|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for VEGFA(NM_001171626.1) Search again
Product ID:
HQP068523
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
L-VEGF, MVCD1, VEGF, VPF
Gene Description:
vascular endothelial growth factor A
Target Gene Accession:
NM_001171626.1(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
|
|
| A | B |
|
Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
|
Summary
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy.
Gene References into function
- Includes data regarding non-AUG translation initiation (CUG) of VEGF
- Includes data regarding non-AUG translation initiation (CUG) of VEGF
- upregulated in eye in experimental herpesvirus retinopathy
- Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts, DU145 prostate cells and CHRF megakaryocytes.
- The VEGF levels were significantly higher in recurrent ALL compared with newly diagnosed ALL.
- VEGF levels were elevated in patients with invasive cancer of ductal/no specific type, ductal carcinoma in situ, and estrogen receptor (ER)-positive tumors.
- Includes data regarding non-AUG translation initiation (CUG) of VEGF
- induction in human glioblastoma cells by acidic extracellular pH via ERK1/2 MAPK signaling pathway
- Significant association with poor survival by VEGF.
- Vascular endothelial growth factor expression in serous ovarian carcinoma: relationship with high mitotic activity and high FIGO stage.
- both VEGF-induced PI 3-kinase activation and beta(1) integrin-mediated binding to fibronectin are required for the recruitment and activation of PKC alpha.
- VEGF expression and intratumoral microvessel density (IMVD) can be considered as a biological indicator of malignant potential in brain astrocytoma.
- Vascular endothelial growth factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells
- modulation of signaling and angiogenic effects by PTEN
- upregulation by interleukin-1 beta in vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway
- Vascular endothelial growth factor-A(165) induces progression of melanoma brain metastases without induction of sprouting angiogenesis.
- Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis.
- essential for developmental angiogenesis and is also required for female reproductive functions and endochondral bone formation.
- VEGF plays an important role in the oncogenesis of human gastric cancer.
- Platelets and vascular endothelial growth factor (VEGF): a morphological and functional study.
- VEGF is highly related to PVBE and angiogenesis of meningoma.
- bFGF and VEGF were synergistic in terms of DAF expression, resulting in enhanced endothelial cytoprotection
- A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR.
- Plasma vascular endothelial growth factor is useful in assessing progression of breast cancer post surgery and during adjuvant treatment.
- VEGF and flt-1 are upregulated in blood vessels in many organs of acute Kawasaki Disease
- Blood levels are elevated in myelodysplastic syndromes and in acute myeloid leukemia. VEGF corrected for the peripheral blood platelet count is a marker of disease progression in MDS.
- NMR structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor
- Vascular endothelial growth factor modulates the Tie-2:Tie-1 receptor complex
- free plasma VEGF levels are high in chronic renal impairment; may contribute to the endothelial dysfunction of uraemia
- prognostic value of matched preoperative serum and plasma vascular endothelial growth factor concentrations in patients with colorectal cancer.
- Prognostic significance of VEGF expression in bone marrow cells in chronic phase chronic myeloid leukemia.
- VEGF upregulates BCL-2 expression and is associated with decreased apoptosis in neuroblastoma cells.
- Chemoattractive and proliferative effects of VEGF-A have been demonstrated on primary human osteoblasts.
- Plasma VEGF levels are significantly increased in chronic myeloproliferative disorders. The highest levles were found in CMD with essential thrombocythemia. Levels were significantly higher in CMD patients with vascular complications.
- Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNase I accessibility
- overexpression in mesangial cells by advanced glycation end products
- tumor cell-VEGF induction may promote angiogenesis in adenocarcinoma of the lung; tumor cell expression may be important prognostic factor in adenocarcinoma of the lung
- expression of tissue factor (TF) and VEGF is frequently observed in colorectal cancer and TF expression is significantly related with VEGF expression and microvessel density
- VEGF as a mediator of OHSS.
- VEGF may play a role in pathogenesis of OHSS.
- Cultured plasma cells from patients with advanced relapsed/refractory multiple myeloma who responded favorably to thalidomide secreted a significantly lower amount of VEGF than did plasma cells from resistant patients.
- thrombin upregulates vascular endothelial growth factor
- VEGF expression and vascular density in colon cancer
- COX-2 is upregulated in endometrial cancer and facilitates tumor growth via angiogenesis produced in associated with VEGF and TP
- copper sulfate induced VEGF expression in primary as well as transformed human keratinocytes
- Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
- the role and intracellular signal pathway of endothelial nitric oxide synthase (eNOS) activation induced by VEGF
- VEGF and p53 are highly expressed in esophageal carcinomas
- VEGF is down regulated in ovarian carcinoma cells and in serous effusions
- HTLV-I-transformed T cells, but not HTLV-I-negative CD4(+) T cells, secrete biologically active forms of VEGF and bFGF and induce angiogenesis in vitro.
- A dynamic shift of VEGF isoforms with a transient and selective progesterone-induced expression of VEGF189 regulates angiogenesis and vascular permeability in human uterus
- Increased expression of VEGF may be responsible for gastric carcinogenesis and tumor aggressiveness of gastric cancer in northern China.
- differential regulation of vascular endothelial growth factor expression in bladder cancer cells (peroxisome proliferative activated receptor, beta)
- level spontaneously secreted by patient CLL B-cells quantified; secreted in 2/3 patient samples; co-expression of VEGF and VEGF receptors suggests autocrine pathways of stimulation.
- REVIEW: Association of expression of VEGF and receptors in human leukemia and lymphoma, resulting in the generation of autocrine loops that may support cancer cell survival and proliferation
- investigation of the immediate effect of ovulation induction with hCG on peripheral VEGF levels in 6 women with primary infertility enrolled in the IVF/ET program
- Overexpression of cyclin DI contributes to malignant properties of esophageal tumor cells by increasing VEGF production and decreasing Fas expression.
- modulation of synthesis by sodium butyrate in colon cancer cell line HT29
- findings suggest that products secreted by schistosome eggs may promote angiogenesis within hepatic granulomas by up-regulating endothelial cell VEGF
- VEGF and IL-6 were both independent prognostic factors for overall survival of aggressive lymphoma.
- Data suggest that VEGF-A may be more than angiogenic in prostate cancer and hence favor tumor progression by affecting tumor cells.
- relationship between serum VEGF levels, alpha(2)M levels and the development of OHSS in hyperstimulated subjects undergoing IVF
- Genotype may influence tumour growth in malignant melanoma, possibly via effects on tumour angiogenesis
- Comparison and modulation of angiogenic responses by FGFs, VEGF and SCF in murine and human fibrosarcomas.
- VEGF-induced proliferation and angiogenesis requires activation of the protein kinase C (PKC) signaling pathway, whereas vascular permeability is enhanced by PKC blockade.
- Hyperthermia acts as an anti-angiogenic strategy by suppressing VEGF expression & thus inhibiting endothelial proliferation and blood vessel ECM remodeling.
- results indicate opposite effects of IFN-gamma and IL-4 on VEGF expression from normal and activated keratinocytes and fibroblasts
- Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation (Integrin alpha6beta4)
- VEGF binds to CTGF and degrades MMPs, inducing physiological or pathologic angiogenesis
- Induction of VEGF in THP-1 macrophages and human microvascular endothelial cells during Bartonella henselae infection
- IL-10 gene expression in esophageal squamous cell cancer specimens was significantly correlated with VEGF121 gene expression. The results suggested that IL-10 stimulates angiogenic factor gene expression.
- VEGF(121) contains a third interchain disulfide bond between Cys116 of each monomer.
- VEGF promotes angiogenesis by paracrining in breast carcinoma, and takes part in tumor invasion and lymph node metastasis.
- A new alternative splicing isoform of VEGF has been identified in the lung tissue of a legally aborted human fetus.
- VEGF is associated with the development and prognosis of colorectal cancer.
- effect of epidermal growth factor on vascular endothelial growth factor secretion by endometrial stromal cells
- Data show that exposure of human colon carcinoma cells to insulin-like growth factor-1 (IGF-1) induces the expression of HIF-1 alpha, the regulated subunit of hypoxia-inducible factor 1, a known transactivator of the VEGF gene.
- expression in colon carcinoma cells exposed to pyrrolidine dithiocarbamate
- role of a variant in competitively and specifically antagonizing the mitogenic effect of the wild-type protein on endothelial cells
- Green tea inhibits induction in human breast cancer cells.
- PTEN modulates angiogenesis in prostate cancer by regulating VEGF expression.
- vascular endothelial growth factor (VEGF) has been demonstrated to have a central involvement in the angiogenic process in rheumatoid arthritis
- Vascular endothelial growth factor (VEGF) expression correlates with p53 and ki-67 expressions in tongue squamous cell carcinoma.
- expressions of iNOS and VEGF may serve as indexes for evaluating staging of gastric carcinoma and forecasting its risk of metastasis
- data suggest that mutations of p53 and activation of the Ras/MAPK pathway may play a role in the induction of VEGF expression in human colorectal cancer
- High level of vascular endothelial growth factor in hemorrhagic pleural effusion of cancer.
- regulation and expression profile of 884 human genes under the influence of either bFGF or VEGF-A alone in the context of human endothelial cells
- cystine knot promotes folding and not thermodynamic stability
- The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.
- VEGF isoforms and mutations in human colorectal cancer.
- Women with ovarian carcinoma who reported higher levels of social well being had lower levels of VEGF
- These results suggest that the expression of HIF-1 and VEGF induced by Cr(VI) may be an important signaling pathway in the Cr(VI)-induced carcinogenesis.
- may play important roles in placental biology and chorionic villus vascular development and remodeling in an autocrine/paracrine manner
- findings implicate altered VEGF and KDR signaling in pituitary tumorigenesis; PTTG stimulation of FGF-2 and VEGF expression in the presence of up-regulated growth factor receptors may account for angiogenic growth and progression of human pituitary tumor
- expression in uterine leiomyoma
- The prognostic value of vascular endothelial growth factor in 574 node-negative breast cancer patients who did not receive adjuvant systemic therapy.
- plays a role in bone formation elicited by bone morphogenetic protein 4, and can significantly enhance BMP4-elicited bone formation and regeneration
- vascular endothelial growth factor expression in human esophageal cancer
- findings underline an essential role of AP-2/Sp1 recognition sites in UVB-mediated VEGF expression by the keratinocyte-derived cell line HaCaT
- Data describe a novel mechanism by which vascular endothelial growth factor induces DNA synthesis in a pathway where sphingosine kinase mediates signaling from protein kinase C to Ras in a manner independent of Ras-guanine nucleotide exchange factor.
- Hb-induced synthesis of VEGF in TF-bearing malignant cells is mediated by protein tyrosine kinase and by MAP-kinase pathways
- Inhibition of p38 MAPK inhibits IL-6 and VEGF secretion in bone marrow stromal cells triggered by adherence of multiple myeloma cells.
- These results demonstrate a novel pathogenic mechanism whereby mutations in BRCA1, via their interaction with ER-alpha, could promote tumorigenesis through the hormonal regulation of mammary epithelial cell proliferation and impaired VEGF function
- results suggest that in the hematopoietic microenvironment an autocrine vascular endothelial growth factor loop contributes to optimal megakaryocytic maturation through Flt1
- Data demonstrate that the paracrine interaction between endothelial and mesenchymal cells potentiates angiogenesis in vitro and that this occurs with vascular endothelial growth factor-A (VEGF-A) but not with growth factor-2 (FGF-2).
- The VEGF expression and tumour angiogenesis are correlated with peritumoural brain edema.
- mediation of proliferation of human pulmonary valve endothelial cells by NFATc1
- vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells is inhibited by NAB2
- FGF2 and VEGF release by platelets support cell survival and cell growth of vascular endothelium cells in coculture.
- up-regulation of vascular endothelial growth factor is associated with submucosal carcinoma of esophagus
- The malignant transformation of endothelial cells may be characterized by VEGF expression in the presence of p53 gene mutation.
- The expression of vascular endothelial growth factor and its receptors KDR and Flt-1 by gastric carcinoma tissues and cell lines was detected to elucidate the molecular mechanism of this growth factor in promoting tumor growth.
- close relationship of VEGF expression with macrophage migration inhibitory factor expression in human glioblastoma
- VEGF might contribute to breast cancer metastasis by enhancing the transendothelial migration of tumor cells through the down-regulation of endothelial integrity
- The in vitro invasive ability of ovarian tumor cells appeared to be positive correlated to high expression of VEGF and MMP-2.
- The high expression of VEGF in esophageal squamous cell carcinoma may promote the tumor progression and lead to dismal prognosis.
- In vivo administration of vascular endothelial growth factor (VEGF) and its antagonist, soluble neuropilin-1, predicts a role of VEGF in the progression of acute myeloid leukemia in vivo.
- Vitreous levels are altered in patients with proliferative diabetic retinopathy
- vascular endothelial growth factor does not discriminate ectopic from abnormal intrauterine pregnancies at 6 weeks gestation
- Differential expression follows BCG immunotherapy in superficial papillary transitional cell carcinoma of the bladder
- review discusses the impact of new vessel formation related to acute leukemia and the relation with various angiogenic factors with focus on VEGF/VEGF receptor signaling
- VEGF is induced by p38 after stimulation by sodium arsenite
- We show here that vascular endothelial growth factor but not basic fibroblast growth factor can induce gene expression of Notch1 and Dll4, in human arterial endothelial cells. The VEGF-induced specific signaling is mediated through VEGF receptors 1 and 2
- This factor is transcribed and translated in chronic renal allograft rejection.
- The induction of maximal neovascularization by VEGF requires the interaction between ephrin-A1 and EphA2.
- Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.
- results suggest that polymorphisms in the promoter region of the vascular endothelial growth factor gene together with the aldose reductase gene may be associated with the pathogenesis of diabetic nephropathy
- regulation of transcription by oxidative stress via Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements
- restoration of PTEN function in gliomas may induce therapeutic effect by downregulating VEGF.
- PTEN mutation and epidermal growth factor receptor activation regulate mRNA expression in human glioblastoma cells by transactivating the proximal promoter
- Stat3 directly regulates VEGF expression and hence angiogenesis, growth, and metastasis of human pancreatic cancer
- VEGF impaired bradykinin-mediated dilatation and enhanced basal tone and permeability of isolated arteries which might indicate a potential role for VEGF in the development of endothelial dysfunction in pregnancy
- A set of loop-1 and -3 structures in this protein family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling.
- Induction of VEGF seems to be regulated by the extent of the IL-6 receptor expression on pancreatic cancer cells.
- We conclude that VEGF -460, -141 and +405 genotypes are not associated with susceptibility to childhood steroid-sensitive nephrotic syndrome
- VEGF found in cerebrospinal fluid of SIDS infants (postmortem) suggests that a single or multiple hypoxic events may precede the SIDS event.
- Progestins activate this gene transcription in endometrial adenocarcinoma cells
- IL-6r and TNF-alpha increase in parallel to VEGF and FGF-2 with increasing stage of multiple myeloma.
- VEGF-A is an estrogen responsive gene and modulation of this gene expression by estrogen is biphasic and can be mediated through ER-alpha dependent pathway.
- exogenous VEGF-A(165) or VEGF-A(121) did not affect the rate of proliferation of either trophoblast cells or breast carcinoma cells, but did reduce their ability to invade through reconstituted ECM (Matrigel)
- The relationship between pituitary tumour transforming gene (PTTG) expression and in vitro growth hormone and vascular endothelial growth factor (VEGF) secretion from human pituitary adenomas.
- vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor and transforming growth factor beta(1) released by endothelial cells
- We have analyzed the impact of the common -460/+405 polymorphism on both basal and stimulated VEGF transcription using the human breast cancer cell line MCF7.
- expression in pancreatic carcinoma cell line evoked by insulin-like growth factor I receptor
- We studied the association of endometriosis with circulating levels of human leukocyte antigens and VEGF in two generations of a single family (mother and three daughters). These markers were expressed distinctly in women with familial endometriosis.
- Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops.
- Significant ethnic differences in C702T and G1612A allele frequencies, but C702T, C936T and G1612A polymorphisms in 3'-UTR of VEGF gene are not associated with risk of RCC in Japanese population.
- A paracrine loop in the VEGF pathway triggers tumor angiogenesis and growth in multiple myeloma.
- VEGF expression plays a role in promoting angiogenesis in invasive ductal carcinoma of the breast, and p53 is likely to be involved in regulating VEGF expression.
- VEGF, but not bFGF, was associated with higher tumor grading of NHL and high-grade transformation of low-grade lymphoma.
- Cyclooxygenase-1 is overexpressed and promotes vascular endothelial growth factor production in ovarian cancer.
- We conclude that IL-6 may promote cervical tumorigenesis by activating VEGF-mediated angiogenesis via a STAT3 pathway.
- IGF-I induces VEGF gene expression and protein secretion in human mesangial cells via a Src-dependent mechanism.
- extracellular pH might play an important role in regulating vascular endothelial growth factor interactions with cells and the extracellular matrix
- These results demonstrate that a seven amino acid VEGF exon 6-derived peptide is an effective inhibitor of ocular neovascularisation in vivo.
- expression is involved in angiogenesis in inflamed synovial tissue in the temporomandibular joint
- expression levels of VEGF and bFGF were correlated with the biological behavior of superficial transitional cell bladder carcinoma.
