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Validated All-in-One™ qPCR Primer for SLC6A4(NM_001045.5) Search again
Product ID:
HQP055447
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT
Gene Description:
solute carrier family 6 member 4
Target Gene Accession:
NM_001045.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
Gene References into function
- A putative three-dimensional arrangement of the human serotonin transporter transmembrane helices: a tool to aid experimental studies.
- The 5-HTT gene is unlikely to play a major role as a susceptibility factor in autism.
- Upstream polymorphisms modulate transcription of SLC6A4 and affect serotonin uptake activity. No association was found, however, with major psychosis symptomatology among 1820 inpatients.
- Data do not support the implication of the serotonin transporter gene (5-HTT) in the psychiatric comorbidities of NF1.
- Transmission disequilibrium mapping at the serotonin transporter gene region in autistic disorder
- A polymorphism in the promoter region of the serotonin transporter gene has been linked to the gender-specific association of suicide attempts by females.
- 5-HTT-VNTR allele 12 is a risk factor for schizophrenic disorders in Chinese populations.
- study did not support the involvement of 5-HTTLPR, TPH, MAO-A, or DRD4 polymorphisms in mood disorders
- SLC6A4 polymorphism is associated with a higher risk of myocardial infarction
- No significant differences in allele/genotype distribution of the 5-HTTLPR were found between 191 controls and obsessive-compulsive disorder
- evaluated the relationship between attention deficit hyperactivity disorder and polymorphism of the two regions of the 5-HTT gene [variable number of tandem repeats (VNTR) and 5-HTTLRR] in a sample of Turkish children
- The silencer activity of the novel human serotonin transporter linked polymorphic regions.
- Absence of association of the serotonin transporter gene polymorphism with the mentally healthy subset of fibromyalgia patients.
- results suggest that differential excitability of the amygdala to emotional stimuli may contribute to the increased fear and anxiety typically associated with the short SLC6A4 allele
- Association of regulatory region polymorphism and abnormal eating behaviors
- VNTR polymorphisms in male opiate addicts
- In generalized anxiety disorder, the number of serotonin transporters is not modified, although the functional efficiency of the transporter might be altered.
- 5-HT transporter gene promoter variants seemingly exert a small effect on 5-HT blood levels in autistic children, which largely does not account for hyperserotoninemia
- Family-based association studies show a link between this gene and major psychiatric disorders.
- the serotonin transporter varients are not a major determinant of the group mean platelet serotonin elevation seen in autism.
- possible involvement of the serotonin transporter in susceptibility to ADHD.
- Study shows no association of reportedly functional promoter polymorphism at SLC6A4 with alcohol dependence or with any of alcoholism subtypes based on sex, comorbid drug dependence, or age of alcoholism onset.
- association between serotonin transporter gene polymorphism and family history of suicide and attempted suicide
- The polymorphism does not appear to be involved in a genetic predisposition to the disease but may affect the frequency of attacks in patients with migraine.
- The variable number of tandem repeats (VNTR) polymorphism significantly influences the age at onset but the serotonin transporter gene linked polymorphic region (5-HTTLPR) polymorphism did not.
- study tested the hypothesis that the 5-HTT gene-linked polymorphic-region (5-HTTLPR) polymorphism is associated with SSRI antidepressant response by evaluating depressive symptoms for Chinese patients diagnosed with major depression
- A relationship of L/S gene with the disease was detected in Russians and Tatars, the presence of heterozygotic genotype was associated with early onset of chronic alcoholizm and acute alcoholic psychosis in Tatars and with later alcoholization in Russian
- present findings failed to replicate prior work suggesting that the short variant of the 5-HTTLPR allele is associated with higher Neuroticism and lower Agreeableness
- Individuals homozygous for the serotonin transporter allele exhibit a weaker loudness dependence (LD) compared to heterozygous subjects; the LD may serve as an endophenotype in human serotonin research.
- Review. The serotonin transporter gene has 2 types of functional polymorphisms which are good candidates for etiological involvement in various psychiatric conditions. Both affect the transcription ratio of 5-HTT gene & its protein expression.
- No significant difference was demonstrated for genotype or allele frequency, when comparing methamphetamine dependent and control cases for 5-HTT serotonin transporter polymorphisms.
- Serotonin transporter promoter polymorphism associated with aggression, attention deficit, and conduct disorder in adoptee population
- HTT genotype frequencies significantly differed between schizophrenic patients who made violent suicide attempts and both, those who attempted suicide with a non-violent method and those who never attempted suicide
- The frequency of the SLC6A4 long (L) allele of the serotonin transporter is significantly higher in African-Americans than has been reported for European-Americans (typically 56-60%).
- No association between either the 5HT transporter or the variable number tandem repeat in ADHD was found.
- Polymorphism of the serotonin transporter gene may contribute to the susceptibility to the symptomatology of schizophrenia but not to the development of the disorder itself, at least in the Korean population.
- analyzed the possible cooperation effect between the PlA2 allele (GPIIIa) and LL genotype (SLC6A4) in the development of myocardial infarction
- a functional polymorphism in the promoter region of the serotonin transporter gene was found to moderate the influence of stressful life events on depression
- Meta-analysis of the 5-HTT promoter 44 bp insertion/deletion polymorphism in suicide behavior showed a significant association following sensitivity analysis. 5-HTT may play a role in the predisposition to suicide.
- Serotonin transporters are preserved in the neocortex of anxious Alzheimer's disease patients.
- Results suggest that the serotonin transporter gene is unlikely to have a major contribution to susceptibility to schizophrenia in Han Chinese population.
