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Validated All-in-One™ qPCR Primer for MMP1(NM_002421.3) Search again
Product ID:
HQP088710
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CLG, CLGN
Gene Description:
matrix metallopeptidase 1
Target Gene Accession:
NM_002421.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III.
Gene References into function
- Patients with detectable concentrations of urinary MMP-1 had higher rates of disease progression and death from bladder cancer than patients with undetectable urinary MMP-1.
- members of the forkhead family of transcription factors play a role in regulation of the collagenase promoter and increased activity of forkhead transcription factors underlie the increase in collagenase expression observed during replicative senescence
- 17beta-estradiol represses MMP-1 synthesis, and this effect may contribute to its action on the inhibition of bone resorption
- Thus, MT1-MMP oligomerization through the hemopexin, transmembrane, and cytoplasmic domains controls its catalytic activity.
- role in degradation of extracellular matrix and joint destruction
- induction in fibroblasts by basic calcium phosphate crystals
- These data suggest that polymorphisms in the MMP1 and MMP12 genes, but not MMP9, are either causative factors in smoking-related lung injury or are in linkage disequilibrium with causative polymorphisms
- Membrane type 1 matrix metalloproteinase regulates cellular invasiveness and survival in cutaneous epidermal cells.
- in the late healing period of radiation-impaired wounds, increased expression of MMP1 may be related to overdegradation of matrixes and difficulty in granulation tissue formation
- A newly identified single nucleotide polymorphism at position -519 in the promoter region of the MMP-1 gene is reported. This polymorphism consists in a guanine to adenine substitution. A linkage between polymorphisms -519A/G and -1607 1G/2G was studied.
- Reduction of cytokine-induced expression and activity of MMP-1 and MMP-13 by mechanical strain in MH7A rheumatoid synovial cells
- Accessory elements, flanking DNA sequence, and promoter context play key roles in determining the efficacy of insulin and phorbol ester signaling through the enzyme motifs
- destruction of the surrounding matrix by endometriosis might be caused by various MMPs, which are mainly produced in stromal cells.
- Oxidized low-density and high-density lipoproteins regulate the production by activated monocytes
- lack of expression in Ewing sarcoma may be due to loss of accessibility of regulatory element to the specific fusion protein in vivo
- Activation of p38 alpha MAPK enhances its expression by mRNA stabilization
- Activation of protein kinase CK2 is an early step in the ultraviolet B-mediated increase in interstitial collagenase (matrix metalloproteinase-1; MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts.
- Results demonstrate that generation of the 44-kDa membrane type-1 matrix metalloproteinase (MT1-MMP) autolysis product regulates collagenolytic activity and subsequent invasive potential.
- keratinocyte-fibroblast interactions are mediated by multiple stimulating agents acting on specific receptors to induce signalling through different mitogen-activated protein kinase pathways leading to altered expression of key biological functions.
- Association of a polymorphism of the matrix metalloproteinase-1 gene with bone mineral density.Bone density for the distal radius was significantly lower in postmenopausal women with the GG/GG genotype.
- MMP1 may play a pivotal role in the formation of capillarylike tubular structures in a collagen-containing fibrin matrix in vitro and may be involved in angiogenesis in a fibrinous exudate in vivo.
- Genotyping was carried out using PCR-RFLP and direct sequencing. In the MMP-1 gene polymorphism, the frequency of the 2G/2G genotype that is associated with higher enzyme activity was significantly increased in colorectal cancer patients
- viral LMP1 and Zta proteins regulate the expression and activity of MMP-1; first evidence that viral proteins are capable of regulating MMP-1 and clues for the role of EBV in nasopharyngeal carcinoma progression
- A novel promoter element was detected in the human MMP1 gene, and the inflammation-responsive transcription factor SAF-1 was found to interact with it in osteoarthritis
- a polymorphism in the promoter region is associated with the severe chronic periodontitis phenotype in non-smokers
- expression and regulation by intestinal myofibroblasts in inflammatory bowel disease
- catalytic activity on the cell surface is regulated through a vacuolar H(+)-ATPase-dependent degradation process
- MMP-1 induces progressive adult-onset emphysema by the selective degradation of type III collagen within the alveolar wall.
