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Validated All-in-One™ qPCR Primer for MTOR(NM_004958.3) Search again
Product ID:
HQP097513
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS
Gene Description:
mechanistic target of rapamycin kinase
Target Gene Accession:
NM_004958.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
Gene References into function
- The mTOR pathway is influenced by the intracellular concentration of ATP, independent of the abundance of amino acids, and mTOR itself is an ATP sensor.
- phosphatic acid mediated mitogen activation of mTOR signaling
- Atrophy and hypertrophy of skeletal muscle are associated with decreases and increases in Ser(2448) phosphorylation, a site in the mammalian target of rapamycin (mTOR) phosphorylated by protein kinase B (PKB) in vitro.
- Predominant nuclear localization in normal and malignant cells in culture.
- Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
- Syncytia from cells expressing the HIV-1 Env gene fused with cells expressing CD4/CXCR4 undergo apoptosis after nuclear translocation of mTOR, mTOR-mediated p53 phosphorylation, p53-dependent Bax upregulation & mitochondrial death pathway activation.
- mTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
- mTOR-catalyzed phosphorylation of 4EBP1 in vitro and mTOR action in vivo require the participation of mTOR binding protein, raptor.
- These functions of TSC1-TSC2 are mediated by inhibition of the mammalian target of rapamycin (mTOR).
- FRAP is a CLIP-170 kinase positively regulating the MT-binding behavior of CLIP-170
- Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin; These studies position mTOR as an upstream activator of HIF-1 function in cancer cells
- hamartin and tuberin function together to inhibit mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1)
- mTOR substrate specificity is regulated by serine in the rapamycin binding domain
- the AMPK and mTOR signalling pathways are possibly linked.
- raptor binds to p70S6k and 4E-BP1 through their respective TOS (conserved TOR signaling) motifs.
- mammalian target of rapamycin regulates STAT1-dependent gene transcription by lipopolysaccharide and interferon-gamma
- mTOR is a critical target for survival signals generated by phospholipase D in breast cancer cells.
- Rheb is a mediator of MTOR.
- TOR-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1
- Identification of domains of FRAP/mTOR which may mediate its association with the endoplasmic reticulum and the Golgi apparatus.
- This review describes recent progress in understanding the control of the mTOR signaling pathway and the role of mTOR-interacting proteins.
- K-Ras-mediated transformation of intestinal epitelial cells involves activation of the PI3K/mTOR pathway.
- Thr2446 as a novel nutrient-regulated phosphorylation site on mTOR
- Activation of hexosamine pathway affects glucose-induced phosphorylation of IRS-1. Impairs coupling of IRS-1 and PI 3-kinase and activativates Akt/mammalian target of rapamycin/phosphorylated heat- and acid-stable protein-1/p70S6 kinase pathway.
- A new form of mTOR elucidates the molecular mechanism underlying mTOR-dependent regulation of RNA synthesis
- PI3K mediates G(1) progression and cyclin expression through activation of an AKT/mTOR/p70S6K1 signaling pathway in the ovarian cancer cells.
- an intact PI3K/mTOR pathway is necessary for the ability of IFNalpha to induce apoptosis, whereas activation of the Jak-STAT pathway alone appears to be insufficient for this specific IFNalpha-induced effect
- mTOR does not have a role in B-Raf kinase activity regulation by tuberin and Rheb
- mTOR regulates PP5, which activates apoptosis signal-regulating kinase 1 signaling
- Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress.
- ANG II activates rapamycin-sensitive mTOR signaling pathway in human coronary smooth muscle cells and involves activation of phosphatidylinositol 3-kinase, p70(S6k), and eukaryotic initiation factor-4E, leading to activation of protein synthesis.
- The rapid activation of PI3K-Akt/PKB-mTOR-p70(S6K) cascade by T3 provides a new molecular mechanism for thyroid hormone action
- Human cytomegalovirus induces mechanisms to maintain the integrity of the eIF4F complex even when mTOR signaling is inhibited.
- PKC-eta targets the Akt and mTOR signaling pathways
- stromal cell-mediated apoptotic protection in B-lineage ALL is mediated by PI3K/mTOR and MEK via a synergistic mechanism
- mTOR may play a major role in IL-12-induced IFN-gamma production by activated T cells
- the mTOR pathway is an important modulator of the signals involved in the acute regulation of insulin-stimulated glucose transport in 3T3-L1 and human adipocytes
- identification of an alternative survival signal that is dependent on phospholipase D and mTOR and is active in a breast cancer cell line where the phosphatidylinositol-3-kinase survival pathway is not active
- Review. TOR is a transducer of information from various sources, including growth factors, energy sensors, hypoxia sensors, & components regulating growth & division. Blocking TOR mimics amino acid & growth factor deprivation & has a cytostatic effect.
