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Validated All-in-One™ qPCR Primer for HLA-B(NM_005514.7) Search again
Product ID:
HQP100178
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
AS, B-4901, HLAB
Gene Description:
major histocompatibility complex, class I, B
Target Gene Accession:
NM_005514.7(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
HLA-B belongs to the HLA class I heavy chain paralogues.
Gene References into function
- magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is related to HLA-A and -B phenotype
- association of TNF alleles with HLA-DR, -DQ and -B alleles in 216 healthy individuals from the north of England
- Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8. HLA-A2, -Cw4, and -Bw46 alleles, or HLA-G1 leads to NK cell apoptosis.
- Disparate binding of chaperone proteins by HLA-A subtypes
- MICA genetic polymorphism and linkage disequilibrium with HLA-B in 29 African-American families
- T8 cells with HLA-B*5701 or 5703 show cross-reactive tetramer binding with common and rare variants of an HIV-1 p24 epitope.
- identification of new allele, B*3805
- Identification of a new HLA-B*07 allele--HLA-B*0726.
- Sequencing-based typing of HLA-B*51 alleles and the significant association of HLA-B*5101 and -B*5108 with Behcet's disease in Greek patients.
- Description of six new HLA-B alleles in the 5C CREG including a B*58 intron two sequence
- Novel HLA-B alleles formed by an inter-locus recombination with HLA-C, HLA-B*0713 and B*6702.
- Polymorphisms in HIV-1 reverse transcriptase were most evident at sites of least functional or structural constraint and frequently were associated with particular host HLA-A and HLA-B alleles
- Distribution of HLA-B alleles in nasopharyngeal carcinoma patients and normal controls in Thailand.
- Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
- isolation of a common peptide ligand bound to three HLA B44 alleles; preliminary crystallographic analysis of recombinant forms of each complex
- subtle peptide conformational alterations may be responsible for the immunobiological differences between the HLA-B27 subtypes
- HLA-B*27 is known to be associated with ankylosing spondylitis and several methods have been applied to determine its presence or absence.
- A uniquely conformed peptide-containing beta 2m-free HLA-B2705 heavy chain has been isolated, a discovery that opens new avenues for further investigation of the role of HLA-B27 in spondyloarthropathies.
- New HLA-B alleles identified and sequences extended in potential bone marrow donors: B*5804, B*4418, B*1558, and B*4805
- Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen.
- HLA-B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais.
- The cDNA matched partial genomic sequences of B*3924, an allele whose distribution appears to be restricted to Mediterranean and Arabian Caucasoids. A single amino acid change exclusive to B*3924 (threonine-98) distinguishes it from B*3903.
- analyzed the HLA-B gene frequencies in 281 healthy individuals from four Mexican Amerindian populations (66 Mayos, 90 Mazatecans, 72 Nahuas and 53 Teenek)
- Cloning and sequencing of full-length HLA-B genes
- HLA-B phenotype modifies the course of Behcet's disease in Moroccan patients
- HLA-A, -B, and -DRB1 alleles in a total of 236 Taiwanese adults with Graves' disease and 533 racially matched normal control subjects were examined
- In Sardinia, 2 distinct haplotypes harbor the non-AS-associated HLA-B*2709 allele or the AS-associated B27 alleles.
- results show that HLA*B2705 and HLA*B2702 are the subtypes most frequently associated with ankylosing spondylitis in a Mestizo population from Venezuela and suggest a possible protector role for HLA*B2708, which was found only in the healthy population
- A computational method was used to predict the serologic specificity of HLA molecules encoded by HLA-B.
- Two new HLA-B alleles are reported in a caucasoid male.
- A Gambian TNF haplotype matches the European HLA-A1, B8, DR3 and Chinese HLA-A33, B58, DR3 haplotypes.
- frequency of HLA-B51 in Iranian patients with Behcet's disease
- white B22 serogroup alleles (B*55 and *56) appear to predispose to unfavorable outcome of HIV infection as strongly as some or all B*35 and B*53 alleles
- Results appeared to indicate association of HLA-B* 4601 with the severity of SARS infection in Asian populations.