- Gene expression for MMP-1 after UVA1 irradiation was induced in all fibroblasts, but the induction rate was greater in systemic sclerosis fibroblasts than in normal ones.
- MMP1 has a role in tumor invasion [review]
- MT1-MMP-catalyzed release of beta-amyloid precursor protein leads to reduction of the extracellular matrix-associated gelatinase A inhibitor, sAPP, thus making it feasible for gelatinase A to exert proteolytic activity only near its activator, MT1-MMP
- MMP-1 epitope increased interleukin 4 (IL-4) production of rheumatoid arthritis lymphocytes and decreased IL-4 production by control lymphocytes
- These data provide evidence that tissue factor pathway inhibitor-2 does not bind to matrix metalloproteinases-2, -9 or -1, or regulate matrix metalloproteinase-1, in the extracellular matrix.
- Hypoxia may be responsible for delayed wound healing by inducing an increase of MMP-1 synthesis.
- MMP1 is a senescence-associated gene in normal human oral keratinocytes.
- A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter is associated with renal cell carcinoma
- study showed no change in metalloproteinase-1 production in response to varying estrogen levels in fibroblasts that were derived from incontinent women
- Patients with deteriorating heart failure have increased expression of TIMP1 and MMP1 mRNA. Correlation with pro-inflammatory cytokines suggests common pathways of regulation and potential activation by IL-6 and IL1-beta.
- Upregulation of mmp-1 ia assiciated with neoplasm invasiveness in Hereditary nonpolyposis colorectal cancers
- monocyte matrix metalloproteinase-1 and -9 are differentially regulated by interferon gamma through tumor necrosis factor-alpha and caspase 8
- reported association between the matrix metalloproteinase 1 promoter polymorphism and ovarian cancer risk was not supported by our
- Cultured vascular smooth muscle cells infected with Chlamydia pneumoniae secreted increased quantities of MMP-1 protein.
- Postmortem brain tissue analysis demonstrates accumulation of MMP-1 in macrophages/microglial cells in Durck's granulomas of patients with cerebral malaria.
- Matrix metalloproteinase 1 (interstitial collagenase)is upregulated in endothelial cells by prostaglandin-J2.
- EWS-ER81 and EWS-Fli-1 interact with and thereby activate the MMP-1 promoter, which is potentiated by the cofactor p300 and the proto-oncoprotein c-Jun.
- We found a correlation between promoter polymorphism and MMP-1 expression, and that this SNP was correlated with the clinical stage of cervical cancer.
- catabolic role of ET-1 in osteoarthritis cartilage via MMP-1 and MMP-13 up-regulation.
- MIF is involved in the up-regulation of UVA-induced MMP-1 in dermal fibroblasts through PKC-, PKA-, Src family tyrosine kinase-, MAPK-, c-Jun-, and AP-1-dependent pathways.
- Overexpressed in ulcerative colitis and serve as biological markers.
- results suggest that matrix metalloproteinase-1 can stimulate dephosphorylation of Akt protein and neuronal death through a non-proteolytic mechanism that involves changes in integrin alpha2beta1 signaling
- High levels of MMP-1 expression, which may contribute to the invasive potential of these breast cancer cells
- stimulated expression of MMP-1 and MMP-9 may contribute to the invasive activity and the bone and cartilage loss in pigmented villonodular synovitis
- induction by calveolin 1
- Low levels of MT1-MMP, MMP-1 and AI were found to be favourable markers significantly associated with longer survival in advanced colorectal carcinoma.
- Mutant MMP1 lacking the cytoplasmic tail is recruited to membrane microdomains in breast carcinoma cells.
- Rb protein negatively regulates p38 activation, leading to decreased MMP-1 secretion in rheumatoid arthritis synovial fibroblasts.
