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Validated All-in-One™ qPCR Primer for GSTP1(NM_000852.3) Search again
Product ID:
HQP099826
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
Gene Description:
glutathione S-transferase pi 1
Target Gene Accession:
NM_000852.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq].
Gene References into function
- Genetic polymorphism of exon 5 of GSTP1 may be associated with COPD because the GSTP1/Ile105 genotype is predominantly found in COPD. It is suggested that the GSTP1/Ile105 genotype may be less protective against xenobiotics in tobacco smoke.
- low level of expression seen in prostatic intraepithelial neoplasia and prostate adenocarcinoma, suggesting lack of detoxification activity that may be associated with carcinogenesis of the prostate
- Expression in nasopharyngeal carcinoma
- Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide.
- Data suggest that GST-pi expression in tumor cells are related to drug resistance in epithelial ovarian cancer.
- gene expression level of beta-TUB, Bcl-XL, and GSTpi was closely correlated with the IC50 for docetaxel
- To determine the extent of promoter hypermethylation in early lung tumorigenesis, we analyzed promoter methylation status of the p16, death-associated protein kinase (DAPK) and glutathione S-transferase P1 (GSTP1)
- Genetic determinants of lung cancer short-term survival: the role of glutathione-related genes
- expression in malignant tissue and plasma levels in human colorectal and gastric tumors increased depending on tumor stage
- The GSTP1 gene encodes the pi class glutathione S-transferase.
- Glutathione S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of P16(INK4a) and O(6)-methylguanine-DNA methyltransferase in sputum.
- Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells
- Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates. Frequency of genotype lower in airway hyperresponsiveness to methacholine.(GSTP1)
- polymophism related to chronic lymphocytic leukemia
- The GSTP1 gene encodes for an enzyme, glutathione S-transferase pi (GSTpi),involved in detoxification of carcinogens. An aminoacid substitution (I105V) in GSTP1 produces a variant enzyme with lower activity and less capability of effective detoxification
- Association beetween polymorphism and survival in colorectal cancer
- Etoposide treatment was able to induce GST P1-1 polymerization and activation of apoptosis
- GSTpi expression is a possible mechanism by which esophageal adenocarcinoma cells can protect themselves against the cytotoxic or antiproliferative effects of free radicals in the tumor microenvironment
- that lipid peroxidation in the bile ducts with reduced expression of glutathione-S-transferase-pi, may be an important pathologic process leading to the bile duct damage of primary biliary cirrhosis.
- Interindividual variation and organ-specific patterns of glutathione S-transferase ,GSTP1, GSTA1, and GSTA2 were major components
- The polymorphism of GSTP1 gene is linked to a genetic susceptibility to COPD.
- The deficient genotypes for GSTM1 and GSTP1 seem thus to be important risk modifiers for lung cancer, especially in combination.
- GSTP1 is transcriptionally regulated by cAMP- and CREB-1 in human tumor cells
- Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S-transferase P1 polymorphism.
- Variants of this gene confer differential cytoprotection against anticancer agents in E coli.
- Associations between carcinogen0-DNA damage, enzyme genotype and risk of lung cancer
- Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase p1-1.
- role in susceptibility to childhood acute lymphoblastic leukemia
- Does not increase in transformed keratinocytes and melanocytes in culture. No increase in GSTP1-1 observed after treatment with antioxidant response element-mediated inducers. Effect of c-Ha-ras on GSTP1-1 expression in HaCaT cells appears limited.
- Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells.
- HBV infection may increase expression of PCNA and GST-pi.
- Genotype and allele distributions of GSTP1 polymorphism in patients with schizophrenia are not significantly different from those of the controls, suggesting GSTP1 polymorphism may not confer susceptibility to schizophrenia in the Korean population.
- that prostate cancer cells induce an injury response in the stroma during progression to hormone independence, which results in GST pi expression.
