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Validated All-in-One™ qPCR Primer for MMP2(NM_001127891.2) Search again
Product ID:
HQP059438
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1
Gene Description:
matrix metallopeptidase 2
Target Gene Accession:
NM_001127891.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Gene References into function
- involvement of MMPs in microinvasive carcinomas
- non-steroidal anti-inflammatory drugs suppress MMP-2 expression via repression of transcription
- Activated matrix metalloproteinase-2--a potential marker of prognosis for epithelial ovarian cancer.
- results indicate that two kinds of pro-form and active-form matrix metalloproteinases, MMP-2 and MMP-9, and their degradation products, are present in human seminal plasma
- 17beta-estradiol had no influence on production in MG-63 cells or human osteoblast cultures
- Cancer cell-associated fibronectin induces release of matrix metalloproteinase-2 from normal fibroblasts.
- design, synthesis and characterization of potent slow-binding inhibitors
- repression of expression by ATF3
- in differentiating trophoblasts Nitric Oxide regulates the induction of MMP-2 and MMP-9 required for invasion during embryo implantation
- shed as membrane vesicle associated components by endothelial cells and this may be a mechanism for regulating focalized proteolytic activity vital to invasive and morphogenic events during angiogenesis
- Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas
- in pancreatic cancer, invasion into large veins and destroyed type veins could be a risk factor for liver metastasis and that increased expression MMP-2 and MMP-9 were related to such invasion.
- MMP-2 expression seemed to have an important role to play in the epithelial differentiation of tumour cells in synovial sarcoma.
- SB203580, a p38 MAP kinase inhibitor, reduces MMP-2 expression in melanoma cell line MeWO.
- increasing expression and endometrial carcinoma appear closely related
- A study of the col-1 module of MMP2; structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains.
- Levels of MMP2 mRNA were reduced in two neuroblastoma clones treated with 300 nM PAF, which was accompanied by an inhibition of invasiveness through Matrigel and by a promotion of differentiation.
- activation by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species
- activation associated with malignant lung cell phenotype; correlation between low hemoglobin level and T/N ratio of MMP-2 may indicate indicate significance of MMP-2 for angiogenesis
- Significantly increased activity of MMP-2 was recognized in tumors showing tenascin-C degradation.
- expression level of MMP-2 mRNA may regulate with invasion ability of cervical cancer
- Increased gelatinase activity in Systemic Sclerosis fibroblasts seems to be regulated at translational and/or post-translational level.
- Overexpression of MMP-2 and MMP-9 in squamous cell carcinomas of immunosuppressed patients.
- destruction of the surrounding matrix by endometriosis might be caused by various MMPs, which are mainly produced in stromal cells.
- N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells
- MMP2 inhibition by NSAIDs via suppression of the ERK/Sp1-mediated transcription.
- Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanism.
- Coexpression of glucose transporter 1 and matrix metalloproteinase-2 in human cancers
- role in A549 cell migration on laminin-10/11
- solution structure of a catalytic domain of MMP-2 complexed with a hydroxamic acid inhibitor (SC-74020), determined by three-dimensional heteronuclear NMR spectroscopy
- data indicate the involvement of matrix metalloproteinase 2 and matrix metalloproteinase 9 in the cervical ripening process
- calcium regulates MMP2 activation in a MT1-MMP-dependent manner in oral squamous cell carcinoma cells
- Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2.
- Human fibronectin and MMP-2 collagen binding domains compete for collagen binding sites and modify cellular activation of MMP-2.
- MMP2 activation is increased by Eph B4 receptor stimulation in human cells
- endometrium from women with endometriosis expressed higher levels of MMP-2 and MT1-MMP and lower levels of TIMP-2 than did endometrium from normal women
- role of acidic residues in TIMP-2 and TIMP-4 in binding hemopexin C domain
- MMP-9 level and TIMP-1 levels increased after birth but are not linked to bronchopulmonary dysplasia outcome; low MMP-2 level at birth is associated with the development of BPD
- MMP2 may play a pivotal role in the formation of capillarylike tubular structures in a collagen-containing fibrin matrix in vitro and may be involved in angiogenesis in a fibrinous exudate in vivo.
- Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates enzyme and cd44 in cox-2-dependent invasion
- strong MMP-2 expression correlated with a favorable prognosis of Hodgkin's lymphoma
- correlation between expression of MMP-2, TIMP-2 protein and the ratio of MMP-2/TIMP-2 and clinical-pathological parameters of patients with gallbladder carcinoma
- The in vitro invasive ability of ovarian tumor cells appeared to be positive correlated to high expression of VEGF and MMP-2.
- Changes in plasma MMP-2 and TIMP-2 during cardiopulmonary bypass may play an important role in LV remodeling after cardiac surgery.
- up-regulation of MMP-2 in stromal cells of chronic inflammatory demyelinating polyneuropathy and in vasculitic neuropathies
- laminin-5 as a substrate for mTLD, suggesting a role for laminin-5 processing by mTLD in the skin.
- There are two TIMP binding sites on the hemopexin domain of MMP-2: one with high affinity that is involved in proMMP-2 or hydroxamate-inhibited MMP-2; and the other with low affinity involved in formation of the complex of active MMP-2 and TIMP-2.
- The over-expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 may play a key role in invasion and lymph-node metastasis of in squamous carcinoma of the cervix.
- Peptide binding results in perturbation of signals from residues located in the gelatin-binding pocket and flexible parts of the molecule.
- No difference in MMP-2 between RG and SG. Only an increase with time under both conditions.
- data demonstrated a moderate elevation of matrix metalloproteinases-2 and significant upregulation of matrix metalloproteinases-9 in stable cell lines overexpressing gamma-synuclein
- gelatinase A is inhibited by amyloid precursor protein, specifically in the decapeptide region
- matrix metalloproteinase-2 and 9 and membrane-type 1 matrix metalloproteinase mRNA expression in endometriosis was higher than in normal endometrium whereas E-cadherin, alpha- and beta-catenin mRNA expression was not suppressed in endometriosis
- MMP-2 may contribute to eosinophil and mast cell migrations into nasal polyp tissue.
- Data show that cells grown on oxidized ultra-high molecular weight polyethylene (UHMWPE)discs decreased the release and activity of metalloproteinase 2 (MMP-2) but not MMP-9 compared to cells grown on control and non-oxidized UHMWPE discs.
- MMP-2 is associated with tumor size, invasiveness and survival in breast cancer.
- TIMP-2 is significantly increased in cerebrospinal fluid of Alzheimer's and Huntington's disease patients.
- In the recurrent implantation failure group, the MMP score and IL-1beta concentration were significantly higher than those in the control group, whereas concentrations of IFN-gamma and IL-10 were significantly lower.
- MMP2 is regulated by IL-8 in invasive pancreatic cancer
- MMP2 is induced by snail protein in squamous cell carcinoma
- triple-helical peptides are highly selective substrates for and are hydrolyzed by human MMP2 and MMP9
- expression and regulation by intestinal myofibroblasts in inflammatory bowel disease
- Gelatinase A is an estrogen-responsive gene and the loss of function polymorphism within an operational estrogen receptor binding site associated with a decrease in genetic fitness underscores the biologic significance of promoter polymorphism analyses.
