "stress index" was associated with higher expression of total LPS-stimulated TNF-alpha and IL-6 between rest and 60min post-stress
- the lung epithelial cell is a possible target of dengue viruses and IL-6 and RANTES may play pivotal roles in lung related immuno-pathogenesis
- both splanchnic organs and kidneys affect in a significant way the disposal of IL-6 in humans
- the polymorphism in IL-6 gene promoter (-174 G/C) does not appear to be a genetic risk factor for Henoch-Schonlein pur-pura in Northwest Spain.
- Serum IL-16, IL-16 mRNA expression and IL-16 protein in mucus and tissue specimens were significantly associated with the presence of aEos in polyps of ECRS patients.
- polymorphic variations of pro-inflammatory cytokines play an important role in susceptibility to multiple sclerosis
- This study demonstrated a significant association between CSF levels of IL-1beta, Il-6, and IFN-gamma and the severity ot EV71 brain stem encephalitis.
- the median serum concentration of IL-6 had a significant positive correlation with the liver dysfunction biological markers and vitamin B12
- an evident association exists between the carriage of the GG genotype and the extent periodontal disease
- Substance P and Titanium particles acted synergistically to increase PGE2 and IL-6 secretion in fibroblasts from periprosthetic membrane.
- Intermittent hypoxia increases IL-6, improving aerobic fitness and minimizing the risk of thromboimflammation.
- capacity of bladder cells to mobilize secondary messengers and evoke a more rapid IL-6 response via TLR4 protein might be critical in their role as first responders to microbial challenge
- Inhibition of ERK phosphorylation decreased expression of IL6.
- IL-6 receptor activation may have a role in the pathogenesis of arteriovenous fistula failure in hemodialysis patients.
- Transcription factors glucocorticoid receptor, STAT-3, and HNF-1alpha bind to the angiotensinogen gene promoter mediating IL-6 induced promoter activity of this gene.
- Immunohistochemical analyses revealed plasma cells in the synovial lining of the high producers as the source of IL-6 in osteoarthritis
- Il-6 and matrix metalloproteinase-9 provide a link between inflammation, matrix degradation and the development/progresion of acute coronary syndrome.
- Results showed that the viral nucleocapsid (N) protein activated IL-6 expression in a concentration-dependent manner; promoter analyses suggested that NF-kappaB binding element was required for IL-6 expression regulated by N protein.
- In Hodgkin's lymphoma Carriers of the IL-6-174GG genotype had a significantly lower probability of freedom from treatment failure
- Results show IL-6 levels in symptomatic periapical lesions showed significantly higher concentration in comparison with control group.
- Results show obsessive compulsive disorder patients showed increases in IL-6 levels compared to the healthy controls.
- in peripheral blood mononuclear cells, C5a activates the p38 cascade, and this pathway plays a major role in the C5a enhancement of LPS-induced IL-6 and TNF-alpha production
- the presence of the IL6 VNTR allele B could be detrimental for reaching extreme longevity
- there is a clear genetic influence of IL6 -572C>G polymorphism on plasma levels of fibrinogen and CRP, but this polymorphism does not lead to elevated blood pressure.
- main finding of the present study is that the -174C/G polymorphism is not associated with sudden infant death syndrome in Norway
- administration of IL-6 could activate receptor gp80/gp130 signaling pathways including downstream extracellular signal-regulated kinase 1/2 and STAT3 phosphorylation in EPCs.
- elevated spontaneous production of IL-6 in patients with major depression
- Interleukin-6 (IL-6) was expressed in monocytes and B cells, IL-10 in monocytes, and suppressor of cytokine signaling 3 in monocytes and T cells from patients with active disease.
- Sequestration of the interleukin-6 (IL-6) ligand led to a decrease of phosphorylated Stat3 levels in breast cancer.
- Down regulation of HuR expression by siRNA prevents atazanavir-induced increase of TNF-alpha and IL-6, suggesting that HuR might have an impact on pathophysiological processes of HIV PI-induced atherosclerosis
- Our results indicate that IL-6 expression is regulated through NF-kappaB transcription factor and stereoid-receptor signalling pathways in ARPE-19 cells.
- Heterozygocity for the gene polymorphisms did not occur more often in preeclamptic women compared with controls (TNF-alpha: 29.0% versus 24.3%, p>0.05; IL-6: 46.7% versus 51.4%, p>0.05; or IL-10: 49.5% in each).
- These results suggest that IL-10 and IL-6 gene polymorphisms may affect susceptibility to Brucellosis and increase risk of developing the disease.
- Findings suggest that individuals higher in trait positive emotional style show decreased in vitro production of the early inflammatory mediators interleukin-6 in response to stimulation with endotoxin.
- We observed an association between GG allele of IL6 on -174 base with gastric cancer.
- Serum of subjects with endometriosis contains significantly higher levels of interleukin-6, monocyte chemotactic protein-1, and interferon-gamma than control women.
- IL6 and ESR1 polymorphisms may have a role in breast cancer risk associated with active and passive smoking
- IL-6 may have a potential role as a mediator between cardiovascular risk factors and several biological mechanisms for cardiovascular disease
- IL-6 was elevated in colostrum of mothers of neonates with jaundice.
- No significant difference was found regarding the frequency of IL-6(-174 )G/C polymorphisms in rheumatic heart disease compared to controls (p > 0.05).
- Staphylococcal enterotoxin C1 may act through an NADPH oxidase mechanism to release reactive oxygen species
- changes in IL-6 mRNA expression in open discectomy and microendoscopic disectomy groups varied significantly at 1 h, 12 h post-op, 10.26-fold versus 4.42-fold and 52.15-fold versus 26.78-fold increase, respectively
- Interleukin-6 inhibits human peroxisome proliferator activated receptor alpha gene expression via CCAAT/enhancer-binding proteins in hepatocytes.
- androgens, IL-6 and IL-8 may form a common amplifying signaling cascade to modulate ovarian carcinoma growth
- IL-6 may contribute to tumor growth by modulation of expression of selected miRNAs, such as miR-370.
- IL6 gene is significantly associated with adiposity.