- HLA-B*3520 and B*1801 subtypes were more commonly observed among HIV individuals in Maharasthra, India compared with controls, which reached statistical significance (P<0.01)
- HLA-B haplotypic variation was observed in population groups with ancestry of Africa South of the Sahara.
- a new HLA-B allele (HLA-B*5808) detected in an Italian white volunteer bone marrow donor.
- The frequency of haplotypes HLA-B in systemic lupus erythematosus group was significantly higher than that of control.
- In patients with autoimmune thyroiditis the HLA-B27 frequency of was higher than control values, while in patients with polyglandular activation of autoimmunity or autoimmune polyglandular syndrome type II, the HLA-B8 frequency was found to be higher.
- HLA-B57 significantly associated with susceptibility to psoriasis among population of Northeast region of Romania
- there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures
- Data indicate that disulfide-linked intracellular heavy chain HLA-B27 complexes are more prone to form and bind molecular chaperone BiP in inflammatory disease-prone wild-type B27 and transgenic B27-C67S rats than in disease-resistant HLA-B7 rats.
- selective down-regulation of HLA-A and HLA-Bw6 allospecificities associated with HLA-Bw4 preservation in leukemic cells
- A significant increased frequency of HLA-B(*)44, HLA-B(*)52, and HLA-B(*)56 was found in Mexican (Mestizos) patients with Behcet's disease when compared to controls.
- A single amino acid polymorphism that distinguishes HLA-B*4402 from B*4405 permits B*4405 to constitutively acquire peptides without any detectable incorporation into transporter associated with Ag presentation (TAP)-associated peptide loading complex
- identified a strong association between HLA-B*0703 and -DRB1*0301 and the development of severe acute respiratory syndrome
- HLA antigens might affect the prognosis in lung cancer.
- Crystal structures of HLA-B*3501 in complex with 14-mer macrophage-colony stimulating factor peptide reveal that the antigenic peptide follows the general rules of major histocompatibility complex binding.
- Residues at positions 63 (glutamic acid) and 67 (serine) of the HLA-B molecule could be the genetic markers for Takayasu's arteritis.
- HLA-B8-presented HPV16 E7 epitope is recognized by T cells from patients with cervical cancer
- HLA B-27 may have a role in spondyloarthropathy as seen by genotypic analysis of Turkish patients
- A study evaluating the associations between HLA alleles and the severity of malaria in a Thai population, polymorphisms of HLA-B and HLA-DRB1 genes were investigated in 472 adult patients in northwest Thailand with P. falciparum malaria.
- A new allele, B*5206, differs from HLA-B*520102 by 1 nucleotide exchange in exon 2 at nucleotide position 274.Substituting T for C leads to an amino acid change at protein position 67 from serine (TCC) to phenylalanine (TTC).
- HLA-B*1585 differs from HLA-B*15010101 at 5 bases in exon 3 causing 3 AA changes at 94 (Thr-->Ile), 95 (Leu-->Ile) & 103 (Val-->Leu). HLA-B*1587 differs from HLA-B*15010101 at codons 80-83 (Asn-Leu-Arg-Gly-->Ile-Ala-Leu-Arg) replaced by HLA-Bw4 motif.
- Compared to B*070201, B*0734 differs at four nucleotide positions, 412 (G-->A), 539 (G-->T), 559 (G-->A) and 560 (A-->C) causing three amino acid substitutions, at postion 138 Asp-->Asn, at position 180 Arg-->Leu and at position 187 Glu-->Thr.