- MRP, GST-pi, topo IIalpha,and LRP play important roles in the primary MDR of gastric carcinoma. The expression of them are associated with the differentiation, but are not associated with the invasion degree and lymph node metastasis.
- In this study, we have used quantitative PCR to analyse expression of beta-tubulin III, stathmin, RRM1, COX-2 and GSTP1 in mRNA isolated from paraffin-embedded tumor biopsies of 75 nonsmall-cell lung cancer patients treated as part of a randomized trial
- patients with the less stable variant have a decreased ability to detoxify chemotherapeutic substrates, including melphalan, and have an altered outcome following treatment for multiple myeloma.
- There was no association between GSTT1 or GSTP1 genotype and survival in the overall study population, nor in a subgroup of patients treated with chemotherapy.
- we found Phe151Leu substitution in an African-American subject (1 out of 111). Analysis of the three-dimensional structure showed that substitution of Phe 151 with Leu produces a hydrophobic cavity in the GSTP1 core, thereby destabilizing its structure
- There are no associations between the genotypes and the risk of developing acute leukemia.
- There seems to be an association between the GSTP1 AG genotype and higher cytological grading of exfoliated urothelial cells from formerly benzidine-exposed workers.
- In human placenta homogenate, GSTP1-1 is the primary target of DNDGIC; it binds the complex almost stoichiometrically and stabilizes it for several hours, perhaps acting as storage protein for nitric oxide
- dinitrosyl-diglutathionyl-iron complex, a natural carrier of nitric oxide, binds with extraordinary affinity to GSTA1-1, which is explained by molecular modeling and related to molecular evolution
- GST-pi showed no significant relationship with either response rate or survival in patients with unresectable non-small cell lung cancer.
- GSTP1 CpG island hypermethylation was not detected in normal epithelium or in hyperplastic epithelium, but was found in 4 of 64 lesions of prostatic proliferative inflammatory atrophy.
- These results suggest, that the presence of GSTpi in breast cancer tissue is a bad prognostic indicator, and these tumors are largely resistant to chemotherapy.
- GSTP1 GG increases the lung cancer risk associated with pack-years of smoking
- Altogether, these results demonstrate for the first time the implication of GATA-1 in differentiation-specific variations of GSTP1-1 expression.
- The estimated lung cancer risk for GSTM1 null, GSTP1 Ile/Val and GSTP1 Val/Val combined genotype was 1.44 , implying no effect on lung cancer predisposition.
- GSTP1 is up-regulated by antiestrogens mediated by estrogen receptor beta.
- GST-pi amplification is a common event in head and neck squamous cell carcinoma and may be associated with cisplatin resistance and poor clinical outcomes in head and neck cancer patients treated with cisplatin-based therapy.
- The frequency of individual genotypes GSTP1, GSTM1, and GSTT1 and haplotypes was determined in patients with atopic dermatitis and healthy children.
- GST-pi can be used as a diagnostic marker for hepatocellular carcinoma as well as in detecting other chronic liver diseases
- Variant of GSTP1 may play a role in the manifestation of hypertension in pregnancy together with other independently and/or synergistically acting factors, particularly in primiparous pregnancy.
- GSTP1 has a role in cell cycle arrest after antineoplastic agent treatment in tumor cell lines
- GSTP1 polymorphism is not a significant contributor to drug eruption risk.
- GSTP1 and GSTM1 polymorphisms have a role in survival from anaplastic astrocytoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma
- polymorphism of glutathione S-transferase pi is associated with an increased susceptibility to thyroid cancer
- GSTP1-1 may have a synergistic role in the process of MRP1 transporting inorganic arsenic as a tri-GSH conjugate
- polymorphism and susceptibility to cirrhosis or pancreatitis in alcoholics
- GSTP1 blocks As(2)O(3)-induced apoptosis in lymphoma cells by decreasing intracellular amounts of H(2)O(2) by catabolism.