- IL-6 -174 G/C polymorphism is not associated with the risk of premature CAD, and does not contribute to cardiovascular risk stratification.
- We conclude that Hsp20, HspB8 and HspB2 are present in CAA in HCHWA-D, and that A beta did not affect cellular sHsps expression in cultured human brain pericytes and astrocytes.
- Data shows that serum interleukin-6 in patients with burning mouth syndrome is decreased and negatively correlated to chronic pain.
- A higher gene expression of CRP, IL-6, and both IL-6 membrane receptors in subcutaneous samples of inflamed patients than in healthy controls.
- IL-6 levels significantly increased following the mental calculation stress test in ulcerative colitis patients compared with in the volunteers
- These results suggest that IL-10, TNF-alpha and TGF-beta1 gene polymorphisms may affect host susceptibility to lung cancer and the outcome of the patients.
- This study investigated whether the single nucleotide polymorphism (SNP) in the promoter region of the IL-6 gene is associated with a development of chronic glomerulonephritis.
- IL-6 and IL-10 genotypes may be useful in predicting disease severity in autoantibody-positive and autoantibody-negative rheumatoid arthritis patients, respectively.
- Azithromycin suppressed NF-kappaB activation and reduced synthesis of IL6/IL8 in tracheal cells from preterm ventilated infants.
- Response rates to HCV-specific treatment are higher in HCV/HIV-positive patients carrying the IL-6 HP genotype, which might be because of IL-6 mediated STAT3 activation.
- The secretory levels of PGE(2), TXB(2) and IL-6 were highest in ruptured abdominal aortic aneurysms and statistically higher than those in intact abdominal aortic aneurysms.
- Among older adults free of clinical cardiovascular disease specific IL-6 promoter appeared to confer positive associations of alcohol consumption with IL-6 concentrations
- IL-6 plays a role in the development and progression of atherosclerosis.
- IL-6 homozygous genotypes were significantly more often detected in oral lichen planus patients.
- IL-6 -572C>G has a greater response over time to the inflammatory effects of smoking and this may result in smokers having higher oxidative stress in subjects with G/G compared to C/C or C/G
- C allele of the rs1800796 IL6 polymorphisms and the GG genotype of the rs1800795 IL6 polymorphisms was associated with a statistically significantly reduced the risk of colon (OR 0.76 95% CI 0.57, 1.00), but not rectal (OR 1.49 95% CI 1.02,2.16) cancer.
- Treatment of MG-63 cells with adenosine and pharmacological ADORA agonist NECA or CGS21680 inhibits LPS-induced IL-6 release. This inhibition was protein kinase A-dependent and mimicked by treatment with the adenylate cyclase activator forskolin.
- Plasma concentration of C-reactive protein and IL-6 concentrations increased, and was positive correlated with Thrombosis In Myocardial Infarction frame count in patients with slow coronary flow compared with normal coronary flow subject
- An elevated IL-6 concentration was independently associated with prolonged hospitalization.
- Septic plasma permanently suppressed the production of IL-6 and IL-10 in stimulated whole blood.
- There is a relationship between VEGF, TNF-alpha, IL-6 and the development of the diabetic retinopathy in children with diabetes mellitus type 1.
- norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression
- The impact of the IL6 -634G allele on serum C-reactive protein elevation is greater in nonsmokers than in current smokers.
- Glycogen degradation was accelerated by IL6
- Raloxifene treatment reduces bone turnover markers, parathyroid hormone and induces vitamin D in postmenopausal women. Serum levels of IL-6 and TGF-beta1 in the patient group after treatment, decreased to levels lower than those in the control group.
- IL-6 induces the phosphorylation and promotes its relocalization from the cytoplasm to podosome-like structures. Further, IL-6-induced HGAL phosphorylation increases its interaction with myosin II and is associated with inhibition of cell migration
- IL-6-dependent mechanisms controlling L-selectin adhesion are conserved over hundreds of millions of years of vertebrate evolution as a beneficial focal point regulating immune surveillance during febrile inflammatory responses.
- Cervical IL-6 and IL-8 might have predictive value for cases of recurrent miscarriage.
- IL-6 gene G-174C polymorphism is not a major risk factors in renal transplantation.
- IL-6 -174G/C polymorphism may have a significant effect on insulin resistance
- LIF and IL6 skew monocyte differentiation into tumor-associated macrophage (TAM)-like cells by enabling monocytes to consume monocyte-CSF. Depletion of LIF, IL-6, and M-CSF in ovarian cancer ascites suppressed TAM-like cell induction
- polymorphism not associated with an increased risk of benign migratory glossitis development
- Elevated IL-6 serum concentrations are prospectively associated with an increased risk of spontaneous ventricular tachyarrhythmia or ventricular fibrillation in patients with heart disease who use a therapeutic implantable cardioverter defibrillator.
- While genetic variation in the IL-6 gene was associated with circulating IL-6 and CRP concentrations, there is little evidence for association between common IL-6 gene variation and adverse cardiovascular outcomes in this population of older adults.
- IL-6 production of umbilical cord vein endothelial cells after proinflammatory stimulation is not influenced by the single nucleotide polymorphism at nucleotide position -174.
- A novel observation of genetic predisposition to systemic inflammatory response syndrome, sepsis and septic shock is associated with a polymorphism in the IL-6 gene.
- IL-6 gene polymorphisms and erythropoetin dose requirements in chronic haemodialysis patients
- The IL-6/STAT3 antiapoptotic pathway is induced by short exposure to bile acid cocktail and low pH.
- HGF and IL-6 levels in combination with prostate volume were shown to be useful parameters for prostate cancer screening in patients with gray-zone PSA levels.
- IL-6 genotype did not associate with risk for first ever intracerebral hemorrhage or ischemic stroke
- In long-lasting persistent AF, lower levels of IL-6 appear to be associated with maintenance of sinus rhythm after pharmacological cardioversion irrespective of the use of RAS inhibitors
- IFNalpha is able to interfere with IL-6 signaling by inhibiting STAT3 activity and that accounts for the ability of IFNalpha to induce apoptosis in myeloma cells.