- A new allele, HLA-B*5514 differs in 6 positions (360, 361, 369, 412, 419, and 527)in exon 3 from HLA-B*5612. 4 AA substitutions in exon 3 ar: Arg121Val, Asn138Asp, Tyr140Ser, Val176Glu
- analysis of coding sequences and haplotypic associations of HLA-B and HLA-DRB1 and association to HLA-DRB3 and HLA-DRB4 loci
- identification of novel allele HLA-B*1586*
- Exons 1, 4, and 5 sequences of 39 different HLA-B alleles were elucidated by allele-specific sequencing, and the polymorphism observed in these exons merely reflects the lineage-specificity of HLA-B.
- The human leukocyte antigen-Bw4I80 epitope and the KIR3DS1 gene were more frequent in HCV carriers than in patients with hepatocellular carcinoma, and the associations were not independent of each other.
- The HLA-B loci are highly polymorphic in Monba population of Xizang Autonomous Region. Compared with other ethnic groups in China, the Monba ethnic group is close to Tibetan ethnic group.
- genetic analysis of HLA-B27 polymorphism in Mumbai, Western India
- new HLA class I alleles found in Caucasian population: A*3012, B*270505, B*3541 and Cw*0716
- analysis of the new HLA-B*0739 and its alloreactivity when mismatched with HLA-B*0702
- analysis of novel HLA-B*5517 allele
- Gene expression analysis of giant cell myocarditis offers novel insights into its pathogenesis, namely the role of T-cell activators of the Th1 subset and immune response genes previously implicated in heart failure.
- findings showed that Kaposi's sarcoma-associated herpesvirus MIR1 promoted down-regulation of HLA-B7 molecules lacking lysine residues in their intracytoplasmic domain
- HLA class I and class II genes do not contribute to susceptibility to HAU.
- HLA-B alleles which may share HLA-B*5703 peptide-binding specificity may have the capacity to present overlapping peptide repertoires that may implicate them in long-term nonprogression of HIV infection.
- In a northwest Chinese Han population, fifteen alleles for the locus HLA-A, 28 alleles for the HLA-B locus and 13 alleles for the HLA-DRB1 were detected. The results showed that the most frequent HLA alleles found were A02, B13, and DRB1*15.
- Guangdong Han population in China has twelve HLA-A, 23 B, 11 Cw and 13 DRB1 alleles and a total of 9 HLA-A-B, 20 Cw-B, 7 A-Cw, and 8 A-DRB1, 9 B-DRB1, 10 Cw-DRB1 haplotypes.
- a new HLA-B allele, B*5615, has been identified in a Caucasian individual by sequence-based typing
- HLA-B14 subtypes (B*1402 and B*1403) differentially associated with ankylosing spondylitis differ substantially in peptide specificity but have limited peptide and T-cell epitope sharing with HLA-B27
- Mismatches at the HLA-B locus, but not at the HLA-A or HLA-DR loci, and anti T-cell antibody therapy were both independently associated with development of posttransplant lymphoproliferative disease
- The HLA-A*02 and -A*03 were observed increased frequencies in patients less than 50% hair loss, and HLA-B*27 equally in patients of 50-99% hair loss, alopecia totalis and alopecia universalis.
- HLA-B7 is associated with the development of breast cancer
- 12% AND 13% postive in psoriatic arthritis in Sardinia and Italy
- The HLA-A,-B,-DRB1 distribution in Shanxi Han population shares some genetic characteristics with other Han populations in northern part of China, but it exhibits its own characteristics.
- conformational dimorphisms of MHC class I-bound peptides might be connected with the occurrence of self-reactive cytotoxic T lymphocytes
- MHC class I glycoproteins may regulate the immune response by modulating the expression and function of other genes, whose products are essential for proper antigen processing and presentation.
- We found limited associations between HLA class I gene polymorphisms and Th2-like (IL-4) immune responses after measles vaccination, indicating that HLA class I molecules may have a limited effect on measles-vaccine-induced IL-4 secretion.
- HLA-B allele frequency distributions were consistent with the Hardy-Weinberg equilibrium in a group of indigenous Hans in Shenyang, China.
- For HLA class I antigens, HLA-B13 frequency was marginally increased in patients with RHD compared to controls without reaching statistical significance.The HLA-DRB1*13, DRB5* and DRB3* were protective against the development of rheumatic valve damage.