- Increased expression of MMP-2 in advanced stage and high grade renal cell carcinoma might be associated with tumor invasion and metastasis
- Pathogenic amyloid beta stimulates expression and activation of matrix metalloproteinase-2 (MMP-2); the increase in activation is largely due to increased expression of membrane type-1 (MT1)-MMP. MMP-2 inhibitors increased HCSM cell viability
- Exploiting their astrocyte environment, glioma cells activate MMP-2 through the urokinase-type plasminogen activator-plasmin cascade, and this leads to the increased invasiveness of glioma cells in the central nervous system.
- PR-3 is able to degrade matrigel components and denatured collagen and to directly activate secreted but not membrane-bound pro-MMP-2
- Increased in situ mmp-2 activity in renal cell tumor tissues correlates with tumor size, grade and vessel invasion
- plays a critical role in inducing tumor cell infiltration, and this invasive phenotype is caused by activation of MMP-2
- Ultraviolet A downregulates MMP-2 in keratinocytes.
- The present results indicate that MMP-2 can be helpful in diagnosing Takayasu arteritis [TA] and that MMP-3 and MMP-9 can be used as activity markers for TA
- Both active gelatinases were detected in tears of severe corneal ulcer or severe ocular burn cases. The active form of gelatinase expression may be related to the severity of ulceration.
- differences in the levels of MMP-2, MMP-9, TIMP-1 and TIMP-2 in the normal ovary and ovarian tumours of different histology, including clear cell carcinoma
- palpable tumours demonstrated significantly more MMP-2 and significantly less MMP-9 expression than nonpalpable tumours
- MMP2 increased VEGF release by SKOV3 and OVCAR3 ovarian carcinoma cells.
- results suggest that matrix metalloproteinase 2 plays an important role in tumor invasion and metastasis
- Increased plasma MMP-2 is associated with colorectal cancer
- MMP-2 immunostaining was positive in 4 of 8 cases of invasive carcinoma and stained stromal area around tumor nest. Matrix metalloproteinases are activated in carcinoma in situ and in cervical intraepithelial neoplasia of uterine cervix.
- findings established the existence of a novel alternative/complementary pathway by which furin increases tumor cell invasion through an amplification/activation loop between MMP-2 and TGFbeta
- ANG II, via AT(1)R, modulates the secretion of TNF-alpha and MMP-2 from vascular endothelial cells and TNF-alpha mediates the effects of ANG II on MMP-2 release.
- effect of titanium, zirconia and alumina ceramics on activity and secretion in human osteoblasts
- Laminin-5 gamma 2 chain and MMP-2 may contribute synergistically to the formation of budding colorectal tumor cells.
- Increased MMP-2 expression by malignant prostatic epithelia is an independent predictor of decreased prostate cancer disease-free survival.
- a possible of marker for microangiopathies in children and adolescents with type 1 diabetes.
- Serum MMP-2 does not relate to the late phase of hepatic ischmeic reperfusion injury after human orthotopic liver transplantation.
- Tissue from lateral and medial rectus muscles had different levels of expression of TIMP-1 and 2, MMP-2, and BMP-4,which may underlie different characteristics of these extraocular muscles and may influence wound healing after strabismus surgery.
- one of the mechanisms by which S100A4 may exert its effect on metastasis of some tumors is by regulating the MMP-2 activity.
- the methionine residue and the Met-turn of MMP2 play an essential role in catalysis or active site structure
- data supports a role for MMP-2 in breast cancer progression, both in the growth of primary tumors and in their spread to distant organs
- Stromal MMP-2 occurs early and may play a role early in ovarian adenocarcinoma invasion.
- matrix metalloproteinase-2 has a role in progression of breast carcinoma
- MMP and TIMP may be involved in the feto-neonatal development and may contribute to the pathogenesis of bronchopulmonary dysplasia and/or intraventricular hemorrhage in critically ill preterm neonates
- Various growth factors induce migration of human non-small cell lung cancer cells in the presence of extracellular matrix (ECM) components MMP-2 and MMP-9.
- MMP-2, TIMP-1 and TIMP-2 are downregulated in human orthotopic liver transplantation
- downregulated by Cytomegalovirus IL-10 activity in uterine microvascular endothelial cells and differentiating-invading cytotrophoblasts
- Matrix metalloproteinase-2 may play a role in the pathogenesis, invasion, and metastasis of cutaneous squamous cell carcinoma.
- Analysis of promoter MMP-2 gene variability could help us to understand individual susceptibility to MMP inhibitor treatment of the coronary artery disease.
- In control myometrium only 10% of Gelatinase A (MMP-2)exists in an active form, whereas in uterine leiomyomas, especially in large ones, the values reach 30%
- elastin derived peptides following interactions with S-Gal elastin receptor can favor melanoma cells invasion through a three-dimensional type I collagen matrix by upregulating MMP-2 activation.
- MMP-2 and MMP-9 expressions are prognostic factors predicting the recurrence of meningioma, independent of proliferative potential.
- matrix metalloproteinase 2(MMP-2) was uterine smooth muscle tumor of uncertain malignant potential(STUMP), and in 48% of leiomyosarcoma
- MMP-2 correlated negatively with fractional shortening & positively with LV dimension. Changes in the release & activity of MMP-2 may be associated with the mechanisms responsible for cardiac remodeling in patients with hypertrophic cardiomyopathy.
- MMP-2 or MMP-9 mediated tumor cell invasion requires integrin cytoplasmic-tail motif EKQKVDLSTDC
- although there is a seemingly high structural similarity between TACE and MMP-2, these enzymes are significantly diverse in the electronic and chemical properties within their active sites
- Helicobacter pylori infection results in substantially increased in the gastric mucosa, probably contributed to in large part by tissue-resident macrophages
- Active involvement of MMP-2 and -9 in end-stage liver disease and orthotopic liver transplantation.
- results suggest that matrix metalloproteinase-9 and matrix metalloproteinase-2 contribute to caspase-mediated brain endothelial cell death after hypoxia-reoxygenation by disrupting cell-matrix interactions and homeostatic integrin signaling
- Activated protein C (APC) and MMP-2 are coordinately up-regulated and tightly bound in rheumatoid arthritis (RA) synovial fluid and colocalized in synovia. APC may modulate MMP-2 activity in RA.
- marked difference in MMPs and their inhibitors in the in vitro fertilized women and normally ovulating women
- EGFR, c-erbB-2, VEGF and MMP-2 and MMP-9 play an important role in tumor growth, invasion and metastasis in squamous cell carcinoma of the head and neck
- endothelial cell-associated cathepsins B and L are not involved in the invasive growth of capillaries from existing blood vessels and the presence of collagen is necessary for MMP2 expression in endothelial cells
- a mechanism for ROS function in Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell MMP2 and MMP9 during VCAM-1-dependent lymphocyte migration
- Streptococcus pyogenes SpeB activates proMMP-2 with subsequent release of proapoptotic TNF-alpha and sFasL leading to apoptosis, tissue damage and streptococcal invasion in the host.