- Significant elevation of IL-6 in blood and bronchoalviolar lavage during the first few hours after reperfusion of the graft was related to developed of primary graft dysfunction.
- In both control and diabetic patients, polymorphisms within a linkage disequilibrium block spanning approximately 42 kb were significantly associated with plasma IL-6 levels.
- Analyzing inflamed specimens from UC patients compared with control samples, interleukin (IL)-6 was sharply the most induced cytokine. Similar results were found in activated PBLs; IL-6 was confirmed to be the most induced.
- There's a relationship between inflammatory activation of peripheral blood mononuclear cells (enhanced mRNA expression of TNF-alpha and IL-6) and renal involvement (increased urinary albumin excretion) in type 2 diabetic patients.
- CTR9 participates in the transcription of IL-6-responsive genes through the regulation of DNA association of STAT3 and modification of histone methylation
- systematic review of interleukin-6 174G/C polymorphism and ischemic stroke [review]
- IL-6 and IL-8, and probably midkine and VEGF-A, appear to participate in the development of cancer-related cachexia in gastroesophageal malignancies.
- IL-6 and -8 may contribute to the increased levels of sialyl-Lewis(x) and 6-sulfo-sialyl-Lewis(x) epitopes on human airway mucins from patients with CF
- Data show that serum IL-6 values correlate significantly with IL-6-174 genotypes in nonfunctioning pancreatic neuroendocrine tumors (PETs) and gastrointestinal NETs (p<0.05), but not in functioning PETs.
- 24 hrs following surgery, CRP and IL-6 levels were significantly higher in the abdominal hysterectomy group compared to laparoxcopic hysterectomy and total laparoscopic hysterectomy with transsection of uterine vessels
- Visfatin, TNF-alpha, and IL-6 mRNA expressions are increased in peripheral mononuclear-monocytic cells from women with type 2 diabetes.
- The significant IL-6 mRNA increase in endometriosis compared with in eutopic endometrium may play a role in the development of endometriosis.
- an IL-6-inducible STAT3 and CDK9 binding to the proximal gamma-FBG promoter as well as increased loading of RNA Pol II
- Disturbed sleep during pregnancy is associated with increased levels of IL-6.
- The IL-6-174 GC genotype seems to be a potential risk factor for breast cancer.
- IL-6 may contribute to the complex immunopathology of CLL through its inhibitory effects on T cell activation, the CD40L system and induction of a Th2 cytokine response
- Blocking Hsp90 disrupts IGF-I and IL-6-induced proangiogenic signaling cascades by targeting IGF-IR and STAT3 in pancreatic cancer
- interleukin-6 has a role in preventing the action of bortezomib in multiple myeloma, as shown by inhibition with CTNO 328 monoclonal antibody
- decrease in frequency domains of resting heart rate variability would be associated with elevated plasma levels of interleukin (IL)-6 and soluble tissue factor (sTF)
- We identified 3 separate sites on IL-6 where interactions are made with IL-6R & with each of 2 copies of gp130. The structural consequences of losing an exon lead to a unique pattern of lost interaction with different components of the receptor complex.
- Increased expression of some IL-6 cytokine family members (oncostatin M, gp130, CT-1, LIF) in cutaneous inflammation might contribute to the promotion of hair loss.
- IL-6 initiates the expression of RAGs in circulating B cells, and extends those in tonsil B cells.
- The presence of urinary IL-6 in patients with bladder pain syndrome/interstitial cystitis to find a possible correlation with the symptoms before and after glycosaminoglycan substitution therapy, was investigated.
- Infection of THP-1 cells with Brucella abortus inhibited expression of major histocompatibility class II molecules and antigen processing through interleukin-6 secretion via Toll-like receptor 2.
- Results found a lack of robust association between the IL-6-572G-->C genotype and cogitive performance.
- results show that the IL-6 -174 G-allele is implicated in a greater cardiovascular risk. results show that the IL-6 -174 G-allele is implicated in a greater cardiovascular risk.
- The IL-6 572G>C polymorphism is associated with abdominal aortic aneurysms (AAAs), however it is too rare to be an important cause of most AAAs.
- Data demonstrate that the occurrence of C allele of IL-6 -174 G>C gene polymorphism in people with excessive body weight is accompanying a higher risk of developing obesity-related metabolic disorders, especially insulin resistance.
- the IL6-174 G/C promoter genotype is associated with shock in patients with sepsis; functionally, the mutated C-allele is correlated with low IL6 serum concentrations, but a high ex vivo secretion after LPS stimulation
- MMP-3 and IL-6 promoter polymorphisms constitute important factors for the genetic predisposition to scoliosis
- Mechanisms regulating IL-6 production led to the discovery that the Tec kinase bone marrow tyrosine kinase gene in chromosome X (Bmx) regulates Toll-like receptor 4-induced IL-6 production.
- IL-6 might utilize PI3K/Akt and cyclin A1 to promote tumor cell survival in prostate cancer.
- visual prognoses strongly correlate with the vitreous level of IL-6, whereas the duration of retinal vein occlusion strongly correlates with the vitreous level of VEGF
- The enhancement of FGL1 levels in vitro by IL-6 and its induction after turpentine oil injection suggest that it is an acute phase reactant.
- results confirm that TPO acts as an acute phase protein but exclude the possibility that it is uniquely responsible for thrombocytosis of inflammatory disorders, which might recognize in IL-6 a credible candidate as a cooperating factor.
- Reduced endometrial pSTAT3 and IL-11 may be involved in secretory transformation of glandular epithelium during receptivity. Reduced IL-11 production and STAT3 phosphorylation may contribute to unexplained infertility in some women.
- Coincubation of platelets with monocytes induced EMMPRIN-mediated nuclear factor kappaB activation in monocytes with increased MMP-9, interleukin-6, and tumor necrosis factor-alpha secretion by monocytes
- Proinflammatory cytokines seem to be only partly involved in the pathophysiology of complex regional pain syndrome 1, as indicated by the lack of coherence between TNF-alpha and IL-6 levels and the signs and symptoms of inflammation and disease duration
- acute myocardial infarction from information on functional gene variants that favor inflammation or modulate cholesterol metabolism: IL6 -174 G/C, TNF -308 G/A, IL10 -1082 G/A, SERPINA3 -51 G/T, IFNG +874 T/A, HMGCR -911 C/A, and APOE epsilon2/3/4
- EGFR could activate the gp130/JAK/STAT3 pathway by means of IL-6 upregulation in primary human lung adenocarcinomas, making this pathway a potential target for cancer treatment.