- Gene frequencies and haplotypic associations within HLA-A loci were determined at a high-resolution allelic level and should provide useful information in anthropology, bone marrow donor registry, legal medicine, and disease association studies.
- A novel identification of HLA-B*07 allele, HLA-B*0743
- Characterization of the novel allele HLA-B*3710
- Identification of HLA-B*4905
- HLA-B*1586 is a novel, hybrid HLA-B15/B22 allele with unique serology and haplotypic association
- Intrathecal production and fluctuations in CSF and serum concentrations of sHLA-I were reciprocal in multiple sclerosis.
- Tyrosine320 of HLA-B27 is most likely part of a cytoplasmic sorting motif involved in spontaneous endocytosis and shedding of histocompatbility class I molecules.
- X-ray diffraction analysis of crystals from the recombinantly expressed human major histocompatibility antigen HLA-B*2704 in complex with a viral peptide and with a self-peptide
- analysis of crystals from the human major histocompatibility antigen HLA-B*2706 in complex with a viral peptide and with a self-peptide
- Authors suggest that HLA-B*1502 could contribute to the pathogenesis of CBZ-SJS/TEN, and that genetic susceptibility to CBZ-induced cADRs is phenotype-specific.
- The association of the HLA-B51 and HLA-B52 alleles with pulmonary tuberculosis in HIV-positive and HIV-negative patients and in healthy subjects is reported.
- analysis of HLA-B2704 and HLA-B2705 in lymphoblastoid and transfected adherent cells
- Data show that HLA-B27 was significantly relative to ankylosing spondylitis and the increased frequency of MICA alleles may be due to its strong linkage disequilibrium with HLA-B27.
- The data indicated a high degree of haplotypic diversity and strong linkage disequilibrium between MICA-STR and HLA-B in a southern Chinese Han population
- A statistically significant HLA-B maternal-fetal genotype-matching effect on schizophrenia was demonstrated for female offspring (P=.01; parameter estimate 1.7 [95% confidence interval 1.22-2.49]).
- genotyped the HLA-B alleles in 56 Caucasian patients with varying severities of carbamazepine hypersensitivity
- German patients were distinct from Italian and North American patients with respect to DQ2 and from the North American patients with respect to B8-DR3-DQ2 HLA in autoimmune hepatitis (AIH) type 1 [HLA-B8].
- Results for antigens and allele frequency of various HLA Loci in vitiligo patients and control subjects suggested that HLA-B7, Bw6, Cw6, Cw7, and DRB4*010101 could be susceptible to vitiligo.
- We here describe the identification of the novel allele HLA-B*3565Q.
- Basic immunological features are shared by B*2704 and B*2705, the two major HLA-B27 allotypes associated with ankylosing spondylitis in human populations.
- HLA-B*15 was a significant risk factor for generalized aggressive periodontitis and was positively correlated with the disease. severity.
- There is a positive association between HLA-B18 antigen and tuberculosis, while HLA-B7 and HLA-B61(40) antigens seem to protect against the disease.
- are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia.
- Examination of the peptide-binding specificity of HLA-B*41 alleles.
- HLA-B35 regulates apoptosis in human mononuclear blood cells and transfected mouse fibroblasts in a haplotype-specific manner.
- Prospective screening for HLA-B*5701 avoids abacavir hypersensitivity reaction in the ethnically mixed French HIV population.
- MHC micropolymorphism of HLA-B at positions outside the primary anchor residue binding pockets can have a major influence on determinant selection in antiviral T cell responses.