- mTOR/S6K1 overactivation contributes to elevated serine phosphorylation of IRS-1, leading to impaired insulin signaling to Akt in liver and muscle
- diverse control signals converge on the mTOR-S6K1 signaling pathway
- Overexpression of phospho-mTOR is associated with liver neoplasms
- Subependymal giant cell astrocytoma cells show high levels of phospho-S6K, phospho-S6, and phospho-Stat3, all proteins downstream of and indicative of mTOR activation.
- DGKzeta-derived phosphatidic acid acts as a mediator of mTOR signaling
- RTP801 and RTP801L work downstream of AKT and upstream of TSC2 to inhibit mTOR functions
- An inhibitor of this and of the EGF receptor pathwway inhibits growth of glioma in a xenograft mousse model.
- RSPRR motif interacts with a negative regulator of S6K1 that is normally suppressed by mTOR.
- During recovery, the inhibition of mTOR by AMPK is suppressed, and its activation is maximized by the presence of AA.
- Rrapamycin inhibits fibronectin-induced vascular smooth musscle migration through a pathway that involves mTOR.
- results show show that target of rapamycin (TOR) kinase and its associated protein rictor are necessary for AKT/PKB Ser473 phosphorylation and that a reduction in rictor or mammalian TOR (mTOR) expression inhibited an Akt/PKB effector
- S6 kinase 1 is essential for the control of muscle cytoplasmic volume by Akt and mTOR
- EGF and hypoxia induce CXCR4 in non-small cell lung cancer, a process regulated by the PI3-kinase/PTEN/AKT/mTOR signaling pathway and activation of HIF-1alpha
- binding of mTOR to Rheb mutants that are unable to bind guanyl nucleotide in vivo is inhibited by amino withdrawal; inhibitory effect of amino acid withdrawal is exerted through action on mTOR, at a site distinct from that responsible for binding Rheb
- p70S6 kinase is a major effector of mTOR phosphorylation at Ser-2448 in response to both mitogen- and nutrient-derived stimuli
- S6 kinase 1 is a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
- The mainly anti-apoptotic mTOR signalling is downregulated in cellular and transgenic models of Alzheimer's disease and in peripheral cells of patients, and could contribute to the pathogenesis of the disease.
- Data show that the farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling.
- activation of mTOR by Akt-mediated cellular energy and inhibition of AMPK is the predominant pathway by which Akt activates mTOR in vivo
- hVps34 is a nutrient-regulated lipid kinase that integrates amino acid and glucose inputs to mTOR and S6K1
- levels of p-mTOR (Ser2481), and p-4E-BP1 (Thr70 and Ser65) dramatically increase in Alzheimer disease, and are positively significantly correlated with total tau and p-tau
- T-cad overexpression in vascular endothelial cells protects against stress-induced apoptosis through activation of the PI3K/Akt/mTOR survival signal pathway and concomitant suppression of the p38 MAPK proapoptotic pathway
- phospholipase D suppresses protein phosphatase 2A and is involved in the mTOR survival pathway in the transformation of human cells
- simultaneous blockade of mTOR and NF-kappaB pathways synergize to significantly inhibit or abrogate the proliferative responses of BM endothelial cells to mitogenic stimuli
- A redox-sensitive mechanism regulates the phosphorylation of the raptor-mTOR effector S6K1, the interaction between raptor and mTOR, and the kinase activity of the raptor-mTOR complex.
- the inhibition of EGFR and mTOR has distinct as well as common signaling consequences in glioblastoma multiforme cells
- the mTOR pathway plays an important role during megakaryopoiesis by regulating ploidy, cell size, and maturation, in part by regulating p21 and cyclin D3.
- mTOR maneuvers on and off the eukaryotic initiation factor 3 translation initiation complex.
- HIF1a has a role in determining sensitivity to inhibitors of mTOR in kidney cancer
- Raptor directly binds to and serves as a scaffold for mTOR-mediated phosphorylation of IRS-1 on Ser636/639.
- mTOR nuclear import is required for its cytoplasmic signaling to S6K1
- Taken together, these results demonstrate that an intact mTOR pathway is critical for IFN-gamma-induced suppression of pY-STAT3 and apoptosis.