- IL-6 treatment triggered Notch-3-dependent upregulation of the Notch ligand Jagged-1 and promotion of MS and MCF-7-derived spheroid growth
- exposure to LPS evoked a weak and transient induction of TNFalpha mRNA whereas induction of IL-6 and IL-8 mRNA were pronounced
- IL-6 predicts critical coronary stenosis with high sensitivity and specificity.
- The production of GRO-alpha, IL-6 and IL-8 was shown to account for the ability of the HeLa cell culture medium to stimulate the migration of monocytes/macrophages, suggesting a key role for p38 MAPK and ERK1/ERK2.
- Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter
- IL6 mRNA levels in human subjects are significantly higher in adipose tissue than in other tissues (vein, skeletal muscle) known to express IL6
- IL6 polymorphisms are associated with drug-induced liver injury and Alzheimer's disease
- Depressed heart rate variability is associated with high IL-6 blood level and decline in the blood pressure in septic patients.
- IL-6 may play a role in fatigue, especially in the physical dimension, in terminally ill cancer patients
- Adherence to the Mediterranean diet was associated with reduced levels of interleukin-6
- IL-1beta and IL-6 were found increased in plasma and tuberculous pleural fluid, indicating an inflammatory status
- the results presented herein clearly demonstrated a moderate and strong expression of IL-6 in exocrine and endocrine cells of patients with chronic pancreatitis.
- In contrast to apparently healthy subjects, the IL-6 -174 G/C polymorphism showed no association with plasma IL-6, CRP, fibrinogen and PAI-1 levels in PAOD patients.
- Interleukin-6 overexpression was more frequently observed in cases with absent lymph node metastasis.
- Association of interleukin-6, interleukin-12, and interleukin-10 gene polymorphisms with essential hypertension in Tatars from Russia
- IL-6 -174 polymorphic C allele may be a prognostic marker in Fabry disease, especially in females.
- The IL-6-174 C/C genotype was significantly higher in thrombotic children with an infection history (P<0.05); there were no differences between the groups in mean allele frequency
- The implication of the -174 interleukin-6 G/G genotype in increasing sites, with bleeding of gums upon probing, is demonstrated in Caucasian pregnant women.
- Increased levels of IL-6 were found in the whole group of untreated patients with B non-Hodgkins lymphoma in comparison with normal controls: IL-6 levels were lower in complete responders
- These findings suggest that IL6 polymorphisms influence on CRP circulating levels but are not associated with invasive pulmonary aspergillosis susceptibility.
- serum IL-6 level of >13 pg/mL correlates with gastric tumor progression and is an independent predictor of poor survival after resection
- -174G/C IL-6 polymorphism is not a risk factor of major importance for breast cancer in the Ukrainian population. However, there is a trend for association between the mutant C-allele and susceptibility to uterine leiomyoma.
- Overexpression of an IL-6 variant with extreme sensitivity to IL-1beta causes massive release of IL-6 from undifferentiated tumor cells in vitro that accelerates progression toward malignancy on tumor cells with a still functioning IL-6 signaling pathway
- present study investigated cellular factors involved in TLR-4-mediated IL-6 in VSMC in terms of MAPK and transcription elements
- Specific cytokines (IL-1alpha, IL-4, and IL-6) are acutely elevated during hyperglycemia in children with type 1 diabetes, and these elevations persist for hours after hyperglycemia has been corrected.
- These data taken together suggest that IgE in the absence of antigen promotes human lung mast cell survival through the autocrine production of IL-6.
- Data show that cognitive and affective dimensions of hostility, and traitnegative affect are positively associated with plasma levels of IL-6.
- An altered pattern of IL-6 release was observed in trauma patients treated with catecholamines.
- Il-6 gene polymorphisms were found to be associated with fat, but not lean, mass in elderly men.
- IL-6 genotypes may influence breast cancer risk in conjunction with central adiposity.
- SAA is a significant inducer of IL-6, which is critically involved in rheumatoid arthritis pathogenesis.
- we speculate that immediate increase of portal pressure, reflecting sinusoidal tensile/shear stress, accelerates liver regeneration through immediate induction of IL-6 and HGF.
- the polygenotype of VEGF (vascular endothelial growth factor) +405/intercellular cell adhesion molecule (ICAM)-1 +241/IL6 (interleukin6)-174 (C-A-G) conferred an increased risk for Progressive Massive Fibrosis in Coal miners
- Presence of G alleles at common IL-6 polymorphic promoter loci was associated with the more severe distal interphalangeal osteoarthritis outcomes, symmetrical and symptomatic.
- The association between IL-6(interleukin 6) and anemia of chronic disesase (ACD) suggests that IL-6-mediated bone marrow suppression is the main mechanism for development of ACD in Rheumatoid arthritis.
- Laryngeal squamous carcinoma cells could modify T lymphocytes activity and production of proinflammatory cytokines IL-6 and IL-8.
- New evidence points toward IL-6 as one of the mediators coordinating the interface between adaptive and innate immunity
- findings show IL-1beta NFkappakappaB- & C/EBPbeta-dependently induces IL-6-synthesis in hepatocytes; IL-6 consecutively stimulates C-reactive protein production; this mechanism may be crucial for acute phase response in general & CRP production in part..
- Interleukin-1B (IL1B) and interleukin-6 (IL6) gene polymorphisms may have a role in chronic lymphocytic leukaemia
- Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2.
- highly significant contribution of IL-6 in the occurrence of oral squamous cell carcinoma
- Serum IL-1beta, IL-6, IL-8, and TNF-alpha are mediators of inflammation in neonatal sepsis
- Ghrelin, TNF-alpha, and IL-6 may have roles in cyanotic and acyanotic congenital heart disease in children
- IL-6 and IL6-R SNPs were analyzed for associations with preterm birth.