- MMP-1 is ERK dependent and is upregulated after cigarette smoke exposure
- general role for elevated MT1-MMP in promoting both the selective invasion and increased growth of malignant melanoma in vivo.
- polymorphism in the promoter region may be associated with early implant failure
- A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer
- a matrix metalloproteinase 1 promoter gene polymorphism may be associated with lymphnode metastasis in patients with breast cancer
- peroxidation and the production of peroxides are important events in the signalling pathway of MMP-1 activation by ultraviolet A rays
- collagenase-1 (MMP-1) levels increase during melanoma progression through mitogen-activated protein kinase (MAPK) pathway
- 2G genotype in MMP-1 promoter was associated with the risk of oral squamous cell carcinoma
- The presence of the MMP1-2G and MMP3-6A alleles seemed to be associated with decreased risk of head and neck squamous cell carcinoma but mainly when they were carried by the same haplotype.
- Beta-carotene suppresseds UVA-induction of MMP-1.
- No general associations of MMP-1 and MMP-3 genes to primary sclerosing cholangitis(PSC) or ulcerative colitis(UC) among Norwegians, but specific alleles were associated to subsets of PSC patients with UC and cholangiocarcinoma.
- matrix metalloproteinase-1 (MMP-1) has been suggested to be involved in skin photodamage.
- PHGPx modulates the induction of MMP-1 and collagenase.
- polymorphisms do not influence susceptibility to periodontitis in Japanese patients
- Polymorphisms in MMP-1 is associated with renal cell carcinoma
- MMP-1 is found to be less efficient at processing triple-helical peptidase substrates than is MMP-14, which may explain the relative collagen specificity of MMP-1.
- Overexpression of MMP-1 is associated with non-small cell lung cancer
- Intra-articular hyaluronic acid may rescue inflamed joints from bone and cartilage destruction by reducing the production of MMP-1.
- results show that activated collagenase (MMP-1) moves processively on the collagen fibril; the mechanism of movement is a biased diffusion with the bias component dependent on the proteolysis of its substrate, not adenosine triphosphate (ATP) hydrolysis
- overexpression of p21SNFT in HepG2 cells leads to repression of matrix metalloproteinase-1 by 70-80%
- The specific reduction of invasive behavior by human chondrosarcoma cells transfected with matrix metalloproteinase-1 (MMP-1) siRNA supports the hypothesis that MMP-1 is involved in initiation of chondrosarcoma metastasis.
- MMP1 single nucleotide polymorphism does not appear to have a role in the progression of chondrosarcoma
- heat shock-induced expression of MMP-1 and MMP-3 is mediated via an IL-6-dependent autocrine mechanism
- The catalytic metalloproteinase domain and the C-terminal hemopexin domain show the classical MMP-fold, but the structure has revealed new features in surface properties
- Functional polymorphisms of MMP1 acting in cis is associated with allelic expression imbalance in nornal lung
- gene expression regulation in Lyme disease
- the level of matrix metalloproteinase (MMP)-1 mRNA expression was markedly increased in fibroblasts receiving keratinocyte releasable stratifin
- Single nucleotide polymorphism in Ets binding site of the matrix metalloproteinase-1 promoter is associated with nasopharyngeal carcinoma
- Polymorphism in the promoter region of the MMP-1 is associated with colorectal cancer
- MMP-1 in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion.
- MMP-1 expression is maintained at a low level by Cdc42 via a repression of the Rac1 and ERK1/2 pathways when cell/extracellular-matrix interactions via integrins induce cytoskeleton organization
- essential role for soluble factors, mainly IL-1alpha and bFGF, in the stimulation of dermal fibroblasts by human melanoma cells to secrete MMP-1.
- Over expression of MMP-1 is associated with lymphatic metastasis of nonsmall cell lung carcinoma
- The expression of MMP-1 was significantly increased in the Crohn's disease
- Cytokine-stimulated monocytes release Angiotensin II, which is an integral component of the signal transduction pathway that leads to MMP-1 production.