- expression levels of VEGF and bFGF were correlated with the biological behavior of superficial transitional cell bladder carcinoma.
- mast cells may play an active role in the angiogenesis of basal cell carcinoma through the production of VEGF
- increased in gingival tissues of diabetic patients, especially those with periodontal disease
- The expression of EGF in hepatocellular carcinoma, HCC underlies the overexpression of VEGF in HCC.
- Local VEGF expression was correlated significantly with tumor size, advanced stage and lymph node metastasis, but not correlated with peripheral VEGF levels
- VEGF secreted by retinal pigment epithelial cells upregulates pigment epithelium-derived factor expression via VEGFR-1 in an autocrine manner.
- The effects of VEGF and low-levels of Ras were studied in two transformed cell lines. In each case, the growth curve was less than Ras alone and much higher than low-levels of Ras alone.
- expressed during angiogenesis in human ovarian cancer cells in vivo
- Results suggest that up-regulation of vascular endothelial growth factor enables and supports the pathogenesis of external ear canal cholesteatoma.
- Serum VEGF activity may be used to evaluate angiogenic and metastatic activity in breast cancer patients.
- With the progression of tumor grade, the positive rate of VEGF gene expression significantly increased.
- Distortion of autocrine transforming growth factor beta signal accelerates malignant potential by enhancing cell growth as well as PAI-1 and VEGF production in human hepatocellular carcinoma cells.
- The expression of VEGF was significantly correlated with gastric cancer differentiation & vascular invasion.
- In pregnancies complicated by trisomy 21 VEGF levels were significantly lower than in healthy controls. May be sign of imbalance of placental vascularization and altered endothelial function.
- vascular endothelial growth factor gene expression is suppressed by pigment epithelium-derived factor through anti-oxidative properties, which inhibits leptin-induced angiogenesis
- heme oxygenase activity up-regulates VEGF production and augments the capability of endothelial cells to respond to exogenous stimulation
- ADAMTS1 significantly blocks VEGFR2 phosphorylation due to direct binding and sequestration of VEGF165, with consequent suppression of endothelial cell proliferation.
- Significant difference between normal individuals and stone patients in distribution of VEGF gene polymorphism as well as an odds ratio of 1.30 per copy of the "T" allele.
- Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1.
- Gene transfer of VEGF during PTCA and stenting shows that intracoronary gene transfer can be performed safely; no differences in restenosis rate or lumen diameter were present after 6-month follow-up, and increased myocardial perfusion was detected
- possible blood biological marker of Yersinia infection and may be involved in the development of chronic conditions
- Submaximal exercise, suitable for humans with low cardiovascular fitness, induces decrease in VEGF arteriovenous balance that is likely to be of clinical significance in promoting angiogenic effects.
- VEGF-A might play a main role in the COX-2 angiogenic pathway.
- In the luteal phase, VEGF and IP-10, in the normal human breast, exhibit a proangiogenic profile. This may be one mechanism by which sex steroids contribute to breast cancer development.
- Expression of VEGF has a significant correlation with microvascular density in colorectal carcinoma.
- The promoter of human vascular endothelial growth factor contains 7 consensus binding sites for beta-catenin/TCF. Transfection of normal colon epithelial cells with activated beta-catenin up-regulated levels of VEGF-A mRNA and protein.
- Tumor-derived VEGF interacts with Angs/Tie-2 system in host stromal endothelial cells & induces in a paracrine manner the remodeling of host vasculature to support angiogenesis during tumor growth.
- Pterygia exhibit significantly lower PEDF but higher VEGF levels than those in normal corneas and conjunctivae.
- Bombesin stimulates nuclear factor kappa B activation and expression of this angiogenic factor in prostate cancer cells.
- VEGF has a regulatory role in focal adhesion complex assembly in human brain microvascular endothelial cells via activation of FAK and RAFTK/Pyk2
- VEGF is produced locally and plays a fundamental, but not specific, role in diabetic retinal neovascularisation and proliferation.
- VEGF is a modifier of motoneuron degeneration in amyotrophic lateral sclerosis
- vascular endothelial growth factor and matrix metalloproteinase-9 expression in osteolytic lesions of bone co-relates well with the extent of bone destruction and local recurrence
- Vascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1
- human oral squamous cell carcinoma cells produce VEGF, which in turn regulates PEDF production, and this balance may be contributing to neovascularization in tumors.
- expression or function in acute and chronic allograft rejection; an important proinflammatory cytokine after transplantation and its expression pattern might identify patients at risk for the development of GVD
- thrombin-induced VEGF mRNA expression is associated with the regulation of hypoxia-inducible factor 1alpha in vascular endothelial cells
- Although VEGF seems to play a pivotal role locally in the implantation and development of endometriotic lesions, the disease is not associated with a significant modulation in the levels of circulating VEGF.
- COX-2 and VEGF are expressed in head and neck squamous cell carcinoma and may have a role in tumor invasiveness and angiogenesis
- COX-2 or VEGF, but not cyclin D1 may play roles in breast cancer with poor prognosis
- VEGF is regulated by her2/neu and contributes to Wilms tumor angiogenesis in vivo
- VEGF has a role in pathologic angiogenesis and is downregulated by antisense oligonucleotides
- Serum VEGF concentration was increased in arteriosclerosis obliterans (ASO) and thromboangitis obliterans, but increased concentration of M-CSF was seen only in ASO.
- VEGF gene C/T polymorphism is a suitable genetic marker of prostate cancer but cannot be used in the prediction of the outcome of patients who have received hormonal therapy.
- Plasma VEGF levels are significantly higher than in gastric tumor patients than those in 10 healthy controls
- Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas
- In patients with advanced ovarian carcinoma, intense VEGF immunostaining was more often detected in peritoneal metastases than in primary tumors.
- Secreted VEGF protein levels were significantly lower in IGF-IR dominant negative cells. Autocrine activation of IGF-IR system significantly affects VEGF expression and angiogenesis in human pancreatic cancer.
- in humans: 1) VEGF, KDR, and Flt-1 mRNA are increased by acute systemic exercise; 2) the time course of the VEGF, KDR, and Flt-1 mRNA responses are different from those previously reported in rats
- Our findings suggest that hyperhomocysteinemia could promote the development of atherosclerotic lesions through VEGF induction in macrophages.
- Activated MMP9, and, to a lesser extent, MMP2, increased VEGF release by SKOV3 and OVCAR3 ovarian carcinoma cells.
- Biological dressing effect of cultured epidermal sheets(CESs) is mediated by EGF family, TGF-beta, and VEGF.
- High-level expression of angiopoietin-2 and VEGF receptors was observed in the endothelium of verruga peruana. Surprisingly, the major source of VEGF production in verruga peruana is the overlying epidermis.
- Postmortem brain tissue analysis demonstrates activation of the proangiogenic VEGF signaling cascade in patients with cerebral malaria.
- vascular endothelial growth factor expression is regulated by HIF1a and HIF2a, and has a role in nodular malignant melanomas of the skin
- Progression of multiple myeloma to a vascular phase is accompanied by increase in microcirculation and and in VEGF.
- Expressed in multiple myeloma cells and in bone marrow cells.
- role of neuropilin-1 on endothelial cell migration
- Increased expression of vascular endothelial growth factor is associated with myeloproliferative disorders
- VEGF is upregulated by cyclooxygenase-2 in human gastric carcinoma
- Hepatocyte growth factor mediates angiogenesis in cultured cancer cells by regulating the expression of this protein and thrombospondin 1.
- VEGF may serve as an important modulator of mitogen-induced VSMC proliferation after vascular injury.
- data suggest that human peritoneal mesothelial cells contribute to the development of peritoneal metastases and the accumulation of malignant ascites due to the production of vascular endothelial growth factor
- VEGF may play an important role in the hydrosalpinx fluid formation, possibly by promoting vascular and epithelial permeability and therefore serum transudation.
- in umbilical cord plasma, a developmental increase was evident in concentrations of vascular endothelial growth factor(VEGF) and angiogenin during the last trimester of gestation, and VEGF level was lower in term fetuses born to mothers with diabetes
- IGF-I stimulates VEGF synthesis in thyroid carcinomas in an Akt-dependent pathway via AP-1 and HIF-1 alpha
- Both of the IRS proteins modulate VPF/VEGF expression in pancreatic cancer cells by different mechanistic pathways.
- Intrauterine VEGF levels are regulated in a cycle-dependent way. Increasing levels in the late secretory phase are clearly correlated with decidualization.
- the protein level of VEGF can reflect the compensation status of cirrhosis patients and may act as an anti-cirrhotic factor
- VEGF expression was enhanced in the macrophage-derived foam cells
- results suggest that VEGF(165) plays some role in the development of albuminuria in diabetic nephropathy due to type 2 but not type 1 diabetes.
- airway smooth muscle-derived VEGF, through modulation of the extracellular matrix, may play an important role in airway remodeling seen in asthma.
- VEGF concentration decrease after insulin infusion.
- the presence of c-Kit and VEGF overexpression is associated with the presence of second primary tumors in patients with melanoma; VEGF is preferentially overexpressed in amelanotic melanoma
- splicing switch in relation to podocyte phenotype suggests that alternative splicing of the VEGF pre-RNA is a regulated process that is open to manipulation
- VEGF may play an important role in keloid formation by altering ECM homeostasis toward a state of impaired degradation and excessive accumulation.
- Estradiol regulates VEGF gene expression in human breast cancer cells through interaction of estrogen receptor alpha and transcription factor Sp1.
- VEGF plays a pivotal role in the retinal microvascular complications of diabetes.
- VEGF, VEGFR-1 and VEGFR-2 are concomitantly expressed in pre-B ALL cells. Expression of the receptors is limited to the intra-cytoplasmic compartment and may suggest either internalization or a block in trafficking of the receptor to the surface.
- Clinically active MGN is associated with diminished expression of VEGF protein and mRNA, mainly in podocytes, and expression remains depressed in persistently active and/or progressive disease. VEGF may have a protective role in the evolution of MGN
- VEGF modulates the phosphorylation, subcellular localization, and transcriptional activity of the forkhead family members by a PI3K/Akt signaling pathway, all of which is blocked by the PI3K inhibitor LY294002.
- a role for VEGF-A165 during erythropoiesis of differentiating human embryo stem cells
- Upregulation of vascular endothelial growth factor (VEGF) expression and its receptors may be important to the pathogenesis of pheochromocytomas in humans.
- Exercise can increase plasma VEGF in both endurance athletes athletes and sedentary men. There is considerable variation in the individual time of the peak VEGF response.
- association of VEGF concentration in follicular fluid with endometriosis-related infertility
- Plasma VEGF and bFGF are elevated in patients with liver cirrhosis, depending on age and are predictors of outcome.
- upregulation of VEGF-A expression by 2-Methoxyestradiol is mediated through ER-alpha
- VEGF mRNA expression was positively correlated only with microvessel density of hepatocellular carcinomas.
- changing of transcriptional activity of VEGF gene and its receptors indicates an autocrine mechanism of regulation of angiogenic gene activity in the first step of carcinogenesis--low-grade intraepithelial lesions of the uterine cervix
- Gelatinase A, which is closely associated with vascular remodeling, enhances the VEGF levels released from platelets. VEGF was clearly detected in the fibrin nets of a thrombus
- VEGF165 expression is enhanced by glucose and induced by IL-6 via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling
- A novel regulatory network RAFTK/Pyk2, Src and p38 appears to be critical for VEGF-induced endothelial cell migration.
- VEGFalpha is activated by ras-induced superoxides after shockwave stimulation
- The expression of VEGF and KDR correlates highly with the normal ocular vascularization in humans.
- higher levels in vitreous body of people with proliferative retinopathy in vitrectomy
- transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors
- Intact caveolae are required for the VEGF/VEGFR-2-mediated MEK/ERK signaling cascade
- 20 of the 26 basal cell carcinomas showed low VEGF expression, while 11 of the 13 squamous cell carcinomas showed high VEGFcDNA levels; a significant association between a high microvessel density and high VEGFmRNA levels was found
- VEGF is upregulated by ionizing radiation by mechanisms independent of HIF-1 transactivation
- results suggest that VEGF expression is involved in the promotion of angiogenesis in cervical neoplasia and that p53 is likely to be involved in the regulation of VEGF expression
- We conclude that induction of HO-1 by 15d-PGJ(2) results in augmentation of VEGF synthesis in normoxia.
- Evaluation of COX-2, VEGF and the microvessel density may give additional prognostic information for first-line chemotherapy and clinical outcome of patients with ovarian carcinoma.
- VEGF levels in blood could play a role as an angiogenic marker of malignant gastrointestinal transformation.
- Externally blocking VEGF blocked KDR nuclear import and inhibited NF-kappaB, p65 and c-rel activation in VEGF-producing leukemia cells.
- identification as regulator of angiogenesis and post-transcriptional regulation
- VEGF(164) expression resulted in increased vascularization of hyperplastic mammary epithelium and dramatic acceleration of tumor appearance.
- during angiogenesis the full enzymatic activity of MT1-MMP is required for a specific up-regulation of VEGF-A through an activation of Src tyrosine kinase pathways.
- VEGF(121) produced a combination of significantly reduced total and perfused vessel spacing, as well as a corresponding reduction in overall tumour hypoxia in MCF-7 breast cancer cells
- VEGF and PlGF induced expression of both full-length FosB mRNA and an alternatively spliced variant.
- VEGF expression is regulated by homocysteine and ATF4
- Data suggest that excessive vascular endothelial growth factor stimulation may play a role in the initiation and development of brain vessel malformations in states of relative endoglin insufficiency in adulthood.
- VEGF overexpression is associated with B-cell chronic lymphocytic leukemia
- VEGF is induced in contusional tissue in very early period after onset, and it increases capillary permeability via KDR/Flk-1 resulting in vasogenic type brain oedema.
- In this model, transbronchial VEGF gene transfer induces pulmonary angiogenesis, proximal pulmonary artery growth and contributes to lung parenchyma recovery.
- Adenovirus encoding-mediated transfer of vascular endothelial growth factor 121 induces an enhancement in regional perfusion in nonischemic myocardium that corresponds to changes in exercise tolerance.
- maximal P-selectin translocation and subsequent neutrophil adhesion was mediated by VEGF-A(165) on the activation of VEGFR-2/NRP-1 complex and required PAF synthesis.
- describe the influence of alternatively spliced coding sequences on codon selection by modulating IRES activity; long range tertiary interactions in the VEGF mRNA regulate IRES activity and thus control start codon selection
- angiopoietin-2 and VEGF at the deepest invasive tumor site may have roles in tumor angiogenesis
- VEGF produced and secreted from adipocytes may be related to rebound weight-gain.
- VEGF may have a role in non-Hodgkin's lymphoma
- VEGF is up-regulated by EWS-ETS oncoproteins and Sp1 in Ewing's sarcoma
- Combined evaluation of VEGF and E-cadherin levels may become a useful indicator of NSCLC biological behavior and provide clinically important evidence on which to base treatment n NSCLC.
- Shc is a critical angiogenic switch for VEGF production downstream from the HGF and ErbB2 RTKs.
- The VEGF -460C polymorphism is a positive independent predictive factor for the development of proliferative diabetic retinopathy, but not proteinuria.
- angiogenic factor HARP can also negatively regulate the angiogenic activity of VEGF165
- VEGF family proteins regulate wound healing, chronic inflammation and tumour angiogenesis and lymphangiogenesis in fibroblasts.
- Association between HER-2/neu and VEGF expression supports the use of combination therapies directed against both HER-2/neu and VEGF for treatment of breast cancers.
- VEGF has a role in developmental angiogenesis and in tumor angiogenesis in the brain (review)
- The overexpression of VEGF in hepatocellular carcinoma(HCC) could be promoted by hypoxia and EGF expression in HCC.
- human VEGF production in islets stimulates graft angiogenesis and enhances islet revascularization.
- both VEGF gene polymorphism and serum VEGF levels are not specifically associated with the risk of HTLV-1 associated myelopathy/tropical spastic paraparesis in our cohort.
- Nck and Crk mediate distinct VEGF-induced signaling pathways that serve overlapping functions in cell migration.
- Transplantation of heart cells and skeletal myoblasts induces vascular endothelial growth factor expression in myocardial scars and is greatly augmented by prior transfection with a vascular endothelial growth factor transgene.
- Nitric oxide enhances VEGF expression.
- Neutrophil-derived VEGF-A is a major mediator of C-X-C chemokine ligand 1/macrophage inflammatory protein-2-induced angiogenesis.
- VEGF expression is increased by ET-1, ET(A)R, and ET(B)R, which has a role in higher vascularity of breast carcinomas and possible regulation of angiogenesis in breast cancer
- vascular endothelial growth factor-1 is induced by prostaglandin E1 in human adult cardiac myocytes but not in human adult cardiac fibroblasts via a cAMP-dependent mechanism
- In peritoneal dialysis patients, the AA genotype of VEGF promoter at -2578 position was associated with progressive increase in peritoneal transport. The CA/AA genotype at -2578 position was also associated with an excess mortality.
- vascular endothelial growth factor plays a critical role in glomerular development and function, and provides the foundation to develop novel diagnostic or therapeutic tools for patients with glomerular disease--REVIEW
- vascular endothelial growth factor expression is increased by vasoactive intestinal peptide in prostate cell lines
- Results describe the relationship between the expression of vascular endothelial growth factor and inducible nitric oxide synthase in gastric cancer.