- HLA-B*350802 is a novel allele which has arisen by silent mutation at codon 67
- the novel HLA-B*9518 allele is identical to B*150101 with an exception of one base substitution at position 19 of exon 3 where a 'G' change to 'T' resulting in codon 97 changed from AGG (Arg) to ATG (Met)
- analysis of a novel human leukocyte antigen (HLA)-B*56 allele, B*5618 and an extension of B*2736 that were found during routine high-resolution sequence-based typing in a Chinese Han individual
- analysis of the novel HLA-B*5813 allele which is identical to HLA-B*5801, except for a nucleotide substitution that changes GAG to AAG at codon 128, resulting in an amino acid change from glutamic acid to lysine in the protein
- The only allele conferring risk to ankylosing spondylitis expression in Israeli Jews was B( *)2702, as was previously described in Mexican Mestizos.
- A new human leukocyte antigen (HLA) allele, named B*1576, was identified.
- The genetic distance (GD) estimated according to HLA-A, -B, and -C allele frequency indicates that Mongolian and Hui have the closest relationship.
- Study suggests a difference in the distribution of HLA-B alleles in patients with takayasu arteritis and tuberculosis.
- Increased frequency of HLA A2, A11, and B35 alleles in unselected pediatric Henoch Schonlein purpura patient population may be a risk factor for susceptibility.
- phenomenon of strong association between the HLA B14 allele and the CYP21 V281L mutation found in this congenital adrenal hyperplasia population study can be used to distinguish between homozygote and hemizygote carrying the V281L mutation
- polymorphism, evolution, distribution and current pathogenetic hypotheses are presented [review]
- did not observe any association in between HLA-B51 gene, its polymorphism, expression and Denizli Province patients
- evidence of a primary association of HLA-C, and to a lesser extent HLA-B, with Graves' disease
- The novel -646A TNFalpha allele was associated with the expression of HLA-B51 in Korean Behcet disease, although no genetic role of TNFalpha promoter polymorphisms was found in the susceptibility to Behcet's disease.
- frequency of HLA antigens was significantly increased suggesting that brain cavernoma susceptibility may be associated with HLA antigens
- Genes mapping in the HLA region have an HLA-B27-independent role in susceptibility to ankylosing spondylitis.
- in the HLA-B(major histocompatibility complex class I B) 27 positive patients with RS in this study there was predominance of HLA-B 2705 allele
- study examined whether predisposition to HPV 16/18-related cervical cancer because of p53 proline homozygosity among Indian women was mediated singly or jointly with immunogenetic risk factors such as HLA-B*07 or homozygosity of HLA-DQB1*03
- results strongly imply that the HLA-B8, -DRB1*0301, -DQB1*0201 haplotype genetically & primarily determines predisposition to sarcoidosis in the Croatian population.
- Mycobacterium tuberculosis-specific CD8(+) T cells are found in high frequency in infected individuals and are restricted predominantly by HLA-B alleles.
- Sera from patients with ankylosing spondylitis show complement-dependent cytopathic activity against sheep red cells coated with HLA-B27 peptide antigens
- a novel HLA-B allele, officially named HLA-B*5618
- a novel HLA allele in Chinese population
- results suggest that HLA genotype relates to the muscular necrosis and the pathogenesis of Duchenne muscular dystrophy
- The A1-B8 haplotype hitchhiking with the hemochromatosis C282Y mutation was not associated with a more efficient iron absorption
- HLA-B27 has a role in Beta 2-microglobulin amyloid deposit, as shown in transgenic rats
- Male gender and the spondylitis subgroup were statistically associated to the positive HLA-B27, and the oligoarthritis subgroup was associated to the negative HLA-B27 in psoriatic arthritis in Brazil
- Amino acid substitution at residue 156 of HLA-B alleles is shown to be important for T-cell recognition of other HLA molecules, such as HLA-B44 subtypes in transplantation.
- existence of a small, discrete group of HLA-B27 promoters, potentially able to mitigate the deleterious effect of this allele, has not been confirmed
- pinpoint disease susceptibility to the MHC class I genes HLA-B and HLA-A, in addition to the established associations of the MHC class II genes
- The allele HLA-B*1301 is strongly associated with TCE-induced hypersensitivity dermatitis among exposed workers in China.