- in hepatocellular carcinoma cells, fibril- and fixed-collagen have opposite effects on MMP-1 production without affecting TIMP production
- The 2G or 1G SNP in the MMP1 promoter might not modify the risk of esophageal squamous carcinoma and gastric cardiac adenocarcinoma development
- These observations strongly suggest that intracellular association of MMP-1 to mitochondria and nuclei confers resistance to apoptosis and may explain the well-known association of this enzyme with tumor cell survival and spreading.
- MMP-1 is a candidate marker that may be useful for identification of breast lesions that can develop into cancer.
- MMP1 promoter SNP haplotype may modify susceptibility to endometriosis.
- results demonstrate that EPA can inhibit UV-induced MMP-1 expression by inhibiting the MEK1/ERK/c-Fos and SEK1/JNK/c-Jun pathways
- MMP-1 gene polymorphisms account for some of the variability in the progression of HCV-related chronic liver diseases.
- in affected tissues the oxidative stress-elicited overexpression of MMP1, and probably other matrix metalloproteinases involved in cytoskeleton remodeling, may play an important role in the pathogenesis
- MMP-1 expression by latanoprost requires prior up-regulation of COX-2
- stratifin stimulates fibroblast MMP-1 levels through the activation of c-fos and MAPK pathway
- The capability of ANG II to induce functionally active MMP in human smooth muscle cells may contribute to the altered plaque composition seen in complicated stages of atherosclerosis
- Monocyte and macrophage cells in the breast tumor microenvironment play an important role in the modulation of MMP-1.
- In both endometrial glands and corresponding endometriotic epithelium, the distribution of MMP-1 is correlated with estrogen receptor beta.
- Although MMP-1 is not detected in patients with persistent ovarian cysts, MMP-2 and MMP-9 are expressed in all of the cysts
- Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-1 is associated with breast cancer
- These results demonstrate that UVB-irradiated keratinocytes promoted MMP-1 production in UVA-irradiated fibroblasts in a paracrine manner while IL-1Ra reduced MMP-1 production through inhibiting c-Jun mRNA expression.
- overexpression of SphK1 up-regulated MMP1 protein, MMP1 mRNA, and MMP1 promoter activity, and this action of SphK1 required activation of the ERK1/2-Ets1 and NF-kappaB pathways
- results suggest that gingival fibroblast are stimulated by monocytes resulting in enhanced expression of MMP-1 and TIMP-1 and that the enhanced MMP-1 expression, in contrast to TIMP-1, is partly mediated by ICAM-1 and the signal pathway p38 MAPK
- matrix metalloproteinase 1, 3 and 12 haplotypes may associated with development of lung cancer, particularly among never smokers and men
- in gastric epithelial cells, H. pylori up-regulates MMP-1 in a type IV secretion system-dependent manner via JNK and ERK1/2
- The active MMP-1 and MMP-9 plasma levels were found to vary in the menstrual cycle
- expression of MMP-1 was repressed significantly and consistently at the RNA, the protein, and the secretory levels in uninfected newborns of HIV-1 infected mothers as compared to newborns of non-infected mothers
- Coordinated down-regulation of collagen & TIMP-1 and up-regulation of MMP-1 occurs in fibroblasts exposed to proteasome inhibitors, indicating the proteasome's role in fibrosis and extracellular matrix remodeling.
- demonstrate a novel role for CCAAT/enhancer binding protein (C/EBP), beta in interleukin-1beta-induced connective tissue disease and define a new nuclear target for the Extracellular Signal-Regulated MAP Kinases pathway in MMP-1 gene activation
- matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs
- C-reactive protein augmented MMP-1 and -10 messenger ribonucleic acid expression in vascular endothelial cells. Might provide a link between inflammation and plaque vulnerability.
- There was a clear increase in the number of MMP-1-reactive capillaries and fibroblasts in congenital diaphragmatic hernia lungs compared with controls.
- MMP-1 showed only slight variation between the dilated, ischaemic and valvular cardiomyopathy.
- Pge2 abolished the MEKK1-induced MMP-1 promoter luciferase activity.
