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Validated All-in-One™ qPCR Primer for ATF6(NM_007348.3) Search again
Product ID:
HQP088417
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ACHM7, ATF6A, ATP6alpha
Gene Description:
activating transcription factor 6
Target Gene Accession:
NM_007348.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[supplied by OMIM].
Gene References into function
- Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP
- luminal domain senses endoplasmic reticulum stress and causes translocation of ATF6 from endoplasmic reticulum to Golgi apparatus
- coordination of transcription and degradation by a domain shared with the viral transcription factor VP16
- Distinct roles in transcription during the mammalian unfolded protein response
- p38MAPK is activated by phosphorylated ATF6 and induces HSPA5 binding
- stimulated by HCV replicons
- The endoplasmic reticulum stress pathway mediated by ATF6 and by IRE1-XBP1 systems seems essential for the transformation-associated expression of the grp78 gene in hepatocarcinogenesis
- the transport of ATF6 from the ER to the Golgi apparatus and that from the Golgi apparatus to the nucleus are distinct steps
- ATF6 antagonizes SREBP2 to regulate the homeostasis of lipid and glucose
- ATF6 and Ire1p signaling do not define the magnitude of UPR-dependent mRNA increases, even though they may be necessary for gene activation.
- the bulky ATF6 luminal domain blocks its site-2 protease cleavage
- ATF6 and XBP1 have roles in activation of endoplasmic reticulum stress-responsive cis-acting elements
- Our results clearly establish HBx as an inducer of UPR and the activator of the ATF6 and IRE1-XBP1 pathways of UPR.
- Owing to the presence of intra- and intermolecular disulfide bridges formed between the two conserved cysteine residues in the luminal domain, ATF6 occurs in unstressed endoplasmic reticulum in monomer, dimer, and oligomer forms.
- A study evaluting 64 single nucleotide polymorphisms (SNPs) spanning >213 kb in 95 people for their role in the development of type 2 diabetes and the prediabetic state is reported.
- one or more variants in ATF6 are associated with disturbed glucose homeostasis and type 2 diabetes
- Shorter ATF6alpha message lacks exon 7 and may have a regulatory role in the Unfolded protein response.
- the relative levels of ATF6 alpha and -beta, may contribute to regulating the strength and duration of ATF6-dependent ERSR gene induction and cell viability
- NUCB1 is the first-identified, Golgi-localized negative feedback regulator in the ATF6-mediated branch of the UPR
- The aim was to study the activation of ATF6 and Grp78 in transfected human epithelial cells expressing the DeltaF508-CFTR protein.
- Compared with COPD and donor lungs, protein levels of ER stress mediators, such as ATF-6 and ATF-4 and the apoptosis-inductor CHOP as well as XBP-1, were significantly elevated in lung homogenates and AECIIs of IPF lungs
- ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
- Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6