- MMP-2 plays a pivotal role in oxLDL-induced activation of the sphingomyelin/ceramide signaling pathway and subsequent smooth muscle cell proliferation.
- matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 processing and transport in cultured human vascular smooth muscle cells is regulated by serum fetuin
- Identified,in the promoter region of the human MMP-2 gene, a cAMP responsive element binding protein (CREB) consensus domain that is highly responsive to IL-10-dependent down-regulation or MMP2 expression in a primary human prostate tumor cells.
- biochemical analysis of in-tandem fibronectin type II repeats from human matrix metalloproteinase 2
- Brg-1 plays a role in regulating the recruitment of Sp1, Sp3, AP-2, and polymerase II to the MMP-2 promoter.
- data suggest that the MMP-2/TIMP2 system and an activated extrinsic coagulation pathway could cooperate in conditions of elevated SOX and could influence arterial remodeling resulting in the presence of CVD in haemodialysis patients
- Overexpression of MMP-2 is associated with non-small cell lung cancer
- the hemopexin domain of MT1-MMP is not required for the activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen
- Increased gelatinase in culture medium of toxic epidermal necrolysis or Stevens-Johnson syndrome skin maintained in organ culture and in blister fluid indicates that these gelatinases may be responsible for detachment of epidermis in these diseases.
- MMP-2 status in stromal fibroblasts, not in tumor cells, was a significant prognostic factor associated with angiogenesis in NSCLC.
- MMP-2 -1306 C-->T polymorphism may be associated with colorectal cancer development and invasion
- clearance of pro-matrix metalloproteinase (MMP)-2.tissue inhibitor of MMPs (TIMP-2) complex involves binding to the cell membrane and subsequent low density lipoprotein receptor-related protein (LRP)-dependent internalization and degradation
- The Matrix Metalloproteinase-2 was expressed of cultured human uveal melanocytes, and analysis revealed the Matrix Metalloproteinase-2 mRNA.
- The expression of MMP-2,MMP-9, TIMP-1 and TIMP-2 was lower in the benign and low malignancy ovarian tumors compared with the malignant ones.
- MMP-2 plays an essential role in tumor invasion and metastasis, while TIMP-2 is shown to strongly inhibit cancer invasion and metastasis.
- Expression of MMP-2 and MMP-9 in breast cancer seems to be partly related to expression of AP-2 and HER2
- In melanoma cells microtubule-dependent traffic of MMP2/MMP9-containing vesicles and exocytosis are critical steps for invasive behavior.
- breast cancer phenotype and outcome can be influenced by common functional polymorphisms in MMP genes.
- secreted pro-MMP-2 and pro-MMP-9 are downregulated by farnesyltransferase inhibitors in carcinoma cells
- alphav integrins and MMP2 have roles in migration of human ovarian adenocarcinoma cells through endothelial extracellular matrix
- This study found an up-regulation of TIMP-1, TIMP-2 and MMP-2 RNA in Duchenne Muscular Dystrophy muscle.
- The correlation between macrophage infiltration and MMP-II supports the role of macrophages in the development of chronic allograft nephropathy.
- Abeta1-42 may play an important role in the negative regulation of TGF-beta1-induced MMP-2 production via Smad7 expression
- furin can directly cleave the RXXR amino acid sequence in the propeptide domain of proMMP-2 leading to inactivation of the enzyme.
- These findings suggest that epimorphin contributes to repair of pulmonary fibrosis in nonspecific interstitial pneumonia, perhaps partly by inducing expression of matrix metalloproteinase 2, which is an important proteolytic factor in lung remodeling.
- MMP-2 is an important determinant of cancer cell behavior but is not inhibited by the collagen binding segment of fibronectin.
- MMP2 may have a role in cervical cancer recurrence
- Hypoxia increased pro-MMP-2 expression, on collagen type I or type IV further via Erk1/2 and p38 MAP kinase signaling for lung fibroblasts
- Inactivating mutations in MMP-2 cause Winchester syndrome, a multicentric osteolysis syndrome.
- up-regulation of Ang2, MMP-2, MT1-MMP, and LN 5 gamma 2 is associated with the invasiveness displayed by human gliomas
- High MMP2 expression is associated with breast cancer
- E1AF positively regulates transcription from MT1-MMP genes, which plays an important role in invasion and metastasis of squamous cell carcinoma of the tongue by converting pro-MMP-2 into active-MMP-2
- Hypoxia induces an increased invasive capacity via gelatinase up-regulation without loss of cell viability in adenocarcinomas
- Age-related MMP-2 upregulation occurs in the human aorta but not in the internal mammary artery.
- MMP-2 is required for the mitogenic and proinvasive effects of reactive oxygen species on hepatic stellate cells and demonstrate that ERK1/2 and PI3K are the main signals involved MMP-2 expression.
- expression up-regulated in Helicobacter species-infected colon and bile duct epithelial cells and hepatocytes.
- Lysophosphatidic acid and sphingosine 1-phoshpate enhanced MMP-2 expression in mRNA, protein levels, and also enzymatic activity of cells of the EAhy926 human endothelial cell line.
- Migration of CD4+ T cells is dependent on MMP2 expression; T-helper type 1 (Th1) cells secrete higher levels of MMP2 and have higher migratory capacity in comparison to Th2 cells.
- expression of CD147 is upregulated during the differentiation of monocyte THP-1 cells to macrophage cells, and CD147 induces the secretion and activation of MMP-2 and MMP-9 and enhances the invasive ability of THP-1 cells
- furin and PC5 play a role in a MT-MMP-MMP-2 proteolytic cascade, involving provision of macrophage MT1-MMP for the activation of pro-MMP-2; furin and PC5 are expressed in monocytes and colocalize with MT1-MMP in macrophages in the atherosclerotic plaque
- MMP-2 may play an important role in the development of invasion and metastasis of gastric cancer.
- MMP-2 was significantly higher in cell extracts from pseudoxanthoma elasticum patients than in control cells, whereas differences were negligible in the culture media.
- HIV-1 interaction with mannose receptor induces promotion of MMP-2 through mannose receptor-mediated intracellular signaling in astrocytes.
- Leptin induced human oarticc smooth muscle cell proliferation and MMP-2 expression through a PKC-dependent activation of NAD(P)H oxidase
- MMP-9 but not MMP-2 was associated with internal elastic lamina degeneration, intimal hyperplasia, and luminal narrowing in giant cell arteritis
- melanoma cells cross-present, in an alpha v beta3-dependent manner, an antigen derived from secreted matrix metalloproteinase-2 (MMP-2) to human leukocyte antigen A*0201-restricted T cells
- Plasma MMP-2, TIMP-1 and hs-CRP concentrations were significantly increased in type-2 diabetic patients.