- during coupled transport, the currents represent different states of the same permeation path through hSERT and coupling occurs in a common pore
- The genetic variation in the serotonin transporter gene effects the response time to sertraline and provides complementing evidence that this polymorphism affects response time to other serotonin transporter.
- The 5-HTTLPR variants may have an effect on the platelet 5-HT concentrations in migraine patient.
- Results indicate a relationship between sudden infant death syndrome(SIDS) and the 12-repeat allele of the 5-HTT gene in African-Americans, and a significant role of the haplotype and the promoter L-allele in defining SIDS risk in African-Americans.
- We examined the association of serotonin (5-HT) transporter linked polymorphic region (5-HTTLPR) alleles to comorbid alcohol dependence and major depression.
- The commonly observed sex difference in HR reactivity may be, in part, genetically mediated and perhaps occur only among individuals homozygous for the short allele at the serotonin transporter gene-linked polymorphic region.
- 5-HTT gene polymorphism appears to determine the severity of pulmonary hypertension in hypoxemic patients with COPD.
- The "S" allele of the serotonin transporter gene-linked polymorphic region may identify patients at risk for developing insomnia or agitation with fluoxetine treatment.
- The results provide modest evidence for a possible association of the 5HT transporter gene with a completed suicide.
- Study results do not support a significant contribution of the 5-HTT promoter genotype and 5-HT2c Cys23Ser polymorphism to a putative common genetic predisposition of attention-deficit hyperactivity disorder and alcohol dependence.
- Attenuated concentration of extracellular serotonin due to longer variants may cause higher susceptibility to chronic fatigue syndrome.
- uncommon coding region SERT mutation, Ile425Val, in two unrelated families with obsessive compulsive disorder and other serotonin-related disorders.
- genotype distribution and allele frequencies were strongly associated with DSM-IV depression subtypes.
- For depressed patients under the age of 25 yr the T allele of the G protein beta3 subunit was associated with a markedly poorer response to nortriptyline, while serotonin transporter polymorphisms did not predict antidepressant response.
- In a sample of normal-eater controls and purging type bulimics, no differences were found considering the frequencies of genotypes, alleles or haplotypes of both polymorphic regions of the 5-HTT gene.
- Brief review of role of the 5-HTT gene promoter region polymorphism and its role in mediation of normal and abnormal emotional states.
- The 5-HTT short allele is associated with lower self-directedness scores in seasonal affective disorder patients, whereas there are no significant differences in personality patterns between patients and controls in carriers of the long allele.
- the human serotonin transporter has an interaction domain in transmembrane domains 11 and 12 that supports oligomer formation
- These findings support a role for the serotonin transporter and GABA(A) alpha6 subunit in depression-related traits.
- 5-HTTLPR may in fact have a small but reliable influence on personality, particularly in the manifestation of trait anxiety when measured with a neuroticism scale based on the five-factor model of personality
- These results do not suggest higher central SERT levels in association with the long allele in European American subjects but point to a more complex relationship between SLC6A4 genotype and protein availability.
- These findings support the notion that there is no general association between the 5-HTTLPR and anxiety-related traits.
- There were no observed differences in the frequencies of allele and genotype between obsessive-compulsive disorder patients and control groups for serotonin transporter gene polymorphisms.
- Review. The influence of polymorphisms in the serotonin transporter gene (SERTPR (or 5-HTTLPR) and STin2) on SSRI response.
- allelic variation at the repeat polymorphism in the regulatory region of the serotonin transporter (5-HTT) gene moderates the influence of social position on central nervous system serotonergic responsivity
- Low-activity of serotonin transporter is Associated with heroin dependence
- In human infant and fetal medulla, no significant age-related changes in serotonin transporter binding are observed at any time.
- Study assessed genetic factors influencing antidepressant response to fluoxetine. Results implicate SLC6A4 in general response to fluoxetine.
- The increased growth response of PA-SMCs from patients with primary or secondary PH, or pulmonary veno-occlusive disease to 5-HT or serum was entirely attributable to 5-HTT overexpression, which is a common pathogenic mechanism in various forms of PH.
- the DRD2 -141C Ins allele and the serotonin transporter-linked polymorphic region short allele are genetic risk factors for alcoholism in Mexican-Americans
- PCR-based genotyping of a 44-bp insertion/deletion polymorphism in 5-HTTLPR was performed in 138 cocaine-dependent African-Americans. All 3 genotypes in cocaine-dependent patients had comparable Bmax reductions from corresponding genotypes in controls.
- Specific SLC6A4 variants are associated with an increased risk for hyperserotonemia in our sample of autistic patients.
- possible association between SERT variants and lithium outcome in bipolar disorders.
- This study results provide significant evidence supporting the association of the s allele of the serotonin transporter gene promoter polymorphism with suicidal behavior in the psychiatric population, also with violent suicide.
- serotonin transporter (SERT) mRNA was mainly detected in chorionic villi
- Individuals with one or two copies of the short allele promoter region of the 5-HTT who exhibited significantly increased levels of anxiety-related traits, state anxiety, and enhanced right amygdala responding to anxiety provocation.
- Patients with major depressive disorder possessing the serotonin transporter linked polymorphic region may exhibit a better long-term outcome when treated with antidepressants.