- in human skeletal muscle, acute exercise increases total VEGF mRNA, an increase that appears to be explained mainly by an increase in VEGF(165) mRNA
- Cardiac myxoma cells possess a VEGF-autocrine system, which could contribute to the malignant potential of histologically benign myxomas through direct stimulation of tumor cell growth as well as through induction of angiogenesis.
- Increased levels of VEGF in circulating blood is associated with non-Hodgkin's lymphoma or Hodgkin's lymphoma
- vascular endothelial growth factor and placental growth factor-2 effects in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production
- Increased VEGFR-1 expression may alter VEGF- mediated function on trophoblast and endothelial cells in preeclamptic placentas.
- in granulosa cells the mRNA of various growth factors is detectable by RT-PCR and that VEGF-A and ANG2 is regulated by the gonadotropic hormone choriogonadotropin.
- vascular endothelial growth factor (VEGF) is strongly expressed in villous cytotrophoblast cells and subsequently in Hofbauer cells while its receptors Flt-1 and Flk-1 are found on vasculogenic and angiogenic precursor cells
- In chronic lower limb ischemia, growth factor-1 (IGF-1) and IGF-2, were upregulated in atrophic and regenerating myocytes together with attenuated HIF, VEGF, and VEGFR-2 expression in the same cells.
- An early reduction of both nitric oxide and VEGF may be responsible of an impaired placental vascular development and endothelial regulation that may lead to fetal death
- CpG binding transcriptional repressor proteins including MeCP2 may be of importance in VEGF biology.
- PCB 104 may contribute to tumor metastasis by inducing VEGF overexpression that stimulates endothelial hyperpermeability and transendothelial migration of cancer cells
- evidence that the multifunctional cytokine, IL-6, may induce VEGF expression which increases angiogenesis in gastric carcinogenesis
- C-Myc over-expression was significantly associated with high sVEGF and normal sFlt-1 level in DLBCL patients, suggesting a complex interrelationship between c-Myc oncogene expression and angiogenic regulators
- Accelerates wound healing in a mouse model of type 2 diabetes.
- VEGF together with pRb2/p130 may have a role in hepatocellular carcinoma in a p27((KIP1))-independent manner
- Elevated VEGF expression contributes to the ability of human breast cancer cells to form brain metastases in nude mice.
- intratumoral VEGF-A expression is one of the significant prognostic factors in patients with adenocarcinomas, and that intratumoral VEGF-C expression is one of the significant prognostic factors in patients with squamous cell carcinomas
- VEGF is regulated by PAIP2 in tumor cells
- VEGF promotes SRF expression and nuclear translocation and increases SRF binding activity to DNA in endothelial cells through both Rho-actin and MEK-ERK dependent signaling pathways.
- Low VEGF CSF levels in ALS patients during the 1st year of the disease, independent of promoter polymorphism, suggests a possible role for VEGF gene regulation in the pathogenesis of ALS.
- activin A is a novel stimulus of vascular endothelial growth factor gene expression in hepatocellular carcinoma
- findings suggested that quantitative and qualitative changes in vascular endothelial growth factor expression are present in type 2 diabetic patients with nephropathy
- IGF-II enhances the expression of VEGF in HaCaT cells by increasing HIF-1alpha levels.
- VEGF may play a minor role in immediate bronchoconstriction in chemically-induced asthma
- VEGF-induced MM cell proliferation and survival are mediated via Mcl-1; VEGF up-regulates Mcl-1 expression in a time- and dose-dependent manner in 3 human MM cell lines and MM patient cells
- Sp1 and VEGF may have roles in the progression of gastric neoplasms
- THBS 1 and VEGF are proangiogenic factors that stimulate angiogenesis in hepatocellular carcinoma
- Percentages of nodules with VEGF-positive tumor and sinusoidal cells were low in primary lesions of the control and metastasis groups, while high in metastatic lesions in the metastasis group.
- No correlation was found between renal function, circulating vascular endothelial growth factor levels and metabolic control in diabetes in association with hypertension
- COX-2 plays a key role in VEGF production in gastric fibroblasts stimulated by IL-1 in vitro, and angiogenesis induced by the COX-2-VEGF pathway might be involved in gastric ulcer healing.
- VEGF-A does not have a functional role in preventing the early onset of senescence
- EGFR, c-erbB-2, VEGF and MMP-2 and MMP-9 play an important role in tumor growth, invasion and metastasis in squamous cell carcinoma of the head and neck
- The effect of VEGFA on the expression of its tyrosine kinase receptors followed by activation of a neuropilin-1-dependent signaling pathway was studied in bone marrow cells.
- An intense expression of VEGF and MMP-9 in carotid plaques is related to plaque instability, high degree of stenosis and presence of symptomatic carotid occlusive disease.
- DSCR1 induced by VEGF in endothelial cells plays role in angiogenesis by regulating cell migration and cell adhesion.
- VEGF165, produced by tumor cells, acts as an autocrine survival factor and that SEMA3B mediates its tumor-suppressing effects, at least in part, by blocking this VEGF autocrine activity.
- VEGF mRNA expression levels seem to be directly associated with VEGF functions at the protein levelin breast cancer, whereas this seems not to be the case for CD105 (endoglin) mRNA levels.
- Use of PKC agonists and isozyme-specific pseudosubstrate peptide antagonists suggested a role for PKCalpha and -epsilon in VEGF-mediated DAF up-regulation, mediating A cytoprotective pathway in ECs.
- vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway
- Although differences may exist in CD and capillary-to-fiber area ratio between lean and obese skeletal muscle, the present results provide evidence that VEGF and VEGF receptor expression are not different between lean and obese muscle.
- Elevated maternal serum levels of VEGF, as early as 11 days after embryo transfer, are associated with ectopic pregnancies after in vitro fertilization.
- Expression of VEGF is significantly correlated to the malignant biological behaviors of gastric carcinoma
- Increased VEGF level is an important parameter in lung cancers.
- Nondiabetic patients had higher HIF-1alpha and VEGF expressions in myocardium compared with diabetic patients (P < 0.001).
- Plasma VEGF may be useful in predicting treatment response, monitoring disease course after chemoembolization therapy and judging the effect of different regimens in hepatocellular carcinoma.
- carriers of -634C and I alleles are associated with susceptibility to developing Behcet's disease
- Interaction of VEGF with nephrin in cultured human podocytes reduces apoptosis.
- Sp1 has a role in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism
- Regulation of endothelial exocytosis may explain part of the proinflammatory effects of VEGF
- Endothelin-1-induced prostaglandin E2-EP2 and EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion
- results indicate that transforming growth factor TGFbeta1 treatment may regulate angiogenesis in pituitary cells by initially increasing levels of pro-angiogenic growth factor VEGF-A and then stimulating anti-angiogenic thrombospondin -1 and 2 levels
- VEGF increased cAMP-hydrolytic activity by up-regulating the expression of PDE2 and PDE4 isozymes
- Results show that Down syndrome critical region 1 (DSCR1) is greatly induced in endothelial cells in response to VEGF
- Follicular blood flow may be a more effective prognostic marker of the pregnancy outcome of IVF than follicular fluid VEGF or NO concentrations.
- VEGF is the angiogenic factor responsible for the implantation and placentation of an ectopic pregnancy in the fallopian tube.
- mRNA and protein expression of vascular endothelial growth factor were upregulated in a hypoxic condition.
- VEGF and thymidine phosphorylase expression was also associated with a significantly higher level of Cyclooxygenase-2, as well as greater intratumoral microvessel density
- Data suggest that vascular endothelial growth factor expression is inhibited via degradation of hypoxia-inducible factor-1alpha through interference with the function of heat shock protein 90.
- Ang1 regulates Glioblastoma Multiforme (GBM) vascularity in a VEGF-A dependent manner, synergizing the initial pro-angiogenic response that is triggered by VEGF-A and promoting the vascular growth of GBM.
- Data show a positive relationship between vascular endothelial growth factor expression and hemorrhage in pituitary adenoma.
- High intensity focused ultrasound can destroy VEGF in experimental melanoma.
- inactivation of PTEN gene and over-expression of VEGF contribute to the neovascularization and progression of gastric cancer
- novel nonhypoxic regulation of VPF/VEGF-A production in the glomerulus of the kidney during physiologic states
- findings underline the frequent expression of vascular endothelial growth factor (VEGF) in advanced-stage multiple myeloma (MM) and the absence of prognostic importance
- VEGF and its receptor, KDR, genes contributed to the development of coronary artery lesions in Kawasaki disease patients.
- Hypoxia increased both VEGF secretion and number of cells containing VEGF and thymidine phosphorylase.
- Direct injection of VEGF into the mouse ovary results in the development of an enhanced vascular network promoting follicular development and diminishing apoptosis.
- VEGF and HIF-1alpha expression are inhibited by SU5416 through the inhibition of PI3K/AKT/p70S6K1 pathway in ovarian cancer cells
- HIF-1alpha expression resulted in increased VEGF expression and the HIF-1alpha/VEGF pathway operates in angiogenesis in chondrosarcoma
- Intravascular human VEGF gene transfer enhanced angiogenesis in the adventitia but did not reduce neointimal formation in rabbits.
- Recombinant human VEGF overexpression in mice accelerated reendothelialization & increased luminal endothelial cell proliferation after arterial injury, resulting in decreased neointima formation.
- VEGF increases vascular permeability, which in turn causes pleural effusions.
- We concluded that VEGF is highly expressed in localized NE cell proliferations without potential of malignancy and might participate in local development of fibrosis.
- VEGF attenuates TGF-beta action in the human endothelial cell, specifically at the level of transcription of PAI-1 gene and Smad2/3 phosphorylation
- The Vascular endothelial growth factor (VEGF)were expressed by prostate cancer cells in vitro and by prostate tumors in vivo and their expression was elevated at sites of bone metastasis compared to original prostate tumor.
- the circulating thrombospondin 1/VEGF balance is diminished in cancer patients
- During tumour progression there is a change in the relative amounts of soluble VEGF-A receptor FIt-1 and VEGF-A in the circulation.
- IL-12-positive cell density tended to be inversely correlated with plasma levels of VEGF in gastric cancer.
- To determine whether VEGF may play a role in the recurrence of nasal polyps
- effect of VEGFA and PLGF on gene expression profiles obtained for HUVEC, dose effect, and variability between cells obtained from different individuals
- expression was up-regulated in colorectal adenocarcinomas; T-1498C (G-1190A) and C-7T were associated with higher levels of VEGF mRNA, and may be a risk factor for the development of liver metastasis and/or prognosis of colorectal adenocarcinoma
- 17beta-E2 also induces VEGF-A mRNA expression in ER-negative and ER-positive tumor cell lines, with a variant ER-alpha(var2) acting as active receptor in ER-negative cells.
- Endostatin diminishes the levels of nitric oxide (NO) whereas NO donors enhanced VEGF expression and collagen XVIII expression.
- adenovirus (Av)Bv8 or AvEG-VEGF delivered just before 5-fluorouracil injury promoted the survival of hematopoietic cells and enhanced progenitor mobilization
- effects of DNA-binding small molecules on hypoxia-inducible transcription of VEGF
- Plasma levels in type 2 diabetes are selectively elevated in patients with diabetes and are associated with indexes of endothelial damage/dysfunction.
- Intracerebroventricular delivery of recombinant Vegf in SOD1(G93A) rat model of amyotrophic lateral sclerosis(ALS) delays onset of paralysis, improves motor performance and prolongs survival. Largest effects achieved by protein delivery.
- VEGF is a potential therapeutic target because VEGF is expressed in renal cell carcinoma and associated cell populations such as endothelia and monocytes/macrophages.
- Increased microvascular density in penetrating gastric carcinomas has an intimate causal relationship to high VEGF expression.
- Myc stimulates VEGF production by a rapamycin- and LY294002-sensitive pathway.
- a VEGF-dependent autocrine loop mediates proliferation and capillarogenesis in bone marrow endothelial cells of patients with multiple myeloma
- VEGF functions as an important regulator and key protein of angiogenesis, even in Hereditary hemorrhagic telangiectasia
- Hepatocyte growth factor/scatter factor appears to activate cellular pathways inducing release of VEGF
- It was concluded that elevated FF-leptin and VEGF levels are associated with failure of conception in IVF cycles and may serve as markers in clinical practice.
- role of VEGF in patients with dengue hemorrhagic fever
- VEGF 936C>T polymorphisms had a major impact on 18F-FDG uptake in breast cancer patients.
- We found statistically significant lower levels of vascular endothelial growth factor in patients with BRCA1 gene mutation as compared with breast cancer patients without this mutation.
- VEGF and sFLT-1 can actively take part in the pathogenesis of diabetic nephropathy
- These data support the involvement in melanoma growth and survival of a VEGF-dependent internal autocrine loop mechanism, at least in vitro.
- bone marrow expression in myelofibrosis with myeloid metaplasia
- VEGF may have a role in the development of sepsis-associated capillary leak
- ET-1 from the microvascular endothelium is inhibited by vascular endothelial growth factor and does not have a role as a growth factor in human benign prostatic hyperplasia
- Transforming growth factor-beta1 stimulation of VEGF production by fibroblasts is regulated by Smad3 but not by Smad2 signaling
- The VEGF expression, as a marker of angiogenesis, was evaluated in myomas obtained after surgery.
- The higher expression of isoform VEGF165 mRNA in noncancerous liver remnant of patients with hepatocellular carcinoma may be a significant biological indicator of the invasiveness of postoperative recurrence.
- Patients with high postoperative VEGF-A should be scanned for metastases in colorectal cancer.
- AMPK has a major role in the post-transcriptional regulation of VEGF and a potential role in tumor angiogenesis
- there does not appear to be a clear relationship between VEGF expression and progression of breast cancer
- Increased free plasma VEGF on ascent to altitude is associated with acute mountain sickness (AMS) and may play a role in pathophysiology of AMS.
- higher serum levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) in polycystic ovary syndrome (PCOS) women may be related to the increased vascularity that underlies the increased ovarian blood flow
- Our study, reflecting both VEGF-A ligand and receptors, implicates metabolic perturbation as a regulator of human muscle angiogenesis.
- results provide a molecular cascade showing nitric oxide-Heme oxygenase(HO)-1-vascular endothelial growth factor (VEGF)-interleukin-8 sequence in human endothelial cells
- The VEGF is binding to VEGF receptors upon the surface of HUVEC.
- TFF3 and the essential tumor angiogenesis regulator VEGF(165) exert potent proinvasive activity through STAT3 signaling in human colorectal cancer cells.
- VEGF-C as well as VEGF-A may be involved in the pathogenesis of ovarian endometrioma.
- expression is regulated by fatty acid synthase and hypoxia-inducible factor-1alpha in cancer cells overexpressing her-2/neu oncogene
- VEGF is overexpressed in a significant number of uveal melanomas but has no obvious correlation with disease status
- autocrine VEGF as an important mediator of the antiapoptotic effect of CD40 ligation, and thus provide new insights into CLL-cell rescue by CD154 in lymphoreticular tissues.
- Over-expression of VEGF may be correlated with elevated STAT3 activation in parental cell line
- High expression of VEGF-A was associated with early-stage prostate cancer.
- Surrounding stromal cells activity correlates strongly and positively with VEGF mRNA expression in lung cancer.
- in vivo EPO does not affect the functionality and/or production of components of the VEGF/Flt-1 system in diabetics with normal or reduced renal function
- KSHV-infected cell lines expressed higher levels of B-Raf and VEGF-A; B-Raf-induced VEGF-A expression was demonstrated to be sufficient to enhance tubule formation in endothelial cells
- Recombinant protein treatment of coturnix embryos caused an increase in the population of newly gastrulated mesodermal (NGM) cells.
- induced by Rhinovirus infection of primary human airway fibroblasts
- estrogen-dependent vascular endothelial growth factor (VEGF), especially VEGF165, and basic fibroblast growth factor(bFGF) might work on growth via angiogenesis in the human placenta throughout all trimesters of gestation
- VEGF and alpha4beta1 integrin have roles in chemokine-induced motility on and through endothelium in chronic lymphocytic leukemia cells but not in normal B lymphocytes
- The vegf of two polymorphisms(-2578A/A and -1198C/T) within the promoter region of the VEGF gene confer greater risk for Alzheimer's disease.
- HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE regulate Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
- VEGF may play an important role in the angiogenesis and prognosis of hepatocellular carcinoma, as well as in the angiogenesis of liver cirrhosis.
- Combined effects of uric acid and ascorbic acid on the expression of VEGF in umbilical vein endothelium.
- The -460T/+405C haplotype in the VEGF gene, which is associated with lower promoter activity, was significantly less common in women with endometriosis than in controls.
- crucial role in the development of coronary artery disease
- In the development of esophageal varices in portal hypertensive rats, increased TNF-alpha and VEGF may be not an early event, and probably play a role in weakening the esophageal wall and the rupture of esophageal varices.
- bFGF, but not VEGF, may havea role in systemic hypoxia and anemia in solid tumor patients
- Important role in maintaining tissue integrity. We confirmed ischemic crisis in ischemic colitis at molecular level, demonstrating overexpression of HIF-1 alpha and VEGF in ischemic lesions. May play important role in pathophysiology of ischemic colitis.