- The -1607(1G>2G) in promoter region of MMP1 is associated with susceptibility to lung cancer in Northwestern Chinese population of Han nationality.
- Matrix metalloproteinase-I genetic variants may play a role in myocardial infarction
- This study suggests that a single nucleotide polymorphism in the MMP-1 promoter region of -1607bp may be associated with severe chronic periodontitis in a Chinese population.
- decrease in Tat-induced neurotoxicity and HIV transactivation is due to Tat's enzymatic cleavage by MMP-1
- Significantly higher mRNA expression of MMP-1 was found in brain-seeking 231-breast cancer clones in comparison to bone-seeking and parental cells.
- These results suggest that CXCL12/CXCR4 interaction transduces the two signaling pathways to promote Natural Killer-cell invasion, which stimulates pericellular degradation of extracellular matrix proteins by membrane-associated MMP-1.
- Results describe the crystal structure of the active form of human matrix metalloproteinase-1 at 2.67 A resolution.
- MMP-1 expression was confirmed by using specific PI3K inhibitors in metastatic prostatic cancr.
- MMP1 plays a pathogenic role in human emphysema.
- Individuals with the 2G insertion polymorphsim who smoke may be predisposed to enhanced MMP-1 expression in the lung, contributing to the development of COPD.
- No association between polymorphism and gingival enlargement was revealed in kidney transplant patients who were administered cyclosporin A as a principal immunosuppressive agent
- All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II.
- Data show that UVB irradiation increases PTEN/Akt phosphorylation in dermal fibroblasts, and inhibition of PTEN and activation of Akt by phosphorylation are involved in UVB-induced MMP-1 and -3 secretions through upregulation of AP-1 activity.
- MMPs play a key role in regulating the balance of structural proteins of the articular cartilage matrix according to local mechanical demands
- Excessive expression of MMP-1 and TIMP-1 in the diseased colonic mucosa causes excessive hydrolysis of the extracellular matrix (ECM) and ulceration in ulcerative colitis (UC) patients.
- No convincing evidence was found to support the association of MMP1 SNPs with increased breast cancer risk or survival.
- Screening for Wnt5a-regulated genes in cultured endothelial cells identified several encoding angiogenic regulators, including matrix metalloproteinase-1, an interstitial collagenase, and Tie-2, a receptor for angiopoietins.
- analysis of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1
- High levels of MMP-1 in tumour and mucosa as well as MMP-2 in plasma may be correlated to risk of developing distant metastases.
- These data show a relationship betweeen MMP1 polymorphism and risk of small adenomas associated with colorectal neoplasms.
- nicotine stimulates bone matrix turnover by increasing production of tPA and MMP-1, 2, 3, and 13, thereby tipping the balance between bone matrix formation and resorption toward the latter process
- Emphasis of this review is on membrane type-1 matrix metalloproteinase (MT1-MMP)-induced chromosome instability which leads to the transition from normalcy to malignancy.
- simvastatin, by inhibiting Rac1 activity, reduces MMP1 expression and collagen degradation in human smooth muscle cells.
- colorectal carcinoma patients with the 2G/2G genotype for the MMP-1 single nucleotide polymorphisms had significantly better 5-year survival compared to patients with a 1G allele (P<0.05).
- enhanced cell cycle entry, increased MAPK signaling, and downregulated MMP-1 and MMP-3 seen in diabetic arterial vasculature could have a role in progressive atherosclerosis and postangioplasty restenosis in diabetic patients
- We conclude that induction of MMP1 participates in cell invasion and also plays an important role in HIF-1alpha-induced activation of MMP2.
- These results suggest that the polymorphisms exert haplotype effects on the transcriptional regulation of the MMP1 gene in cancer cells.
- epiregulin, COX2, and MMP1 and 2 collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis
- Accumulation of AGE may have a role in the development of osteoarthritis by increasing MMP-1, -3, and -13, and TNF-alpha.