- polymorphisms in serotonin transporter gene is associated with bipolar affective disorder
- Ulcerative colitis and irritable bowel syndrome are associated with similar molecular changes in serotonergic signaling mechanisms
- S allele frequency was significantly higher in those diagnosed as anorexia nervosa (AN) at eating disorders onset than in those diagnosed as AN in this study. The 5-HTTLPR S allele might play some role in the development of AN with persistent disease
- the association of SERT with lipid rafts may represent a mechanism for regulating the transporter activity
- The polymorphic VNTR domains differentially respond to exogenous YB-1 and that YB-1 will bind to the VNTR in vitro in a sequence-specific manner.
- Results partly confirm previous findings of a significant gene-environment interaction of SLC6A4, indicating higher mental vulnerability to social stress and chronic disease. The sample characteristics and risk were highly different from previous studies
- our results do not confirm the hypothesis that there is a simple correlation between single gene polymorphisms in the serotonin transporter and personality trait measurement
- An excess of the short-genotype and of the Short-allele was found among depressive disorders children. The family-based results suggested that the Short-allele was preferentially transmitted to depressed children
- Polymorphic in affective disorders.
- 5HTT VNTR polymorphism is associated with measures of aggressive behaviour in a sample of children displaying extreme, persistent and pervasive aggression.
- evidence in support of interaction between the MAOA and serotonin transporter (SERT) genes in 114 anorexia nervosa nuclear families (patient with AN plus biological parents)
- This study suggests that the 5-HTT may be implicated in the mechanisms underlying violent behaviors.
- 5-HTTLPR genetic variation moderates the development of depression after stress in a study of maltreated children
- During viewing of aversive pictures, healthy carriers of SLC6A4 short(s) allele showed stronger activation of amygdala on functional magnetic resonance imaging. s carriers also showed greater coupling between amygdala and ventromedial prefrontal cortex.
- alcoholics with the LL genotype of the 5'-HTTLPR region of the 5-HTT gene have reduced 5-HTT function
- We demonstrate that one of the mitogen-activated protein kinases (MAPKs), p38 MAPK, regulates the serotonin transporter (SERT).
- A less active short 5-HTT allele is involved in the polygenic etiology of migraine with aura.
- In a suicidal group of Ashkenazi Israeli adolescent psychiatric inpatients, a significant positive correlation between platelet SERT density and anger scores and a negative correlation between platelet count and trait anxiety are observed.
- decreased expression of the gene encoding the 5-HTT transporter, due to "S" promoter polymorphism, may be associated with an increased availability to experiment illegal drugs among adolescents
- The short allele of 5-HTTLPR was significantly more frequent in patients than in control subjects (45.5% vs. 39.9%; p = .006; odds ratio = 1.26).
- Results show that SLC6A4 may be a Quantitative Trait Loci for attention deficit hyperactivity disorder.
- Presence of serotonin hydroxylase polymphism may increase the risk of general anxiety disorder.
- the combined effect of the serotonin transporter and the 5-HT(1A) receptor genes could be related to the clinical outcome of depressive patients treated with citalopram
- A functional polymorphism in the 5-HTT gene, but not the 5-HT1A gene, affects 5-HT1A receptor availability in man.
- study suggests a putative role of the 5-HTTLPR for alcoholism in the Korean population
- Data suggest that a decreased expression of the gene encoding the 5-HTT transporter, due to "S" promoter polymorphism, may be associated with smoking behavior among adolescents.
- The observed odds ratio could be regarded simply as a very small but detectable effect of the 5-HTT gene in bipolar disorder (review)
- two common alleles in a variable repeat sequence of the promoter region have been differentially associated with a display of abnormal levels of anxiety and affective illness
- S-allele is likely to be important in psychosocial development, particularly in those settings that increase risk of anxiety and alcohol use problems.
- Serotonin transporter gene polymorphism appears to be associated with the occurrence of obstructive sleep apnea, especially in male patients.
- Serotonin transporter short-allele carriers showed relative uncoupling of this circuit. Furthermore, the magnitude of coupling inversely predicted almost 30% of variation in temperamental anxiety.
- Our findings suggest that it is unlikely that DNA variations in the SLC6A4 gene play a significant role in the genetic predisposition to autism in the Chinese Han population.
- The 5-HTTLPR polymorphism may be associated with the persistence score of the the 5-HTTLPR polymorphism may be associated with the persistence score of the Temperament and Character Inventory in a normal Korean population.
- the 5-HTTLPR polymorphism is associated with temperamental traits--activity and emotion activity.
- A polymorphism in the promoter region of the serotonin transporter (SERTPR) was associated with efficacy for a range of antidepressant drug treatments to depression.
- Associated by VNTR with schizophrenia.
- Polymorphism may affect response to selective serotonin uptake inhibitors in bulimia nervosa.
- Increased synaptic availability may indicate a response to reduced serotonin tone.
- Radiolbeled N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines demonstrate affinity for recombinant SERT.
- Gene is associated with anxiety.
- These results support an association between response to SSRIs and deoxyribonucleic acid variation at the serotonin transporter locus. And identified a potentially important functional variant that contributes to this association.
- SLC6A4 alleles confer susceptibility to autism and rigid-compulsive behaviors
- We found that homozygosity for the long variant of 5HTT was highly associated with idiopathic pulmonary hypertension in children, suggesting perhaps a more important role for 5HTT gene function in the pathogenesis of early onset disease.
- We measured the effect of nutritional intervention on clinical data, including fasting blood glucose (FBG), and their association with polymorphisms of the serotonin transporter-linked polymorphic region (5-HTTLPR) which might affect adherence.
- Increased expression of 5HTT mRNA in peripheral leukocytes may be related with the pathophysiology of depression and its reduction after treatment may reflect the adaptive change induced by the antidepressant.