- did not detect any mutations in the regulatory or coding regions of VEGF in amyotrophic lateral sclerosis
- angiogenesis develops early in lung carcinogenesis and is associated with overexpression of VEGF
- Dual high expression of stromelysin 3 and VEGF is associated with progression from precancerous to cancerous state in oral cancers
- TNF-alpha, VEGF, and the ECM regulate extravillous trophoblast behavior, including cell survival and endovascular differentiation, through integrin signaling during establishment and maintenance of successful human pregnancies.
- Mediates murine hepatocellular carcinoma and angiogenesis when transfected into mice.
- the -1154G/A VEGF gene polymorphism is associated with idiopathic recurrent abortions
- High production of VEGF and low production of IL-18 by polymorphonuclear leukocytes of cancer patients may promote neoangiogenesis and may be important for benign tumour cells to acquire metastatic phenotype in the early stage of oral cavity cancer
- Suggest that HIF-1alpha induces VEGF/ET-1/iNOS during gastric ulcer healing.
- High expression of VEGF-A stimulated bone mineralization
- Targeting the release of VEGF from tumor epithelial cells as well as blocking interactions between VEGF and VEGFR-2 on both endothelial and tumor epithelial cells may facilitate the development of antiangiogenic therapies for breast tumors.
- CA IX and GLUT 1 as well as VEGF and IL 6 have roles in response of in head and neck squamous cell carcinoma to radiotherapy +/- chemotherapy
- Data supports the cyclooxygenase-2/prostaglandin E2/hypoxia-inducible factor-1alpha/vascular endothelial growth factor pathway possibly contributing to tumor angiogenesis in gastric carcinoma.
- VEGF expression may play an important role in the development of both invasive and intraductal carcinoma components, especially those carcinoma components of less aggressive histological features.
- Recombinant human protein prevents liver ischemic reperfusion injury in mice.
- Homozygote recipients for the -2578 A allele, the low producers of VEGF, are more vulnerable to tissue injury, resulting in worse kidney graft survival.
- The VEGF concentration was several hundred fold higher in the hematoma fluid than in corresponding plasma samples. A significant correlation was found between the number of neutrophils and the VEGF content in the hematoma fluid.
- This suggests that the 180 aa ORF is involved in VEGF-mediated angiogenic processes.
- Upregulation of Id-1 induced VEGF secretion through activation of the VEGF gene transcription in prostate cancer.
- role for Npn-1 in regulating endothelial barrier dysfunction in response to VEGF.
- HIF-1alpha and CA IX, but not VEGF or MMP-9, may have a role in progression of surgically resected non-small cell lung cancer
- When transplanted to the kidney capsule of diabetic mice, insulin promoter rat insulin promoter VEGFislets significantly enhanced microvascular density and functional blood flow to the graft compared with controls.
- Increased VEGF levels in blood is associated with non-small cell lung cancer
- These results show that VEGF and VEGFR expression in various types of brain tumors differ and are not necessarily parallel.
- HHT is an angiogenic disorder characterized by an over-expression of VEGF, TGF-beta1 and ALK1
- confirm the basic role of VEGF in the angiogenic development of prostate carcinoma
- VEGF C-634G polymorphism is a genetic risk factor for macular edema as well as diabetic retinopathy
- PGE2 increases VEGF transcriptionally and involves the Sp-1 binding site via a cAMP-dependent mechanism involving EP2 and EP4 receptors
- This finding suggests that eNOS and VEGF may have cooperative effect in tumor angiogenesis and play an important role in the pathogenesis of primary astrocytoma.
- the VEGF +405 C/G polymorphism may be associated with the risk of advanced stage endometriosis in the Korean population
- induced endothelial cell migration and proliferation under certain circumstances
- Furthermore, by using DCs derived from Id1(-/-) mice that are defective in Flt-1 signaling, we demonstrated that the inhibitory function of VEGF on DC function is most likely mediated by Flt-1.
- These findings are consistent with the idea that the chemotactic effect of VEGF-A on MPC is mediated via VEGFR-1, and that VEGF-A and PlGF-1, have a functional role for recruitment of osteoprogenitor cells.
- expression is mediated by cyclin A1 in cooperation Rb- and androgen-dependent pathways in prostate cancer
- VEGF may contribute to the neovascularization and proliferation of the placenta and gestational tissue, and EGF may play an important role in regulation of VEGF production in the placenta
- resting VEGF protein and the VEGF mRNA response to exercise are lower in aged compared with young women
- VEGF may play a role in melanocyte behavior in skin
- tumor-upregulated VEGF and angiogenic-activated microvasculature are relevant guidance signals for neural stem cell tropism toward brain tumors
- Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor.
- dynamin-2 regulates KDR expression and function and hence plays an important role in VPF/VEGF mediated angiogenesis
- Increased expression of VEGF-A and VEGF-C was found in tumor tissues compared to normal epithelium
- VEGF inhibits PDGF-stimulated total calcium influx and, in particular, PDGF-stimulated intracellular calcium release in vascular smooth muscle cells
- CXCR4 may contribute to the high level of VEGF produced by malignant glioma cells
- High VEGF is associated with peritoneal metastasis from gastric cancer
- IL-8 is responsible for tumor progression and liver metastasis of colorectal cancer(CRC), and activation of plasminogen activator system induced by IL-8 and VEGF may play important role in progression of CRC.
- bacterial antigen-induced changes in soluble VEGF may be related to the number of circulating neutrophils
- VEGF acts in an autocrine manner in rhabdomyosarcoma cell lines and can be inhibited with tretinoin.
- VEGF gene increased risk of Alzheimer's disease.
- Aspirin-triggered Lipoxin A4 inhibits VEGF-induced endothelial cell migration through actin polymerization and focal adhesion assembly
- VEGF gene polymorphism plays and important role in the development of severe ischemic manifestation of giant cell arteritis.
- VEGF may regulate epithelial ovarian cancer invasion and migration through VEGFR-mediated secretion and activation of matrix metalloproteinases
- Src activity contributes to constitutive and EGF-induced VEGF expression and angiogenic potential in pancreatic cancer cells
- These results confirm that skeletal muscle capillarization and VEGF expression are lower in aged compared with young men.
- Up-regulation of VEGF-A in capillaries in menorrhagia could be involved in abnormal endometrial vascular structure and permeability.
- HIF-1alpha accumulation and VEGF expression could be modulated by the antioxidant enzyme MnSOD.
- stimulation of VEGF production by lysophosphatidic acid in peritoneal mesothelium might have an important role in the growth of cancer cells disseminated in the peritoneal cavity
- VEGF 121 isoform, which has an exclusive ability to cause hyperpermeability of blood vessels, was predominantly detected in psoriatic scales
- The lack of correlation between VEGF and HIF-1alpha expression suggests HIF-independent VEGF production in IgA nephropathy
- Angiogenesis in keloids is promoted by endogenous TGF-beta1 and VEGF.
- The helix region 17-25 of VEGF is involved in VEGF receptor activation.
- expression may be regulated in part through ERK/MAPK and PI3K pathways
- the cell-associated isoform of VEGF (VEGF189), but not the soluble isoform (VEGF121 and VEGF165) appears to play important role in tumour progression
- VEGF may play a critical role in the development and progression of diabetic retinopathy.
- VEGF assessed immunohistochemically from preirradiation tumor biopsies may be a useful marker of rectal tumor response to preoperative radiotherapy.
- An immunohistochemical analysis of VEGF in pituitary adenomas was made.
- show that 120 protein spots in a 2-D gel analysis were affected during vascular endothelial growth factor-A-induced endothelial cell tubular morphogenesis in vitro, as a result of changes in charge or expression level of the corresponding proteins
- Evidence that specific G-quadruplex structures can naturally be formed by the G-rich sequence within the polypurine/polypyrimidine tract of the human VEGF promoter region.
- The expression of VEGF was related with tumor angiogenesis.
- Lytically induced VEGF secretion may potentially contribute to viral pathogenesis in lymphoblastoid cell lines.
- Blockade of either VEGF or its receptors with neutralizing antibodies significantly reduced cell viability and increased apoptosis levels of the VEGFR-positive thyroid tumour cell line.
- The detailed angiogenic profile of VEGF in chronic myeloid leukemia may help in developing new therapeutic strategies for this myeloproliferative disorder.
- Ganoderma lucidum Polysaccharide Peptide induces VEGF in lung cancer cells.
- Advanced glycation end products up-regulate VEGFR-2 and decrease heparan sulfate proteoglycan sites, and might participate in blocking glomerular angiogenesis
- androgen receptor is involved in VEGF and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer
- serum vascular endothelium growth factor is elevated in adrenocortical cancer and aldosterone-producing adenoma
- Significantly higher level of VEGF in breast tissue of premenopausal women was found.
- MCP-1 and M-CSF, critical for monocyte recruitment, activation, and differentiation, differentially regulate VEGF-A expression and may play an important role in monocyte/macrophage- mediated tumor angiogenesis
- Mechanically induced VEGF is involved in the destruction and endostatin in the maintenance of avascular tissues of the bone and joint system. (review)
- the up-regulated VEGF and angiogenesis in tissue from women with endometriosis may reflect failure of neutrophil differentiation
- Results suggest that VEGF induced by hyperbaric oxygen is through c-Jun/AP-1 activation, and through simultaneous activation of ERK and JNK pathways.
- conclusion, we found that VEGF -2578/-1154/-634 haplotype impacts VEGF gene expression in human myoblasts and is associated with Vo2 max.
- PPARalpha activators LY-171883 and WY-14,643 were able to diminish transcriptional induction of COX-2 and VEGF by inhibiting AP-1 (activator protein-1)-mediated transcriptional activation.
- the heparin binding domain of VEGF provides the binding site for the aptamer and is the primary determinant for the affinity and specificity in the VEGF(165)-aptamer complex
- The VEGF level was detected in endometrial stromal cell culture media and was increased significantly when E2 or MCP-1 was added to the media, especially in the presence of E2 plus MCP-1.
- These data suggest that LRP6, VEGF, and VLDLR may play a role in the risk of developing (age-related macular degeneration)AMD.
- Genotype-dependent regulation of VEGF was demonstrated in psoriasis.
- VEGF plasma concentrations were significantly higher in patients with cerebral arteriovenous malformations (AVMs) than controls; findings suggest that VEGF plasma concentrations might play a role in the pathogenesis of cerebral AVMs
- The Vascular Endothelial Growth Factor is expressed in bone marrow cells in patients with myelodysplastic syndromes(MDS).
- differential regulation of human telomerase reverse transcriptase and VEGF in p63-positive breast carcinomas may contribute to the clinically more aggressive behavior of these neoplasms
- VEGF, extracellular matrix, and intracellular motor protein MyH9 are all essential for the novel function of nucleolin in angiogenesis.
- REVIEW: this paper describes the unbalanced expressions of VEGF and PEDF as a cause of CNV
- NFkB has a role in VEGF signaling in endothelial cell survival
- The reduction in vegf expression seen in amyotrophic lateral sclerosis.
- The IGF-I-mediated phosphorylation and inhibition of PARP represent a novel mechanism of VEGF protein expression.
- Polymorphism of VEGF gene is associated with susceptibility for chronic renal failure in male patients.
- the VEGF system is integrated into the p53 transcriptional network by an SNP in the flt-1 promoter
- Local delivery of VEGF(165) gene into the outer compartments of balloon-injured porcine coronary arteries reduced lumen area loss due to distinct positive remodeling (arterial enlargement).
- Results demonstrate that a post-transcriptional mechanism contributes to VEGF gene expression in activated macrophage cells.
- VEGF 121 isoform that exclusively induces hyperpermeability of blood vessels was a predominant component in the lesional scales suggesting that this factor plays an important role in the persisting erythema and edema in the atopic dermatitis lesions
- Rhinovirus infection induces VEGF production in bronchial epithelial cells and airways, an effect enhanced in an atopic environment; Rhinovirus-associated, VEGF-mediated angiogenesis may contribute to airway remodeling in asthma
- VEGF expression was associated with a significantly higher level of microvessel density and might play a proangiogenic role in cholangiocellular carcinoma.
- The VEGF-A expression was associated with MVD in univariate analysis, however, it was not an independent factor.
- Immunoreactivity of VEGF, p53 and ICAM-1 was found in epithelial, fibroblast and vascular endothelial cells.
- data show a positive interrelation between high circulating VEGF levels, the number of tumor-associated macrophages, and p53 overexpression, a relationship that might have an important role in the enhanced angiogenesis processes in breast cancer
- cultured mouse podocytes produce ROS in response to high glucose, and PKC is involved in high-glucose-induced ROS and VEGF production by podocyte.
- results suggest that vascular endothelial growth factor (VEGF) is closely related to organ dysfunction in severe acute pancreatitis, and that VEGF may function as a protective factor via the anti-apoptotic effect against the organ injuries in this diseas
- Results suggest that the p53-VEGF pathway can regulate tumor angiogenesis in human gallbladder carcinoma.
- Under hypoxic conditions, the ANG and VEGF secreted by renal proximal tubular epithelial cells may modulate angiogenesis and vascular remodeling in the renal interstitium via an increase in the production of HIF-1
- Thymosin beta10, but not thymosin beta4, have direct inhibitive effects on endothelial migration and tube formation that might be mediated via downregulation of VEGF, VEGFR-1 and integrin alphaV in HCAECs.
- These results demonstrate the presence of an insulin-like growth factor-1 regulated VEGF autocrine loop in head and neck squamous cell carcinomas.
- A protective role of VEGF in the development of type 1 diabetes was proposed.
- This study describes the first specific antagonist of VEGF-A165 binding to NP-1 and demonstrate that NP-1 is essential for optimum KDR activation and intracellular signaling.
- bone morphogenetic protein 4 may play a role in the regulation of ocular angiogenesis associated with diabetic retinopathy (DR) by stimulating VEGF release from retinal pigment epithelial cells
- Increased VEGF in ovarian cancers ascitic fluid may have an important role in its peritoneal spread and be a prognostic factor.
- These results show that AICAR and insulin/IGF-1 regulate VEGF expression through different mechanisms.
- We conclude that IL-6 triggers VEGF-induced angiogenic activity through increasing VEGF release, up-regulates KDR expression and phosphorylation through activating ERK1/2 signaling, and stimulates MMP-9 overexpression.
- Results suggest that carriers of VEGF(+405)G allele have a decreased susceptibility to pre-eclampsia (PE) and that the progression of PE may be modified by the presence of VEGF(-2578)A allele.
- Blood levels are usesful in the prognosis of antiviral treatment of chronic hepatitis C.
- Rsults suggested that VEGF expression in the primary site had predictive value for the osteosarcoma patients, who developed lung metastasis.
- High mFlt-1/VEGF tumor showed a significantly lower microvessel density and patients with high mFlt-1/VEGF tumor had a significantly favorable survival.
- VEGF and Ang-2 may have roles in microvessel growth in invasive ductal carcinoma of the breast
- Normal amounts of BRCA1 function in hypoxia to regulate HIF-1alpha stability, probably by interacting with HIF-1alpha, leading to reduced levels of VEGF.
- there is an alternative mechanism for the hypoxic induction of VEGF in colon cancer that does not depend upon HIF-1alpha but instead requires the activation of PI3K/Rho/ROCK and c-Myc
- Human VEGF165 gene delivery exerts a marked beneficial action by enhancing both arteriologenesis and cardiomyocyte viability in infarcted myocardium.
- Heme oxygenase-1 is involved in hemin-induced VEGF expression in human keratinocytes & may play a role in hypoxic regulation of this protein. HO-1 overexpression may be beneficial in restoring the proper synthesis of VEGF disturbed in diabetic conditions
- The current study does not demonstrate an association between VEGF (-2578) and VEGF (-634) genotypes or haplotypes and Alzheimer disease.
- VEGF gene and allele associations may be associated with increased risk of congenital vulvuloseptal heart defects.
- Intracellular calcium and membrane potential are influenced by several key signaling cascades of VEGFR-2 activation in human umbilical vein endothelial cells.
- Fndings suggested some interaction among -1154G/A, -7C/T, and 13553C/T variants in the determination of risk for vascular dementia.
- the concentration of VEGF-A was significantly reduced in the women with menorrhagia, as was the VEGF-A mRNA level.
- Overexpression of VEGF was associated with sentinel lymph node micro-metastasis in breast cancer patients
- endothelial VEGF expression is upregulated by 100% after administration of Tenilsetam [(+/-)-3-(2-thienyl)-2-piperazinone]
- An elevated VEGF level in peripheral blood was a risk factor for subsequent development of cardiovascular disease in urology patients.
- Tumor-shed membrane vesicles carry VEGF and release it in a bioactive form in conditions typical of the tumor microenvironment to facilitate tumor angiogenesis
- VEGF and HIF-1alpha are elevated in malignant gliomas. HIF-1alpha inhibition results in VEGF secretion inhibition.
- -2578C and -1154G VEGF alleles are associated with increased risk for invasive but not in situ breast cancer in postmenopausal women.
- Simultaneous up-regulation of sFlt-1 secretion by these cells under hypoxic conditions may prevent excessive up-regulation of vascular permeability.
- The production of and expression of VEGF from leukemia cells and its involvement in the pathogenesis of T-cell prolymphocytic leukemia.