- polymorphisms in the gene promoter do not contribute significantly to the interindividual periodontitis susceptibility
- hemoglobin stimulates the secretion of uPA, MMP-2 and MMP-9 by synovial tissues; possible role of hemoglobin in joint damage after intra-articular bleeding
- generation and modulation of MMP-2 may be directly involved in the different responses seen in knee ligament injuries
- MMP-2 seems to be associated with the chronic progressive phase of the multiple sclerosise.
- The most invasive cell line secreted the highest amounts of MMP-2 and MMP-9.
- MMP2 immunoreactivity was present in polymyositis and dermatomyositis
- MMP-2 may play an important role in the invasion and metastasis of oral squamous cell carcinoma.
- Pro-MMP-2 levels were higher at early stages of the degenerative disc disease
- Smad4, but not Smad2, mediates TGF-beta1-induced MMP-2 expression in invasive extravillous trophoblasts
- The expression of MMP2 is consistently significantly higher in neoplastic brain tissue compared to normal brain tissue, and may be involved in the process of metastasis of breast cancer to the brain.
- monocyte and macrophaage cells in the breast tumor microenvironment play an important role in the modulation of MMP-2.
- MMP-2 may be a marker of microangiopathy
- Although MMP-1 is not detected in patients with persistent ovarian cysts, MMP-2 is expressed in all of the cysts
- FAK regulates integrin-dependent MMP-2 and MMP-9 expression and release by T lymphoid cells through src kinase
- PAF stimulated the gelatinase activity of MMP-2 by activating transcription and MMP-2 expression
- MMP-2/-9 activity correlated positively with cardiomyocyte apoptosis. MMPs have pivotal roles in acute cardiac dysfunction during early multiple organ failure in combined vasoconstrictor-masked hypovolemic and endotoxemia shock.
- Results suggest that MMP-2 might contribute in the pathogenesis of chronic kidney disease.
- Obese women with polycystic ovary syndrome have elevated serum concentrations of MMP-2.
- variations in EMMPRIN glycosylation forms are associated with either MMP-2 or MMP-9 activity
- These findings strongly indicate that increased MMP-2 expression in uterosacral ligaments is associated with pelvic organ prolapse.
- Active MMP-2 levels are constant during the menstrual cycle.
- ATP induced phosphorylation of intracellular JNK, and inhibition of the JNK pathway blocked ATP-stimulated MMP-2 release, indicating signaling via this pathway.
- MMP2 activity in human endothelial cells exposed to high glucose is inhibited by acetylsalicylic acid
- These results suggest the activation of proMMP-2 as an important event in the process of uveal melanoma progression.
- Both MAPKAPK2 and HSP27 are necessary for TGFbeta-mediated increases in MMP-2 and cell invasion in human prostate cancer.
- MMP-9 and MMP-2 are mediators of inflammation in chronic otitis media with effusion
- TGF-beta1 increases in vitro airway wound repair via MMP-2 upregulationin respiratory epithelial wound repair.
- Results of this study provide evidence that MMP-2 immunoreactive protein is prognostic in estimation of the aggressive clinical course of head and neck squamous cell carcinoma.
- The colocalization of EMMPRIN, MT1-MMP and TIMP-2 in human cervical carcinomas seems to be involved in a specific distribution pattern of tumor cell bound MMP-2, which is related with local proteolytic activity.
- results strongly suggest that Src induces MMP-2 expression via transcription activation and the ERK/Sp1 signaling pathway is involved in this process
- variations in the MMP2 gene do not contribute to the development of abdominal aortic aneurysm
- MMP-2 expression was increased in posterior wall of thoracic aortic aneurysms.
- association between oxidative stress and the MMPs/TIMPs system in hemodialysis patients could represent one of the mechanisms involved in the progression of atherosclerosis in this population
- PDK1 mediates mammary epithelial cell growth and invasion in part by MT1-MMP induction, which in turn activates MMP-2 and modulates the ECM proteins decorin and collagen
- p16 attenuates Sp1 binding to the MMP-2 promoter to suppress gene transcription and overexpression of Sp1 may counteract p16-induced downregulation of MMP-2.
- potential role of VEGF-A, MMP-2 and MMP-9, and TNF-alpha in the mechanism of idiopathic excessive uterine bleeding; active form of MMP-2 was reduced in women with menorrhagia
- Higher MMP2 activity is associated with breast cancer
- chitooligosaccharides may play an important role in the prevention and treatment of MMP-2 mediated several health problems such as metastasis and wrinkle formation
- Basal secretion levels of active matrix metalloproteinase-2 respond to various extracellular matrix proteins, cytokines, and growth factors in normal human melanocyte cells and melanoma cell lines from different stages of neoplastic progression.
- MMP-2 expression has significant correlation with tumor invasion, tumor differentiation and lymph node metastases; MMP-2 may participate in the development of lymph node micrometastasis of gastric carcinoma
- Up-regulation of MMP-2 expression was observed in atypical and anaplastic meningiomas.
- an imbalance between the MMP-2 and TIMP-2, caused primarily by an increase in TIMP-2 activity, contributes to the pathogenesis of diabetic nephropathy.
- Increase in serum levels eight days after IVIG treatment in neuromuscular disease.
- When all three proteases are studied in combination, a tendency was found for tumors with high MMP-2, high MMP-14 and low TIMP-2 expression to predict a poor prognosis but the results did not reach significance
- In artery samples in diabetic patients relative to nondiabetic patients, capillary density was reduced to 30%, VEGF expression was reduced by 48%; the expression and the gelatinolytic activity of MMP-2 and -9 were upregulated.
- MMP-2 could be associated with aggressive behavior, but MMP-9 expression diminishes in high-grade tumors.
- These results indicate a temporal relationship between MMP-2 production by endothelial cells and the onset of angiogenic event.
- plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal extracellular matrix metabolism
- overexpression of matrix metallopeptidase 2 and mutant p53 is associated with hydatidiform mole
- Two androgen response elements are shown to be responsesible for androgen-induced MMP-2 expression in prostate cancer cells.
- Inhibition of MMP-2 in transgenic mice may offer an additional approach for treatment of chronic kidney diseases.
- Results demonstrated higher expression of MMP-2 protein in meningiomas with subsequent recurrences compared with meningiomas from patients who had no recurrences.
- gelatinase is constantly upregulated by sunlight in the facial epidermis of most women during their daily lives, and may be an etiological factor in photoaging, e.g., by promoting wrinkle formation
- Loss of MMP-2, MMP-3 and FN in lichen planus may be associated with the destruction of the epidermal basal layer and these MMPs may be involved in the pathogenesis of interface dermatitis.
- All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II.
- A pathogenic role for MMP-2 is sugggested for MMP-2 in the alteration of the extracellular matrix of cerebral arteries during aneurysm formation.
- TIMP-1 may serve as a useful laboratory marker to predict the clinical outcome of patients presenting with severe sepsis.
- Valproic acid causes a change in acetylation of this gene.
- Data show that MMP2 may be relevant with carcinogenesis, development and metastasis of adenoid cystic carcinoma, and different metastasis potential may result from different subtype of MMPs gene family.
- No convincing evidence was found to support the association of MMP2 SNPs with increased breast cancer risk or survival.