- glutathione S-transferase P1 polymorphism is not solely responsible for reducing GSTPi activity or CDDP resistance in head and neck squamous carcinoma
- GSTT1(null) and GSTP1(val/val) polymorphisms not associated with increased risk of developing Behcet's disease.
- PCR for GSTP1 detected prostatic cancer with a 75% sensitivity.
- there is a xenobiotic substrate site in hGST P1-1, which can be occupied by benzyl isothiocyanate
- GSTP1 is a specific XBP in human macula that interacts with (3R,3'S-meso)-zeaxanthin and dietary (3R,3'R)-zeaxanthin in contrast to apparently weaker interactions with (3R,3'R,6'R)-lutein
- Up-regulation of glutathione S-transferase pi is associated with breast cancer
- phosphorylation of a serine residue in the C-terminal portion of GSTP1 where JNK binds, was identified in GSTP1 purified from Kato III cells, but not in GSTP1 purified from human erythrocytes
- For GSTP1 polymorphism, no difference was found between controls and esophageal cancer cases, whatever their histological status.
- the GSTP1 I105V polymorphism does not have a role in familial or sporadic prostate cancer
- cytochrome P-450c17alpha(CYP17), glutathione S-transferase pi(GSTP1), and paraoxonase (PON1)polymorphisms appear to be common genetic traits that are associated with an increased risk for prostate cancer
- Frequency of GSTP1 gene in North Indian population is lower than Japanese and African American populations for wild and mutant genotypes
- Increased glutathione S-Transferase P1-1 is associated with advanced non-Hodgkin's lymphoma
- GSTT1 and GSTM1 null genotypes and the GSTP1 Val/Val polymorphism may play important roles in asthma pathogenesis
- Polymorphic in brain cancer.
- GSTP1 promotor hypermethylation occurs during carcinogenesis and is considered to be a major event of prostate carcinogenesis.
- Whereas GST-M1 null will increase cyclophosphamide efficacy, GST-P1 polymorphism seems to be related to enhanced susceptibility to further relapses.
- Significant reductions in risk of CNS relapse were observed for patients homozygous for the GSTP1 Val105 allele as well as for patients with the MDR1 3435T/T or C/T genotype in acute lymphoblastic leukemia
- Polymorphism (Ile105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with methamphetamine abuse in Japanese population.
- High GSTP1 gene expression is associated with chemotherapy resistance in esophageal cancer
- Exposure to environmental carcinogens is related to altered methylation of GSTP1 that is involved in hepatocarcinogenesis
- polymorphisms in the GST genes are associated with increased risk of bladder cancer among Egyptians
- Findings suggested that the GSTP1 Ile(105)Val polymorphism was associated with an increased risk of endometrial cancer.
- GSTP1 polymorphism might modulate the risk of endometriosis with significantly decreased risk for GSTP1 val/val and marginally increased risk for GSTP1 ile/ile
- We could not demonstrate any significant association between the GSTM1, GSTT1, and GSTP1 polymorphism and age-related hearing loss in this population.
- Decreased expression in reticulocalbin and overexpression in GST-pi with the acquisition of cisplatin-drug resistance in non-small cell lung cancer.
- In Koreans the genotype frequencies of GSTP1 is 62% for the type of Ile/Ile, 34.3% for the type of Ile/Val, 3.7% for the type of Val/Val, and the allele frequencies are 0.792 for IIe and 0.208 for Val.
- GSTP1 can act in a combined fashion with MRP1 to protect melanoma cells from toxic effects of etoposide
- GSTP1 variant allele (Val) is associated with a poorer prognosis of esophageal cancer.
- GSTP1 gene polymorphism does not confer increased susceptibility to tardive dyskinesia
- Low/null activity polymorphisms of this enzyme is not with the risk of developing aplastic anemia in Caucasian patients.
- GST pi expression on both mRNA and protein levelwas significantly decreased in PBMC of amyotrophic lateral sclerosis patients.