- The mTOR protein activation, as measured indirectly by augmented levels of phospho-S6 protein, was more frequent in tumors with gene alterations in either EGFR or KRAS than in their wild-type counterparts.
- MSL complex interacts with components of the nuclear pore, in particular Mtor/TPR and Nup153. Knockdown of Mtor or Nup153 results in loss of the typical MSL X-chromosomal staining and dosage compensation in Drosophila male cells but not in female cells.
- eukaryotic translation initiation factor 4E binding protein 1(4E-BP1) overexpression is associated with prostate cancer, especially when combined with phosphatase and tensin homolog(PTEN) and mammalian target of rapamycin(mTOR) expression data
- mTOR may have a role in increasing survival of cervical cancer patients who are treated with cisplatin-based neoadjuvant chemotherapy
- The higher expressions of mTOR protein was associated with worse outcome in glioblastoma.
- 4E-BP1 binds to eukaryotic initiation factor-4E (eIF4E) to prevent the formation of the active translation complex and dissociates from eIF4E by phosphorylation through the mammalian target of rapamycin (mTOR) in the cells stimulated by amino acids.
- the mTOR pathway regulates mitochondrial oxygen consumption and oxidative capacity
- Inhibition of mammalian target of rapamycin (mTOR) with rapamycin (10-100 nmol/L) had no significant effect on HIF-1alpha induction in a variety of cell lines, a finding that was confirmed using mTOR siRNA.
- TOR multimerization is a conserved mechanism for TOR functioning
- Results suggest that lysosomal turnover of GABARAP-PL is activated during the differentiation of C2C12 cells to myotubes without inactivation of the mTor kinase-signaling pathway.
- Activation of mammalian target of rapamycin is associated with postmenopausal ovarian endometriosis
- Mammalian target of rapamycin (mTOR) inhibitor rapamycin enhances the sensitivity of PTEN-deficient tumor cells to the EGFR kinase inhibitor erlotinib
- mTOR kinase hyperactivation is a molecular mechanism underlying the development of cytomegalic neurons
- These studies suggest that, through serine phosphorylation, Raptor-mTOR and S6K1 promote the depletion of IRS1 from specific intracellular pools in pathological states of insulin and IGF-I resistance and in lesions associated with tuberous sclerosis.
- We demonstrate, for the first time in human skeletal muscle, that the regulation of Akt and its downstream signalling pathways GSK-3beta, mTOR and Foxo1 are associated with both the skeletal muscle hypertrophy and atrophy processes.
- activity assays in Hela cells suggested that,in phase G2 and M, the activity of mTOR was maintained at a higher level than in any other phase
- eIF3i overexpression fosters the integration of growth signals by mTOR into the mRNA translation process, promoting protein synthesis and tumor growth.
- levels of mTOR in lymphocytes could follow the cognitive decline in Alzheimer's disease
- It would seem that this increase in VEGFR-3 occurred via the ERK and mTOR pathways, since their respective inhibitors U0126, LY294002 or rapamycin were responsible for a decrease of VEGFR-3
- Results reveal that the SIN1-rictor-mTOR function in Akt-Ser473 phosphorylation is required for TORC2 function in cell survival but is dispensable for TORC1 function.
- Phosphorylated-mTOR levels and mTOR activity were dramatically increased in HEK 293 cells with RIalpha levels reduced by siRNA.
- In multiple myeloma cells mTOR inhibition results a more complete abrogation of VEGF translation, and ultimately, angiogenesis.
- The TSC/Rheb/mTOR pathway plays a critical role in the regulation of E(2)-induced proliferation.
- Results suggest that FLCN, mutated in Birt-Hogg-Dube syndrome, and its interacting partner FNIP1 may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.
- S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt
- data demonstrate the ubiquitous activation of the mTOR signaling pathway in post-transplant lymphoproliferative disorder
- mTOR is regulatd by polycystin-1 in polycystic kidney disease [review]
- Bcl-3 is required for condensation of fibrin by activated platelets, demonstrating functional significance for mTOR-regulated synthesis of the protein
- mTOR-dependent pathways have roles in IFN signaling and 4E-BP1 and TSC1-TSC2 are key components in the generation of IFN-dependent biological responses
- These findings suggest that the mTOR signaling pathway is activated and may contribute to cell cycle progression and tumor cell survival in MCL.
- inhibition of mTOR by 5'-AMP-activated protein kinase is circumvented
- model whereby nutrients signal to mTOR via activation of MAP4K3.