- This study suggests that circulating levels of IL-6 and its related proteins such as CRP and fibrinogen are associated with genotype at a promoter polymorphism (-572C>G) of the IL-6 gene in Korean men with CAD not taking LLD.
- The IL-6/C-174 polymorphism and increased IL-6 level is strongly associated with inflammation and coronary artery disease.
- Alzheimer's disease patients demonstrated statistically enhanced IL-6 levels.
- Set-association analysis did not reveal an independent or an interactive effect of IL-6 on the PD risk.
- only IL-6 and age were independently associated with mortality in hemodialysis patients
- TLR2/TLR4 stimulation was associated with NF-kappaB p65 nuclear translocation and proinflammatory cytokine production (TNF-alpha and IL-6) in adipose tissue
- production by myelodysplastic syndrome blasts
- Our results suggest that TGF-beta1 gene Arg(25)-->Pro, TNFalpha gene G-308A, and IL-6 gene G-174C polymorphisms are not risk factors or markers of progression in Caucasian patients with IgA nephropathy.
- CRP and pro-inflammatory cytokines (IL-6 and IL-8) are strong predictors of all-cause and cardiovascular mortality.
- Allicin supplementation significantly reduced plasma IL-6 level and reduced perceived muscle soreness after exercise.
- Synergistic and cumulative effects of polymorphisms between specific genotype patterns of PAI-1 and IL-6 and smoking determine the risk of cardiovascular disease.
- SDF-1 alpha from osteoblasts could induce release of IL-6 in human squamous cell carcinoma cells via activation of CXCR4, ERK and NF-kappaB pathway and thereby promote osteoclastogenesis.
- No significant differences were found in the polymorphisms of IL-6 and IL-10 promoter genes between patients with psoriasis and healthy controls.
- Blood oxygenation affects exercise-induced IL-6 response in hypoxemic chronic obstructive pulmonary disease patients.
- corticosteroid-induced MKP-1 contributes to the repression of IL-6 secretion in ASM cells.
- the interleukin-6 and metallothionein 1a genes act in a concerted manner to control zinc-regulated gene expression
- This is the first observation of any prognostic genotype among sciatica patients. The IL6 haplotype GGGA predicted the number of days with back or leg pain and also sickness absence.
- Hypoglycemia increases IL-6 levels in healthy individuals.
- IL-6 -174 G/C is not a genetic marker for identifying women at increased risk of common pregnancy complications
- The purpose of this study was to verify the association of two functionally active polymorphisms (-174 G>C and -572 G>C) in the promoter region of the IL6 gene with the risk of aneurysmal subarachnoid haemorrhage (SAH) in an Italian population.
- Data show that the patients infected with HIV, strong Type C coping is associated with greater stimulated IL-6 production.
- Stat1/3 directly controls promoter P1 of the CASR, and the Stats indirectly regulate promoter P2 of the CASR via Sp1/3 in response to IL-6
- IL-6 and TNF-alpha, and the level of an anti-inflammatory cytokine IL-10, but not their gene polymorphisms, provide novel and important prognostic information in patients with ADHF.
- IL6 -6331T is associated with increased IL-6 concentrations in an acute inflammatory state via a mechanism involving binding of the Oct-1 transcription factor.
- Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), MIF, and matrix metalloproteinase-9 (MMP-9), decreased significantly after weight loss.
- IL-6 alone was able to upregulate TLR2 in airway epithelial cells. Hog confinement dust upregulates TLR2 in the airway epithelium through an IL-6-dependent mechanism.
- The available data are not consistent with more than a modest association between the IL-6 (-174C) polymorphism and neonatal sepsis in VLBW infants.
- IL-6 may serve as a photoreceptor neuroprotectant in the setting of retinal-retinal pigment epithelium separation.
- IL6 polymorphism was associated with detection of A. actinomycetemcomitans and P. gingivalis. Haplotype analysis of IL-6 polymorphisms confirmed association with detection of A. actinomycetemcomitans.
- Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe unstable angina.
- Plasma Il-6 decreased in response to exercise in multiple sclerosis patients and controls.
- Increased concentrations of TNF-alpha in cord blood and of IL-6 in cord blood were associated with psychomotor developmental index <85; Increased concentrations of TNF-alpha in cord blood and IL-8 in cord blood were associated with cerebral palsy.
- Adolescent girls carrying the G allele of IL-6 gene at -634C/G and S allele of CASR gene at A986S could potentially be the risk population of lower bone mass accrual.
- A bedside IL-6 test is a new tool that may help to initiate early goal-directed therapy in sepsis.
- Variation in the rs8102284 SNP in the IL-6 receptor gene does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis.
- except for IL-6 and eotaxin, CLL B-cells and their normal counterparts produce and secrete similar amounts of cytokines and cytokine receptors in vitro.
- Long-term IL-6 levels are associated with coronary heart disease (CHD)risk about as strongly as are some major established risk factors, but causality remains uncertain. These findings highlight the potential relevance of IL-6-mediated pathways to CHD.
- Bmx is involved in the regulation of LPS-induced IL-6 and VEGF production via mRNA stabilisation in fibroblasts from rheumatoid synovium.
- Regulation of IL6 expression involves a much larger upstream region than previously examined and the control of IL6 transcription is likely to be regulated by a complex mechanism of modular cis-regulatory elements.
- Patients with the rheumatoid arthritis and with CC genotype of the -174 gene IL-6 polymorphism have lower frequency of the dry eye syndrome presence.
- polymorphism -174C>G at the IL6 locus determines the difference in both fasting and postprandial triglyceride metabolism. This phenomenon could be responsible for the observed association of this genetic variant with cardiovascular disease risk.
- Elevated IL-6 could serve as a marker for carotid stenosis but was not useful to identify plaques at risk for symptomatic conversion.