- SERT coding variants and altered transporter regulation by means of PKG/p38 MAPK-linked pathways may influence risk for disorders attributed to compromised 5-HT signaling.
- These results indicate that SLC6A4 might not play a major role in SCZ and BP in Japanese patients, a finding that agrees with both the common disease-common variant hypothesis and common disease-rare variant hypothesis.
- No association is found between any of three serotonin transporter gene markers and attention deficit hyperactivity disorder in either the United Kingdom or Taiwanese populations.
- Transmission-disequilibrium test of both polymorphisms and haplotype analysis for association with attention deficit hyperactivity disorder fails to detect linkage disequilibrium.
- Results lend support to role of serotonin transporter gene SLC6A4 functional variant V425 in the susceptibility to complex neuropsychiatric phenotypes.
- recurrent aphthous stomatitis patients have a tendency to show polymorphism associated with anxiety-related traits
- 5-HTT genotype affects neural systems controlling affective, cognitive, and motor processes.
- influence of 5HTT gene polymorphisms on longevity; frequency of the l/l genotype & the l allele was significantly greater in centenarians than in control subjects; the l allele may carry a longevity advantage possibly through behavioral mechanisms
- volunteers homozygous for the VNTR2 12 allele had a faster rate of decline for all cognitive tests. No association was observed between the HTTLPR polymorphism and the rate of cognitive decline.
- Allele transmissions to individuals diagnosed with autism were biased only for HTTLPR, both for the narrow diagnosis of autism and for the broader diagnosis of autism spectrum. The short allele of HTTLPR was significantly overtransmitted.
- A significant association of suicide completion with having at least one copy of the STin2 10 allele was found. No differences were found for the 5-HTTLPR variable number of tandem repeats.
- SERT availability decreased by a mean 36.5% in a study of brain bioavailability in obsessive compulsisve disorder.
- Association between AVPR1a and SLC6A4 reflects the social communication, courtship, and spiritual facets of the dancing phenotype.
- Data show that the allele 10 of 5-HTT-VNTR might be a susceptible factor in the pathogenesis of sleep apnea syndrome.
- Results suggest that 5HTT may contribute to the genetic susceptibility to binge eating disordeer.
- The interactions between 5-HTTLPR and TNFA -238/-308 polymorphisms doesn't cause susceptibility to schizophrenia, and isn't associated with clinical variables, antipsychotic response and other features, except for family history ,in a Korean population.
- Modeling Neuropsychiatric Inventory symptom-endophenotype-genotype relationships, & taking into account possible confounds by latent variable models, COMT & 5-HTTLPR genetic variation correlated with frontal & psychosis endophenotypes in Alzheimer diseas
- Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of hSERT interact to establish high affinity recognition of antidepressants
- The intron 2 VNTR polymorphism in serotonin transporter gene may influence suicidal behaviour in schizophrenia.
- anxiety- and novelty seeking-related personality dimensions are differentially associated with different SERT(promoter polymorphism) haplotypes
- 5HTTLPR of the SLC6A4 gene examined in relation to phobic anxiety and cognitive function in an aging population.
- 5HTT-LPR genotype was significantly associated with both neuroticism and lifetime major depression, and neuroticism with lifetime major depression. Neuroticism accounted for 42.3% of the effect of 5HTT-LPR genotype on lifetime major depression.
- The hypothesis that gene variants could influence temperamental traits in mood disorders patients was tested. Homozygosity for the short SERTPR allele was associated with low novelty-seeking scores.
- The correlation of the SERT promoter polymorphism with age at diagnosis in FPAH suggests a possible relationship between the SERT and BMPR2.
- the functional serotonin transporter gene promoter (5-HTTLPR) polymorphism is involved in migraine pathogenesis
- The 5-HTTLPR S/L variants may have an impact on personality traits.
- No association of 5-HTTLPR with personality dimensions in anorexia nervosa patients was observed.
- Variation of the serotonin transporter gene appears unlikely to confer significant susceptibility to pulmonary arterial hypertension.
- Possesses several plymorphic loci that affet expression or function.
- studies found an association between 5-HTTLPR and auditory-evoked potentials
- We showed that the C-terminus is crucial for the delivery of SERT to the plasma membrane and that the deletion of this part of the transporter results in a lack of mature glycosylation and impaired trafficking to the plasma membrane
- Regulation of SERT mRNA is independent of SERTLPR (SERT linked promoter region), but could be associated with polymorphisms in partial linkage disequilibrium with SERTLPR.
- There was a significant three-way interaction between BDNF(variant val66met) genotype, scl6a4, and maltreatment history in predicting depression.
- no evidence for an association between 5-HTTLPR genotypes, or the presence of the S allele, and depression in Parkinson disease
- The authors examined variations of serotonin transporter-linked promoter region (5-HTTLPR) functional polymorphism in 26 stroke patients with major depression and in 25 unrelated nondepressed stroke subjects of Caucasian descent.
- The effects of amino acid substitution at the Glu136 residue of SERT on protein conformation and the transport of substrates is reported.
- The 5-HTTLPR 44-base-pair insertion/deletion polymorphism is not related to completed suicide.
- Studies indicate significant preferential transmission of the SLC6A4 intron-2 STin2.12 (A12) allele to attention-deficit-hyperactivity disorder patients.
- The frequencies of the SERT S allele and the SS genotype were associated with the second factor including obsessions regarding symmetry and compulsions involving repeating, counting, and ordering/arranging.
