|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for TRPV1(NM_080706.3) Search again
Product ID:
HQP061702
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
VR1
Gene Description:
transient receptor potential cation channel subfamily V member 1
Target Gene Accession:
NM_080706.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq].
Gene References into function
- Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues
- ASICs are leading acid sensors in human nociceptors and VR1 participates in the nociception mainly under extremely acidic conditions.
- In rectal hypersensitivity, nerve fibres immunoreactive to TRPV1 were increased in muscle, submucosal, and mucosal layers.
- calmodulin binds to a 35-aa segment in the C terminus of TRPV1, and disruption of the calmodulin-binding segment prevents TRPV1 desensitization
- Proposal that residue Y671 is critical for the high relative Ca(2+) permeability of TRPV1 and participates in the structural rearrangements of the channel protein leading to Ca(2+)-dependent desensitization.
- Ser-116 and possibly Thr-370 are the most important residues involved in the cyclic AMP-dependent protein kinase pathway reduction of desensitization of capsaicin-activated currents.
- Ser-116 and possibly Thr-370 of vanilloid receptor TRPV1 are the most important residues involved in the mechanism of PKA-dependent reduction of desensitization of capsaicin-activated currents
- in fibers of human tooth pulp ... may play a role in perception of dental pain
- vanilloid receptor 1 has a role in regulating vanilloid binding with Ca2+/calmodulin-dependent kinase II
- VR1 is widely distributed in the skin, suggesting a major role for this receptor, e.g. in nociception and neurogenic inflammation.
- Review notes that high expression of TRPV1 has been detected in inflammatory diseases of the colon and ileum, whereas neuropeptides released upon sensory nerve stimulation triggered by TRPV1 activation may play a role in intestinal motility disorders.
- Our observations suggest that the homologous TRP domain in the TRP protein family may function as a general, evolutionary conserved AD involved in subunit multimerization
- temperature sensing is tightly linked to voltage-dependent gating in the cold-sensitive channel TRPM8 and the heat-sensitive channel TRPV1
- There is a minor role for transient receptor potential vanilloid receptor-1 as a mediator of cutaneous acid-induced pain.
- TRPV1b receptors are expressed in trigeminal ganglion neurons and contribute to thermal nociception.
- Piperine was agonistic to TRPV1 as measured by patch-clamp techniques. TRPV1 was antagonized by the competitive antagonist capsazepine and the non-competitive TRPV1 blocker ruthenium red.
- Ca2+-dependent desensitization of TRPV1 might be in part regulated through channel dephosphorylation by calcineurin
- Increased urothelial TRPV1 in patients with neurogenic detrusor overactivity may play a role in the pathophysiology, in concert with increased TRPV1 nerve fibers.
- expression of vanilloid receptor subtype-1 and acid-sensing ion channel genes in the human trigeminal ganglion neurons
- TRPV1 as a significant novel player in human hair growth control.
- A progressive loss of TRPV1 expression in the urothelium as TCC stage increased and cell differentiation was lower.
- several endogenous non-cannabinoid N-acylethanolamines activate TRPV(1)
- Gadolinium activates and potentiates the TRPV1 by neutralizing two specific proton-sensitive sites on the extracellular side of the pore-forming loop.
- may play a role in maintenance of the physiologic condition of the TMJ
- NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
- Results describe the modification of 12-phenylacetyl-ricinoleoyl-vanillamide and its activity at TRPV1 and CB2 receptors.
- Both TRPV1 and TRPV2 are found in human peripheral blood lymphocytes.
- PAR2 activates PKCepsilon and PKA in sensory neurons, and thereby sensitizes TRPV1 to cause thermal hyperalgesia
- Opioid receptor agonist morphine acts via inhibition of adenylate cyclase to inhibit protein kinase A-potentiated TRPV1 responses.
- TRPV1 antagonists, including TRPV1 siRNAs, have potential in the treatment of both, neuropathic and visceral pain
- Here, we review the potential therapeutic indications and adverse effects of TRPV1 antagonists.
- TRPV1 may play a role in urinary sensory urgency and premature first bladder sensation on filling.
- data support the hypothesis that the TRPV1b splice variant is a naturally existing inhibitory modulator of TRPV1.
- We propose a new model for nerve growth factor (NGF)-mediated hyperalgesia in which physical coupling of TRPV1 and PI3K in a signal transduction complex facilitates trafficking of TRPV1 to the plasma membrane.
- These data do not rule out involvement of TRPV1 in the aetiology of burning dysaesthesia following lingual nerve injury but suggest that TRPV1 at the injury site does not play a primary role.
- Gingerols and shogaols activated TRPV1 and increased adrenaline secretion.
- we assigned a novel role to capsaicin-sensitive TRPV1 channels. They are important Ca2+ influx channels required for cell migration.
- TRPV1 is a nonselective cation channel with significant permeability to calcium, protons, and large polyvalent cations--{REVIEW}
- Capsaicin-induced calcium influx through TRPV1 channels prevents adipogenesis, prevents downregulation of TRPV1 expression and prevents obesity.