- The -572 polymorphism, a unique variation in the IL-6 promoter in the Chinese Han population, may be used as a relevant risk estimate for sepsis in trauma patients
- in HLFs derived from patients with ILDs, the proliferative mechanisms activated by TGF-beta1 are at least in part mediated by an increased release of IL-6, leading to phosphorylation-dependent MAPK activation
- IL6 and CRP levels are associated with presence of white matter lesions (WML) and brain infarcts (BI)
- activation of the TRPM8 variant in human lung epithelial cells leads to increased expression of IL-1alpha, -1beta, -4, -6, -8, and -13, granulocyte-macrophage colony-stimulating factor (GM-CSF), and TNF-alpha.
- azacitidine has an effect on interleukin-6 signaling and nuclear factor-kappaB activation
- results indicate that the three promoter polymorphisms in the IL-6 gene act in a cooperative fashion and suggest that IL-6 haplotypes could play a role in the pathogenesis of gingivitis in Caucasian children
- the SNPs IL4-590 and IL6-174 may be useful markers for colorectal cancer prognosis
- IL6 gene polymorphisms appear to be important genetic factors in premature coroanry artery disease, and in the regulation of key atherogenic markers in Asian Indian families.
- galectin-3-binding protein as a factor secreted by neuroblastoma cells that stimulates the expression of interleukin-6 in bone marrow stromal cells and provides a novel function for this protein in cancer progression.
- Examine the association of plasma interleukin-6 (IL-6) concentrations with adiposity and fat cell metabolism in women.
- IL-6 is an important regulator of host defense against C. rodentium by protecting the mucosa against ulcerations which can act as a microbial niche for the bacteria.
- HIF-1alpha protein is selectively required for down-regulation of ASK1 activated during lipopolysaccharide-induced TLR4 downstream signalling.
- decidual cell-derived IL-6 may contribute to excess circulating IL-6 levels that can promote both endothelial cell dysfunction (and subsequent vascular dysfunction) and the pathogenesis of preeclampsia
- Genetic variants in the IL-6 gene significantly modify changes in IL-6 serum concentrations in response to long-term exercise training programs.
- the IL-6-634G allele is associated with increased susceptibility to cachexia and decreased survival time of Chinese patients suffering from pancreatic cancer
- These results indicate that the IL-6 family of cytokines modulates STAT3 activation by desumoylation and inactivation PML through SENP1 induction.
- in diffuse large B-cell lymphoma patients, pretreatment elevated levels of IL-6 (interleukin 6) were associated with worse survival and more adverse disease
- analysis of how inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells
- This study is the first demonstration of IL-6- and EGF-stimulated proliferation of spinal cord progenitor cells via JAK2/STAT3 and MAPK signalling pathways.
- The promoter polymorphism -174G>C of interleukin 6 was significant;y associated with immunoglobulin A deficiency.
- The results showed that among the Chinese Han subjects, there were significant differences in genotypic distribution and allele frequencies between aneurysmal patients and controls.
- Data show that IL-6 is overexpressed in experimental models of seizures in brain areas of seizure generation and propagation, prominently by glia and to a lesser extent by neurons.
- analysis of hepcidin, interleukin-6 and iron markers in males before and after heart surgery
- An IL6 haplotype on chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.
- IL-6 stimulation per se did not affect t-PA mRNA.
- gingival fibroblasts may influence the pathogenesis of periodontal disease through osteotropic IL-6-type cytokine production mediated by activation of MAP kinases
- the IL6(-174G/C) polymorphism may have a role in increasing survival after treatment initiation in Waldenstrom macroglobulinemia patients aged 65 years or less
- Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1
- Circulating IL6 can be used as a tumor marker for hepatocellular carcinoma.
- Normal levels of C-reactive protein and IL-6, along with the elevated levels of IL-8 in patients with permanent atrial fibrillation (AF), but not in those with paroxysmal AF, suggest a link between a low-grade inflammatory reaction and long-lasting AF.
- peripheral blood monocytes cells in aggressive periodontitis patients might be hyper-responsive in terms of IL-6 production
- increases in IL-6, MMP-13, and RANKL (receptor activator of nuclear factor kappa B ligand)expression in osteoarthritis (OA) subchondral bone osteocytes suggest that in subchondral bone OA progression involves abnormal osseous tissue remodeling.
- A logistic regression analysis, adjusted for age and sex, has been used to determine the association between tertiles of IGF-1 and IL-6 and metabolic syndrome X.
- Concluded that IL-6/sIL-6R enhances cathepsin B and L production via IL-6/sIL-6R-mediated Cav-1-JNK-AP-1 pathway in human gingival fibroblasts.
- the anemia of chronic kidney disease was associated with up regulation of TNF-alpha, and possibly IL-6 and IL-8 along with increased levels of these proinflammatory cytokines in patients treated with epoetin.
- extension of coronary artery disease is significantly associated with the expression of adiponectin and IL-6 mRNA in epicardial adipose tissue
- procalcitonin and IL-6 appear to be helpful in early assessment of pediatric sepsis
- Inflammatory markers associated with the acute-phase response (IL-6, TNF-alpha, C-reactive protein, and fibrinogen, but not IL-18) are associated with risk of recurrent stroke
- The results of present study suggest that the TNF-alpha -308 and the IL-6 -174 promoter polymorphisms may be the genetic factors influencing the renal allograft survival.
- the genetic composition of the IL-6 promoter area plays a significant role in the pathogenesis of chorioamnionitis and neonatal infections
- elevated in men with obstructive sleep apnea
- In 15 patients with aneurysmal subaarachnoid hemorrhage, hypothermia and barbiturates reduce cerebrospinal fluid il6 levels.
- data suggest that IL-6 and TNF-alpha may be involved in maintaining immunological disturbances in remission stage of pemphigus vulgaris.
- IL6 gene-wide haplotype is associated with susceptibility to adult respiratory distress syndrome.
- Results indicate that IL-6 and TNF-alpha are only partially responsible for the signs and symptoms of complex regional pain syndrome type 1.
- IL-6 was the only biomarker related to progressive erosive disease in patients with early Rhematoid arthritis
- No significant differences of IL-6 concentration were observed between patients with active immune thrombocytopenic purpura and the control group
- findings suggested that more chronic, severe inflammation might be involved in the pathogenesis of variant angina, manifested by increased counts of circulating inflammatory cells and elevated plasma levels of CRP and IL-6.