- from RNA of differentiated Caco-2 cells;cloned and sequenced;identical to human brain Na/Cl dependent SERT
- These findings suggest that the variants of 5-HTTLPR interacted with the DAT1 gene polymorphism to influence the HA and RD temperament subscales of TCI.
- 5-HTT expression in pulmonary artery smooth muscle cells leads to pulmonary hypertension(ph) in mice. Central role for 5-HTT in pathogenesis of PH, making 5-HTT a potential therapeutic target.
- SLC6A4 variants do not appear to be significantly involved in the liability to autism
- The L(A) allele was twofold overtransmitted to the patients with obsessive-compulsive disorder (OCD). The HTTLPR L(A)L(A) genotype exerts a moderate (1.8-fold) effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD.
- Serotonin transporter gene variation may play a role in the etiology of borderline personality disorder.
- Polymorphism in a group of comorbid addictive disorders among alcohol-dependent individuals.
- 3' UTR polymorphism of the serotonin transporter gene is associated with sudden infant death syndrome
- No allelic HLA or 5-HTTLPR polymorphisms were specifically associated with autism spectrum disorders.
- it was concluded that the SLC6A4 promoter polymorphism is not a major determinant of smoking behavior in Caucasians
- Data showed that ITGB3 and SLC6A4 expression levels are correlated.
- Serotonergic activity might be involved in the development of migraine without aura and variable repeats within intron 2 of serotonin transporter gene might be one of the genetically contributing factors
- This is the first study to report a significant association between the 5-HTTLPR gene and childhood aggression.
- SERT genotype is hypothesized to lead to the onset of major depression via its influence on reaction to adversities, particularly in females.
- Girls without the DRD4 7-repeat allele and who were homozygous for the long allele of 5-HTTLPR displayed the highest smoking and drinking activity
- A218C polymorphisms play no significant roles in the pathogenesis and clinical symptomatologiy of panic dissorder in a Korean population.
- Patients with bipolar disorder and depressive disorder showed a significant variations in genotype and alleles.
- association between atherosclerosis events and the LL genotype of 5HTTLPR
- SCAMP2 plays an important role in the regulation of the subcellular distribution of SERT
- 5-HTT binding was elevated in cortical and subcortical areas in unipolar and bipolar disorder relative to controls, but differed significantly in the brainstem of unipolar versus bipolar groups. A [11C]DASB positron emission tomography study.
- suggest a novel physiological role for alpha-Syn in regulating SERT activity and may be of relevance in certain mental illnesses and in depression, in which SERT function is believed to be dysregulated.
- SERT genotype determines vulnerability to the effects of tryptophan depletion. ss volunteers showed improved memory and attention suggesting a possible evolutionary advantage to possession of the s allele.
- The 5-HTTLPR s-allele is associated with increased drinking and drug use among college students who have experienced multiple negative life events.
- Reduced caudate nucleus volume in older patients with major depression was associated with the short allele of the 5HTT gene.
- Gene-by-environment interactions were observed between the 5-HTTLPR and both early family environment and current adversity/stress. Individuals homozygous for the short allele had greater depressive symptomatology if they had experienced adversity.
- Gene frequency of variations not significant in normal controls and obsessive-compulsive disorder.
- found preferential transmission of the S allele of the 5-HTTLPR polymorphism (chi(2) = 5.751, P = 0.016) to probands with ADHD
- No evidences for biased transmissions of both HTR2A -1438 A > G and SLC6A4 polymorphisms to ADHD youths were observed.
- CpG island in the 5' region of the 5HTT gene that contains an alternative exon 1 and possible promoter for 5HTT
- The relationship between exposure to abuse and elevated depressive symptoms was more pronounced in the 5-HTTLPR s/s allele group than in the s/l group and the l/l group, but this was detected only after excluding women with recent use of psychotropics
- These findings support a role of the 5-HTTLPR polymorphism in the modulation of personality and temperamental traits.
- A strong association found between the ss genotype of the serotonin transporter gene (SLC6A4)and conduct disorder.
- analysis of the cytoplasmic substrate permeation pathway of serotonin transporter
- These findings do not support a major role for common 5-hydroxytryptamine transporter, TPH1, and monoamine oxidase A polymorphisms in contributing to susceptibility to premenstrual dysphoric disorder.
- Our findings indicate the contribution of the SLC6A4 gene to susceptibility for suicidal behavior in women, but not in men.
- The regulatory mechanism(s) of the human SERT (hSERT) in heterologously expressed Xenopus oocytes is presented.
- Results did not reveal an association between anxiety disorders and 5-HTTLPR genotype. There were no moderating effects of early life stress or gender.
- This study indicated strong association between the 5HTTLPR polymorphism of the SLC6A4 gene and Anxiety in the same group of BN patients (p = 0.004).
- The 5-HTTLPR s/s genotype at the serotonin transporter gene (SLC6A4) increases the risk for depression in a large cohort of primary care attendees.
- The elevated number of pulvinar neurons in subjects with a SERT-ss genotype may serve to enhance subcortical input of emotionally relevant stimuli to the limbic system.
- Ecstasy-induced reduction of SERT availability in SERT-rich brain regions reported previously indicates reduced SERT binding potential rather than being an artifact of tracer kinetic modelling.
- investigate seven genetic variants in three genes (serotonin transporter (5-HTT), serotonin receptor 1B (5-HTR1B) and serotonin receptor 2A (5-HTR2A)), which have previously been shown to be associated with ADHD
- Neither this polymorphism nor a systematic analysis with single nucleotide polymorphisms capturing the main haplotype diversity of the SLC6A4 locus provided evidence for a contribution of SLC6A4 to the predisposition of complex inherited MA.
