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Validated All-in-One™ qPCR Primer for FGF1(NM_001257209.1) Search again
Product ID:
HQP057495
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1
Gene Description:
fibroblast growth factor 1
Target Gene Accession:
NM_001257209.1(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq].
Gene References into function
- Alternative type I and I' turn conformations in the beta8/beta9 beta-hairpin
- possible role of fibroblast growth factors in expression of genes of the plasminogen activator system in breast fibroblasts
- bFGF and aFGF may suppress endothelial-dependent monocyte recruitment and thus have an anti-inflammatory action during angiogenesis in chronic inflammation but inhibit the immunoinflammatory tumor defense mechanism
- identification of rare partially unfolded states in equilibrium with the native conformation
- Recombinant human FGF-1 binds to both the catalytic alpha-subunit and to the regulatory beta-subunit of CK2. A correlation between the mitogenic potential of FGF-1 mutants and their ability to bind to CK2 alpha was observed.
- Maintenance of the human umbilical vein endothelial cell phenotype and differentiation into smooth muscle-like cells are reciprocally controlled by fibroblast growth factor-1 and activin A.
- The mitogenic acitivity of AFGF was inhibited by the synthetic peptide Ac-ValTyrMetSerProPhe-NH2.
- The conformational stability and dynamics of FGF1 have been measured on the basis of amide proton-exchange kinetics, monitored by two-dimensional NMR spectroscopy.
- No associations of intracranial aneurysm and FGF1 were found.
- According to phase of menstrual cycle, endometrial stromal cells from endometriosis patients in late proliferative phase had higher bFGF mRNA values and lower 1B FGF-antisense mRNA compared with controls
- Binding studies demonstrated no high-affinity interaction of FGF-1 with fibrinogen or fibrin; unlike FGF-2, FGF-1 can support vascular endothelial cell growth only if continually present in soluble form.
- An alternative core packing group, involving a set of five positions, has been introduced into human acidic FGF-1
- FGF1 transcriptionally induces membrane type-1 matrix metalloproteinase expression in a prostate carcinoma cell line.
- Data show that mouse and human fibroblast growth factor 1 (FGF-1) internal ribosome entry sites show similar activity profiles, and have a conserved structural domain at both the nucleotide sequence and RNA structure levels.
- Promoter polymorphism and genetic susceptibility for Alzheimer's disease
- 1.10-A atomic resolution X-ray structure of human fibroblast growth factor 1 (FGF-1), a member of the beta-trefoil superfold, has been determined
- FGF-1 is a key human adipogenic factor, involved in fat tissue growth.
- residues flanking the the beta4/beta5 and beta8/beta9 beta-hairpin turns of human acidic fibroblast growth factor are a primary structural determinant of the conformation within the turn
- FGF-1 contains a second putative NLS (NLS2), which is located near the C-terminus. It is a bipartite NLS consisting of two clusters of lysines separated by a spacer of 10 amino acids.
- FGF-1 regulates HO-1 expression through Nrf2
- A recombinant nonmitogenic form of aFGF (nhaFGF) was purified and the mitogenic activity of the purified nhaFGF was decreased dramatically comparable to that of the wild-type aFGF (haFGF).
- Data indicate that after endocytosis, fibroblast growth factor receptor (FGFR)4 and its bound ligand, FGF1, are sorted mainly to the recycling compartment, whereas FGFR1-3 with ligand are sorted mainly to degradation in the lysosomes.
- FGF1 dimerization upon heparin was favored over monomeric interactions even when a large excess of saccharide was present
- FGF-1 might have both autocrine and paracrine functions in renal inflammation
- A type I 4:6 turn at turn 1 of FGF-1 appears essential for efficient mitogenic function.
- Data suggest that minor changes of local kynurenic acid concentration may modulate fibroblast growth factor-1 release, cell proliferation, and ultimately tissue damage in different pathological conditions.
- Two molecules of suramin appear to bind simultaneously to one molecule of hFGF-1 with high affinity
- Hsp90 is required for translocation of FGF-1 and FGF-2 across the endosomal membrane
- FGF-1 can have an antifibrogenic role, inducing apoptosis of fibroblasts and inhibiting myofibroblast differentiation
- analysis of heparan sulfate-related oligosaccharide binding to fibroblast growth factors 1 and 2 and their receptors
- Can be efficiently expressed in Pichia pastoris.
- Amplification of FGF-1 at 5q31 in ovarian cancer tissues leads to increased angiogenesis, and autocrine stimulation of cancer cells, which may result in poorer overall survival in patents with high-grade advanced stage serous ovarian cancer
- Results describe the stabilization of human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions.
- FGF1 was scored as one of several lead candidate gene products to modulate the transdifferentiation process and is shown here to exert inhibitory effects on adipogenic commitment and differentiation.
- FGF and PDGF have roles in cell proliferation and migration in osteoblastic cells
- genetic variation within FGF1 cosegregates with elevated blood pressure in hypertensive families and that this association is likely to be mediated by upregulation of renal FGF1 expression.
- FGF and FGFR may have a role in cleft lip and cleft palate
- the induction of apoptosis through the inhibition of endogenous FGF signaling is caspase-9 pathway- dependent
- The Asx-Pro-Asx-Gly type I beta-turn motif stability in FGF1.
- integrin alphavbeta3 binding to FGF1 plays a role in FGF1 signaling
- FGF-1-induced cell permeabilization and derived consequences depend on the Cx composition of connexin hemichannels
- FGF antagonizes Wnt signaling by inhibiting Wnt-induced transcription and suggest that multiple mechanisms, including downregulation of TCFs and Wnt receptors, contribute to this effect.
- the FGF binding domain and the heparin binding domain are necessary for the hBP3 interaction with endogenous FGF and the activation of FGFR signaling in vivo
- klotho is a potential tumor suppressor and an inhibitor of the IGF-1 pathway and activator of the FGF pathway in human breast cancer
- Myometrium conversion into leiomyoma and an increase in its mass is accompanied by a significant increase in aFGF gene expression.