- Compared to normoglycaemia, acute hyperglycaemia increased the interleukin (IL)-6 concentrations by 39% in patients with type-1 diabetes
- Zinc deficiency increases activation of NF-kappaB and up-regulates expression of VEGF, IL-6 and IL-8 in androgen-independent PC-3 and DU-145 prostate cancer cells.
- Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression.
- Insulin stimulates interleukin-6 expression and release in LS14 human adipocytes.
- Data show that particulate matter induces cyclooxygenase-2 expression and IL-6 release through both a reactive oxygen species (ROS)-dependent NF-kappaB pathway and an ROS-independent C/EBPbeta pathway in human bronchial epithelial cells in culture.
- Bradykinin-induced IL6 expression through bradykinin B2 receptor, phospholipase C, protein kinase Cdelta and NF-kappaB pathway in synovial fibroblasts is reported.
- increased expression in periodontal tissues was observed across patients with neither diabetes nor periodontal disease, patients with periodontal disease alone, and patients with both diseases
- Pravastatin immunomodulates IL-6 and C-reactive protein, but not IL-1 and TNF-alpha, in cardio-pulmonary bypass
- Patients with symptomatic carotid atherosclerotic disease have elevated serum IL-6 levels compared with asymptomatic patients, and have more intense macrophage infiltration of the atherosclerotic plaque
- Data show that IL6 is elevated in both the treatment responders and the non-responders with major depression.
- Atorvastatin induces associated reductions in platelet P-selectin, oxidized low-density lipoprotein, and interleukin-6 in patients with coronary artery diseases.
- Increased Il-6 serum levels may be correlated with tumor size and the presence of liver metastases in patients with pancreatic adenocarcinoma.
- study found that the C allele of the G-174C SNP and the A3 allele of the CA polymorphism are associated with increased bone mineral density (BMD) (p<0.0001) in Mexican women, whereas the G-572C SNP is not (p=0.19)
- Heme oxygenase-1 expression decreased LPS-stimulated secretion of MCP-1, IL-6, IL-10, and TNF-alpha at both 4 and 24 h in murine and human macrophages
- Report the influence of increased training volume on Il-6 concentration in college level male rowers.
- Fibroblasts that overexpress ST18 by transient transfection exhibit significantly increased apoptosis and increased expression of TNF-alpha, interleukin (IL) -1alpha, and IL-6.
- HPV 16/18 up-regulates the expression of interleukin-6 and antiapoptotic Mcl-1 in non-small cell lung cancer
- IL-6 plus interleukin-1 beta enhance the binding of transcription factor C/EBPbeta to the C-reactive protein promoter in Hep3B tumor cells.
- Airway smooth muscle cells maintain human lung mast cell survival in vitro by a direct cooperative interaction between the two cell types via a mechanism dependent upon interleukin (IL)-6, stem cell factor, and cell adhesion molecule (CADM)1.
- Middle aged hypertensives with obstructive sleep apnea had increased levels of CRP, IL-6, IL-18, TNF-alpha, and asymmetric dimethyl-arginine.
- it could be concluded that serum level of IL-6 and IL-8 are useful prognostic factors in metastatic breast cancer patients
- Results of the study suggest that the diabetic children, who have IL-6 gene -174GG genotype may have an increased risk for celiac disease development.
- Genotyping of IL-6 polymorphisms at positions -174, -572 and -597 was performed. -597G/A and -174G/C polymorphisms were not associated with disease. The -572G/C polymorphism was associated with COPD susceptibility under a dominant model of inheritance
- There was no significant association of IL-4 and IL-6 gene polymorphisms with the risk of prostate cancer, however, an IL-6 gene variant may be associated with prostate progression and bone metastasis.
- IL6 variant may have a protective effect on the development and disease severity of coal workers' pneumoconisis.
- IL-6 were associated with some incident cancers in our cohort
- NFATc2 has a role in colitis by controlling mucosal T cell activation in an IL-6-dependent manner
- IL-6 is necessary for the expansion of pancreatic alpha-cell mass in response to high-fat diet feeding.
- MyD88 is important in IL-6 and MMP-1 expressions in both acutely UV-irradiated skin and in chronically sun-exposed human skin
- IL6, even in low concentrations and under physiologic conditions, modulates adrenal cortex responsivity to ACTH
- The level of serum IL-6 or genetic IL-6 polymorphism is correlated with the complexity of coronary plaque in patients with stable coronary artery disease (CAD).
- IL6 (-174) and TNFA (-308) promoter polymorphisms are associated with systemic creatine kinase response to eccentric exercise.
- Data show that the interleukin-6 -634C/G and estrogen receptor-alpha PvuII polymorphism were significantly associated with bone mineral density accrual and that they have an interactional effect on BMD accrual in Chinese adolescent girls.
- Endothelial cells secrete IL-6 and that endothelial cell-derived factors regulate adrenal IL-6 synthesis which does not alter adrenal aldosterone secretion.
- Intermittent hypoxia during sleep may contribute to systemic inflammation and result in an elevation of serum IL-6 in severe obstructive sleep apnea syndrome patients
- STAT3 NH(2)-terminal domain plays an important role in the interleukin-6 signaling pathway by interacting with the p300 bromodomain, thereby stabilizing enhanceosome assembly.
- Serum IL-6 and sIL-6R markedly increased after tocilizumab administration in both RA and Castleman disease.
- Results suggest that gene polymorphism of IL-6 -174 G>C is a risk factor for polycystic ovary syndrome in Turkish patients.
- release of systemic inflammatory cytokines, mainly IL-6, corresponds to an increase in treatment-related multiple-symptom burden during the nadir period of allogeneic hematopoietic stem cell transplantation
- the il2/-174CC genotype characterizes a subgroup of patients whe oare at higher risk of developing erythema nodosum in the setting of sarcoidosis
- IL-6 -572 G/C and IL-8 3'-UTR 2767A/G polymorphisms are not associated with the risk of developing rheumatoid arthritis
- VEGF, IL-6 and IL-8 contribute to the haematological malignancies in which bone marrow angiogenesis plays a role in the pathogenesis and progression
- No differences were found in the IL-6 variants between a group of brucellosis patients from southern Spain and the controls.