- IGF-I and insulin enhance TRPV1 protein expression and activity, and impaired pain sensation might result from distorted TRPV1 regulation in the peripheral nervous system
- Together, these results indicate that tonic TRPV1 activation regulates body temperature. TRPV1 function in thermoregulation is conserved from rodents to primates.
- Recent studies indicate that primary sensory neurons of the pancreas express transient receptor potential V1 (TRPV1) channels whose activation induces pancreatic inflammation
- TRPV1 gene and protein expression inversely correlated with glioma grading, with marked loss of TRPV1 expression in the majority of grade IV glioblastoma multiforme.
- The advantage of SH-SY5Y(hTRPV1) is the ability of hTRPV1 to couple to neuronal biochemical machinery and produce large quantities of cells.
- Heat-shock-induced MMP-1 expression is mediated by activation of TRPV1 and is dependent on a calcium-dependent signaling process in human epidermal keratinocytes.
- TRPV1 activation induces inflammatory cytokine release in corneal epithelium through MAPK signaling.
- accumulation of TRPV1 and TRPV3 in peripheral nerves after injury, in spared axons, matches our previously reported changes in avulsed DRG.
- Here, we demonstrate the expression of TRPV1 in synovial fibroblasts (SF) from patients with symptomatic osteoarthritis (OA) and rheumatoid arthritis (RA).
- a novel group of compounds that activate TRPV1 and, consequently, provide a molecular mechanism that may account for off tastes of sweeteners and metallic tasting salts
- TRPV1-positive fibres were overall significantly increased in tongue of Burning mouth syndrome.
- We conclude that phosphoinositides have both inhibitory and activating effects on TRPV1, resulting in complex and distinct regulation at various stimulation levels.
- Tonic activation of TRPV1 channels in the abdominal viscera by yet unidentified nonthermal factors inhibits skin vasoconstriction and thermogenesis, thus having a suppressive effect on body temperature.
- These data provide the first clinical evidence that a TRPV1 antagonist may alleviate pain and hyperalgesia associated with inflammation and tissue injury.
- Incorporation of multiple nonsynonymous polymorphisms, informed by the population-specific haplotype block structure of the TRPV1 gene
- TRPV1 expression was significantly increased in distal small nerve fibre neuropathy compared with controls.
- Increased expression within the pulps of hypomineralised teeth may be indicative of an underlying pulpal inflammation
- Testicular hyperthermia in mice lacking transient receptor potential vanilloid receptor-1 results in a much more rapid and massive germ cell depletion from the seminiferous tubules than in wild-type animals.
- several proton-sensitive sites on the extracellular side of the pore-forming loop of the TRPV1 channel may play an important role as a brake to suppress the excessive activity of this channel under physiological conditions.
- TRPV1 may be involved in pain mechanisms associated with cervical ripening and labor.
- Ara C treatment blocked insertion of TRPV1 in the cell membrane, resulting in accumulation of the receptors in the cytoplasm, loss of capsaicin sensitivity, and membrane-bound immunostaining, which was restored with a rebound on withdrawal of Ara C.
- Increased translocation and multimerization of TRPV1 channels provide a cellular mechanism for fine-tuning of nociceptive responses that allow for rapid modulation of TRPV1 responses independent of transcriptional changes.
- The results of this study support the hypothesis that 4-ONE is a relevant endogenous activator of vagal C-fibres via an interaction with TRPA1, and at less relevant concentrations, it may activate nerves via TRPV1.
- TRPV1 mediates heat shock-induced MMP-1 expression via calcium-dependent PKCalpha signaling in HaCaT cells
- expressed in airway C fibers and activated by neurogenic inflammation which leads to provocaion of cough reflex.
- findings suggest that modification of I696, W697, & R701 to alanine altered channel function by affecting events downstream of initial stimuli-sensing step & imply that intersubunit interactions within the TRP box play an important role in TRPV1 gating.
- PI(4,5)P(2), and not other phosphoinositides or other lipids, is the endogenous phosphoinositide regulating TRPV1 channels
- TRPV1 regulates the expression and secretion of endothelial cell-derived CGRP.
- TRPV1 signaling is a significant, previously unreported player in human sebocyte biology
- Disease-free survival was significantly better in HCC patients with high versus those with low VR1 expression levels.
- May be a mediator or part of a critical pathway in chronic hypoxia-induced proliferation of human pulmonary artery smooth muscle cells.
- Full-length TRPV1 has been modeled by assembly of its major modules: the cytosolic N-terminal, C-terminal, and membrane-spanning region, by modeling of the vanilloid receptor in the closed and desensitized states.
- Although keratinocytes express TRPV1 mRNA, neither responded to vanilloids with Ca(2+)-cytotoxicity
- relative gene expression ofTRPV1-4 in leukocytes is: TRPV3 < TRPV4, TRPV1 and TRPV2; leukocytes in hyposensitive subjects showed up-regulation of TRPV1, which was almost doubly expressed
- Together with TRPV1, the capsaicin receptor, transient receptor potential cation channel subfamily A member 1 ankyrin may contribute to chemical hypersensitivity, chronic cough, and airway inflammation --{REVIEW}