- immunoglobulin A deficiency in Polish population is strongly associated with HLA-B*08:DRB1*03 haplotype rather than with single alleles
- polymorphisms in some alleles of B and C in HLA class I genes are associated with Kawasaki disease in Korean children.
- Our results indicate that the major susceptibility gene for BD is HLA-B*51 and that the association between MICA*009 and BD arises from a strong linkage disequilibrium with HLA-B*51.
- Certain HLA-B27 subtypes are associated with ankylosing spondylitis e.g. HLA-B*2705, while others e.g.HLA-B*2709 are not; the difference correlates with an opening of the HLA-B*2705 binding groove and a partial detachment of the C-terminal peptide anchor
- Study reports a newly discovered allele B*480102, a variant of B*4801, detected in a 55-year-old Taiwanese patient of Minan origin (southern China).
- In this study, samples from 95 SARS patients and 403 healthy controls were typed for HLA-A, -B and -DRB1 alleles and no association was found between HLA variations and SARS.
- HLA-B27 is not associated with joint pain after Campylobacter; A significant association between HLA-B27 and severity of joint pain was observed after gastrointestinal infections
- HLA-B27 subtype folding is determined by the overall heavy-chain structure, since the effect of a given polymorphism depends on its structural context; Heavy chain misfolding does not explain the association of B*2707 with ankylosing spondylitis
- We investigated the genetic polymorphisms of HLA-A, B, DRB1 alleles and haplotype frequencies in Mongols from Inner Mongolia, China.
- Selective targeting of CD8 T cell Env through HLA-B*5802 is associated with higher viral loads and lower CD4 counts and a lack of immune selection pressure in HIV infected persons.
- HLA-B27 is strongly associated with ankylosing spondylitis and identified that the major subtypes of HLA-B27 positive patients with AS in Korea are B*2705 and B*2704.
- HLA-B27 subtype B*2705 associated with ankylosing spondylitis in Iran
- hla-b haplotypes were associated with higer occurrence of lymphoproliferative disorders after renal transplantation
- data report distribution of the rare HLA-B*2730 allele among Croatians & the structure of the B*2730 extended haplotype
- Activation of HLA-B27 promoter is a sequential event, and that TNF-alpha and IFN-beta are major participants at different timepoints.
- Certain HLA alleles are found in Chinese patients with psoriasis (HLA-A*30, -Cw*06, -DR*07) and psoriatic arthritis (PsA) (HLA-B*27). Psoriasis patients with the HLA-B*27 and/or -Cw*12 may have higher risk of developing PsA.
- while all observed R(264) mutations (K, G, Q, and T) reduced peptide binding to HLA-B27 and impaired viral replication, the replicative defects of the alternative mutants were actually less pronounced than those for R(264)K
- analysis of the ability of most common HLA-B alleles and HLA-A alleles with Bw4 serologic reactivity to protect target cells from lysis by KIR3DL1-dependent NK cells
- Low frequency of HLA-B27 and clinical variations in ankylosing spondylitis may be due to different genetic and/or environmental factors in Turkey.
- Co-occurring HLA alleles across loci seem to be more important than individual allelesin squamous cell cervical cancer risk.
- The present study suggest that the susceptibility to advanced endometriosis, unlike in the Japanese population, is not associated with HLA-B antigens in the Korean population.
- Abnormal expression of HLA-B is associated with regulation NF-kappaB signal pathway via regulating S100A8 in the laryngeal carcinoma
- We demonstrated using in vitro models of immune activation that the production of interferon-gamma was specifically induced by abacavir treatment in PBMCs obtained from hypersensitive patients carrying the HLA-B*5701 allele.
- mutual electrostatic interactions of peptide and HLA molecule, including peptide- and subtype-dependent protonation of key residues, modulate complex stability and antigenic features of the respective HLA-B27 subtype
- The significant increase of HLA-A* 26 in the BD patients without HLA-B*51 suggests that this allele itself might be one of the primary susceptibility genes involved in the development of BD independently of HLA-B*51.