- Lack of association between response to SSRIs and variation at the SLC6A4 locus in this large sample, strongly suggests that SSRI response in major depression is not determined by DNA variation at this locus.
- Boys and girls with the combination of presence of the short 5-HTTLPR, and homozygosity for the long AP-2beta genotype scored significantly lower on Self-Transcendence and Spiritual Acceptance.
- 5-HTT gene polymorphisms do not associate with obesity.
- Failure to detect an association between the serotonin transporter gene and borderline personality disorder.
- Amygdala activation was increased in Serotonin transporter carriers during undefined states such as the presentation of a fixation cross compared with emotionally neutral conditions.
- Polymorphic region of this protein is associated with higher cogitive funtion and lower interpersonal sensitivity in an aging population
- The results of this study indicate a possible association between the Stin2.12 allele of the VNTR polymorphism and obsessive-compulsive disorder.
- SLC6A4 and ITGB3 gene interactions have roles in autism etiology and in serotonin level determination
- The serotonin transporter (5-HTT))-linked polymorphic region (5-HTTLPR) long (A/G) polymorphism influences 5-HTT density leading to higher putamen 5-HTT binding potential in healthy L(A)/L(A) carriers of Caucasian ancestry.
- No straightforward association between serotonin receptor polymorphism and neuroticism, anxiety and depression
- study reports the learning process of decision-making in suicide attempters to be modulated by four serotonergic gene polymorphisms, 5HTTLPR, TPH1 A218C, MAOA u-VNTR, and TPH2 rs1118997
- This in vivo study provides further evidence that subjects homozygous for the L (A) allele display increased expression of 5-HTT in the midbrain, the origin of central serotonergic projections.
- Colonic mucosal expression of SLC6A4 in inflammatory bowel disease is normal
- The long allelic variant of 5-HTTLPR was preferentially transmitted in the ASD subjects.
- Our study has, for the first time, produced evidence that the potential for therapy in patients with schizophrenia is related to the HTTRLP polymorphism in the HTT gene and haplotype L-12 may help to predict risperidone treatment efficiency.
- results suggest that variations of the serotonin transporter gene influence the risk of obsessive-compulsive disorder
- alleles of SERT have been shown to confer functional variation in stress (Review)
- The S allele of the SLC6A4 promoter variant is associated with overweight being an independent genetic risk factor for obesity.
- Our findings show that the 5-HTTLPR polymorphism affects 5-HIAA and HVA concentrations among treatment-resistant patients with mood disorders.
- Results of study suggest the long variant (LL) of the 5-HTT is associated with elevated pulmonary artery pressure in patients with heart failure.
- These findings indicate complex interactions between genetic variation of the serotonergic circuitry and environmental factors arguing against simplistic, mono-causal explanations of violent behavior.
- Our study demonstrates for the first time a significant increase of brainstem SERT-availability in migraineurs, suggesting a dysregulation of the brainstem serotonergic system.
- 5-HTT s allele was associated with both significantly lower delayed recall and higher waking cortisol levels. Presence of the s allele interacted with higher waking cortisol to negatively impact memory.
- Logistic regression showed increasing risk of a suicide attempt with increasing reports of childhood trauma scores; in addition, this increase was exaggerated among those with low expression forms of the 5-HTTLPR genotype.
- No statistical difference was observed between the genotype and allele frequency in the group of OLP and controls (p=0.51). Moreover no association between 5HTTLPR alleles and OLP was found in the multivariate analyses.
- our data provide no support for association in this large OCD patient sample and point toward the need to examine other genes as candidates for risk determinants in OCD.
- 5HTTLPR s/s homozygous participants required minimal exposure to threatening life events (TLE) to acquire a level of risk for depression that was only found among l/s or l/l individuals after significantly higher exposure to TLEs (two or more TLEs).
- The frequency of the L/L genotype in the serotonin transporter gene-linked polymorphic region was significantly higher in patients with constipation than in controls (25.0% vs. 7.3%).
- genetic variations of the serotonin transporter may increase risk for chronic depression by altering limbic neural activity on the level of emotion processing.
- Children homozygous for the short alleles are significantly shyer, by maternal report, than those with at least one copy of the long allele of the serostonin transporter gene
- SERT binding levels in PD were lower than those in controls in all examined brain areas, with the changes statistically significant in orbitofrontal cortex (-22%), caudate (-30%), putamen (-26%), and midbrain (-29%).
- we did not find significant genotype and environmental (G x E) interactions between the 5-HTTLPR genotype and recent stressful life events or childhood adversity on symptoms of depression
- Study demonstrates that 5HTTLPR and two addition SNPs contribute to variation in the expression of the serotonin transporter gene in cell lines genotyped by the HapMap consortium.
- The SS SERT genotype is marginally associated with OCD in this report.
- Study showed evidence of interactions between 5-HTT and major depression susceptibility in baseline cortisol measures indicating a role for these genotypes in stable-state endocrine regulation.
- higher activity genotypes (L(A)/L(A), L(A)/S, L(A)/L(G)), rather than the low activity genotypes (S/S, S/L(G), L(G)/L(G)), are associated with an increased incidence of major depressive disease in the presence of environmental trauma
- Gene expresssion may operate to moderate emotional responsitivity to stress and anxiety.
- There was a significant influence (p=0.016) of the SERTPR polymorphism on treatment outcome, without differences between active and sham stimulation.