- IL-6 and IL-1Ra polymorphisms can be considered genetic markers for bronchial asthma susceptibility and/or severity among Egyptian children.
- An uncommon haplotype within the promoter region of the gene for IL-6 is positively associated with osteolysis.
- IL-1beta and IL-3 stimulated endothelium induces proliferation and differentiation of myeloid precursors, while IL-6 treatment induced a benefit of HPC survival.
- IL-6-174G>C polymorphism may be a risk factor for brain arteriovenous malformation in Latinos.
- neutralization of IL-6 biological activity in the cell culture supernatants of IFN-tau-treated macrophages led to a decrease in the antiretroviral effects of IFN-tau towards HIV RNA.
- Elevated IL-6 levels seem to have an important negative influence on growth in children with juvenile idiopathic arthritis
- Annexin A2 has a role in malignant phenotype and secretion of IL-6 in DU145 prostate cancer cells
- Data support a negative association between the GG genotype of IL-6 SNP and longevity in Italian centenarians, with males who carry the genotype being two times less likely to reach extreme old age compared with subjects carrying CC or CG genotypes.
- These findings suggest that combined NFkappaB and STAT3 targeting can overcome apoptosis resistance of multiple myeloma cell lines.
- Urinary IL-6 is elevated whether the stone is present or not.
- NF-kappaB p50 subunit mediates melanoma angiogenesis by specifically upregulating IL-6
- Interleukin 6 expressed in pancreatic cancer is a factor that induces the haptoglobin production; IL6 induced the expression of fucosylation-related genes.
- Results show that the designer fusion protein H-IL-6, consisting of IL-6 and its specific receptor IL-6R-alpha, but not IL-6 alone, mediates both neuro- as well as gliogenesis.
- determined that IL-6 promoted growth and invasion of breast cancer cells through signal transducer and activator of transcription 3-dependent up-regulation of Notch-3, Jagged-1, and carbonic anhydrase IX
- This preliminary report shows no connection between polymorphism 174 G/C of IL-6 and the incidence of AD
- this preliminary study on 56 donor-recipient pairs revealed IL-6-174 single nucleotide polymorphisms as a risk factor for the development of acute graft-versus-host disease and decreased survival after aHSCT
- Patients with detectable PB IL-6 at diagnosis had significantly lower event-free survival rates (P<0.008).
- IL-6 and tumor necrosis factor-alpha levels were higher in type 2 diabetes mellitus patients with proliferative diabetic retinopathy.
- Polymorphisms in IL6-17G/C may be important modulators of pain control and treatment.
- at least in Italian Caucasian females, the FM% is a major determinant of an increase in IL-6 production and insulin resistance. -174 G/C IL-6 promoter polymorphism represents a marker to identify individuals at risk of age and obesity related diseases
- Data show that overexpressed PARP-1 promotes PARP-1/NF-kappaB/DNA complex formation, enhancing the expression of TNF-alpha and IL-6 in circulating mononuclear cells of unstable angina patients.
- Increased level of MMP-3, MMP-9, and IL-6 may be responsible for ectasia formation in patients with coronary artery ectasia.
- Provide evidence that the IL-6-174G/C polymorphism may be involved in the pathogenesis of coronary artery disease, contributing to genetic susceptibility for myocardial infarction.
- Positive reactions for interleukin 6 were observed in tissue elements of lymphatic, hematopoietic, digestive, reproductive, exocrine, endocrine, neural, muscular, epidermal, respiratory, and urinary systems of human and cynomolgus monkey tissue panels
- cerebrospinal fluid (CSF) IL-6 could be used in chronic progressive patients who have normal CSF cell, or protein levels to detect disease activity
- These results suggest that the interaction of SOCS3 with MAP1S and the integrity of the microtubule cytoskeleton play an important role in the negative regulation of SOCS3 on IL-6 signaling.
- Early measurements of IL-6 in extracorporeal membrane oxygenation patients could give prognostic information beyond that of C-reactive protein.
- IL-6 was constitutively higher in systemic lupus erythematosus umbilical vein cells whereas IL-8 was lower
- Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes are not associated with prostate cancer, while allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis
- The present study suggests that Chlamydia pneumoniae may modulate the expression of IL-6 and IL-10 by human gingival fibroblasts.
- Although COX-2-765G>C and IL-6-174G>C polymorphisms were associated with inflammation, consuming a Mediterranean diet either supplemented with virgin olive oil or nuts reduced the concentration of inflammation markers.
- The interleukin-6-174 G/C polymorphism is associated with increased arterial stiffness and pulse pressure.
- Report effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB.
- Results support the hypothesis that interleukin 6 polymorphisms and haplotypes are moderately associated with periodontitis, possibly acting through influencing tissue levels of IL6.
- LDL concentration and degree of oxidation synergistically stimulate NO and IL-6 production, but only NO release is largely mediated by the TP receptor. LDL facilitates ET-1 release independent of concentration and degree of oxidation
- we have found modest differences in genotype distribution for two functionally significant polymorphisms, IL-6 +174 and IL-10 -592, between patients with decompensated ALD and heavy-drinking controls.
- Posttraumatic stress disorder was associated with low cortisol and higher levels of DHEA and greater production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) compared to traumatized and healthy controls.
- IL-6 related gene variations influence susceptibility to multiple myeloma.
- The IL6 polymorphism was significantly associated to angiographic significant coronary artery disease.
- Interaction between STAT3 and Fer was observed in all prostate cancer cell lines tested, and this interaction is modulated by interleukin-6.
- Simultaneous carrier-state of MTHFR, IL-6 and ICAM1 genes increased the risk of Coronary artery disease.
- upregulated expression in luteal phase of menstrual cycle
- results indicate that TGF-beta1 participates in the regulation of basal expression and the stretch-induced expression of IL-6 and suggest the possible existence in cultured human trabecular meshwork cells of an autocrine loop between IL-6 and TGF-beta1
- Our findings suggest that common genetic variation in IL6 genes may contribute to heterogeneity of COPD population associated with systemic inflammation