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Validated All-in-One™ qPCR Primer for IL11RA(NM_001142784.2) Search again
Product ID:
HQP055452
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CRSDA
Gene Description:
interleukin 11 receptor subunit alpha
Target Gene Accession:
NM_001142784.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors.
Gene References into function
- IL-11Ralpha was expressed in both epithelial and stromal cells, with epithelial staining being more intense
- expression and function in human endometrium
- the interleukin-11 receptor alpha-chain has evidence of antiapoptotic effects in human colonic epithelial cells
- IL-11Ralpha is a candidate target for translational clinical trials against advanced and metastatic prostate cancer.
- interleukin-11 receptor is expressed in CD38-positive cells from patients with multiple myeloma
- High expression of interleukin-11 receptor alpha is associated with Hodgkin's lymphoma
- High interleukin 11 receptor is associated with breast cancer
- IL-11/IL-11R pathway plays an important role in the progression of colorectal adenocarcinoma.
- The objectives of this study were to clarify the role of IL-11 and IL-11Ralpha in human gastric carcinoma.
- binding site of il-11 to IL-11R alpha is characterized
- IL11 inhibits human extravillous trophoblast invasion via STAT3, indicating a likely role for IL11 in the decidual restraint of EVT invasion during normal pregnancy.