- Polymorphisms within GSTP1 do not play a major role in the development of bronchial asthma in German children.
- Isoleucine 105 allele is associated with an increased risk of bladder carcinoma and suggest that individuals who smoke and possess the Ile allele might be at increased risk for bladder carcinoma.
- Finds no association of the GSTPI Ilel105Val gene polymorphism with AIA phenotype in the Korean population.
- Hypermethylation of GSTP1 is asspciated with prostate tumorigenesis
- genetic polymorphisms of GSTT1, GSTM1, and GSTP1 are not associated with higher risk of esophageal cancer
- frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms were evaluated in 1,051 Korean male subjects
- A feasible meachanism is proposed to account for the reactivation of oxidized 1-cysteine peroxiredoxin by glutathione S-transferase (GST) pi.
- GSTP1 was methylated in the tumor epithelium of all five prostate cancer patients and in the tumor-associated stroma in four of the five patients.
- The present study suggests that the GSTM1 (null) and GSTT1 (null), GSTM1 (null), and GSTP1 (mutant) combinations may be a genetic risk factor for the development of exudative age-related macular degeneration.
- Genetic polymorphisms in the GST genes could slightly modulate arsenic urinary profiles.
- All these results suggest that Cys47 (of the flexible helix alpha2 of hGST P1-1) plays a key role in intersubunit cooperativity and that under certain pathological conditions S-nitrosylation of Cys47 by GSNO is a likely physiological scenario.
- The possible links between GSTM1, GSTP1, GSTT1 and NAT2 variants and the frequency of micronuclei (MN) in human lymphocytes, was studied.
- This study evaluates the combined effects of genetic polymorphisms of GSTM1, GSTT1, and GSTP1 on susceptibility to cervical cancer and interaction of these genes with smoking.
- GSTP1-1 plays an important regulatory role in TNF-alpha-induced signaling by forming ligand-binding interactions with TRAF2, which provides insight for analysing the protective effects of GSTP1-1 in tumor cells.
- To find out the association of GST variants with risk of gallbladder cancer, the distribution of polymorphisms in the GST family of genes (GSTT1, GSTM1, GSTP1, and GSTM3) were studied in 106 cancer patients and 201 healthy controls.
- GSTP1 CpG islands hypermethylation, but not GSTP1 protein expression, is associated with a poor prognosis of breast cancers
- asthmatic children with glutathione S-transferase M1 null and glutathione S-transferase P1 Valine/Valine genotypes appear more susceptible to developing respiratory symptoms related to ozone exposure
- The GSTM1, GSTT1 and GSTP1 gene polymorphisms in diabetic patients and healthy individuals were investigated to test whether polymorphisms in GST genes are associated with diabetes mellitus (DM) in the Turkish population.
- study showed the joint effects on the risk of carotid atherosclerosis between the genetic polymorphisms of GSTP1 and p53, and arsenic exposure
- GSTP1 Ile/Ile genotype was higher in chronic obstructive pulmonary disease than controls; GSTP1 Ile/Val & Val/Val genotypes were associated with decreased risk of COPD compared to the Ile/Ile genotype; we suggest Val allele may have a protective effect
- tocopherols bind at a novel site, where an aromatic residue at position 79 is essential for binding
- GSTP1 Ile105Val polymorphism and are exposed at high levels to occupational polycyclic aromatic hydrocarbons are associated with prostate cancer
- Genetic predisposition influences dermal arsenism toxicity. The GSTP1 A1578G (Ile105Val) status might be a susceptibility factor for arsenic-related skin lesions.
- GSTM1, GSTT1, and GSTP1 are involved in the synergy of alcohol and tobacco in oral, pharyngeal, and laryngeal carcinoma
- Statistically insignificant association of GSTP1 gene polymorphism with thyroid cancer was observed in studied group of patients.
- GSTP1*105Val allele may be protective for people occupationally exposed to asbestos.