- IGFBP-2 is regulated predominantly through the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway
- mTOR pathway is active in 40% of patients with hepatocellular carcinomas undergoing orthotopic liver transplantation
- ASCT2 silencing inhibits mTORC1 (mTOR/raptor)signaling and leads to growth repression, followed by enhanced survival signaling via mTORC2 (mTOR/rictor)and apoptosis of hepatoma cells.
- Rapamycin stimulates insulin-mediated glucose uptake in men under conditions known to activate the mTOR pathway.
- A bout of aerobic exercise restores the anabolic response of muscle proteins to insulin by improving endothelial function and Akt/mTOR signaling in older subjects.
- Withdrawal of Notch signals prevented stimulation of the mTOR pathway by mitogenic factors. These findings collectively suggest that the mTOR pathway is positively regulated by Notch in T-ALL cells
- Changes in tissue pressure during inflammation may regulate macrophage phagocytosis by activation of PI-3K, which activates Akt2, mTOR, and p70S6K.
- one rational approach for mTOR-targeted lung cancer therapy is to use an mTOR inhibitor in combination with a drug that blocks PI3K/Akt activation such as a PI3K inhibitor, as we demonstrated in our study.21
- It was demonstrated that immunoprecipitation of Protor-1 or Protor-2 results in the co-immunoprecipitation of other mTORC2 subunits, but not Raptor, a specific component of mTORC1.
- mTOR functions as a placental nutrient sensor, matching fetal growth with maternal nutrient availability by regulating placental nutrient transport. Provide a mechanism for the changes in placental leucine transport in intrauterine growth retardation.
- Rheb signaling to mTOR in vivo requires a Rheb switch 2-dependent interaction with an element other than the three known polypeptide components of TOR complex 1
- the PI3K/AKT/mTOR signaling pathway is involved in regulation of SphK1, with AKT2 playing a key role in PDGF-induced SphK1 expression
- vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors
- mTOR is inactivated during hypoxia.
- analysis of the mammalian target of rapamycin signaling pathway in cancer [review]
- mTOR regulates the phosphorylation and activation of Akt in endothelial cells and a major effect of mTOR inhibition in endothelial cells is to suppress Akt-inducible pro-survival signals
- used 401 to test the cellular effect of mTOR inhibition without the complicating side effects on PI3K
- These results strongly suggest that the G1 arrest and the decrease in translation induced by eRF3a depletion are due to the inhibition of mTOR activity and hence that eRF3a belongs to the regulatory pathway of mTOR activity.
- P-Rex1 links mTOR signaling to Rac activation and cell migration
- ULK1 knockdown inhibited rapamycin-induced autophagy consistent with a role downstream of mTOR
- PRAS40 acts downstream of mTORC1 but upstream of its effectors, such as S6K1 and 4E-BP1
- IKK alpha controls mTOR kinase activity in Akt-active, PTEN-null prostate cancer cells, with less involvement by IKK beta
- AKT amplification and the mTOR/p70S6K1 pathway play an important role in human lung cancer cells acquiring CDDP resistance
- the major mechanism of HER2-mediated induction of FASN and ACCalpha in the breast cancer cells used in this study is translational regulation primarily through the mTOR signaling pathway.
- This study identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a new regulator of iron-transferrin uptake
- Proarteriosclerotic effects of interferon gamma are associated with mammalian target of rapamycin raptor complex (mTORC1) and PI-3 kinase activiation.
- peptidoglycan make it coincidental the release of arachidonic acid with a rapid induction of cyclooxygenase-2 protein regulated by a signaling cascade involving phosphatidylinositol 3-kinase, mTOR, and the translation machinery
- Dysregulation of the tuberous sclerosis 1/mTOR signaling pathway significantly contributes to inflammation-mediated cancer pathogenesis.
- Finally, using dual-cistronic luciferase constructs we demonstrate that apoB 5' UTR may have weak internal ribosomal entry (IRES) translation which is not affected by insulin stimulation, and may function to stimulate basal levels of apoB translation.
- Overexpression of Akt1 upregulates glycogen synthase activity and phosphorylation of mTOR in IRS-1 knockdown HepG2 cells.(
- mTOR inhibition increases eIF4E phosphorylation through a PI3K-dependent and Mnk-mediated mechanism.
- PLD1 and phospho-mTOR are coexpressed in a subset of phospho-Akt-negative breast carcinomas.