- the Rho-ROCK signal pathway contributes to VEGF-induced hyperpermeability. Myosin light-chain phosphorylation and actin stress fiber formation occur concomitantly with the increase in permeability upon VEGF stimulation.
- Polymorphisms in the 5' UTR and promoter region of VEGF could be regarded as a major genetic risk factor for diabetic retinopathy.
- VEGF as an important effector for 12-lipoxygenase-mediated stimulation of tumor angiogenesis
- This study shows that expression of vascular endothelial growth factor messenger ribonucleic acid can be detected from the oocyte to the blastocyst stage.
- VEGF regulates MMP-9 expression and plays a critical role in initiation and maintenance of asthma.
- Patients with normal gonadotropin responses who were undergoing IVF demonstrated increased VEGF production to glycodelin, whereas poor responders had a decreased response to glycodelin.
- Immunohistochemical staining showed that VEGF were expressed in epithelial, stromal and endothelial cells.
- PAR2 signaling through MAPK pathways leads to the production of proangiogenic VEGF in breast cancer cells.
- In colorectal cancer, CXCR4 triggers stimulation of clonogenic growth and induction of VEGF release.
- In this study, we demonstrate that 1121B Fab is able to strongly block KDR/VEGF interaction, resulting in potent inhibition of an array of biological activities of VEGF, including activation of the receptor and its signaling pathway.
- NF-kappaB-dependency of the platelet-activating factor -induced increase in VEGF expression is due to decreased p53 activity, which is reciprocally regulated by increased NF-kappaB activity.
- Gene expression data suggest that pharmacologic inhibition of COX-2 and VEGF may be useful adjuncts in targeted therapy for esophageal adenocarcinoma.
- Overexpression of VEGF but not PlGF exacerbated the lipopolysaccharide-mediated toxic effects, supporting a pathophysiological role for VEGF in mediating the sepsis phenotype
- Central mechanism for PEDF inhibition of the AGE signaling to vascular permeability is by suppression of NADPH oxidase-mediated reactive oxygen species generation and subsequent VEGF expression.
- progenitor cells are potent sources of VEGF, HGF, and IGF-I
- there is no association between the three selected functional VEGF polymorphisms and systemic sclerosis
- VEGF and VEGFR-2 may have a role in progression of gastric cancer
- Estimated systolic pulmonary artery pressure and plasma concentrations of endothelin-1 and VEGF are increased in patients with Chuvash polycythemia.
- In human astrocytic gliomas, VEGF-A was significantly up-regulated in high-grade vascularized gliomas. Moreover, VEGF-A expression significantly correlated with microvessel density and tumour grading.
- VEGF polymorphism is associated with breast cancer
- p110alpha and AKT1 play an important role in tumor growth by inducing angiogenesis and by increasing VEGF expression. This work provides a better understanding of the molecular mechanism of human cancer induced by the activation of PI3K signaling.
- results show that in both tumor and fibroblast cells EMMPRIN regulates VEGF production via the PI3K-Akt pathway but not via the MAPK, JUN, or p38 kinase pathways
- In artery samples in diabetic patients relative to nondiabetic patients, capillary density was reduced to 30%, VEGF expression was reduced by 48%; the expression and the gelatinolytic activity of MMP-2 and -9 were upregulated.
- Deciphering the precise role of VEGF at the neurovascular interface promises to uncover new insights into the development and pathology of the nervous system, helpful to design novel strategies to treat (motor) neurodegenerative disorders.
- microvessel density and VEGF expression do not appear to play a critical role in osteosarcoma
- Our findings point towards the involvement of excitotoxicity, VEGF and NO in periventricular white matter damage in response to hypoxia
- Tumors that constitutively express VEGF-A present with different vascular beds than tumors in which VEGF-A is expressed as a response to central hypoxia.
- VEGF-A influences the balance between development of blood and lymphatic vasculature during lung organogenesis
- Incubation of pulmonary microvascular endothelial cells with VEGF resulted in dose- and time-dependent increases in calpain activity and protein content of calpain-2.
- PTHrP, TGF-beta1, and VEGF expression was significantly altered and indicated degenerative changes in Kashin-Beck disease cartilage
- VEGF, FGF2, TGFB1, EGF and IGF1 have roles in the development of both prostate cancer and benign prostatic hyperplasia
- Effect of culturing bone-targeted, metastatic C4-2B prostate cancer cells and bone stromal derived cells under hypoxic conditions on expression of vascular endothelial growth factor family members.
- Dominant Ang-2 expression against Ang-1 through Tie2 receptor in the presence of VEGF plays a critical role in initiating early neovascularization and transformation of noncancerous liver to hepatocellular carcinoma.
- REVIEW: The binding of VEGF-A to VEGFR-2 causes receptor dimerization, kinase activation and autophosphorylation of specific tyrosine residues within the dimeric complex.
- overexpression of VEGF, its receptors flt-1, KDR/flk-1 and TGF-beta interaction may play an important role in the ovarian cancer biology, with potential effects on tumor growth and angiogenesis
- iodide at high concentration decreases the expression of the angiogenic factors VEGF-A, VEGF-B, and PG
- In this review we critically analyze the data supporting the notion that VEGF is a factor involved in motor neuron degeneration and review the studies linking VEGF to other diseases of the peripheral and central nervous systems.
- VEGF is involved in the pathogenesis of MM, and VEGF may differentially affect a subset of plasma cells.
- The prevalence of VEGF(-2578) "A" allele was lower in preterm boys with severe ROP (stages 4-5) than in those without or with mild ROP (stages 1-3).
- Senescent cells may facilitate age-associated cancer development by secreting factors that promote malignant progression.
- The effect of 2-oxoglutarate on the production of erythropoietin and vascular endothelial growth factor (VEGF), was examined.
- VEGF may be one of the key mediators that lead to lobar pneumonia and parapneumonic effusion.
- co-expression of vascular endothelial growth factor and interleukin-1 receptor antagonist can improve the outcome of islet transplantation better than either gene alone
- Genetic variations in VEGF may predict not only prostate carcinoma risk but also tumor aggressiveness.
- VEGF-induced endothelial cell migration involves vascular endothelial-cadherin tyrosine phosphorylation mediated by Src kinase on Tyr685.
- Data suggest that creeping fat is an important source of VEGF secretion, and that the characteristics of inflammatory changes in Crohn's disease might be due to the lack of VEGF downregulation that is seen in diverticulitis.
- perlecan secreted by VEGF165-stimulated endothelial cells may be involved in the regulation of cellular behavior during angiogenesis
- There are associations between sudden infant death syndrome and particular polymorphisms.
- Expression of HIF-1alpha and HIF-2alpha are both necessary for VEGF expression in renal call carcinoma cells.
- VEGF, in addition to targeting angiogenesis, may also target tumor cells directly
- VEGFR-2 expressed on HaCaT cells plays a crucial role in VEGF-mediated regulation of cell activity
- evidence of VEGF production in cutaneous T-cell lymphoma, which is promoted by aberrant activation of Jak3 and the JNKs
- ANG is one of the neovascularization factors of gastric carcinoma and may work in coordination with VEGF, and promote the proliferation of gastric carcinoma cells
- case-control study where 45 individuals with neovascular age-related macular degeneration and 94 age-matched controls were genotyped for 14 single nucleotide polymorphisms (SNPs) in the VEGF promoter and gene
- In conclusion, the results demonstrate that NOX3, a reactive oxygen species generating NADPH oxidase, plays an integral role in insulin-induced p42/44 Mitogen-activated protein kinase signal transmission and VEGF-A production.
- Endometrial transplants from patients with endometriosis express more VEGF and MMP-2 than endometrium in control women. VEGF and MMP-2 may expedite formation of endometriosis in its early stage.
- vascular endothelial growth factor and its receptors are inhibited in pulmonary adenocarcinoma cell by TNP-470 in combination with gemcitabine
- VEGF may play an important role in the development of interstitial fibrosis via mononuclear cell-induced cytokine production chronic kidney graft rejection.
- Increased serum levels of VEGF is associated with advanced stage non-small cell lung cancer
- c-myc and VEGFA may be involved in the regulation of angiogenesis in esophageal adenocarcinoma
- VEGF-A destabilizes atherosclerotic plaques through an angiogenesis-independent mechanism. VEGF-A induced a differential expression of VCAM-1 & PECAM-1 in endothelial cells.
- HO-1 expression and activity in endothelial cells are present only in advanced atherosclerosis, whereas VEGF expression is present in early as well as in advanced atherosclerosis and the degree of expression increases with severity of atherosclerosis.
- These results suggest that rhVEGF-165 enhances IL-18 production via the generation of ROI and ERK1/2 phosphorylation, which results in the increased migration of gastric cancer cells.
- vascular endothelial growth factor expression is induced through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells
- VEGF regulation of angiogenesis may in part be due to enhanced proliferation of VEGFR-1 and VEGFR-2
- VEGF165 blocks SNP-induced Bcl-2 down-regulation as well as sodium nitroprusside-induced Bax translocation from the cytosol to the mitochondria
- AKT prevents VEGF during internl ribosome entry site activity in myeloma cells during mTOR inhibition.
- suggest that VEGF-upregulation of TFPI-2 expression in endothelial cells may represent a mechanism for negative feedback regulation and modulation of its pro-angiogenic action on endothelial cells
- PPARbeta/delta is a novel regulator of endothelial cell proliferation and angiogenesis through VEGF.
- Basophils could play a role in angiogenesis and inflammation through the expression of several forms of VEGF-A and their receptors.
- These results demonstrate a complex regulation of VEGF-A during neuroinflammation and suggest that VEGF-B is not involved in the pathogenesis of MS.
- Tumor necrosis factor-alpha-stimulated vascular endothelial growth factor secretion by these cells may control oviductal fluid secretion by regulating vascular permeability.
- VEGF modulates angiogenesis via increased expression and activation of alpha6beta1 integrins, which may promote VEGF-driven tumor angiogenesis in vivo.
- cross-talk between TGF-beta1 and Vascular Endothelial Growth Factor(VEGF) signaling converts VEGF/flk-1-activated p38(MAPK) into a proapoptotic signal
- Gliostatin/thymidine phosphorylase and VEGF have synergistic effects on angiogenesis in rheumatoid synovitis, and GLS/TP has a role in regulating VEGF
- Individual isoforms of transgenic VEGFA induce distinct vascular phenotypes in the eye during embryonic development. Their relative doses provide instructive cues for vascular patterning.
- Chorionic gonadotropin produced during pregnancy could induce the biosynthesis of VEGF and by this means stimulate the development of breast cancer cells during pregnancy.
- Our results do not support the association of the VEGF gene promoter polymorphism and the risk of advanced ROP.
- The D allele of the VEGF polymorphism is an independent risk factor of diabetic retinopathy after controlling for other clinical variables.
- serum VEGF concentration might be closely related to atherosclerosis accelerating factor, especially in men
- may play an important role in the maintenance of a blood supply for developing pre-cancerous and invasive oral lesions
- activation of peroxisome proliferator-activated receptor delta up-regulated VEGF in colon carcinoma cells
- High VEGF is associated with carcinogenesis and portal vein tumor thrombus formation in human hepatocellular carcinoma
- This paper reviews individual and combined roles of VEGF and Ang-1 in asthma and angiogenesis.
- VEGF-A, STAT5 and AKT are downregulated in acute myeloid leukemia blasts of patients treated with SU5416
- Gab1 is a novel critical regulatory component of endothelial cell migration and capillary formation with a key role in the activation of VEGF-evoked signaling pathways required for angiogenesis
- VEGF gene expression was constant during early pulmonary organogenesis.
- eIF4E, along with VEGF and cyclin D1, has a role in translational regulation of proteins related to angiogenesis and growth
- VEGF-C expression in tumour tissues is indicative of lymphatic metastasis, whereas VEGF-A expression is more likely to be associated with haematogenous metastasis
- VEGF transgenic mice show delayed motor neuron loss and prolonged survival in an animal model of amyotrophic lateral sclerosis.
- This is the first demonstration showing that the VEGF -460 C>T polymorphism in men is not associated with sporadic prostate cancer in the Turkish population.
- The combination of PDT and CPI could be a useful approach in tumour therapy as the two agents appear to be synergistic and probably decrease VEGF production by the tumour tissue.
- overexpression of caveolin-1 overcame the VEGF-mediated inhibition of adhesion and restored ICAM-1 clustering
- SAF-1 induces VEGF transcription by directly binding to its promoter; markedly higher levels of SAF-1 interaction with the VEGF promoter was detected in the cartilage tissues of arthritic mice as well as human osteoarthritic patients.
- VEGF expression drives the migration and proliferation of endothelial cells to support the extensive angiogenesis in renal cell carcinoma [review]
- The enhancement of VEGF IRES A- and B-dependent translation represents a rapid and efficient mechanism by which protein synthesis can be induced as a result of the application of an acute stress.
- Coexpression of hVEGF and hIL-1Ra suppressed nitric oxide production, total caspases, apoptosis, and necrosis in the presence of inflammatory cytokine cocktail consisting of IL-1beta, TNFalpha, and IFNgamma.
- the higher expression levels of VEGF mRNA in the peripheral leukocytes are associated with the depressive state.
- Allele -634C/VEGF in homozygosity is an independent risk factor for the development of proliferative retinopathy in type 2 diabetic patients of European ancestry.
- Stimulation of AMPK via Ca(2+)/calmodulin-dependent protein kinase kinase represents a novel signalling mechanism utilised by VEGF in endothelial cells that contributes to eNOS phosphorylation and NO production.
- Expression of vascular endothelial growth factor by plasma cells in the sclerotic bone lesion of a patient with POEMS syndrome.
- diabetes mellitius affects VEGF levels of periodontal soft tissues in periodontal disease
- The present findings suggest that IL-13 is a regulatory factor of VEGF and sFlt-1 production in the human fallopian tubes.
- Some VEGF genotypes may have effects on renal cell carcinoma progression o prognosis, possibly through altered VEGF expression.
- Osteoclast-derived osteopontin and VEGF from myeloma cells cooperatively enhance angiogenesis and also induce osteoclastogenic activity by vascular endothelial cells
- Vascular endothelial growth factor gene polymorphisms have a role in progression of ovarian cancer
- estradiol-induced secretion of vascular endothelial growth factor is inhibited by flaxseed and its lignans
- Binding of VEGF to membrane-distal immunoglobulin-like domains causes receptor dimerization and promotes further interaction between receptor monomers through the membrane-proximal immunoglobulin-like domain 7.
- Pain symptoms in ovarian endometriosis are not correlated with VEGF serum levels and VEGF cellular expression.
- Intracytoplasmic sperm injection patients with serum progesterone above 0.9 ng/ml have elevated serum concentrations of vascular endothelial growth factor.
- CREB may regulate VEGF transcription via a hypoxia-inducible factor-dependent mechanism in normoxic conditions.
- Genetic variants in the regulatory regions of VEGF that could be associated with bladder cancer risk.
- estrogen seems to be a key factor for regulation of VEGF expression in bone
- Endometrial blood vessels possess a discrete morphology that is characterized by endothelial gaps, and these gaps are more pronounced in women with menorrhagia and overexpression of VEGFA.
- VEGF-A release by tumor cells is impaired by glutamine deprivation.
- Results suggest that VEGF polymorphisms might be associated with a higher risk of preterm birth and in the development of perinatal complications such as enterocolitis necrotisans and acute renal failure.
- High levels of VEGF-A is associated with angio and lymphangiogenesis in breast cancer
- The study does not support a diagnostic value for serum VEGF measured by proliferative activity on HUVEC cells, but suggests it could have a prognostic value in colorectral neoplasms.
- The prognosis was worst in patients with cancers that were VEGFA-positive and THBS1 methylation-positive.
- THPO and VEGF play an important synergistic role in the formation of early ES-derived hematopoietic progenitors that occurs through the c-mpl and VEGF receptors.
- Diffuse large B-cell lymphoma specimens showing higher local VEGF expression showed correspondingly higher microvessel density, implying that lymphoma cells induce local tumor angiogenesis.
- The aim of this study was to determine distribution of VEGF in normal renal parenchyma using immunohistochemical methods.
- Effects of shRNA targeting VEGF on VEGF mRNA expression in gastric cancer cells are reported.
- Relationship between the changes of VEGF level and the dendritic cells in peripheral blood of patients with hepatocellular carcinoma after TACE are reported.
- There was a trend toward a higher VEGF A expression in highly vascularized tumors but the levels failed to reach statistic significance with survival.
- Results suggest that strong expression of VEGFA and VEGFC is essential to lymphatic metastasis of stomach neoplasms.
- Analysis of VEGF gene polymorphisms can help identify patient subgroups at high risk of a poor disease outcome and survival in gastric cancers.
- These results suggest that the formulation of siRNA-PEG/KALA PECMs could be widely applied for intracellular delivery of various therapeutic siRNAs.
- We found that BPQ did not inhibit HIF-1alpha mRNA level, but inhibited its protein expression in a proteasome-dependent manner.
- therefore examined the methylation status of two genes, SOD1 and VEGF, which are implicated in ALS.
- Strong expression of vascular endothelial growth factor protein is associated with non-Hodgkin's lymphoma
- HIF-1alpha may induce the angiogenesis in gastric carcinoma by upregulating the transcription of VEGF gene, and take part in tumor invasion and metastasis. They can be used as prognostic markers of gastric cancer in clinical practice.