- The association of HLA-B44 alleles with idiopathic chronic urticaria (CU) suggests that there is a genetic component in the pathogenesis of CU.
- HLA-B*27/HLA-B*07 in combination with D6S273-134 allele is associated with increased susceptibility to juvenile spondylarthropathies in Croatian children.
- The aim of the study was to compare the distribution of the residues 63 and 67 on the HLA-B molecule in patients with Takayasu's arteritis and tuberculosis in order to establish a genetic relationship between these two diseases.
- the allelic diversity in our population is similar to other Caucasian populations; however we found a series of less frequent alleles, in addition to as-yet-undescribed haplotypic associations in other populations of Caucasian origin
- HLA-A, -B and -DRB1 allele frequencies in the Bangladeshi population.
- HLA-B27 heavy-chain homodimer formation can be induced by dendritic cell activation.
- HLA-B18 showed a significant increase in frequency in children with Congenital adrenal hyperplasia -type 21-hydroxylase deficiency
- Soluble HLA-B serum level is significantly increased in allergic rhinitis patients with pollen allergy.
- in a cohort of idiopathic juvenile arthritis,there was a higher proportion of HLA-B27-positive boys with older age at disease onset
- HLA-B27 positivity and/or M694V mutation may play a role in the development of sacroiliitis and the severity of seronegative spondyloarthropathy.
- More than 1000 endogenously bound peptides have been eluted from six closely related HLA-B35 molecules, some of them representing N-terminal-extended versions of canonical peptides containing an appropriate HLA-B35 peptide motif.
- HLA-B23 and HLA-B46 allele are associated with severe malaria in endemic populations
- Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B are reported.
- Present results suggest that there is a significant relationship between nasal polyposis and HLA-B allele frequency among the Turkish population.
- HLA-B*1403 is the only factor to increase the risk of AS in a sub-Saharan African population, whereas HLA-B27 was virtually absent in patients with ankylosing spondylitis
- Polymorphisms outside of the Bw4 epitope, and which determine peptide binding, also alter the interaction of Bw4positive HLA-B with killer cell inhibitory receptor KIR3DL1.
- Across HIV Gag protein, the rise of polymorphisms from independent origin during the last twenty years of epidemic was related to an association with an HLA allele accumulated in one of either B or F subtypes
- Data demonstrate that the influence of ZNRD1 alleles on disease progression rates are attributable to HLA-A10, help clarify the relationship between the HCP5, HLA-C and HLA-B*57 alleles, and reaffirm a critical role of HLA-B*57 alleles in HIV disease.
- HLA-B51 (major histocompatibility complex class I B51) was significantly more common in Behects patients than in health controls
- the folding, maturation, and stability of B*1403 differ more from B*2705 than from B*1402; Thus, these features cannot account for the fact that only the 2 former allotypes are associated with ankylosing spondylitits
- HLA-B27 transgenic rats show a reduced bone mass, and suggest an involvement of the RANKL/OPG system in the mechanism of bone loss in this disease
- Prevalence of HLA-B27 ligands with dibasic N-terminal sequences is influenced by availability of cytosolically stable peptides conferring to HLA-B27 a unique capacity to present antigens generated in low amounts but resistant to intracellular degradation
- HLA-B*0702 transgenic mice responded to influenza NP(418-426) and PB1(329-337) consistently and NP(473-481) intermittently while ligands from HA and M1 were not recognized
- Major histocompatibility complex (MHC) polymorphism can alter the dynamics of the peptide-MHC landscape, resulting in fine-tuning of T cell responses between closely related allotypes.
- HLA allele and haplotype frequencies in addition to phylogenetic tree and principal component analyses based on the four-digit sequence-level allele frequencies for HLA-A, HLA-B, and HLA-DRB1 showed that Western Javanese was closest to Southeast Asians.
- protection from HIV disease associated with inherent host HLA B allele-mediated ability to induce broader Gag T-cell targeting coupled with apparent virological control