- CYP1A1 and GSTP1 polymorphisms have been associated with a higher risk to develop several cancers, including oral squamous cell carcinoma (OSCC), which is closely related to tobacco and alcohol consumption.
- Val/Val genetic polymorphism of GSTP1 may exert some protective effects in allergic inflammation.
- Herbicide exposure may be an effect modifier of the relation between glutathione S-transferase pi gene polymorphisms and onset age in familial PD.
- dinitrosyl-diglutathionyl-iron complex bound to Alpha class glutathione S-transferases with extraordinary high affinity in hepatocytes
- GST-pi expression predicts prognosis in stage I and II squamous cell lung carcinoma, and manipulation of GST-pi may be a potential basis for treatment of some non-small cell lung cancers.
- Native GSTP1 encoding the fully active transferase variant should play a relevant role in dopaminergic neuroprotection
- GSTP1*C variant conferred a possible protective effect against pancreatic cancer in older individuals and a significant survival advantage in patients who received 5-florouracil
- SNPs involving the GSTP1, MnSOD and GPX2 genes were not associated with Barrett's esophagus or esophageal adenocarcinoma
- GSTT1 wildtype and GSTP1 GG are associated with increased risk of skin lesions.
- The results show significant differences between individuals with and without self-reported chemical-related sensitivity with regard to the distribution of NAT2, GSTM1, GSTT1, and GSTP1 gene variants.
- Hypermethylation occurred in the promoter region flanking the GSTP1 gene in the peripheral circulation in prostate cancer.
- An association between polymorphisms in GSTP1 and ABCB1 and risk of acquiring intratumoral TP53 mutations suggests the existence of putative predisposing genotype backgrounds.
- GSTP1 GG increases risk for melanoma in the subgroup of individuals with dark eyes or hair.
- the Ile105Val variant in GSTP1 is associated with CT scan distribution of emphysema
- GSTP1 Ile 105Val appears to be associated with a modest increase in the risk of bladder cancer--a meta- and pooled analysis
- The results of this study suggested that the Ile(105)Val GSTP1 polymorphism may play some role in colorectal cancer susceptibility.
- high and low P-glycoprotein, glutathione S-transferase pi expression, excision repair cross-complementing 1 alterations, and tumor suppressor p53 mutation were candidates for future clinical trials of chemosensitivity tests in lung cancer patients.
- in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and the DNA becomes methylated and inaccessible resulting in transcriptional silencing.
- Subjects who had the mutant alleles of the GSTP1 and CYP1A1 and homozygous wild type of MPO, showed approximately 5-fold-higher risk for lung cancer than the reference.
- Methylation of GSTP1 was correlated to IGFBP3 methylation in early stage prostate cancer.
- A higher risk for highly malignant bladder disease was also observed in variant allele carriers than non-carriers of the GSTP1 polymorphism.
- GSTP1 B allele carriers were more frequent among the patients with Barrett's esophagus(BE) when compared to controls; GSTP1 gene might be one of the risk factors associated with susceptibility to reflux esophagitis, especially to BE
- GSTP1 promoter hypermethylation is early event in breast carcinogenesis and appears to functionally silence GSTP1 expression. GSTP1 promoter hypermethylation in the precursor lesions of breast cancer may be used as a target for cancer chemoprevention.
- Data shows asthmatic children had a higher prevalence of the GSTP1Ile105 allele than the control group.
- Methylation status of GSTP1 could be an indicator of drug response and a prognosticator for diffuse large B cell lymphoma
- GSTP1 contributes to doxorubicin and cisplatin resistance in osteosarcoma, which may be mediated in part by the activation of extracellular signal-regulated kinase 1/2
- In conclusion, 105V/114V alleles of GSTP1 and 113H/139H alleles of mEPHX and the combination of genotypes with same alleles associated with imbalanced oxidative stress and lung function in patients.
