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Validated All-in-One™ qPCR Primer for NLRC4(NM_001199139.1) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM].
Gene References into function
- Apaf-1 protein expression did not correlate with Apaf-1 mRNA levels in human leukaemic blasts.Apaf-1 DNA promoter methylation might contribute to the inactivation of Apaf-1 expression
- CLAN regulates several events central to host defense mechanisms against invading bacteria: modulating relative sensitivity of macrophages to lipopolysaccharide and peptidoglycan, and impacting host-pathogen interactions.
- p53 can directly induce Ipaf gene transcription, which contributes to p53-dependent apoptosis in at least some human cells
- Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis
- hNAIP and hIpaf mediate innate intracellular defense against flagellated Legionella in human cells.