- Glial cell-derived cytokines such as GDNF and VEGF regulate the blood retinal barrier, implying that glial cell can be a possible therapeutic target in diabetic retinopathy.
- VEGF expression in breast cancers was associated with high grade and ER negative tumours
- in human diabetic nephropathy, a decrease of VEGF-A, rather than the reported increase as described in some rodent models, may contribute to the progressive disease
- There may be a hormonal and hypoxia-independent regulatory mechanism coordinating the expression of HIF-1alpha, HIV-2alpha, VEGF, the androgen receptor, and FOXP1 in prostate tumors.
- rHuEpo treatment in anaemic cancer patients do not induce angiogenesis or increased levels of endoglin or vascular endothelial growth factor
- VEGF genetic polymorphisms/serum levels were not associated with endometriosis.
- vascular endothelial growth factor is differentially regulated by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors
- wild-type WT1(A) has both transcriptional and post-transcriptional effects on VEGF mRNA levels.
- Insulin and IGFs promote VEGF-A production in luteinized granulosa cells, but the response patterns are different in polycystic ovary cells
- These findings provide evidence for a novel cooperative interaction between VEGFR2 and RET that mediates VEGF-A functions in ureteric bud cells.
- Major oxygen-dependent HIF isoforms are strongly upregulated in psoriatic skin with HIF-1alpha mainly in the epidermis, in an expression pattern similar to VEGF mRNA.
- Serum VEGF level did not increase with stage progression of non-small cell lung cancer, and only had a trend toward elevation in distant metastasis
- IP-10 levels significantly reverse-correlated with vascular endothelial growth factor (VEGF) levels in uterine cervical cancers.
- The increased values of VEGF, PLA2-LDL and P-selectin in patients with long standing pulmonary hypertension are related to severe endothelial dysfunction and may have prognostic values.
- COX-2 expression correlates with VEGF expression and might be a useful prognostic factor for more frequent tumor recurrence in esophageal squamous carcinoma patients undergoing neoadjuvant chemoradiotherapy.
- we show that VEGF is a potent activator of HUVEC-mediated fibrinolysis.
- multiple VEGFA variants are associated with the development of severe retinopathy in type 1 diabetes
- These novel results indicate the involvement of Fes in VEGF-A-induced cellular responses by cultured endothelial cells.
- Results suggest that VEGF and Ang-1 may contribute to fibrogenesis by acting as hypoxia-inducible, autocrine, and paracrine factors able to recruit myofibroblast-like cells.
- IL-18 has a unique role in inducing the secretion of angiogenic SDF-1alpha/CXCL12, MCP-1/CCL2, and VEGF in rheumatoid arthritis synovial tissue fibroblasts, via distinct signaling intermediates.
- there was an important association between the polymorphism of the VEGF gene and age of amyotrophic lateral sclerosis (ALS) onset
- VEGF levels may be regarded as a good indicator of active psoriasis arthritis.
- High VEGFA is associated with localized prostate cancer
- Results show a unique survival system in breast cancer cells by which VEGF can act as an internal autocrine (intracrine) survival factor through its binding to VEGFR1, and may lead to a strategy for tumor therapy based on the inhibition of angiogenesis.
- Distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis.
- Although no immediate effects were observed in soluble VEGF levels, percutaneous coronary intervention affected intracardiac angiopoietin-1 with a systemic release of angiopoietin-2
- CXCR4/CXCL12 signaling axis can induce angiogenesis and progression of tumors by increasing expression of VEGF through the activation of PI3K/Akt pathway
- low-VEGF-production T allele is strongly associated with increased risk for oral squamous cell carcinoma.
- High VEGF expression is associated with intracranial schwannomas
- Dichlorodiphenylchloroethylene alters the expression of the ovarian growth factors VEGF and IGF-1 in vitro.
- VEGF(121) binds directly to NRP1; however, unlike VEGF(165), VEGF(121) is not sufficient to bridge the NRP1.VEGFR2 complex.
- Leukemia patients showing parallel activation of the studied proteins trended to exhibit higher incidence of fatal outcome.
- The VEGF 936 CT genotype and T allele appear to be associated with good outcome in renal transplantation and, if confirmed, might be helpful for the pretransplant identification of recipients with low risk of graft rejection.
- Our findings demonstrate that ABCA12 is highly expressed in fetal skin and suggest that ABCA12 may play an essential role under both the wet and dry conditions.
- Both VEGF-A and angiopoietin-2 upregulated the expression of VEGFR-3 in cultured lymphatic endothelial cells
- VEGF-A/TGF-beta1 polymorphisms could be genetic markers of the process of urinary tract infection and vesicoureteral reflux.
- among women with confirmed endometriosis, there was a significant increase (P=0.002) in the mean peritoneal VEGF level in those in the late secretory phase compared with those in the proliferative and early secretory phases.
- The correlation between PEDF and VEGF striatal levels in PD patients suggests that concerted neurotrophic functions of these factors or structural changes in blood vessel walls play an important role in the pathophysiology of PD.
- These results describe a unique anti-inflammatory pathway in which IFN-gamma-dependent induction of VEGF-A mRNA is translationally silenced by the same stimulus.
- VEGF-1499T allele, or an allele in linkage disequilibrium with this allele, is associated with susceptibility to diabetic nephropathy in the Irish population
- Injection of mouse brains with VEGF-expressing cancer stem cells led to the massive expansion of vascular-rich glioblastoma multiform, tumor-associated hemorrhage, and high morbidity, suggesting that VEGF promoted tumorigenesis via angiogenesis.
- VEGF, Ets-1, and ERK1 act synergistically in the development of diabetic retinopathy.
- Mammary epithelium-derived VEGF is partially dispensable for angiogenesis during pregnancy and lactation in transgenic mice; by regulating vascular function during lactation, VEGF transgene is crucial to mammary gland differentiation and milk production.
- -634C allele was in a significant protective association against ventricular septal defect (VSD), suggesting that VEGF dysregulation was involved in the pathological processes of VSD.
- VEGF-mediated up-regulation of CCN1 in osteoblasts that attracts endothelial cells and promotes angiogenesis. Such a loop could be operative during fracture healing.
- functional characterization of the VEGF164 heparin-binding domain
- These findings indicate that the development of restenosis depends on both complement activation regulated by the MBL2 gene and pathologic processes leading to enhanced production of VEGF and PDGF during the very early postoperative period.
- Single nucleotide polymorphisms are not related to ovarian, cervical or endometrial cancer.
- Smoking is implicated as a potential cause of raised airway levels of vascular endothelial growth factor (VEGF) in the bronchitis type of chronic obstructive pulmonary disease (COPD) patients lacking alveolar destruction.
- do not support the hypothesis that VEGF polymorphisms are associated with breast cancer risk.
- IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo
- In hematopoietic stemm cell transplantation patients, vascular endothelial growth factor (VEGF) levels on day +15 were associated with significantly better overall survival
- VEGF-165 was found to be potent vasodilator of fetoplacental circulation. This vasodilatory effect was mediated by VEGFR-2 receptor and nitric oxide in manner-independent of involvement of prostacyclin and src-family tyrosine kinases.
- increase in VEGF in AR with and without asthma despite a higher Flk-1 in AR patients with asthma may be a possible explanation for the presence of angiogenesis in the airway wall in patients with asthma but not in those with pure AR.
- findings suggest that VEGF polymorphisms may be significant prognostic indicators for hepatocellular carcinoma patients
- VEGF serum levels are not associated with Parkinson's disease.
- hyperoxia enhances the expression of VEGF(121/165) proteins
- These observations imply that the VEGF gene polymorphisms may be associated with the susceptibility to gastric cancer.
- VEGF, MMP2, 7 and 9, and COX-2 expression is related to progression of advanced uterine cervical cancer in young women
- endothelial and lung cancer cells seem to interact via various paracrine pathways, e.g. by the reciprocal induction of VEGF and PDGF-BB
- High frequency of expression in central nervous system lymphomas may be associated with tumorigenesis may lead to futural therapeutic trials.
- The angiogenic growth factor VEGF-A is strongly expressed in hyperplastic epithelium overlying granulation tissue in airway stenosis.
- bFGF augments hypoxia induced VEGF release in breast cancer cells mainly through the PI3K pathway and partly depending on HIF-1 activity.
- HPV18 E6 oncoprotein contributes to tumor angiogenesis by inducing VEGF transcription from the promoter in a p53-independent manner.
- vasoactive intestinal peptide induced vascular endothelial cell growth factor expression at both mRNA and protein levels following a time-dependent pattern
- Evaluation of VEGF-mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells.
- Vav2 acts downstream of VEGF to activate Rac1.
- VEGF can be a helpful factor to improve healing in large bone defects, in which bone substitutes will otherwise not be vascularized and replaced by fresh bone
- data suggest that the VEGF -2578C > A polymorphism, at least in Koreans, is a genetic determinant of colon cancer risk
- KBP reduces expression of VEGF and HIF-1alpha nuclear translocation
- There is a relationship between VEGF, TNF-alpha, IL-6 and the development of the diabetic retinopathy in children with diabetes mellitus type 1.
- small concentrations of oxLDL promote capillary tube formation by inducing the expression of VEGF via LOX-1-mediated activation of NADPH oxidase- MAPKs-NF-kappaB pathway.
- VEGF signaling plays a protective role in the setting of these renal stressors
- plays a key role in periodontal disease progression and can be considered a biomarker of periodontal disease progression
- Fibrin gel-immobilized VEGFA and BFGF efficiently stimulate angiogenesis in the AV loop model.
- Vascularization and VEGF and Flk-1 expression are significantly higher in deeply infiltrating endometriosis affecting the rectum.
- Vascular endothelial growth factor reduces Fas-mediated acute liver injury in mice.
- HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2 and pyruvate dehydrogenase kinase 1.
- VEGF appeared more common as compared to CD 34 in early liver fibrosis.
- carriage of the +936T allele of the VEGF gene may be associated with increased susceptibility to the development of preeclampsia and may be an independent risk factor for preeclampsia
- Occurrence of the -634C allele appears to be associated with increased VEGF gene promoter activity, and the G/C polymorphism might serve as a predictive factor for the development of diabetic retinopathy.
- VEGF levels were significantly increased in patients with chronic myeloproliferative diseases compared to healthy individuals
- macrophage migration inhibitory factor directly up-regulates alphavbeta3 integrin and VEGF expression in human endometrial Ishikawa cells
- Tristetraprolin might represent a novel antiangiogenic and antitumor agent acting through its destabilizing activity on VEGF mRNA
- Active lymphangiogenesis is ongoing within sentinal lymph nodes from NSCLC patients, even before metastasis.
- VEGF-634 G/G genotype may be involved in the development of KD in Taiwanese children.
- HARP negatively affects diverse biological activities in C6 glioma cells, mainly due to binding of HARP to VEGF, which may sequester secreted VEGF from signalling through VEGFR2.
- Angiogenic response to aerobic exercise training is not altered during ageing in humans. Muscular activity-associated increases in interstitial VEGF protein may play an important role in maintenance of skeletal muscle capillarization across the life span
- We conclude that edaravone inhibits VEGF expression in astrocytes exposed to hypoxia, at least partly, through the down-regulation of HIF-1alpha.
- Serum VEGF concentration might be used as an additional marker of thyroid cancer with distant metastases.
- 48-year-old man POEMS syndrome had bilateral optic disc edema,bilateral cystoid macular edema, anasarca, and elevated serum vascular endothelial growth factor (VEGF).
- A1 AR-selective agonist CP stimulated a 1.7-fold increase in VEGF release from the mononuclear cells
- Data show that adipose tissue-derived stem cells (ASCs) secrete significant amounts of VEGF (810.65+/-56.92 pg/microg DNA) and IGF-I (328.33+/-22.7 pg/microg DNA).
- NADPH oxidase-derived ROS selectively modulate some but not all the effects of VEGF on endothelial cell phenotypes
- MMP-2 processing of HARP and CTGF released vascular endothelial growth factor (VEGF) from angiogenic inhibitory complexes.
- The CC and TC genotypes of the vascular endothelial growth factor gene polymorphism were associated with significantly higher rates of PSA recurrence after radical prostatectomy
- Marked expression of VEGF by the epithelial proliferative lesions and neoangiogenesis is associated with breast cancer
- HIF-1 activity does not require rapid proteolytic turnover of the vascular endothelial growth factor promoter-bound transactivator, nor is the activator-promoter complex constantly disassembled by chaperones
- VEGF overexpression was significantly associated with sentinel lymph node micro-metastasis
- Mechanisms underlying GLP-2 induced intestinal wound repair seem to involve the secretion of VEGF and, subsequently, TGF-beta1 from subepithelial fibroblasts.
- IL-6 and IL-8, and probably midkine and VEGF-A, appear to participate in the development of cancer-related cachexia in gastroesophageal malignancies.
- Reduction in VEGF expression and loss of intra-epidermal nerve fibers occurs in the foot skin of diabetic patients with increasing neuropathic severity.
- The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression.
- the investigated common polymorphisms in the VEGF-gene are not associated with individual susceptibility to colorectal cancer.
- HIF-1 may be involved in angiogenesis by controlling expression of VEGF in vivo. Possible strategy for treatment of angiogenesis by targeting HIF-1 alpha in ischemic retinopathies.
- Data demonstrate that Notch1 and VEGFR-3 interact genetically, that Notch directly induces VEGFR-3 in blood endothelial cells to regulate vascular development, and that Notch and VEGF signaling may function in tumor lymphangiogenesis.
- This review underlines recent advances in the understanding of how VEGF acts through these two malignancies, its potential value as a diagnostic and prognostic marker, as well as the development of new therapeutic strategies targeting the VEGF pathway.
- Expression of VEGF and Ref-1 is associated with Trx-1 overexpression, and poor prognosis in patients with liver metastases from colorectal cancer.
- The A allele of the SNP rs699947 increased the risk of thyroid cancer development and regional lymph node metastasis in men.
- One particular SNP and one haplotype in the VEGF gene have a high possibility of significant associations with the pathogenesis of polycystic ovary syndrome in a Korean population.
- These results suggest that fludarabine reduces survivability of HepG2 cells via VEGF signaling under hypoxia.
- Expression profile of total VEGF, VEGF splice variants and VEGF receptors in the myocardium and arterial vasculature of diabetic patients.
- The VEGF +936 T allele is associated with an increased risk of stage III-IV endometriosis in a Japanese population.
- No correlation was found between plasma and intratumoral VEGF, clinicopathological prognostic parameters or tumour microvessel density.
- The present study failed to demonstrate any association between serum levels of MMPs, VEGF and CA 15.3 and well-known clinicopathological characteristics of breast carcinoma
- study investigated the influence of hepatitis C virus infection on serum profile of sICAM-1 and VEGF in patients with hepatitis C and hepatitis C with superimposed hepatocellular carcinoma
- Role for the +405G>C VEGF polymorphism in endometriosis development.
- data suggest that the C polymorphism at -460 is a genetic risk factor for hydrocele development in lymphatic filariasis
- Level of released VEGF directly corresponds to the resistance of the tumor to irradiation in a squamous cell carcinoma head-and-neck neoplasm cell line.
- structural analysis of semaphorin and VEGF binding
- decrease of all angiogenic effects induced by these growth factors are attributable to the reduction in the amount of VEGF-A165 and PlGF transcripts by 15-LO-1, resulting in reduced protein expression
- Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR.
- findings show that VEGF expression is a predictive factor for early treatment failure and poor survival of gastrointestinal stromal tumor (GIST) patients on imatinib therapy, independent of KIT genotype
- VEGF is expressed not only by reactive cells, but also by neoplastic cells, and NF-kappaB activation is uncommon in angioimmunoblastic lymphoma, as suggested by frequent exclusively cytoplasmic c-REL localization
- vascular endothelial growth factor has a role in regulating angiogenesis and tumor growth with reactive oxygen species
- the ratio between the expression levels of two members of the VEGF family of angiogenic factors, PlGF-1 and VEGF-A, determines the overall angiogenic activity and, thus, the extent of tumor angiogenesis and tumor growth
- VEGF expression correlates with microvessel density in Philadelphia chromosome-negative chronic myeloproliferative disorders.
- These data show that VEGF(165) is a chemoattractant that recruits bone marrow cells into the tumor area.
- Significant correlation between VEGF concentration and HbA1c levels. Contributes to endothelial damage in diabetics.
- An AT1R-mediated VEGF induction suggests the possibility of AT1R blockade as a novel therapeutic strategy to control angiogenesis in PDA.
- To evaluate the significance of the expression of vascular endothelial growth factor (VEGF), its correlation with clinicopathological variables were studied in the tissue of hepatocellular carcinoma (HCC) and surrounding liver.
- Stromal myofibroblasts surrounding colon adenocarcinomas are an important source of VEGF and COX-2 production.
- our data indicate that an excess of local VEGF with respect to its soluble receptor VEGFR-1 may be a key factor in the onset and maintenance of pathological neo-angiogenesis in ovarian cyst formation
- visual prognoses strongly correlate with the vitreous level of IL-6, whereas the duration of retinal vein occlusion strongly correlates with the vitreous level of VEGF
- DRBP76/NF90 isoform facilitates VEGF expression by promoting VEGF mRNA loading onto polysomes
- VEGF marker of tumor angiogenesis may predict survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the ovary
- Lymphocyte microparticles potently suppress neovascularization in vivo and in vitro by augmenting reactive oxygen species generation via NADPH oxidase and interfering with the VEGF signaling pathway
- Data suggest that increased VEGF expression is strongly associated with severe acute rejection and cardiac related death.