- Risk of ill health attributed to organophosphate-containing sheep dip is associated with PON1 genotype and phenotype varied with CYP2D6 and GSTP1 genotype but not consistently with a priori hypotheses
- Polymorphisms of MnSOD and GSTP1 are not associated with chronic alcoholic pancreatitis.
- The detection and biochemical characterization of a novel polymorphism in GSTP1 are reported.
- GSTP1 and MTHFR genotypes may be consider relevant and independent factors of toxicity in adjuvant anthracycline-based treatment of breast cancer.
- The GSTP1 Ile105Val polymorphism was not found to be significantly associated with urothelial cancer susceptibility but it may be associated with myelosuppressive adverse events in M-VAC chemotherapy
- genetic variation of the detoxification enzymes EPHX1 and GSTP1 do not increase the risks of orofacial clefting, nor do they influence the risks associated with maternal smoking.
- Determination of methylation of GSTP1 in preoperative serum samples is the strongest independent risk factor for PSA recurrence after prostatectomy.
- GSTM1 and GSTP1 genotypes do not individually influence susceptibility to breast cancer or fibrocystic breast conditionsin Chinese women
- Single nucleotide polymorphisms of the GSTP1 gene were screened. The study indicated an association between GSTP1 allele and childhood asthma. Also, GSTM1 gene is a modifier of the GSTP1 gene for the risk of childhood asthma.
- GSTP1 polymorphisms is associated with dnan damage induced by tobacco smoke
- ORs were somewhat elevated for the GSTP1 Val/Val genotype (versus Ile/Ile). The respective ORs for esophageal, cardia, and other gastric adenocarcinomas were 1.73 (0.75-4.02), 1.46 (0.57-3.73), and 1.22 (0.48-3.09)
- GSTM1 and GSTP1 polymorphisms may have roles in ozone-induced lung function changes
- A quantitative analysis of GSTP1 promotor methylation has good diagnostic efficacy in prostate carcinoma.
- Associations between specific combinations of three GST gene polymorphisms and breast cancer risk but these did not modify the association between cruciferous vegetable intake and breast cancer.
- An animo acid substituition is a risk factor for breast cancer.
- GSTP1 with an isoleucine-valine substitution may be involved in relapse of childhood acute lymphoblastic leukemia.
- the significant gene-gene and gene-environment interactions of GST genes may confer a substantial risk to upper aerodigestive tract upper aerodigestive tract cancers in the Tamilian population of south India.
- Polymorphisms affecting GSTP1, GST alpha 1 and GSTM3 genes are probably not related to the risk of developing hepatocellular carcinoma in a population of white Spanish patients.
- GSTP1 protein expression, but not GSTP1 methylation status, might serve as a marker for both docetaxel and paclitaxel resistance in primary breast cancers.
- Thioredoxin-1-dependent induction of glutathione 3-transferase P1 (GST-P1) expression is required for apoptosis inhibition in human endothelial cells.
- Polymorphisms at the mt loci alone and in combination with the risk genotype at GSTP1 increased the risk of oral cancer
- Increased generation of urinary 8-hydroxy-2'-deoxyguanosine was found in betel-quid chewers with SULT1A1 and GSTP1 genotypes that affect susceptibility to DNA damage.
- the combined genotype group of SOD2-01 and GSTP1-01 was an independent predictor of progression free survival and breast cancer specific survival in patients with metastatic breast cancer
- frequencies of GSTM1, GSTT1 and GSTP1 polymorphisms in Dong, Yi and Yao ethnic groups from Guizhou
- Promoter hypermethylation of GSTP1 is associated with prostate cancer progression
- allelic analysis showed that subjects AA homozygous for the GSTP1 A-for-G nucleotide substitution at position 313 had higher vitamin C (VC) excretion and blood VC levels than GA heterozygous subjects
- CYP1B1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women.
- Our data have provided evidence that GST polymorphism modifies the susceptibility to HNSCC and have further demonstrated importance of gene-environment interaction in modulating the risk to HNSCC.