- Introduction of mTOR inhibitors to the immunosuppressant regimen in heart transplntation may delay renal functional deterioration caused by calcineurin inhibitors.
- In breast cancer stem-like cells, the STAT3 pathway was found to be positively regulated by mTOR signaling, whereas PTEN served as a negative regulator of both STAT3 and mTOR signaling.
- These data implicate activation of mTOR in the pathogenesis of melanoma, and suggest that Rheb and mTOR may be targets for melanoma therapy.
- Bnip3, a hypoxia-inducible Bcl-2 homology 3 domain-containing protein, directly binds Rheb and inhibits the mTOR pathway.
- Inhibition of mTOR was the idea behind the development of new targeted agents in advanced renal cell carcinoma (Review).
- IFNalpha-induced apoptosis requires activation of ERK1/2, PKCdelta, and JNK downstream of PI3K and mTOR, and it can occur in a nucleus-independent manner, thus demonstrating that IFNalpha induces apoptosis in the absence of de novo transcription.
- findings suggest that FKBP38 is an endogenous inhibitor of mTOR, whose inhibitory activity is antagonized by Rheb in response to growth factor stimulation and nutrient availability
- The PKB-dependent mechanism of insulin-stimulated c-Myc expression in HT29 cells was shown to involve the activation of mTOR in c-Myc translation
- analysis of coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma ce
- metformin-mediated AMPK activation leads to inhibition of mTOR and a reduction in translation initiation
- a key regulatory role of the Akt/mTOR pathway in the generation of the effects of As(2)O(3)
- mTOR signaling pathway is playing a role in the greater synthesis of muscle proteins when resistance exercise is followed by essential amino acids and carbohydrate ingestion
- activation of mTORC1 signalling by phorbol esters does not require PRAS40 to be phosphorylated at Thr(246), bind to 14-3-3 or be released from mTORC1.
- the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose
- The mTOR pathway plays a critical role in histocompatibility antigen HLA class I antibody-induced cell proliferation and cell survival.
- Alexander disease mutant GFAP accumulation stimulates autophagy, in a manner regulated by p38 MAPK and mTOR signaling pathways.
- hamartomatous TSC skin tumors are induced by paracrine factors released by two-hit cells in the dermis, and proliferation with mTOR activation of the overlying epidermis is an effect of epiregulin
- importance of mTOR in CCL5-mediated T-cell mig
- Akt and mTOR activation have distinct functional relevance in mantle cell lymphoma
- The results demonstrate that multiple muscarinic receptor subtypes regulate mTOR, and that both MAPK-dependent and -independent mechanisms may mediate the response in a cell context-specific manner.
- Active AKT and mTOR, were present in all adenomas, carcinomas, and in normal colorectal mucosa.
- after mTORC1 kinase activation by upstream regulators, PRAS40 is phosphorylated directly by mTOR, thus contributing to the relief of PRAS40-mediated substrate competition.
- The PI3K/Akt/mTOR signaling pathway is implicated in the development of cervical cancer.
- CCI-779 inhibits mTOR signaling through an FKBP12-independent mechanism that leads to profound translational repression in cancer cells.
- SKAR-mediated recruitment of activated S6K1 to newly processed mRNPs serves as a conduit between mTOR checkpoint signaling and the pioneer round of translation when cells exist in conditions supportive of protein synthesis.
- Inhibition of protein kinase mTOR, a key nutrient sensor impairs cell proliferation.
- Cav-1 increases the basal and TGF-beta1-induced expression of type I procollagen by regulating two opposite signaling pathways: inhibiting TGF-beta1/smad signaling and activating a PI-3 kinase/Akt/mTOR-dependent pathway in human dermal fibroblasts.
- deregulated PKB/AKT stabilizes Mcl-1 expression in a mammalian target of rapamycin (mTOR)-dependent pathway
- Focal brain malformations: a spectrum of disorders along the mTOR cascade.
- Inhibition of mTOR may provide a nontoxic adjunct to therapy directed against malignant mesothelioma, especially in those with high baseline expression of p-S6K
- We show here that mTOR downstream from Akt controls NF-kappaB activity in PTEN-null/inactive prostate cancer cells via interaction with and stimulation of IKK.
- interaction of PI3K/Akt/mTOR and p53 pathways after their simultaneous blockade using the dual PI3K/mTOR inhibitor PI-103 and the Mdm2 inhibitor Nutlin-3.