- a broad role of the 5-HTT gene in brain function that may be associated with the genetic susceptibility for mood disorders such as depression
- Significant interactions of SLEs with both 5-HTTLPR and BDNF genotypes were observed on risk of depression after adjustment for age, gender, education, and disability. A significant three-way interaction between 5-HTTLPR, BDNF, and SLEs was also found.
- there was a double-recessive interaction effect in which the odds of reporting persisting generalized anxiety were more than twofold reduced among carriers homozygous for both the COMT Met(158) and the 5HTTLPR Short alleles
- Results describe regional differences in expression of TPH-1, SERT, 5-HT(3) and 5-HT(4) receptors in the stomach and duodenum.
- finding of increased SERT binding in the midbrain in the purging BN women raises the possibility that this subgroup of bulimics might differ in serotonergic function from the non-purging ones
- These results suggest that the serotonin transporter gene may play a role in the etiology of temporal lobe epilepsy .
- this study suggests that the 5-HTT LPR polymorphism may be associated with mixed-irritable bowel syndrome, but not irritable bowel syndrome overall
- An association between the S allele of the insertion/deletion polymorphism of the serotonin transporter gene and suicidal behavior but not with bipolar disorder.
- the brain derived neurotrophic factor Met x childhood adversity interaction in turn was moderated by 5-hydroxytryptamine transporter protein,genotype (three-way interaction).
- The 5-HTTLPR and the intron 2 VNTRs do not play a major role in susceptibility to migraine
- These data might suggest that 5-HTTLPR polymorphisms are not major susceptibility factors of psychotic symptoms in PD patients
- These results support our hypothesis that the response to noradrenergic and specific serotonergic antidepressants is significantly associated with the 5-HTTLPR polymorphism.
- No significant association between this protein and conduct problems in adolescence.
- Interaction effect may exist between the erotonin transporter S allele and G-protein beta3 subunit 825T allele in increasing the risk of depressive disorder.
- Results show that the two markers of lower serotonergic capacity, 5-HTTLPR S allele and low platelet MAO activity, have a similar and partly synergistic influence on self-reported as well as performance measures of impulsivity.
- The present findings provide preliminary evidence about the greater risk of suffering MDD for individuals carrying both 5-HTTLPR-S and CYP2C9*3 alleles.
- 5HTT genotype did not influence emotional processing significantly in young people at risk of depression, by virtue of having a depressed biological parent.
- Depressed phases of major depressive disorder and bipolar disorder both were associated with elevated 5-HTT binding in the insula, thalamus and striatum, but showed distinct abnormalities in the brainstem.
- Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control.
- the 5-HTTLPR polymorphism does not have a direct role in the predisposition to adult ADHD
- Gene-environmental interaction (G x E) between a common functional polymorphism in the promoter region of the serotonin transporter gene (5-HTT) and environmental adversity on the onset of mental disorders.
- In age-adjusted models, the l/s genotype was associated with increased volume of total and white-matter lesions among depressed patients. The finding that 5HTTLPR heterozygotes have higher vascular lesion volumes may be related to hypertension.
- Platelet 5-HT and 5-HIAA contents were significantly lower in rotating shift workers than day workers, and there was a significant association between the S variant of SLC6A4 promoter and shift work
- The long variant of the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with higher compulsive alcohol craving at the beginning of alcohol withdrawal.
- the bearing of the 5HTTLPR polymorphism and prior sexual or physical maltreatment upon validated, higher-order personality-traits.
- Among patients with chronic illness, carriers of the s allele of 5-HTTLPR are more vulnerable to depression, perceived stress, and high norepinephrine secretion.
- Variation in 5-HTTLPR genotype was not related to sleep quality as a main effect; however there was a caregiver X 5-HTTLPR interaction, such that the s allele was associated with poorer sleep quality in caregivers as compared with controls.
- coping is influenced by 5-HTT genotype, gender, and their interaction
- traits such as sensation seeking and insecure attachment are, on average, elevated in 5HTTLPR S-allele carriers with bulimic syndromes
- SERT gene polymorphism is associated with the response to paroxetine.
- the data provide a rationale to subdivide the L allele of the 5-HTTLPR into L (A) and L (G) alleles in terms of their serotonin activity
- in the present sample the triallelic 5-HTTLPR polymorphism (S, L(G), L(A)) was not associated with methamphetamine (MAP)-induced depressive disorder, MAP-induced psychotic disorder or suicidal behavior
- a genetic polymorphism in the gene encoding for activity of the serotonin transporter protein is not associated with the irritable bowel - Meta-Analysis
- results indicate that 5-HTT associates with schizophrenia (SCZ) but not with major depressive disorder. It appears that risk for SCZ maps within a specific 5-HTT haplotype block
- Patients with irritable bowel syndrome who were homozygous for the short allele of 5-HTT promoter region or carried a STin2.9 VNTR allele were significantly more likely to have a history of depression
- results extend understanding of the mechanism by which cGMP-dependent protein kinase (PKG) stimulates SERT and how that stimulation is influenced by the I425V mutation, which is associated with multiple psychiatric disorders
- These findings indicate that early stress affects the behavioral response to separation differently as a function of recombinant human serotonin transporter linked polymorphic repeat genotype.
- Children with one or two copies of the short allele of the 5-HTT gene and the long allele version of the DRD4 gene exhibited significantly more internalizing and externalizing behaviors at age 7.
- Low SES and DRD4 long and 5-HTTLPR long alleles, both alone and in interaction, are associated with higher aggressive behavior scores.