- results indicate that MMP-1-1607 bp polymorphism shows ethnic diversity, and that the hypothesis that this polymorphism is associated with epithelial ovarian cancer is not supported by this study in a Korean population
- H. pylori effects on host epithelial MMP-1 expression via ERK, with p38 playing a potential regulatory role
- MMP1 mRNA remains associated with polysomes during hypoxia.
- MMP-1 -1607 1G/1G genotype and MMP-1 1G-MMP-3 6A haplotype may play protective role in the development of adult astrocytoma in northern Chinese
- Heat-shock-induced MMP-1 expression is mediated by activation of TRPV1 and is dependent on a calcium-dependent signaling process in human epidermal keratinocytes.
- Significant differences between cases and controls were observed for MMP3, (but not for MMP1)[5A/6A allele frequencies (p=0.00001) and genotype frequencies (p=0.00001)]; and between cleft types and controls (p=0.00001 for CL/P; p=0.04 for CP).
- Primary colorectal cancers and metastatic liver lesions showed highly significant differences in MMP-1, -10, -11, and TIMP-1.
- MMP-1 is up-regulated by substance P to promote collagen degradation in lung fibroblasts.
- Expression of MMP1 was evaluated in hepatocellular carcinoma and surrounding non-tumor tissue.
- The genetic variation in MMP-1 may represent a marker for the increased risk of nasopharyngeal carcinoma.
- The MMP-1 stimulatory effect of the eta isoform explains its correlation with MMP-1 levels seen in these samples from patients with inflammed joints.
- MMP-1 produced from melanoma cells may play a role in tumor progression by both degrading matrix proteins and generating active growth factors such as TGF-beta in vivo
- MMP-1 is an important gene implicated in the progression of human breast cancer.
- Data suggest a role for MT1-MMP in early tumour progression, expression of MMP-1 during metastasis and focal expression pattern of MMP-3 and the expression profiles may provide markers for early breast cancer diagnoses and potential therapeutic targets.
- TauCl differentially inhibits the expression of MMP-1 and MMP-13in human synoviocytes.
- uPA plays a major role in inducing MMP-1 production in activated human monocytes, which is mediated by a plasmin-dependent mechanism involving signaling through the annexin A2 heterotetramer.
- Type 2 diabetes LDL lipoproteins increasin adhesion molecules by promoting increased expression of MMP1.
- Finds no association between the MMP-1 promotor haplotype -1607 1G/2G and mital valve prolapse.
- this report suggests a crucial impact of the MMP-1 2G allele in the early onset oral squamous cell carcinoma.
- IL-17 induces MMP-1 in human cardiac fibroblasts directly via p38 MAPK- and ERK-dependent AP-1, NF-kappaB, and C/EBP-beta activation.
- Elevated expression of MMP-1 and urokinase plasminogen activator can be used to identify patients with a worse prognosis in skull base chordoma.
- data suggest that the matrix metalloproteinase-1 (MMP-1) promoter polymorphism may not play a significant role in renal cell carcinoma patients in Brazil.
- Therefore, MMP-1, MMP-11 and MMP-19 might be of importance for the development of high-grade astrocytic tumors and may be promising targets for therapy.
- results suggest that the MMP-1 promoter polymorphism might be linked to susceptibility for bladder cancer.
- MMP-1 and TNF-alpha correlate well with the severity of the disease, and therefore, can be used clinically as biological markers to judge the severity of ulcerative colitis.
- 1G genotypes of MMP-1 polymorphism, containing at least one 1G allele, were associated with the presence of endobronchial TB.
- targeted inhibition of MMP-1, a single effector of the Raf/MEK/ERK signaling cascade, prevents the progression of melanoma from a primary to metastatic tumor
- No difference exists in gene expression of MMPs in ascending aorta and AV between patients with BAV and TAV.
- the 2G allele of the MMP-1 promoter polymorphism might not modify the risk of prostate cancer development and might not be used as a putative marker to predict the potential of metastasis in this cancer type, at least in the Turkish population
- upregulation of MT1-MMP by GM-CSF must only occur in cells directly involved in tubule formation
- Genotype frequency of MMP-3, but not MMP-1 and MMP-9 in idiopathic dilated cardiomyopathy patients, was significantly different from that in healthy controls.