- data suggest that in primary colorectal cancer, presurgery circulating VEGF levels are related to VEGF produced by tumour-associated macrophages
- Study strongly supports previous reports that showed the role of VEGF, macrophages, and AGEs in the development of diabetic proliferative retinopathy.
- Cyclooxygenase-2 and VEGF were closely correlated with each other, and both of them appear to play a role in the angiogenesis of ovarian endometriosis.
- Single nucleotide polymorphisms of VEGF gene and Psoriasis risk.
- Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor.
- KSHV-infected endothelial cells are enriched, with VEGF-A and -C molecules playing key roles in KSHV biology.
- In PDGFR-expressing immortalized ovarian cancer cells, PDGF strongly induced VEGF secretion, suggesting a correlation between the PDGF & VEGF networks in ovarian cancer.
- Effects of hyper- and hypoglycemia on blood VEGF levels may be of relevance for the understanding of VEGF alterations in different pathological states such as diabetes mellitus.
- Both PlGF-1 (placenta growth factor) and VEGF-A (vascular endothelial growth factor-A) can activate VEGFR-1-(vascular endothelial growth factor receptor-1)dependent signaling pathways in primary human monocytes
- VEGFA participates in mammary tumor growth through both angiogenesis and nonangiogenic functions
- No evidence of an association of SNPs within the VEGF-A gene being associated with either age-related macular degeneration or any of its subtypes in our population.
- The correlation between soluble P-selectin and VEGF in sickle cell disease and HbSC disease is consistent with the view that VEGF is released from platelets during in vivo activation.
- Anti-hVEGF hairpin ribozyme can effectively inhibit VEGF expression and growth of hepatocarcinoma in vitro and in vivo.
- EGFR expression is associated with tumour progression and VEGF expression may be involved in haematogenic metastasis in cholangiocarcinoma.
- Data show that MCP-1 has a synergistic effect on COX-2 and CCR2 protein expression in CD40L-stimulated HUVECs and stimulates VEGF production in these cells.
- Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways to stimulate angiogenesis.
- passive leg movement, elevating blood flow and causing passive stretch, augments the interstitial concentrations of VEGF
- Increased levels of VEGF and angiogenic markers are associated with poor outcome in endometrioid endometrial cancer patients.
- In vitro, primary effusion lymphoma -induced angiogenesis is dependent on VEGF and VEGF receptors. However, although PEL cells produce VEGF and bFGF transcripts, they only secrete VEGF in vitro
- VEGFR3 single nucleotide polymorphisms andthe haplotype GC in the VEGFA gene are associated with psoriasis in Koreans
- VEGF acts as a survival factor not only for endothelial cells as previously thought, but also for some breast tumour cells, protecting them from apoptosis.
- We conclude that increased CSF and serum VEGF levels are a measure of activity of the disease in neurotuberculosis.
- Support a role for NP-1 in mediating synergistic effects between VEGF-A(165) and FGF-2, which may occur in part through a contribution of NP-1 to KDR stability.
- VEGF gene polymorphism may be an important potential genetic and therapeutic marker of laryngeal SCC.
- VEGF and survivin co-expression is an independent prognostic survival factor for patients with advanced nasopharyngeal carcinoma.
- VEGF gene polymorphisms were found to be an independent prognostic marker for patients with colorectal cancer
- These results provide evidence that a VEGF/KDR/HIF-1 alpha autocrine loop differentially mediates survival of hypoxic colon cancer cells.
- The mRNA expression levels of Vascular Endothelial Growth Factor A was greater in tissues of early and advanced colon cancer compared with colon adenoma
- VE-cadherin has a role in modulating c-Src activation in VEGF signaling
- Osteopontin, cyclooxygenase-2 and vascular endothelial growth factor synergically promote angiogenesis and metastasis in gastric cancer.
- Present results suggest that VEGF gene 936 C/T polymorphism does not seem to be associated with susceptibility to familial Mediterranean fever and its clinical manifestations.
- Vascular endothelial growth factor gene 936 C/T polymorphism in breast cancer patients.
- Increased levels of VEGF(vascular endothelial growth factor ) were found in the whole group of untreated patients with B non-Hodgkins lymphoma in comparison with normal controls
- Data show that integrin beta3 and VEGF expression can synergistically enhance tumor angiogenesis, and may play a crucial role in invasion and metastasis of gastric carcinoma.
- These results indicate that TGF-Beta1-509 and VEGF-460 polymorphisms were not highly associated with the pathology of pterygium.
- elevation of VEGF (vascular endothelial growth factor) appears as a feature of inflammatory reaction during the course of Behcets disease, not a direct determinant of subclinical atherosclerosis
- Data on metastasis of the 839 breast cancer patients shows as association between metastases and VEGF polymorphisms.
- study found polymorphisms of -460C/T, +405C/G, & +936C/T in the VEGF gene do not play a major role in non-small cell lung cancer risk
- VEGF expression was significantly lower in both the myometrium and stroma of the preeclamptic placentas when compared with controls
- higher level of NRP-1 mRNA was expressed in leukemias and NRP-1 promoted proliferation and chemotaxis of leukemic cells in response to VEGF.
- correlation of VEGF mRNA levels between primary tumor and liver metastasis.VEGF mRNA levels in liver metastasis were higher than in primary tumor.Cancer cells in liver metastasis may become more aggressive during metastasis.
- Insight into its applicability for pharmacologic targeting of HIF-1alpha for cancer therapeutic or chemopreventive purposes prostatic cancer.
- oxidative stress and VEGF are significantly increased in patients with primary lung cancer
- VEGF release during frequency-modulated electrical stimulation may help explain the positive effects on nerve conduction velocity in diabetic polyneuropathy, possibly mediated by favorable effects on vasa nervorum microangiopathy.
- The purpose of this study was to investigate whether there is any association between preeclampsia and eNOS, DDAH, and VEGF gene polymorphisms.Polymorphisms in eNOS, DDAH, and VEGF gene do not seem to be risk factors for preeclampsia.
- the polygenotype of VEGF (vascular endothelial growth factor) +405/intercellular cell adhesion molecule (ICAM)-1 +241/IL6 (interleukin6)-174 (C-A-G) conferred an increased risk for Progressive Massive Fibrosis in Coal miners
- We concluded that T homozygotes and T allele of VEGF gene -460 polymorphism are associated with higher risk of leiomyoma development.
- relation of VEGF expression and cortical vascularity with renal pathological changes and clinical parameters in allograft biopsies
- baseline levels of VEGF-A (vascular endothelial growth factor A) showed a significant independent association with the risk of coronary heart disease death.
- The expression of VEGF-C and VEGF receptors is regulated specifically in HL-60 cells during macrophage differentiation.
- the Akt/Girdin signalling pathway is essential in VEGF-mediated postneonatal angiogenesis
- hypoxia and hypoxia-induced VEGF expression are involved in the pathogenesis of progressive atherosclerosis.
- The sulfated polysaccharides dextran sulfate and fucoidan, but not others, reduce endothelial cell-surface levels of NRP1, NRP2, and to a lesser extent VEGFR-1 and VEGFR-2, and block the binding and in vitro function of semaphorin3A and VEGF(165).
- The expression of VEGF in intestinal metaplasia and gastric dysplasia, which could signify an early angiogenic switch during tumorigenesis.
- N-myc is a novel regulator of PI3K-mediated VEGF expression in neuroblastoma
- polymorphisms in VEGF may be associated with survival in early-stage non-small-cell lung cancer
- Overexpression of EBV-LMP1 expression with VEGF-A expression was associated with diffuse large B cell lymphoma
- Tumor cell-secreted or recombinant VEGF-A165 cross-talks with VEGFR1 and neuropilin-1 to activate the phosphoinositide 3-kinase/Akt kinase signaling molecule in VEGFR2-deficient human aortic smooth muscle cells to enhance their migration.
- VEGF, hTERT and Bcl-xl have roles in laryngeal squamous carcinoma
- Homozygosity of the VEGF -1154A gene may serve as a susceptibility factor affecting for recurrent pregnancy loss
- Expression of vascular endothelial growth factor-A and its receptor-1 in a luteal endometrium in patients with repeated in vitro fertilization failure.
- vascular endothelial growth factorgene polymorphisms do not confer increased susceptibility to Kawasaki disease
- The increased expression of sputum VEGF in asthmatic children reinforces the concept that it might have a pathogenetic role in bronchial asthma and may represent a biomarker of airway inflammation.
- This study suggests that the VEGF 936 C allele is associated with vascular invasion in oral squamous cell carcinoma.
- These findings suggest the association of downregulation of bronchiolar VEGF and its receptors with cigarette smoking and COPD.
- IL-8 might be a malignant factor in human pancreatic cancer by induction of vascular endothelial growth factor and NRP-2 and ERK activation.
- Report the production of vascular endothelial growth factor and MMP-1/2 via protease-activated receptor in human endometrial stromal cells.
- a high vascular-endothelial growth factor-A expression in the tumor of a patient responding to an EGF-R inhibitor postulating that there might be a link between both tyrosine kinase pathways.
- The expression of VEGF-A relates to the development of peritumoral brain edema with meningiomas and the histological grade.
- VEGFA and receptor were highly expressed in dysplastic neurons. IR in astroglial and balloon cells was observed for VEGFA and its receptor.Double-labeling also showed expression of VEGFA, VEGFB and VEGFR-1 in cells of the microglia/macrophage lineage.
- Low serum VEGF concentration is a significant and independent prognostic factor in small cell lung cancer patients
- Altered vascular endothelial growth factor expression during GnRH antagonist protocol in women of reproductive age with normal baseline hormone profiles.
- Stromal sublayer of AA patients is characterized by low expression of Ang-1 and VCAM-1 genes and high VEGF expression compared to mean level of healthy donors.
- during CDDP-induced tumor progression the activation of VEGF/Flt1 autocrine signaling leads to the survival and expansion of a highly tumorigenic side-population fraction
- Positive feedback loop involving VEGFA, autotaxin and lysophosphatidic acid that could affect tumor progression in ovarian cancer cells.
- LH induces ovarian follicular angiogenesis via modulation of VEGF-A and its soluble receptor sFlt-1 expression.
- VEGF165 expression in the tumor microenvironment influences the differentiation of bone marrow-derived pericytes that contribute to the Ewing's sarcoma vasculature.
- vascular endothelial growth factor A and fibroblast growth factor 2 have effects on chemotaxis and chemokinesis
- Here we show that overexpression of VEGF165b by tumour cells inhibits the growth of prostate carcinoma, Ewing's sarcoma and renal cell carcinoma in xenografted mouse tumour models. Moreover.
- function is regulated by SPARC by limiting available growth factor
- Results suggest that over-expression of S100A4 and VEGF plays an important role in the development of pancreatic cancer.
- Metformin addition has beneficial effect on VEGF and PAI-1 levels in obese type 2 diabetic patients in combination with exercise and medical nutrition treatment.
- our study demonstrates increased concentrations of VEGF and Bcl-2, but not MMP-3, in serum of melanoma patients
- C(-634)G genotype was found to increase the risk for diabetic retinopathy in patients with microalbuminuria.
- VEGF-A and FGF-2 mRNA levels were higher in the outer definitive zone of fetal adrenal gland than in the fetal zone.
- VEGF may have a role in progression of breast cancer tumors
- MCP-1 and CD40L had a synergistic effect on COX-2 expression and subsequent VEGF production in gastric cancer.
- The molecular mechanism of Leucine Rich Repeat 5 reveals that its anti-migratory effect on endothelial cells is mediated by inhibiting VEGF-stimulated endothelial nitric oxide synthase activation and nitric oxide release.
- Results suggest that stretch-induced increases in cell tension are responsible for matrix-bound VEGFA production.
- VEGF-a in human ovarian carcinoma has a role in vasculogenic mimicry
- Both VEGF +936 C/T and CFH Y402H polymorphisms are dependently associated with wet age-related macular degeneration in the Taiwan Chinese population.
- An important VEGF synthesis by blastocysts occurs during human embryo development.
- analysis of functional polymorphisms of the vascular endothelial growth factor gene and risk of gastric cancer
- Overexpression of vascular endothelial growth factor is associated with tumor growth and angiogenesis in neuroblastoma
- granulosa cell tumors granulosa cell tumors of the ovary express vascular endothelial growth factor as an important stimulator of tumor angiogenesis
- Dissimilar expression of VEGF in inner enamel epithelium, ameloblast and odontoblast during each stage of human tooth development may affect tooth germ formation.
- VEGF T-1498C polymorphism is a candidate marker predictive of poorly-differentiated colorectal adenocarcinomas.
- Overexpression of VEGF receptors on keratinocytes in psoriasis is regulated by calcium independent of VEGF.
- Report effect of antisense-mediated inhibition of survivin, hTERT and VEGF in bladder cancers.
- the present study provides evidence demonstrating that topical oxygen treatment benefits wound healing in patients suffering from chronic wounds, and is associated with an induction of VEGF expression in wound edge tissue and an improvement in wound size
- cyclin-dependent kinase inhibitor p57(Kip2) and vascular endothelial growth factor mRNAs are selectively translated by an IRES-independent mechanism under hypoxic stress
- VEGF-460C polymorphism is associated with pterygium formation in female patients. Females who carried the C allele have increased risk of developing pterygium at a younger age.
- telomerase reverse transcriptase is one of the important proteins in the proliferation-promoting effect of VEGF on tumor cells in prostate cancer
- Inhibition of VEGF expression by sequence-specific siRNA may become a novel approach for the treatment of VEGF-enriched neoplasma such as osteosarcoma.
- Surgical wound-produced host Pro-MMP-9 and tumor cell VEGF might be important mediators leading to metastasis of residual breast cancer after surgery.
- A clear association was demonstrated between VEGF SNPs and severity of diabetic retinopathy.
- HIV-1 induces VEGF and VEGFR2 expression in podocytes, and this may be a critical step in the pathogenesis of HIV nephropathy
- The results of this study did not reveal clinical significance of VEGF overexpression in multiple myeloma.
- EGFR gene mutations are frequently seen in lung adenocarcinomas with bronchioloalveolar differentiation and can be linked to chromosomal imbalances and increased VEGF expression
- Serum VEGF levels in Mmedullary thyroid carcinoma patients are not significantly different from those found in healthy individuals and did not correlate with the extension of disease.
- Estrogen receptor-alpha overexpression suppresses 17beta-estradiol-mediated vascular endothelial growth factor expression and activation of survival kinases.
- characterize unfolded protein response ATF4 branch as an important mechanism mediating up-regulation of VEGF by Ox
- beta(2)GPI inhibits VEGF and bFGF-induced proliferation, migration and papillary-like tubule formation of HUVECs
- sVEGF might be markers of depth of invasion or lymph node involvement in patients with gastric cancers
- This is the first study that shows an association between plasma VEGF levels, markers of renal function, oxidative stress and inflammation in patients with chronic renal failure.
- VEGF expression(in the intimal layer of tendon vessels)in the patellar tendon had a shorter symptom duration than patients with no detectable VEGF.VEGF may contribute to the vascular hyperplasia that is a cardinal feature of symptomatic tendinosis.
- Thus, VEGF mRNA could be a marker similar to VEGF protein in plasma as a possible marker of angiogenesis in colorectal cancer.
- Activator protein-4 expression was associated with the expression of matrix metalloproteinase-9 and vascular endothelial growth factor in the advanced colorectal cancer.
- High VEGF expression occurs in a small proportion of ovarian cancers, and this independently predicts poor prognosis
- Describe local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of experimental prostate neoplasms.
- findings show that IP-10, sTNF-R2 and sFas were independently associated with increased risk of cerebral malaria associated mortality
- cancer cells have a survival system that is regulated by vegf mRNA; both vegf mRNA and its protein may synergistically promote the malignancy of tumor cells
- The expression of VEGF in the corneal tissues was inhibited by curcumin on days 7 and 14 after alkaline burn.
- These findings suggest that the expression of VEGF-A and cytoplasmic translocation of HuR relates to the histological grade, and that HuR is involved in the upregulation of VEGF-A expression, in human astrocytic tumors.
- VEGF is increased in patients with severe sepsis. Low VEGF was associated with hematological and renal dysfunction. VEGF was lower in nonsurvivors than in survivors, but did not adequately predict hospital mortality in patients with severe sepsis.
- Modulation of HDM2 expression could play an important role in tumor angiogenesis and the metastatic process via transcriptional regulation of VEGF.
- Results suggest that the VEGF 936C>T polymorphism might be a genetic determinant for colon cancer, at least in Koreans.
- Sphingosine-1-phosphate stimulated VEGF-A secretion in ML-1 thyroid follicular cancer cell lines
- VEGF induces the phosphorylation of three conserved serine residues in histone deacetylase 7 (HDAC7) via protein kinase D, which promotes nuclear export of HDAC7 and activation of VEGF-responsive genes in ECs.
- Haplotype analysis showed two separate blocks of high-linkage disequilibrium, formed by five polymorphisms upstream of the coding sequence (promoter and 5'-untranslated region) and two polymorphisms downstream of the coding sequence.