- Astrocytes surrounding amyloid plaques show enhanced expression of MMP-2 in aged amyloid precursor protein (APP)/presenilin 1 transgenic mice.
- The effects of turbinatocoumarin and several chalcones from D. turbinata on MMP2 secretion by U87 tumor cells is reported.
- MMP2 was mainly localized in a concentric layer of the ovarian stroma.
- novel mode of proMMP-2 activation mediated by serglycin-dependent mast cells serine proteases
- This is the first report showing the existence of a causal relationship between ornithine decarboxylase expression, Erk and p38 MAP kinase activation, and MMP-2 expression.
- MMP-2 action negatively affects the neutrophils' migration across type IV coated membranes.
- We conclude that ischemic colitis induces increased activity and expression of MMP-9 and MMP-2 in the involved colonic mucosa.
- The identification that induction of MMP-2 and MT1-MMP by CSE from lung fibroblasts is EGR-1-dependent reveals a molecular mechanism for matrix remodeling in cigarette smoke-related emphysema.
- High levels of MMP-1 in tumour and mucosa as well as MMP-2 in plasma may be correlated to risk of developing distant metastases.
- nicotine stimulates bone matrix turnover by increasing production of tPA and MMP-1, 2, 3, and 13, thereby tipping the balance between bone matrix formation and resorption toward the latter process
- type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells
- Immunohistochemical analysis was performed with antibodies to VEGF, EGFR, MMP-2, and COX-2 in relation to human papilloma viral load and persistence of human papillomavirus after conization with negative margins
- identifies Src and MMP-2 as potential therapeutic targets in human herpesvirus 8 associated Kaposi Sarcoma and idiopathic pulmonary arterial hypertension
- in vitro findings suggest that the environment within the airways of patients with asthma enhances MMP-2 and -14 protein and activity by a complex interaction of transcriptional and posttranscriptional mechanisms, which may contribute to ASM migration.
- beta3 integrin in MDA-MB-231 breast cancer cells may lead to increased MMP-2 expression and activity and might contribute to the enhanced invasive potential observed
- Results describe the opposite effects of high glucose on matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in human endothelial cells.
- Plasma concentrations of MMP-2, MMP-9, TIMP-1, and TGF-beta1 significantly differed between the various histopathological types of primary glomerulonephritis.
- the -735C/T MMP-2 polymorphism might be an independent prognostic marker in non-small cell lung cancers
- Chondroitin-4-sulfate, which is expressed on tumour cell surface, can function to bind to pro-MMP-2 and facilitate its activation by MT3-MMP-expressing tumour cells to enhance invasion and metastasis.
- The aim of the present study was to investigate the effect of P. gingivalis on the expression and production of MMP-2, MMP-9, TIMP-1, and TIMP-2 by oral fibroblasts and epithelial cells.
- Parotid saliva of infantile chronic recurrent parotitis patients showed an increased protein concentration, altered mode of protein diffusion
- Infliximab treatment increases MMP-2 in serum of patients with CD, the latter also in the intestine, which extends and confirms our previous ex vivo explants observations.
- This study demonstrates that ATF2 mediates the TGF-beta-induced MMP-2 transcriptional activation, elucidating a molecular mechanism for the malignant progression of human breast epithelial cells exerted by TGF-beta.
- Chondrocytes with low chondrogenic capacity expressed higher levels of IGF-1, MMP-2, aggrecanase 2, while chondrocytes with high chondrogenic capacity expressed higher levels of CD44, CD151, and CD49c.
- MMP2 may have a possible role in the determination of arterial function; has potential implications for involvement in the pathophysiology of cardiovascular diseases.
- The production of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs, and plasminogen activators by gingival fibroblasts stimulated with lipopolysaccharides produced by periodontopathogens, are reported.
- Upregulation of matrix metalloproteinase-2 (MMP-2) expression during early development of knee osteoarthritis (OA) occurs via MAPK ERK, JNK, and p38 signaling pathways and the PI3K signaling pathway in cultured cells debrided from OA knees.
- LPA had no effects on membrane type 1-MMP or tissue inhibitor of metalloproteinase-2 expression, but up-regulated MMP-2 levels, contributing to the induction of MMP-2 activation.
- Plasma levels are increaed diabetic patients which may reflect abnormal extracellular matrix metabolism.
- Elevated activities of MMP-2 in the non-tumorous lung tissues of curatively resected stage I NSCLC patients are associated with tumor recurrence
- We conclude that induction of MMP1 participates in cell invasion and also plays an important role in HIF-1alpha-induced activation of MMP2.
- mRNA contents of MMP-2 and MMP-9 were not associated with any patient characteristics. Positive correlation was found between hepatosplenomegaly and the MMP-2/TIMP-1 and MMP-2/TIMP-2 ratios and between CNS involvement and the MMP-2/TIMP-2 ratio
- No significant variation in MMP2 was present in the diabetic group or in patients with acute coronary disease syndrome.
- We conclude that fetal MMP2 -1306 single nucleotide polymorphism (SNP) is associated with an increased risk for IUGR, but not MMP9 -1562 SNP nor MMP9 microsatellite.
- The results indicate that TIMP-2 and MMP-2:TIMP-2 complex associate with favorable clinical course and could be used as a novel prognostic indicators in bladder cancer.
- Epithelial MMP-2 expression is associated with pancreatic cancer
- may degrade fibrillin-2 and may play a role in the remodeling of elastic system fibers in the periodontal ligament
- Results showed that the endogenous matrix metalloproteinase-2 might be involved in skin development and in maintenance of cutaneous structure and function.
- epiregulin, COX2, and MMP1 and 2 collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis
- MMP-2 is modulated by phosphorylation on multiple sites in a tumor cell line and protein kinase C may be a regulator of this protease in vivo.
- Expression of active MMP-2 was increased in 9L/F344 rat brain during the growth of malignant gliomas at different time intervals, which indicate that 9L/F344 animal model may be a prospective animal model to test new MMPs inhibitors.
- gene polymorphisms for MMP-2 did not show any association with the G-AgP in Chinese subjects with generalized aggressive periodontitis
- AT1R is involved in the progression of gastric cancer and may promote the angiogenesis of gastric cancer cell line (MKN-28), and these effects may be associated with the upregulation of MMP2.
- Transendothelial migration of mesenchymal stem cells is at least partially regulated by MMP-2.
- Activated MMP-2 and MMP-9 were detected in eight out of nine cases of floppy valves.
- Results of this study suggest that Systemic sclerosis patients with anticentromere antibodies positivity, after a primary fibrogenetic noxa, react with a more abundant release of MMP/TIMP, whereas patients with anti-Scl70 antibody show a normal response.
- These experiments identified a collagen-binding domain (CBD)-binding site on type I collagen and demonstrated that a corresponding synthetic peptide can inhibit hydrolysis of type I and IV collagens by competing CBD-mediated gelatin binding to MMP-2.
- proMMP-2 and proMMP-9 secretion are decreased in THP-1 cells infected with Toxoplasma gondii
- Bcl-2 induces the expression of MMP2 in renal cell tumors grown in the orthotopic sites, though no appreciable effects were observed in vitro.
