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Validated All-in-One™ qPCR Primer for FGF7(NM_002009.3) Search again
Product ID:
HQP096033
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HBGF-7, KGF
Gene Description:
fibroblast growth factor 7
Target Gene Accession:
NM_002009.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq].
Gene References into function
- KGF induced proliferation but did not cause significant differentiation of 3 hematopoietic cell lines and bone marrow cells transduced with human K-sam.
- play important roles in lung development, lung inflammation, and repair.
- keratinocyte growth factor (KGF), a key stimulator of epithelial cell proliferation during wound healing, preferentially binds to collagens I, III, and VI.
- possible role of fibroblast growth factors in expression of genes of the plasminogen activator system in breast fibroblasts
- KGF may hold promise for the treatment of very premature neonates with bronchopulmonary dysplasia.
- Following activation by KGF binding, KGF and the KGF receptor remain associated in active complexes through the endocytic pathway, which is described.
- activity is potentiated by dermatan sulfate binding
- Data suggest a causal relation between telomere shortening and reduced expression of KGF and IGF-II in human fibroblasts.
- Increased expression of HGF and KGF by buccal mucosal fibroblasts may partly be responsible for the faster wound healing with less scar formation in the oral cavity compared with normal skin.
- lipopolysaccharide may induce proliferation of periodontal epithelial cells by upregulating keratinocyte growth factor 1 expression via the CD14 and Toll-like receptor signaling pathway
- PAK4 interacts with KGF receptor and mediate anti-apoptosis effects of KGF on epithelial cells.
- In the presence of keratinocytes, fibroblasts from buccal mucosa, periodontal ligament, & skin increased increased HGF and KGF production 2-3 times. This may influence the proliferation & migration of junctional epithelium and affect periodontal disease.
- KGF is capable of inducing human fetal beta-cell expansion.
- keratinocyte growth factor 1 may play a role in limiting mechanically induced apoptotic processes at the epithelial wound edge in a manner that is distinct from its proliferative function.
- may have an important role in cyclosporin-induced gingival overgrowth
- Review. The role of FGF7 in epithelial tissue repair and its therapeutic potential are discussed.
- FGF7 was specifically identified when selecting for in vitro phosphate transport inhibitory activity of tumor-derived cultures and was confirmed as a potent inhibitor of phosphate transport. Finally, FGF7 message was confirmed in PCR products of mRNA>
- Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane
- Results demonstrate a dysregulation of keratinocyte growth factor secretion by idiopathic pulmonary fibrosis fibroblasts; weak response to IL-1beta is associated with a defect of c-Jun expression and activation and a defect of JNK activation.
- in psoriatic lesions activated lymphocytes can stimulate fibroblasts to produce KGF and FGF-10, which in turn contribute to sustain the hyperproliferative status of the keratinocytes
- Human embryonic pancreatic mesenchyme expresses FGF7, which might be used used to expand human embryonic pancreatic epithelial cells.
- Expression of FGF7 in breast neoplasms may have an inhibitory role on the induction of apoptosis, possibly through the overexpression of Bcl-2.
- FGF& overexpression seen in advanced ovarian neoplasms; FGF7 suggested to play significant role in development of ovarian neoplasms
- KGF stimulated the proliferation of cyst-lining epithelial cell in vitro by regulating the expression of cyclin D1 and P21(wafl) genes.
- KGF requires both 1-Phosphatidylinositol 3-Kinase and JNK Mitogen Activated Protein Kinases signaling pathways to induce SREBP-1
- expression of hepatocyte and keratinocyte growth factors and their receptors is preserved in patients with lung emphysema as compared to patients without emphysema
- KGF suppresses alpha2beta1 integrin function and promotes differentiation of the transient amplifying population in prostatic epithelium.
- Evaluation by immunohistochemistry of KGF receptor distribution, showed a down-modulation of this receptor, as previously reported in the presence of increased levels of KGF clear cell acanthoma (CCA).
- The elevated FGF7 protein levels in gastric inflammation and gastric cancer, together with the known oncogenic potential of FGF7.
- KGF/FGF-7 induces NF-kappaB activation and NF-kappaB plays an essential role in regulation of KGF/FGF-7-inducible gene expression and KGF/FGF-7-initiated cellular responses
- adenosine might stimulate hair growth through FGF-7 upregulation in dermal papilla cells
- FGF3, FGF7, FGF10, FGF18, and FGFR1 may have roles in nonsyndromic cleft lip and palate
- Data show that enhanced expression of keratinocyte growth factor and its receptor correlates with venous invasion in pancreatic cancer.
- KGF increased integrin alpha(5) expression by phosphorylating C/EBP-beta
- FGF-7 is not essential for urothelial cell proliferation in response to partial outlet obstruction; however, a significant increase in FGF-10 expression was observed in the obstructed FGF-7-null group
- Expression of keratinocyte growth factor was significantly increased in damaged liver tissue in correlation to the degree of fibrosis.
- These results indicate that KGF enhances the adhesion of colorectal cancer cells to type-IV collagen through ERK and FAK signaling pathways.
- High KGFR/KGF coexpression is associated with well-differentiated esophageal cancer
- KGF-promoted melanosome transfer was more significant in light keratinocytes compared to dark, due to an increased expression of KGF receptor in light skin keratinocytes
- KGFR internalization triggered by either KGF or FGF10 occurs through clathrin-coated pits
- FGF7 improved survival during acute lung injury in mice
- PAR-1 activation strikingly induced FGF-7 production from cultured stromal cells mediated predominantly via ERK1/2 signaling pathway in benign prostatic hyperplasia
- Determine pulmonary and systemic hepatocyte and keratinocyte growth factors in patients with chronic obstructive pulmonary disease.