- Concentrations of the immunoregulatory cytokine TGF-beta(1) and of angiogenic factors VEGF and IL-8 were markedly increased within effusions caused by malignancies.
- VEGF-A protects MDA-MB-231 cells against nab-paclitaxel cytotoxicity
- increased VEGF protein expression in osteosarcoma samples from female patients versus male patients was seen and we also observed a trend describing a relationship between VEGF expression and tumor grade
- in patients with chronic myeloid leukemia, The expression of VEGF (vascular endothelial growth factor) was most pronounced in the Acute phase and it was inversely correlated with degree of splenomegaly and overall survival
- key role of abnormal angiogenesis in arteriovenous malformation pathophysiology suggesting that a disruption in systemic VEGF expression may contribute to the natural history of these lesions
- Based on our observations and previously published data, the association of the VEGF gene promoter polymorphisms and the risk of advanced ROP is weak.
- Increase in rarer T allele at + 813 locus of VEGF gene may diminish susceptibility to sarcoidosis in Turkish population.
- VEGF and VCAM-1 may participate in the pathogenesis of viral encephalitis.
- A novel autocrine function for VEGF in breast tumor cells in driving the expression of Snail, a breast tumor progression factor.
- A positive correlation was seen between the diameter of endometrioma cyst capsules and VEGF labeling intensity and as the size of cyst enlarged, the appearance of non-homogeneous distribution of VEGF immunolocalization became more frequent.
- analysis of the the biological responses and the signaling pathways activated by VEGF 121 and VEGF 165 in human umbilical vein endothelial cells (HUVEC)
- Data show that the COOH-terminal fragment of procollagen type I (C3) induces expression of VEGFA and CXCR4 in MDA MB 231 breast cancer cells.
- These results indicate that FSH increases the expression of VEGF by upregulating the expression of survivin, which is activated by the PI3K/AKT signaling pathway.
- VEGF levels could be a useful tumor marker for malignant ascites, but its value should carefully be interpreted because of lesser reliability in chemotreated ones.
- the VEGF gene polymorphisms may be associated with the susceptibility or clinicopathologic features of colorectal cancer
- it is concluded that P. falciparum infected red blood cells can bind host VEGF-R on the erythrocyte membrane and accumulate host VEGF within the parasitophorous vacuole, which may have a trophic effect on parasite growth
- Initial and 24-h VEGF levels had a significant correlation with the presence of septic shock at 24 h.
- Neuronal and endothelial cells exposed to VEGF up-regulated the expression of SDF-1alpha. CXCR4-positive tumor cells migrated toward a SDF-1alpha gradient in vitro, whereas inhibition of CXCR4 expression decreased their migration
- Serum levels of VEGF-A and its receptor, VEGFR-1, were significantly higher in patients with gastric cancer than in healthy donors.
- VEGF polymorphisms do not influence VEGF mRNA expression in colorectal tumors and susceptibility to sporadic colon cancer.
- Results provide strong evidence that the size of loop regions plays a critical role in determining the most favored folding pattern of the G-quadruplex in the proximal promoter of the vascular endothelial growth factor gene.
- Incubation of lymphatic endothelial cells (LEC) with ESM-1 increased the stimulatory effects of both VEGF-A and VEGF-C on LEC proliferation and migration, whereas ESM-1 alone had no effect
- Zinc deficiency increases activation of NF-kappaB and up-regulates expression of VEGF, IL-6 and IL-8 in androgen-independent PC-3 and DU-145 prostate cancer cells.
- The expression of vascular endothelial growth factor-A is positively correlated with the recurrence rate of hepatocellular carcinoma after curative resection.
- CTGF is primarily a pro-fibrotic factor in the eye, and a shift in the balance between CTGF and VEGF is associated with the switch from angiogenesis to fibrosis in proliferative retinopathy
- PKC-mediated VEGF transcriptional activation is key component in the progression of CsA-induced post-transplantation cancer
- This is the first report demonstrating the inhibitory and stimulatory effects of IFN-gamma on VEGF-A and sFlt-1 secretion, respectively.
- results suggest that VEGF might be a target of Homeodomain-interacting protein kinase-2, at least in part, through regulation of beta-catenin activity.
- vascular endothelial growth factor, receptor KDR and p53 protein are expressed in transitional cell carcinoma of the bladder
- VEGF overexpression exhibited a significant correlation with viremia and survival
- Quercetin suppressed the HIF-1alpha accumulation during hypoxia in human cancer cell lines and reduced hypoxia-induced secretion of VEGF
- Butyrate-induced phosphatase regulates VEGF and angiogenesis via Sp1
- VEGF and sVEGF-R1 were increased respectively to the degree of liver insufficiency in patients with liver cirrhosis.
- Cox regression analysis showed that the VEGF/sVEGFR-1 ratio was an independent predictor for pancreatic cancer survival. Higher VEGF/sVEGFR-1 ratio was significantly correlated with poor outcome in patents with pancreatic cancer.
- endocrine hormone insulin contributes to VEGF release in skin wounds through an Akt1-and 4E-BP1- mediated posttranscriptional mechanism in keratinocytes
- Adenovirus-mediated VEGF gene therapy enhances venous thrombus recanalization and resolution.
- VEGF production is COX-2 dependent in NSCLC cells expressing COX-2; IL-8 production is COX-2 independent in both NSCLC and SCLC cells
- Differentiation of hMSCs into arterial- or venous-specific ECs depends on VEGF and is regulated by the Notch pathway.
- Despite the effect of the -634 C/G VEGF polymorphism on serum and vitreous levels of VEGF in PDR, it failed to contribute to the genetic susceptibility to proliferative diabetic retinopathy.
- Tissue kallikrein decreased GSK-3beta activity via the phosphatidylinositol 3-kinase-Akt pathway and enhanced VEGF and VEGFR-2 expression in endothelial cells.
- terms of serum levels of either VEGF or its soluble receptors VEGFR1, we found no significant difference between healthy individuals and women with benign breast tumors and breast cancer.
- VEGF, sVCAM-1, sICAM-1 and sE-selectin median levels were higher in hemodialysis patients compared to controls.
- Vascular endothelial growth factor is associated with left ventricular systolic dysfunction and mortality in hemodialysis patients
- Focal gains of VEGFA is associated with hepatocellular carcinoma
- VEGF levels in nasal secretions and nasal lavage from allergic rhinitis were higher than in nonallergic rhinosinusitis, after rather than before antigen provocation. VEGF mRNA expression was higher in serous versus mucous acini.
- The a priori hypothesis that 3 common SNPs in the VEGF gene would be a risk factor for AMD, especially the wet form, could not be confirmed.
- Serum VEGF-A levels are significantly higher in obese patients than in lean controls, decreasing after weight loss with bariatric surgery.
- Although limited by sample size, the study did not demonstrated any evidence that VEGF -460 C/T, +405 G/C, and +936 C/T polymorphisms are associated with an increased risk of endometrial carcinomas in Japanese women.
- These results are consistent with a potential autocrine role of the VEGF-VEGFR2 (KDR) interplay as a factor contributing to malignant astrocytoma growth and radioresistance.
- These results suggest that orthodontic tooth movement causes an increase in VEGF and M-CSF levels, which may induce bone remodeling via osteoclastic bone resorption.
- VEGF gene variability represents a susceptibility factor for sporadic frontotemporal lobar degeneration.
- VEGF-induced secretion is largely dependent on PKC-delta and significantly less on [Ca2+]c.
- VEGF levels are higher in patients with essential hypertension (EHs) in the presence of microalbuminuria. These high values may be important in the early diagnosis of vascular damage in essential hypertension.
- VEGF could not be used as individual prognostic factor in invasive breast carcinoma.
- down-regulation of VEGF plays a critical role in apoptosis of endothelial cells induced by high glucose
- serum VEGF (vascular endothelial growth factor) level of children (0-14 years old) was significantly higher than that of adults (over 15 years old)
- cigarette smoking modifies the association between VEGF polymorphisms and esophageal adenocarcinoma risk among Caucasians
- Hepatocyte growth factor inhibits VEGF-FOXO1-dependent gene expression in endothelial cells.
- The VEGF and the soluble Flt-1 levels were more elevated in patients with septic shock than in controls
- VEGF, IL-6 and IL-8 contribute to the haematological malignancies in which bone marrow angiogenesis plays a role in the pathogenesis and progression
- TRPC6 is an obligatory component of cation channels required for the VEGF-mediated increase in cytosolic calcium and subsequent downstream signaling that leads to processes associated with angiogenesis
- head and neck squamous cell carcinoma cells are both targets and effectors for VEGF
- The level of VEGF expression is correlated with the degree of gastric wall injury
- The aim of this study was to analyze the effect of TGF-beta targeting on the expression of angiogenic vascular endothelial growth factor (VEGF), in fibroblasts isolated from radiation-induced chronic dermal wounds.
- VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling.
- there are VEGF-dependent and independent angiogenic stimuli in skin carcinogenesis
- Vascular endothelial growth factor is highly expressed in muscle tissue of patients with polymyositis and patients with dermatomyositis
- Our data support an association between VEGF genotype and median OS as well as grade 3 or 4 hypertension when using bevacizumab in metastatic breast cancer. SNPs included VEGF-2578AA, VEGF-1154A, VEGF-634CC and VEGF-1498TT.
- High circulating VEGF levels are associated with postmenopausal breast cancer patients who had had a previous hysterectomy.
- Highest levels of circulating VEGF are observed in metastatic stage, positive mediastinal nodal status, and poor PS non-small cell lung cancers.
- expression of the VEGF-A 121 isoform is associated with favorable response to treatment in childhood acute lymphoblastic leukemia
- Case Report: Pulmonary tumor thrombotic microangiopathy caused by an ovarian cancer expressing tissue factor and vascular endothelial growth factor.
- These results suggest that CCN2 regulates the expression of VEGF at a transcriptional level by promoting HIF-1alpha activity.
- Different roles for TGF-beta and VEGF in the pathogenesis of the cardinal features of diabetic nephropathy
- Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors.
- in vivo circulating levels of free VEGF in preeclampsia is likely to contribute to compromised fetoplacental vascular patency in this disease
- inhibition of either ERK or Sp1 suppressed M-CSF-induced VEGF at the mRNA and protein level
- Vascular endothelial growth factor expression is significantly increased in port-wine stains, suggesting that VEGF could contribute to the pathogenesis of PWS by inducing vessel proliferation, vasodilation, or both.
- Eag1 interferes with the cellular mechanism for maintaining oxygen homeostasis, increasing HIF-1 activity, and thereby VEGF secretion and tumor vascularization
- ZKSCAN3 regulates the expression of several genes favoring tumor progression including integrin beta 4 and VEGF
- Expression of human VEGF directs HUCB cell differentiation into endothelial cells; neuro-protective effects may stem from the delivery of various neuro-trophic factors from newly formed blood vessels.
- the VEGF plasma levels as well as the VEGF tissue expression in HHT patients with ENG gene mutations did not differ significantly to those of HHT patients with ACVRL1 gene mutations or mutations for both the genes.
- VEGF, HIF-1alpha, and predominantly PDGFRalpha are expressed in neoplastic cells in the majority of Hodgkin lymphomas.
- Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1: requirement for Smads, (beta)-CATENIN, AND GSK3(beta).
- The VEGF 936C>T polymorphism is a susceptibility factor for stomach cancer in Korean patients.
- Autocrine/paracrine hGH secreted from mammary carcinoma cells also promoted HMEC-1 in vitro tube formation as a consequence of increased vascular endothelial growth factor-A (VEGF-A) expression.
- Vector-based vascular endothelial growth factor 165 (VEGF)(165) targeted siRNA expression system (pSilencer(siVEGF)) was used to investigate the ability to inhibit VEGF(165) expression in vitro and suppresses retinal neovascularization.
- forced VEGF overexpression or autocrine VEGF stimulation of VEGFR-2 triggers proliferation and migration/invasion of U-937 leukemic c
- VEGF macromolecules are secreted by the tumor tissue and enter peritumoral normal brain tissue to induce edema.
- Changes in nailfold capillaroscopy, endothelial cell activation markers (VEGF, endothelin-1, E-selectin, and thrombomodulin) and features of systemic lupus erythematosus suggest microvascular abnormalities in the clinical manifestation of the disease.
- Stimulation of the EP3(I) isoform of the human EP3 receptor with prostaglandin E(2) increases the mRNA expression of both VEGF and its cognate receptor VEGF receptor-1.
- define a role for VEGF as an inhibitor of neovascularization on the basis of its capacity to disrupt vascular smooth muscle cells function
- These findings suggest that the Ang and VEGF families may play a role in the process of spiral artery remodelling in normal pregnancy.
- VEGF-A appears to be a novel mediator of IBD by promoting intestinal angiogenesis and inflammation.
- VEGF took part in development and progression of colorectal carcinomas and that Id-1 was associated with regulations of VEGF
- Achieving optimal therapeutic outcomes, the scheduling of radiotherapy and antiangiogenic therapy requires patient-specific post-treatment monitoring of the VEGF pathway.
- We confirmed significant overexpression of osteoprotegerin and vascular endothelial growth factor-A by ELISA from supernatants of SBDS-depleted HeLa cells.
- Association between increment of serum VEGF level and prognosis after transcatheter arterial chemoembolization in hepatocellular carcinoma patients is reported.
- Decreased plasma total antioxidant activity, NO, and VEGF levels in patients with metabolic syndrome may reflect significant endothelial dysfunction.
- mTORC2 and Akt facilitate CD40-inducible expression of VEGF in endothelial cells
- guggulsterone not only induces apoptosis, but also inhibits angiogenesis and metastasis in colon cancer cells by blocking STAT3 and VEGF expression
- the proangiogenetic potential of growth factors may account for accelerated tumour growth when residual tumour cells are exposed to high levels of VEGF165 and HGF
- Results show a significant positive correlation between the concentrations of tissue VEGF and its receptor VEGFR2 in primary breast neoplasms during neoadjuvant therapy, and suggest that VEGFR2 levels may indicate the level of lymphatic metastasis.
- KV11 peptide (from human Apolipoprotein A) suppresses angiogenesis and tumor progression by targeting the c-Src/ERK signaling pathways in VEGF induced cells
- Reduced secretion of VEGF and expression of VEGF-R3 by placental endothelial cells in gestosis can be caused by functional deficiency of the endothelial cells and low viability of endothelial cells.
- VEGF is elevated in patients with recurrent papillary thyroid cancer and distinguishes the presence of distant metastasis
- VEGF may have a protective role in the pathogenesis of aGVHD.
- Plasma VEGF warrants further evaluation as a prognostic marker for treatment outcome in advanced breast cancer patients receiving anti-VEGF therapy.
- analysis of the effects of vascular endothelial growth factor-A antagonists
- Data show that EPAS1 and VEGF, but not HIF1alpha, are overexpressed in pancreatic carcinoma.
- 15-LOX-2 suppresses VEGF gene expression and sustains tumor dormancy in prostate cancer
- Effect of ROS on angiogenesis in tumors expressing hot-spot p53 mutants was correlated with their ability to increase a content of HIF1 transcriptional factor responsible for up-regulation of VEGF-A mRNAs.
- an RNA switch in human vascular endothelial growth factor-A mRNA 3' untranslated region that integrates signals from interferon -gamma and hypoxia to regulate VEGFA translation in myeloid cells
- The positive expressions of VEGF in the synovial tissues of cacroiliac joint of patients with active AS were stronger than those in the control group.
- CXCR4 has a role in VEGF expression and poor survival in soft-tissue sarcoma
- After treatment with everolimus, expression of p-mTOR, HIF-1alpha and VEGF was shown to be sharply depressed in clear cell adenocarcinoma
- VEGF appeared to have a crucial role in osteoblastic differentiation since the inhibition of its receptors reduced the co-culture-stimulated osteoblastic phenotype
- results indicate that in progressive but not in stable proteinuric kidney disease, proximal tubular epithelial cells show an attenuated VEGF-A expression despite an activation of intracellular hypoxia response and VEGF signaling pathways
- Serum levels of sICAM and VEGF were significantly higher in juvenile idiopathic arthritis (JIA) patients with capillary abnormalities than in JIA patients with normal capillaroscopy.
- Colorectal cancer patients had increased plasma VEGF-A, but not endoglin levels.
- miR-16 regulates expression of endogenous VEGF.
- VEGFA single nucleotide polymorphisms were not associated with increased Common carotid intima-media thickness.
- estradiol and tamoxifen may regulate the growth of endometrial carcinoma cells by stimulating VEGF production through Efp
- Intrauterine circulatory imbalance may induce changes in VEGF expression. These alterations may be involved in both donor & recipient in pathogenesis of twin-twin trnafusion syndrome, due to hemodynamic stability between the circulation of twins.
- In cultures of brain microvascular endothelial cells, VEGF-A specifically down-regulated CLN-5 and OCLN protein and mRNA
- Quantification of VEGF-1 expression seems to provide valuable prognostic information in colorectal cancer.
- vascular endothelial growth factor has a role in squamous cell carcinoma [review]
- Microvesicles produced by human cancer cells harboring activated EGFR (A431, A549, DLD-1) can be taken up by cultured endothelial cells, in which they elicit EGFR-dependent responses, including activation of MAPK and Akt pathways.