- stromal fibroblasts play a role in promoting pancreatic cancer metastasis via activation of the uPA-plasminogen-MMP-2 cascade
- Our results suggest that the presence of -1575G allele in the MMP-2 promoter region may be of significance in the assessment of colorectal cancer risk and invasive potential.
- describes the site-specific distribution and activities of MMPs and therefore might help in elucidating the molecular mechanisms in pathologies such as premature rupture of membranes
- Matrix metalloproteinase 2 gene analysis was negative for mutation in the three patients.
- Expression of MMP2 was evaluated in hepatocellular carcinoma and surrounding non-tumor tissie.
- results suggest that MMP2 is a more sensitive predictor than MMP9 of lung cancer progression, metastasis, and survival
- genetic polymorphisms or haplotype in the MMP2 promoter may play a role in mediating the susceptibility to nasopharyngeal carcinoma in Chinese populations
- MMP-2 activity was enhanced in pleural effusions from patients with benign diseases compared with cancer patients.
- Results determine the level of MMP-2, its natural inhibitor TIMP-2, their ratio and HER-2/neu as diagnostic and prognostic factors in breast cancer.
- Binding of two zinc and two calcium ions to the MMP-2 catalytic domain is energetically favored.
- syndecan-2 acts as a suppressor for MMP-2 activation, causing suppression of metastasis
- COX-2, MMP-2 and MMP-9 were expressed in a high percentage of primary endometrial carcinomas and their expressions may be associated closely with parameters of tumor aggressiveness.
- ERM/ETV5 up-regulation activates MMP-2 and thus has a role during myometrial infiltration in endometrial cancer
- MMP-2, MMP-9, and vascular endothelial growth factor C were expressed to similar degrees at all time points in cells exposed to lymphatic flow.
- The data provide evidence supporting a potential role for the endothelial production of MMPs in promoting cancer cell extravasation.
- TIMP-1 and its inhibitory domain, N-TIMP-1, are weak inhibitors of MMP2.
- 6Mercaptopurine decreased HSP27 nucleous expression that was associated with inhibited MMP2 activity and NO production.
- NGF stimulates endothelial cell invasion and cord formation by augmenting MMP-2 via the PI3K/Akt signaling pathway and AP-2 transcription factor, which may be responsible for triggering angiogenesis.
- VEGF, MMP2, 7 and 9, and COX-2 expression is related to progression of advanced uterine cervical cancer in young women
- These findings suggest that MMP-2 -1306C/T polymorphism may be a genetic risk factor related to lumbar disc disease susceptibility in the young adult population.
- fibroblast growth factor 2 release from the lens capsule by MMP-2 is essential to lens epithelial cell viability and survival
- MMP-9, but not TIMP-1 nor MMP-2 expression is increased in plaques causing acute coronary syndrome.
- MMPs also cleave a variety of non-ECM proteins, including cytokines, chemokines, and growth factors, activating or inactivating them, or generating other products that have biological consequences.
- Multidrug resistant breast cancer cells with p-glycoprotein substrates could affect outcome through modulating the production of MMP2.
- Increased mmp-2 is assopciated with squamous cell laryngeal carcinoma
- an interaction between chitosan and matrix metalloprotease 2 decreases the invasive activity of human melanoma cells
- The data suggest that MMP-2 -1306C>T polymorphism strongly contributes to the development of BC
- ROCK-II is a critical mediator of colon cancer cell invasion through its modulation of MMP-2 and -13 at the site of invadopodia but regulates proliferation in non-malignant intestinal cells.
- Nicorandil suppresses the increases in MMP2 and MMP9 levels and activities and prevents the development of ventricular remodeling in acute myocardial infarct
- MMP-2, MT1-MMP and TIMP-2 mRNA expression levels were correlated with clinical stages and histological subtypes of thymic epithelial tumours. The activation of pro-MMP-2 might be mediated by MT1-MMP and TIMP-2 up-regulation.
- direct CpG-oligodeoxynucleotides and TLR-9 interactions in HT-29 cells could provide new approaches in malignant tumor therapeutic strategies
- MMP-2 processing of HARP and CTGF released vascular endothelial growth factor (VEGF) from angiogenic inhibitory complexes.
- SDF-1-CXCR4 interaction activated MMP-9 at the both transcription and protein levels and MMP-2 only at the post-translation level.
- MMP-2 may be implicated in pathogenesis of leiomyoma.
- serum MMP-2 levels in Behcets patients with vascular involvement showed a positive correlation between Leeds activity score
- Mmp2 and Mmp9 gelatinase activity, and caspase3 immunoreactivity in pulmonary epithelial cells were attenuated in the Cd8-deficient mice.
- This study does not provide strong evidence for further investigation into the role of the MMP2 and MMP3 variants in melanoma progression
- MMP2 expression varied with histological type in epithelial ovarian cancers. It was associated with better prognosis. In stromal cells, its expression was correlated with hyaluronan expression.
- The present study failed to demonstrate any association between serum levels of MMPs, VEGF and CA 15.3 and well-known clinicopathological characteristics of breast carcinoma
- MMP-2/9 production is regulated by sPLA2-IB acting as a receptor ligand to activate cPLA2
- One single irradiation of UVB increases the immunohistochemical expression of gelatinases in almost all evaluated cell lines, with the exception of MMP-9 in keratinocytes
- MMP-2 upregulation confers on tumor cells the ability to degrade the subepithelial basement membrane and subsequently invade the cervix.
- Patients with larger aortic diameters have increased MMP-2/TIMP-1. Modifying MMP expression may have a role in development of aneurysms.
- exposure of human melanoma cells to hyaluronan fragments leads to nuclear factor kB (NFk-B) activation followed by enhanced expression of matrix metalloprotease (MMP) 2 and interleukin (IL)-8, factors that can contribute to melanoma progression.
- polymorphisms in MMP1, MMP2, MMP3, MMP9, or MMP10 weren't associated with acute MI compared with angina or with coronary disease. Circulating levels of MMP2 are independently associated with development of an acute MI rather than stable angina.
- EMMPRIN and MMP-2 are the major determinants of malignancy in cancers
- N-acetylcysteine prevented LPS-induced pro-inflammatory cytokines and MMP2 production in gingival fibroblasts.
- MMP-2, MMP-9, TIMP-1 and TIMP-2 play an important role in the pathogenesis of non-melanoma skin cancer. The immunoexpression of these proteins may be useful indicators of cutaneous cancer invasion and progression.
- MMP2, MMP14, and MMP9 might be used as prognostic markers in patients with sinonasal and oral malignant melanoma.
- These results suggest that P. acnes stimulates hDF to produce TNF-alpha, which mediates the expression of proMMP-2 through the NF-kappaB pathway.
- 735C/T polymorphism not related to generalized aggressive periodontitis
- Chorionic gonadotropin promotes trophoblast invasion and migration through activation of ERK and AKT signaling involving their downstream effector MMP-2.