- No field effect, defined as absence of epigenetically transformed cells, for GSTP1 was observed, whereas APC, RARbeta2, and RASSF1A showed a field effect up to 3 mm from the malignant core in three prostatectomy samples.
- Polymorphisms in GSTP1 is not associated with multiple myeloma
- genotypic distribution of GSTP1 was Ile(105)/Ile(105) in 47.3%, Ile(105)/Val(105) in 30.97% and Val(105)/Val(105) in 21.74% of ESRD patients
- No association between GSTP1 gene deletion and an increased risk of hereditary or sporadic breast cancers.
- Event-free and overall survivals were not significantly different as a function of the GSTP1 genotype.
- Homozygosity of high producer IL-12p40 genotype IL-12Bpro-11 and -GG had the highest genetic risk of silicosis development in Bulgarian miners.
- The biotransformation enzymes GSTM1, GSTP1 and EPHX1 may modify the effect of dietary factors on the risk of developing colorectal carcinoma and adenoma.
- the present study highly suggest that GSTP1, MDR1, and MTHFR genotypes could be prognostic factors for Taiwanese patients with breast cancer.
- Absence of GST-M1 leaves more glutathione as substrate for the co-expressed GST-P1. genotyping may be a step towards a more individualized treatment of patients with metastatic testicular cancer.
- Study concludes that the flexible alpha2 loop of GST P1-1, which forms one wall of the G-site and contributes to glutathione affinity, plays a pivotal role in the catalytic action and stability of the protein.
- GSTP1 genotype coding for an enzyme with high conjugation capacity significantly increases the risk of developing asbestosis.
- gene polymorphisms in CYP1A1, GSTT1, GSTP1, GSTM1, and NQO1 were characterized in Saudi individuals with a diagnosis of DLBCL; CYP1A1, GSTT1, GSTP1 demonstrated significant association of DLBCL risk; GSTM1 and NQO1 did not.
- Expression of GSTP1-1 in breast caner cells enhances the rate of intracellular accumulation of chemopreventive sulforaphane and its glutathione conjugate.
- GSTP1 genotypes and allelic variants were not related with the risk for ET with the possible exception of those patients exposed to pesticides.
- genetic polymorphism does not contribute to lung cancer risk in Brazilian population
- Evidence supporting a protective GSTP1 allele is reported, the first genetic association to be reported for polymorphic light eruption.
- The V allele of the GSTP1 may be a risk factor for late-onset Alzheimer's disease, mainly in the presence of the apoE 4 allele, while the presence of GSTT1 may indicate protection against the disease
- Cruciferous vegetable intake may ameliorate the effects of the GSTP1 genotype and risk of breast cancer.
- Variants in both the promoter and coding regions of the GSTP1 locus may contribute to the occurrence of childhood asthma and wheezing and may increase susceptibility to adverse effects of tobacco-smoke exposure.
- Assessed tubular function in diabetic children by measuring Tamm-Horsfall protein and glutathione S-transferase levels in urine.
- The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study.
- GSTT1*0 alone and in combination with GSTM1*0 and GSTP1 variant genotypes is a risk factor for gastric neoplasms in the Indian population.
- Seven placental transcripts characterize HELLP-syndrome.
- Our data suggest the induction of PSA-NCAM by oncogenic K-Ras as a novel molecular mechanism by which E-cadherin-mediated cellular adhesion is reduced and dissemination of tumor cells is facilitated.
- Single nucleotide polymorphism or haplotype of the gene produce risks for susceptibility to drug dependence.
- GST-pi might play important roles in proliferation of androgen-independent human prostate cancer cells.
- different combinations of GSTP1, GSTM1 and GSTT1 polymorphisms do not greatly increase risk of lung cancer
- GSTP1 inactivation through CpG hypermethylation is common in pituitary adenomas and may contribute to aggressive pituitary tumor behavior.
