|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for CALM1(NM_006888.5) Search again
Product ID:
HQP088725
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CALML2, CAM2, CAM3, CAMB, CAMC, CAMI, CAMIII, CPVT4, DD132, LQT14, PHKD, PHKD1, caM
Gene Description:
calmodulin 1
Target Gene Accession:
NM_006888.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
|
|
| A | B |
|
Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
|
Summary
Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium.
Gene References into function
- Microtubules have a role in stabilising the structure of the pericentriolar matrix, involving interaction with one or more proteins that are targets for binding of calmodulin
- differential binding of calmodulin by RalA and RalB
- calmodulin binds to a 35-aa segment in the C terminus of TRPV1, and disruption of the calmodulin-binding segment prevents TRPV1 desensitization
- Calmodulin is a phospholipase C-beta interacting protein
- the calcium binding dynamics of free calmodulin and CaM that is bound to other target proteins are altered by PEP-19
- CaM has a role in Fas-mediated apoptosis
- calmodulin has a role in ATP- augmented von Willebrand factor-dependent shear-induced platelet aggregation
- It is suggested that calmodulin plays a significant role in cytokinesis including furrow formation and regression
- calmodulin has a role in melatonin inhibition of estrogen receptor alpha
- Calmodulin mediates Ca2+ sensitivity of Nav1.2 and Nav1.5 sodium channels
- the majority of CaM nuclear entry occurs by facilitated mechanisms in all cell types examined, in part by a Ca2+-independent and in part by a Ca2+-dependent translocation mechanism
- Ca(2+)-calmodulin assumes a novel conformation when it is part of a complex with the C-terminal tail of the Ca(V)1.2 alpha(1) subunit
- transcriptional level of CALM1 is associated with susceptibility for hip OA
- Calmodulin may be involved directly in SRY nuclear import during gonadal development, and disruption of SRY.
- the Ral-CaM complex defines a multifaceted regulatory mechanism for PLC-delta1 activation
- analysis of calmodulin and its interactions with ligands by circular dichroism
- calmodulin and calcium regulate the binding of filamin A to actin filaments
- CaM binds to the membrane-proximal EpoR cytoplasmic region and plays an essential role in activation of Jak2-mediated EpoR signaling
- Ca2+/CaM has a role in regulating ubiquitination through direct interaction with TRE17
- Membrane trafficking at early steps of the basolateral endocytic pathway in HepG2 cells is regulated by an intricate interplay between calmodulin and PKC.
- The high-resolution structure of the Ca(2+)/CaM-Ca(V)1.2 IQ domain complex was reported.
- recruited CaM is used by the C terminus of AC8 to mediate Ca2+ stimulation
- analysis of calcium/calmodulin binding to the pleckstrin homology domain of AKT1
- CaM was identified in the Fas-mediated death inducing signaling complex (DISC). The amount of CaM recruited into the DISC was increased after Fas-stimulation.
- CaM affect cell morphology and motility through binding to stress fibers and regulate f-actin polymerization.
- analysis of conformational changes of calmodulin upon Ca2+ binding
- The CALM1 core promoter genotype is not a risk factor for knee osteoartrithis (KOA) etiology in Greek Caucasians on its own, but associated with the Asporin (ASPN) D14 or D15 risk allele, it could influence KOA susceptibility.
- The present study suggests that the CALM1 core promoter polymorphism -16C/T is not a risk factor for knee osteoarthritis susceptibility in the Chinese Han population.
- This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.