|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for DHX9(NM_001357.4) Search again
Product ID:
HQP094609
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
DDX9, LKP, NDH2, NDHII, RHA
Gene Description:
DExH-box helicase 9
Target Gene Accession:
NM_001357.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.
Gene References into function
- Nuclear DNA helicase II recruitment to PML nuclear bodies(NBs) is connected with transcriptional regulation of interferon-alpha-inducible genes attached to PML NBs.
- propose that NDH II operates in both nucleoplasmic and nucleolar mode, and that its redistribution reflects accumulations indicating a possible cycling of NDH II between nucleoplasm and the nucleolus
- Overexpression of a truncated RHA peptide that binds to the BRCA1 carboxy-terminus prevents normal BRCA1 function & association with nuclear foci following DNA damage. It induces pleomorphic nuclei, aberrant mitoses with extra centrosomes, & tetraploidy.
- DNA-PK phosphorylated recombinant NDH II in the presence of RNA
- RNA helicase A in the MEF1 transcription factor complex up-regulates the MDR1 gene in multidrug-resistant cancer cells
- RHA interacts with NF-kappa B p65 and functions as a transcriptional coactivator.
- Results suggest that nuclear DNA helicase II plays a role in promoting the DNA processing function of Werner syndrome helicase, which in turn might be necessary for maintaining genomic stability.
- Our results indicate that the nuclear import of RHA is mediated by the importin-alpha3/importin-beta-dependent pathway and suggest that the specificity for importin may regulate the functions of cargo proteins.
- RHA represents the first example of cellular RNA helicases that participate in HIV-1 particle production and promote viral reverse transcription
- Phosphorylated Zic2 protein makes a stable complex with RNA helicase A.
- In vitro dephosphorylation of HeLa cellular HDH II/Ku caused a significant decrease in the DNA helicase activity of this enzyme.
- These results establish a link between the p53 tumor suppressor and RNA processing via hnRNPA2/B1 and RNA Helicase A.
- knockdown of DHX-9 by siRNA did not inhibit the rRNA synthesis or cause the nucleolar disruption
- A 21-day follow-up of the response of HCV replication to the presence and absence of RNAi indicated that RHA is a cellular factor involved in the HCV replication process.