- CYP1B1, GSTM1, GSTT1 and GSTP1 polymorphisms may have a role in susceptibility to breast cancer
- There were some significant interactions between GST genotypes with tobacco smoking and clinocopathological factors but no association of GSTP1 with survival.
- the human glutathione S-transferase P1 gene is a novel transcriptional target of the p53 tumor suppressor gene
- The only significant association between increased risk of breast cancer development and GSTs polymorphisms is found when GSTT1 null, GSTM1 null and the presence of valine in GSTP1 in codon 105 are combined.
- Single-nucleotide polymorphism in GSTP1 is associated with altered protein binding and thus influence GSTP1's contribution to carcinogen and drug metabolism, and possibly disease pathogenesis and/or drug response
- Data indicated that in Caucasians exposed to aromatic amines the GSTP1 A1578G polymorphism did not appear to play a significant role as a predisposing factor for bladder cancer incidence.
- 89.8% PC patients have a mutation in one of the genes GSTT1, GSTM1 or GSTP1.
- Report GSTP1 expression in glioblastomas and the effect of enzyme inhibition on tumor cell response to alkylating agents.
- among children with steroid-sensitive nephrotic syndrome there is an association with response to cyclophosphamide therapy and combination of GSTP1 Val105 polymorphism and the null genotypes of GSTT1 and GSTM1
- These results suggest that individuals with susceptible metabolic GSTP1 and DNA-repair XRCC1 genotypes may be at increased risk of DNA damage due to pesticide exposure.
- REVIEW overexpression of GST-pi was not only seen in typical cases of mantle cell lymphoma associated with t(11;14) and Cyclin D1 overexpression but it was equally overexpressed in a subset of cases that were t(11;14)-negative, and cyclin D1-negative
- GST-pi levels in B-cell lymphoma subtypes and relation to survival
- GSTP1 promoter haplotypes have a role in affecting DNA methylation levels and promoter activity in breast carcinomas
- Data show that high levels of GST-pi in endothelial cells and glial cells/astrocyte correlate to medical intractable epilepsy.
- The significant difference in methylation of GSTP1 observed in the liver neoplasms and liver cirrhosis was not observed in the plasma samples.
- MTHFR 677T and GSTP1 313G polymorphisms confer a significantly decreased risk of developing preeclampsia in the Mexican Maya-Mestizo population.
- GSTP1 polymorphisms were not associated with an earlier age of onset for colorectal neoplasms.
- MDR analysis revealed a three-gene combination, consisting of NOS3 (p.Glu298Asp), GSTZ1 (p.Lys32Glu), and GSTP1 (p.Ile105Val), that provided the highest predictive model for gentamicin-induced vestibular dysfunction.
- analysis of the catalytically active monomer of glutathione S-transferase pi and key residues involved in the electrostatic interaction between subunits
- GSTP1 codon 105 polymorphism may be predictive for the response to irinotecan-based chemotherapy in patients with metastatic colorectal cancer
- The role of regulation of expression and variation of the function of GSTP1 in asthma pathogenesis needs further investigation, especially in the context of oxidative stress and age of diagnosis.
- Catalysis of S-glutathionylation at low pK cysteines in proteins is a novel property for GSTpi
- Cytologic evaluation of GST-pi and P-gp expression may predictor the response to treatment and the survival of patients with advanced NSCLC.
- results suggest that GST gene polymorphisms do not confer increased susceptibility to tardive dyskinesia in patients with schizophrenia but TD severity might be related to GST-P1 variants
- the wild type and hetero type of GSTP1, a metabolism enzyme of Oxaliplatin, were 53.3% and 41.7%, respectively
- GSTP1-val (105) gene polymorphism could be associated with the course of chronic hepatitis B infection.
- An increased intake of cruciferous vegetables was associated with a decreased risk of colorectal cancer, more pronounced in the GSTP1 GG or AG genotype.