- Increased transcript and active MMP1 levels in the most severely affected children, who carried a known SNP (1G/2G) in the MMP1 promoter suggesting increased degradation by metalloproteinases.
- IL-1beta and MIF cytokine network induce MMP-1 and contribute to the loss of interstitial collagen in skin photoaging
- mmp1 inhibition mediates extracellular matrix lysis at cell-matrix adhesions induces the establishment of cell polarity, which facilitates cell-matrix adhesion turnover and subsequent cell migration in tumor cells.
- Investigation of cellular responses to experimental phonation may provide insight into how matrix metalloproteinases and other extracellular matrices contribute to maintenance of the vocal fold and development of pathology.
- A new T > C SNP in the MMP1 promoter was also identified; in a case-control study, the minor C allele was found to be protective against preterm premature rupture of membranes, consistent with its reduced promoter function.
- IR/visible light spectrum of sunlight significantly increased skin MMP-1 expression.
- Melittin did not affect MMP1 secretion by rheumatoid arthritic fibroblasts.
- Alveolar macrophage matrix metalloproteinase 1 and 12 may have a role in the lung structural changes leading to the development of emphysema.
- Cyclosporine therapy after kidney trransplantation does not have a significant effect on gingival MMP-1 levels.
- An analysis of disease-free survival rates showed that the presence of both MMP-1 2G/2G and IL-8 A/A genotypes was associated with a particularly poor prognosis (P=0.0032) and was an independent prognostic factor (P=0.001).
- serum OPG, RANKL, MMP-1 and TIMP-1 may have roles in mediating myocardial healing after myocardial infarct
- Report the production of vascular endothelial growth factor and MMP-1/2 via protease-activated receptor in human endometrial stromal cells.
- In dermal fibroblasts, Akt has dual profibrotic effects, increasing collagen synthesis and decreasing degradation by MMP1 downregulation. Systemic sclerosis fibroblasts were more sensitive to Akt inhibition, with respect to collagen and MMP1 production.
- MMP-1 plays an important role in prostate cancer progression during the invasive and metastatic stages of the disease.
- MMP8, but not MMP1 or MMP13, may affect the metastatic behaviour of breast cancer cells through protection against lymph node metastasis
- Unlike MMP-1 and MMP-9 genotypes, MMP-3 5A allele, with higher transcriptional activity, may be a risk factor for the poor prognosis of hepatocellular carcinoma
- individuals with the presence of D allele for the -1607 promoter polymorphism of MMP1 are about 1.5 times more susceptible to develop DDD when compared with those having G allele only
- MMP7 and MMP1, are overexpressed in the lung microenvironment and distinguish idiopathic pulmonary fibrosis from other chronic lung diseases. Additionally, increased MMP7 concentration may be indicative of asymptomatic ILD and reflect disease progression
- Incubation of cultured human dermal fibroblasts or treatment of human skin with specific antioxidants prevented infrared radiation-induced MMP-1 expression in vitro and in vivo.
- UV damage to keratinocytes of the epidermis may participate in the destruction of collagen in the dermis by release of soluble mediators that signal fibroblasts to release MMP-1.
- Berberine induced down-regulation of MMP1 in gastric neoplastic cells in vitro.
- Increased MMP1 expression in cultured XP-C fibroblasts resulted from MMP1 mRNA accumulation and enhanced transcriptional activity of the MMP1 gene promoter
- MMP-1 overproduction is associated with bone marrow stromal cells in multiple myeloma
- matrix metalloproteinase-1 gene promoter may contribute to interindividual variability in risk of ACS, and help predict susceptible individuals.
- MMP1 is associated with an increased risk for lung cancer, modified by smoking.