- The aim of this study was to analyse the influence of recombinant IFN beta-1a (identical with natural IFN-beta) on MMP-2 and MMP-9 activities
- A high incidence of MMP-2 expression is confirmed in erythroblasts from acute myeloid leukemia (AML) patients and suggests the possible involvement of MMP-2 in the invasive phenotype of AML.
- platelet activation and aggregation is regulated by MMP-2 that specifically interacts with integrin alpha(IIb)beta(3)
- Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways to stimulate angiogenesis.
- data suggest that MMP-2 -735C/T, MMP-9 -1562C/T and MMP-12 357Asn/Ser polymorphisms are not associated with susceptibility to severe CP in Turkish population. T allele of MMP-9 -1562 gene might be associated with decreased susceptibility to severe CP.
- Knockdown of SIM2s in MCF-7 breast cancer cells contributed to an epithelial-mesenchymal transition associated with increased MMP2levels.
- In carotid stenosis MMP-2 levels tended to increase 30 days after carotid endarterectomy.
- The expression level of Matrix Metalloproteinase 2 mRNA showed an increasing trend according to differentiation, lymphatic invasion and Dukes' stage in colon cancer tissues.
- These findings suggest that MMP2 promoter polymorphisms may provide some predictive value for hepatocellular carcinoma recurrence after liver transplantation.
- Report association of polymorphisms of the MMP-2 and TIMP-2 genes with the risk of endometriosis in North Chinese women.
- We conclude that early steps of adipogenesis may be impaired in T2DM independently of obesity due, in part, to an upregulation of the MMP2 transcription.
- Markedly increased levels of serum MMP-2 in infectious, especially bacterial, meningitis may reflect the degree of damage to the blood-brain barrier.
- MMP-2 could be acknowledged as a new prognostic factor in melanoma.
- IR/visible light spectrum of sunlight significantly decreased skin MMP-2 expression.
- The MMP2 rs243865-T allele is not a major rheumatoid arthritis genetic factor in this population.
- These results suggest that MMP-2 overexpression by cancer cells in peritoneal implants and not in the primary ovarian cancer is predictive of ovarian cancer prognosis and more likely reflects the presence of particularly aggressive clones of cancer cells
- MMP-2 -1306C-->T polymorphism contributes to the development of squamous cell cervical cancer in the population studied, especially in women who had first coitus at an early age.
- Data show that enhanced expression of matrix metalloproteinases 2 was detected in colorectal cancer patients with distant metastases.
- MMP-2, TIMP-1 and TIMP-2 levels are significantly higher and MMP-9 lower in children with chronic hepatitis B
- Performed molecular docking simulations to study binding at the S1' pocket in the apo form of MMP2, and identify, at the molecular level, the structural properties relevant for the designing of specific inhibitor of MMP-2.
- results suggest that relaxin may promote the invasive potential of early placental EVTs through up-regulating MMP-2, -9 mRNAs and down-regulating TIMP-1 mRNA in EVTs.
- High numbers of human skin cancers express MMP2 and several integrin genes.
- polymorphisms in the MMP2 is associated with the protective effect of helicobacter pylori on esophageal adenocarcinoma risk
- Crucial participants in tumour invasion and metastases are matrix metalloproteinases, tissue inhibitor of metalloproteinase inhibitors and cellular adhesion molecules. They play roles in tumour invasion and metastasis in non-small-cell lung carcinomas.
- MMP-2, MMP-9 and claudin-4 expression may be phenotypic features, distinguishing intestinal-type and diffuse-type gastric cancer.
- Data suggest that Fra-1 enhances lung cancer epithelial cell motility and invasion by inducing the activity of matrix metalloproteinases, in particular MMP-2 and MMP-9, and EGFR-activated signaling.
- These results indicate an association of MMP-2 -1306C/T polymorphism with the risk of adenomyosis, suggesting a potential role in adenomyosis development in North Chinese women.
- HCG increases the secretion of MMP-2 and -9 in cytotrophoblasts in a dose-dependent manner.
- The dysregulated MMP2 expression is associated with infertility and early pregnancy loss.
- Adenoviral-mediated transfer of RNA interference against MMP-2 results in the retention of neurological function and significantly inhibited tumor growth.
- Increased MMP-2 and -9 and altered beta-catenin may play a role in the pathogenesis of endometriosis.
- MMP-9, but not MMP-2, may have a role in mechanisms for stimulation of cell division and matrix biosynthesis, which cause matrix remodeling in the umbilical cord of preeclamptic newborns
- Report the production of vascular endothelial growth factor and MMP-1/2 via protease-activated receptor in human endometrial stromal cells.
- This study suggests that MMP14 is involved mostly in prostate cancer implantation and that MMP2 and TIMP2 expression by reactive stromal cells might be used as predictors of diease-free survival in T3N0-2M0 Pca.
- Metastatic gastric cancer presents more aggressive histological morphology and higher MMP-2 immunoreactivity than primary gastric cancer.
- the activity of MMP-2 in the internal mammary artery is correlated with age, hypertension, diabetes and estimated glomerular filtration rate.
- Knockdown of MMP-2 did not significantly alter the metastatic potential of the liver cancer cells but lead to a marked inhibition of metastatic foci growth.
- MMP-2 expressed by metastatic ovarian cancer cells functionally regulates their attachment to peritoneal surfaces
- In this study we found the MMP2 rs2287074 A allele may be associated with a lower likelihood of age-related maculopathy in older Caucasian women, particularly those who have never used hormone therapy.
- MMP-2 is valuable in determining the patients with more aggressive form of non-small cell lung cancer..
- Stromal expression of MMP-2 (matrix metalloproteinase-2) was significantly higher in premenopausal endometrial polyps compared to postmenopausal polyps
- Alcohol reduces MMP-2 plasma activity in healthy humans and in isolated vascular smooth muscle cells.
- The study suggested that the C/C genotype of the C-735T SNP in the promoter region of MMP-2 gene may be a potential risk factor for epithelial ovarian cancer, but the C-1306T SNP may have no association with the risk of epithelial ovarian cancer.
- in colorectal neoplasms, MMP-2 expression correlates with the depth of invasion, venous invasion and liver metastasis; MMP-9 and RECK expression correlate with venous invasion
- soluble EMMPRIN probably triggers the promotion of cancer invasion in vivo
- MMP-2 inhibition induced apoptotic cell death in vitro, and suppressed tumor growth of preestablished U-251 intracranial xenografts in nude mice
- These results suggest an important role for MMP-2 and MMP-9 in the induction of T. cruzi-induced acute myocarditis.
- regulation of intervertebral disc ECM metabolism by the THBS2-MMP system plays an essential role in the etiology and pathogenesis of LDH.
- key players involved in transmigration and invasion of MSCs are the endothelial phenotype, VCAM-1/VLA-4, beta1 integrins, MMP-2 secretion and cytokines.
- Berberine induced down-regulation of MMP2 in gastric neoplastic cells in vitro.
- MMP-2 overproduction is associated with bone marrow stromal cells in multiple myeloma
- In prostate adenocarcinoma distant spread is more likely to occur in patients with high levels of VCAM and low levels of MMP-2.