- mTOR signaling pathway is activated in two endometrial carcinoma cell strains and the status of activation is related with PTEN expression of the cells
- SGK1 is an mTOR-raptor substrate and mTOR may promote G1 progression in part through SGK1 activation and deregulate the cell cycle in cancer.
- IL-4 activates mTOR signaling in T-ALL cells, which is critical for cell cycle progression of T-ALL cells
- Studies suggest that TF-FVIIa-FXa-mediated signaling modulates mTOR pathway activation, which regulates in part breast cancer cell migration.
- mTOR inhibition could enhance the effects of 5-aza-dC on suppressing cell proliferation and arresting cell cycle in human gastric cancer cell lines
- ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
- mTOR inhibition by rapamycin alters gene expression in two breast cancer cell lines.
- FKBP38 is a bona fide effector of Rheb and the ability to interact with FKBP38 is important for Rheb as an activator of mTOR
- Study identified a new link between mTOR, p73, and p73-regulated genes associated with autophagy and metabolic pathways.
- phosphatases and pRB have important roles in IGF-I/mTOR-mediated cell survival
- in prostate cancer cells at least two mechanisms of drug resistance are interconnected. PTEN and mTOR signaling were shown: to be involved into regulation of MRP1 and BCRP
- BCR-ABL leukemogenesis inis blocked by PI3K in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells
- The state of activation of components of mTOR, Ras/Raf kinase/ERK, and nuclear factor (NF)-kappaB signal transduction pathways, as well as cell cycle protein analyte correlates in gastric adenocarcinoma cases, was examined.
- MAPK activation is a consequence of mTORC1 inhibition in neoplasms
- Combining MTOR inhibition with metronomic chemotherapy in targeting angiogenesis is reported.
- Inhibition of PI3-K/Akt induces a 40% decrease of cyclin D1 half-life as a result of accumulation of the dephosphorylated/active form of GSK-3beta within the nucleus, where it can phosphorylate cyclin D1 on Thr286 thereby promoting its nuclear export.
- findings show mTOR is targeted for ubiquitination & degradation by binding to FBXW7; breast cancer cell lines & primary tumors showed a reciprocal relation between loss of FBXW7 & deletion or mutation of PTEN, which also activates mTOR
- activation of the Akt-mTOR-p70S6K pathway plays a significant role in HCC progression by promoting neoangiogenesis.
- mTOR inhibition enhances chemosensitivity in hepatocellular carcinoma
- The mTOR activated pS6K(ser240 / 244) was detected in in 86.7% of ameloblastomas.
- Inhibition of PI3K or mTOR reduced the level of Rap1B, which acts downstream of Rheb and mTOR. The ubiquitin E3 ligase Smurf2 mediates the restriction of Rap1B by initiating its degradation.
- These data identify the TSC2-mTOR pathway as a key regulator of innate immune homeostasis with broad clinical implications for infectious and autoimmune diseases, vaccination, cancer, and transplantation.
- mTOR is a indispensable component of PRR signal pathways, which orchestrates the defense program of innate immune cells.
- MTOR signaling has a critical role in the pathogenesis of HCC, with evidence for the role of RICTOR in hepato-oncogenesis.
- expression of hypoxia-inducible factors 1 alpha and 2 alpha is dependent on mTORC1 and mTORC2
- results suggest a novel mechanism by which AMPK activation after hypoxia-induced energy stress may be crucial in regulating REDD1 expression to control the mTOR pathway in head and neck squamous cell carcinoma
- mTOR and eIF4E have a role in preventing progression of ovarian cancer
- FAK, mTOR and IGF-IR are inhibited by TAE226 in esophageal cancer cells
- mTOR may function not only in the proliferation of tumor cells as an effector molecule downstream of EGFR but also possibly in the morphogenesis of AC.
- KAI1/CD82 decreased the metastatic phenotype of H1299 lung carcinoma cells by down-regulating Rac1 expression through the PI3K/Akt/mTOR pathway.
- After treatment with everolimus, expression of p-mTOR, HIF-1alpha and VEGF was shown to be sharply depressed in clear cell adenocarcinoma
- mTOR upregulation in healthy portions of TS patients' skin provides an explanation to such a variety of lesions observed in this neurocutaneous condition
- EGFR signals to mTOR through PKC and independently of Akt in glioma
- activation of mTOR causes the loss of TCRzeta in lupus T cells through HRES-1/Rab4-dependent lysosomal degradation
- Study shows show that cellular uptake of L-glutamine and its subsequent rapid efflux in the presence of essential amino acids is the rate-limiting step that activates mTOR.
- TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.