- TRPV1 mediates heat shock-induced MMP-1 expression via calcium-dependent PKCalpha signaling in HaCaT cells
- limited type Systemic sclerosis was associated with GGA allele of the MMP1(matrix metallopeptidase 1)promoter
- All tested ligands repressed the MMP1 promoter through the L540Q mutant with identical efficacy.
- Positive MT1-MMP expression in 68.2% cases was observed. There was no significant relationship for immunoexpression of MT1-MMP in examined group of patients with advanced laryngeal carcinoma and positive poliCKs stain in lymph nodes
- p53 inhibits basal and UV-induced MMP-1 expression in human dermal fibroblasts.
- anti-MMP-1 autoantibody is a novel autoantibody in Localized Scleroderma.
- Data indicate that the antioxidative properties of triphlorethol-A involve the inhibition of MMP-1 via ERK and AP-1 inhibition.
- HIF-1alpha can regulate MMP1 and MMP3 expressions in human bmMSCs, which might suggest a pathophysiological role of bmMSC expressing high HIF-1alpha in bone diseases.
- suggesting protective roles of MMP1-1607 G allele and MMP1-519 A allele against increase in body mass index in Korean population
- These data demonstrate that the matrix metalloproteinase-1 promoter is a direct target of cigarette smoke in lung epithelial cells.
- MMP1 transsfected into mice may represent an unexpected alternative strategy for the inhibition of this enzyme and prevention of tumor growth.
- Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression.(
- Simvastatin suppresses lipooplysaccharide-induced MMP-1 expression in U937 mononuclear cells.
- Hypoxia upregulates the expression of angiopoietin-like-4 in human articular chondrocytes: role of angiopoietin-like-4 in the expression of matrix metalloproteinases MMP1 and MMP3 and cartilage degradation
- a single nucleotide polymorphism in the -1,607 bp promoter region might be associated with the difference observed in the endogenous expression of MMP-1 in PDL cells under mechanical force
- Data suggest that the -1607 2G polymorphic allele of the MMP-1 gene could be associated with susceptibility to severe chronic periodontitis; the -519AG and GG genotypes may play a role in the outcome of periodontal therapy.
- MyD88 is important in IL-6 and MMP-1 expressions in both acutely UV-irradiated skin and in chronically sun-exposed human skin
- The 2G/2G genotype polymorphism of interstitial collagenase 1 is associated with higher invasion risk of colorectal cancer, especially in male smokers.
- G-1607GG polymorphism is associated with early implant failure, while A-519G polymorphism does not show a significant relationship with implant loss; haplotypes G-1607GG and A-519G may be associated with the osseointegration process
- Cathepsin G increases MMP expression in normal human fibroblasts through fibronectin fragmentation, and induces the conversion of proMMP-1 to active MMP-1.
- This study confirms that Ets-1 is a downstream effector of oncogenic HER2, associated with MMP-1.
- Significantly higher matrix metallopeptidase 1 expression is associated with prostate cancer.
- polymorphisms of the MMP-1 promoter may confer increased risk for idiopathic pulmonary fibrosis and reveal a putative gene-environment interaction between the -755 MMP-1 polymorphism and smoking in this disease
- Results demonstrate that via PAR-1, MMP-1 activates mitogen-activated protein kinase signaling cascades in microvessel endothelial cells, and may complement the activity of thrombin to better facilitate angiogenesis and promote tumor progression.
- Matrix metalloproteinase-1 is a crucial bone metastasis factor in a human breast cancer-derived highly invasive cell line
- no significant association is found for the -1607 1G/2G polymorphism with susceptibility to periodontitis
- Report the effect of 4-hydroxypanduratin A on the mitogen-activated protein kinase-dependent activation of matrix metalloproteinase-1 expression in human skin fibroblasts.
- MMP-1 gene expression might be induced by TNF-alpha via the p50/p50 homodimer of NF-kappaB in activated human hepatic stellate cells.
- 1G genotypes of MMP-1 promoter polymorphism are associated with asthma with persistent airway obstruction, and the heterozygous 1G genotype (1G/2G) poses the most susceptibility to persistent airway obstruction in asthma.