- Higher net MMP-9 (but not MMP-2) activity in gestational hypertension.
- Rap1GAP inhibits tumor growth but induces MMP2- and MMP9-mediated SCC invasion and tumor progression, suggesting a role for this protein as a biomarker for early N-stage, aggressive SCCs
- MMP-2 stimulates keratinocyte survival whereas MMP-9 promotes terminal differentiation.
- High epithelial MMP-2 expression in gastric cancer is associated with poor survival.
- MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not.
- The C allele of MMP-2 -1306C/T polymorphism did not modify the risk of developing endometriosis but significantly increase the risk of developing adenomyosis.
- Neither MMP-2 SNPs nor MMP-9 SNPs revealed significant association with proliferative diabetic retinopathy in single-locus comparisons.
- Demonstrate an association of the MMP-2 gene with the development of lacunar stroke, and no association of MMP-2 with other stroke subtypes.
- The expression of MMP-2 and -9 in tissue samples from keloids was investigated by immunohistochemistry.
- Significantly higher expression of MMP-2 in melanoma-associated spongiform scleropathy(MASS), indicating MMP-2 is involved in development of MASS and is produced by scleral fibroblasts under influence of tumor cells and/or tumor-infiltrating macrophages.
- megsin indirectly links to MMP2 activation via the inhibition of plasmin enzymatic activity
- SRC-3/AIB1 directly regulates transcription of matrix metalloproteinase (MMP)-2 and MMP-13 through its coactivation of AP-1 and PEA3.
- The expression of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and inducible nitric oxide synthase (iNOS) in a verrucous proliferative leukoplakia sample, was investigated.
- Glutamate-induced MMP-2 activity may contribute to neuropathology in various CNS diseases and may generate misleading data in pathogen studies where Middlebrook 7H9 is the culture medium.
- The Matrix Metalloproteinase (MMP-2, MMP-9) to E-cadherin (M/E ratio) characterizes an important aspect of the molecular phenotype associated with the histologic progression of prostate cancer among African American prostate cancer patients.
- proMMP-2 activation involves MT1-MMP dimerization
- Data suggest that KiSS-1 suppresses the motility and invasive ability of renal cell carcinoma cells which possess hOT7T175 with either a negative expression or very low expression level of KiSS-1 through, at least in part, the down-regulation of MMP-2.
- In 560 human breast tumors, AIB1 expression was found to be positively associated with PEA3, MMP2, and MMP9.
- There was significant correlation between immunohistochemical staining for MMP-2 & clinical condition of medullary thyroid carcinoma patients & correlation between state of apparent cure compared to persistence of MTC after thyroid surgery.
- Results describe the relationship between protein expression of VEGF-C, MMP-2 and lymph node metastasis in papillary thyroid cancer.
- Dengue Virus-induced MMP-2 overproduction by direct infection of endothelial cells may contribute to the pathogenesis of severe dengue infection.
- Plasma levels of MMP-2 and MMP-9 are increased in obese patients which may reflect abnormal extracellular matrix metabolism.
- Increased MMP-2 expression is associated with differentiated thyroid carcinoma.
- MMP2 transcription activity is significantly upregulated along with neuron and glial cell apoptosis following spinal cord injury in transgenic mice.
- Data suggest that alpha5beta1 intergrin controls invasion ability of MCF-7/ADR breast carcinoma cells by regulating expression of MMP-2.
- The MMP2 gene does not play a crucial role in conferring risk for nasal polyps in a Taiwanese population.
- Alterations of MMP-2 and -9 expression may play a role in eosinophilic chronic rhinosinusitis, but the association with IL-5 and IL-13 remains unclear
- This study corroborates that stromal cells play an important role in tumor invasion and progression, mediated by the progressive enhancement of MMP-2 expression from CIN3 to advanced invasive tumor.
- a link between RhoA, JNK, c-Jun, and MMP2 activity that is functionally involved in the reduction in osteosarcoma cell invasion by the statin. This suggests a novel strategy targeting RhoA-JNK-c-Jun signaling to reduce osteosarcoma cell tumorigenesis.
- 3,4,5-trihydroxybenzaldehyde from Geum japonicum has inhibition effect on MMP-2 and MMP-9 activities in smooth muscle cells
- Low circulating levels of ProMMP-2 are associated with bladder cancer.
- Gene expression revealed up-regulation of pro-angiogenic (PGF), anti-apoptotics (BAG-1, BCL-2), heart development (TNNT2, TNNC1) and extracellular matrix remodelling (MMP-2, MMP-7) genes in SM.
- MMP-2 activity is associated with treatment failure in childhood acute lymphoblastic leukemia
- Estrogen and progeterone upregulate MT1-MMP/MMP-2 and alter cell migration in vascular smooth cells.
- This study suggest that carriage of the (-1575G/A, -1306C/T) allele may influence the MS disease process through MMP-2 serum level production.
- Significantly higher matrix metallopeptidase 2 expression is associated with prostate cancer.
- increased plasma activity of MMP-2 in women with metabolic syndrome is important because they fit in with an early stage of cardiovascular disease
- Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression.
- The structural changes in the venous wall in addition to the increased expression of MMP-2, MMP-9 and MMP-13 in venous aneurysms suggests a possible causal role for these MMPs in their pathogenesis.
- H(2)O(2) induced cell death and fibronectin mRNA expression, but decreased the amount of MMP-2 mRNA.
- results suggest that MMP-2 activation by MT1-MMP potentially amplifies protease activity, and combination with direct cleavage of substrate causes tissue degradation and enhances tumor invasion and metastasis, which highlights the complex role of TIMP-2
- The data indicates that the decidual microenvironment may exert the key control for trophoblast cell invasion mainly through influencing MMP-2 expression.
- Serous and mucinous ovarian tumors express different profiles of MMP-2.
- MMP-2 and MMP-9, beside their roles in liver injury with tissue remodeling and fibrosis can be markers of acute rejection after liver transplantation.
- Platelet-derived microparticles promote prostate tumor invasiveness, at least in part by stimulation of MMP-2 production
- Matrix metalloproteinase 2 and 9 as the factor of head and neck tumor metastasis
- On the basis of linked-function analysis, we demonstrated that collagen binding domain of MMP2 tuned the cleavage of collagen IV by MMP9, presumably by inducing a ligand-linked structural change on the type IV collagen.
- The role of MMP-2 and the signaling pathway involved in EGF-promoted invasion by human pancreatic cancer cells PANC-1 was investigated.
- The results revealed that mononuclear cells were highly immunoreactive for TIMP-1, TIMP-2 and MMP-9 during viral meningitis and that the expression of TIMPs in polymorphonuclear cells was even higher during bacterial meningitis.
- MMP-2 were identified at higher levels in lung secretions of pediatric ALI patients compared with controls.
- Data strongly suggest that LRP1 promotes glioblastoma cell migration and invasion by regulating the expression and function of MMP2 and MMP9 perhaps via an ERK-dependent signaling pathway.
- Tiotropium bromide suppressed MMP2 production by cultured lung fibroblasts.