- Sexual abuse and the 5-HTT short/short genotype predicted higher depression, anxiety, and somatic symptoms.
- Effects of ATD and the serotonin promoter polymorphism genotype on two aspects of decision-making: (a) decision form, choosing between two objects to gain the greater reward or lesser punishment and (b) between-object reinforcement distance.
- Individuals with at least one copy of the S or L(G) allele at 5-HTTLPR experienced elevated anxious mood on days with more intense stressors, as compared with those who were L(A) homozygotes
- 5-HTT and COMT genes, regulating activity of serotonin and dopamine respectively, are related with accuracy of orientation in time.
- did not demonstrate a significant association between methylphenidate treatment response and the polymorphisms DRD4 VNTR, CHRNA4 (rs1044396 and rs6090384) and the long (L(A) and L(G)) and short (S) forms of the serotonin transporter promoter region
- Serotonin transporter (5-HTT) activity is greater in carriers of the long (L) vs. short (S) alleles of the 5-HTT-linked polymorphic region (5'-HTTLPR) among healthy control subjects but not alcohol-dependent adults.
- Association of this protein with depression varies according to gender and stressful life events.
- The presence of STin2.10 and absence of STin2.12 allele may be defined as a possible genetic endophenotype for cognitive dysfunctions detected in MDD.
- Subjects with a lifetime history of alcohol dependence have higher levels of SLC6A4 mRNA. There is a trend for an association of increased overall CpG methylation with lifetime history of major depression.
- Demonstrate differential expression of SERT across various regions of the human intestine and provide evidence for the existence of a functional SERT capable of removing intraluminal serotonin in human ileal epithelial cells.
- These findings indicate that the 5-HTTLPR polymorphism is associated with biological stress reactivity, which may increase susceptibility to depression in the face of stressful life events.
- In Cloninger subtype 2 alcoholics, the decrease in SERT binding density is present at an early age, but in type 1 alcoholics the serotonergic alterations may be secondary and possibly reflect the alterations in the dopaminergic system.
- Excessive internet use group had higher short allelic variant frequencies and may have genetic and personality traits similar to depressed patients.
- conclude that it is unlikely that there exist two tropane binding sites in close proximity to one another on either the DAT or SERT.
- A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder.
- No significant association was found between the serotonin transporter-linked polymorphic region and the six styles of love conceptualized by Lee.
- magnitude of SERT binding reductions was greater in the forebrain than in the brainstem regions in early Parkinson's disease
- Findings provide support for the effect of the 5-HTTLPR, and for the serotonergic system more broadly, on behaviors related to extraversion.
- There is association between ADHD and 5-HTTLPR genotype.
- Both the 5HTTLPR long allele and low SES, particularly during childhood, are associated with increased CVR to mental stress, which could account, at least in part, for the increased cardiovascular disease risk associated with these characteristics
- Lack of association between the serotonin transporter promoter polymorphism (5-HTTLPR) and personality traits in asymptomatic patients with panic disorder.
- Brain serotonin turnover is elevated in unmedicated patients with major depressive disorder and is influenced by the 5-HTT genotype
- There was an increase in the epidermal fraction of 5-hydroxtrytamine 1A (5-HT1A) receptor and serotonin transporter protein (SERT) immunoreactivity in the involved skin in patients with atopic dermatitis.
- Results do not support initial interest in utilising SLC6a4 genotypes in combination with neuroticism ratings for predicting outcome in smoking cessation clinical settings.
- Our data provide supporting evidence of an association between the STin2 VNTR polymorphism of the SLC6A4 gene and OCD.
- This study analysed whether the serotonin transport mediated by the plasma-membrane transporter SERT is regulated by its Tyr-phosphorylation.
- Review discusses a neurochemical model of alcoholism that suggests type 2 alcoholics have serotoneregic deficits with intact dopaminergic systems, whereas type 1 alcoholics have defective dopaminergic systems.
- An engineered 5HT4b receptor activated solely by a synthetic ligand coupled with constitutive Gs activity induces a dramatic anabolic bone effect in transgenic mice that is significantly different from previous models.
- SLC6A4 gene and adverse life events in adult AXDHD are reported.
- elevated [5HT](ex)"paralyzes" the translocation of SERT from intracellular locations to the plasma membrane by controlling transamidation and Rab4-GTP formation
- SLC6A4 and MAOA genes are implicated in dopamine and serotonin regulation on energy balance.
- 5-HTTLPR polymorphism may be linked with BMI and also with obesity and/or overweight in adult male population, reinforcing the role of the serotonin transporter as a risk factor for the obesity phenotype.
- association of serotonin transporter gene polymorphism with alcoholism in Korean males
- The ss genotype of the serotonin transporter gene contributes to the formation predominantly of manifestations of distress, reflected by increases on the hypochondriasis scale but was was less likely to influence depression.
- genotypic variation in 5-HTTLPR modulates both the amplitude within and the functional connectivity between different components of the visual object-processing neural system to emotionally salient stimuli
- These results indicate that the s-allele of the serotonin transporter gene is associated with a vulnerable cognitive style related to the appraisal of negative emotions.
- Girls homozygous for the 5-HTTLPR long allele and with high platelet MAO activity, both considered indicators of a higher capacity 5-HT system, exhibited higher scores of drive for thinness.
- We found evidence for an additive effect of serotonin transporter and tryptophan hydroxylase-genotype in affective processing
- Data suggest that polymorhisms in SLC6A4 may influence the expression of the brain serotonin transporter in suicide attempters.
- support an unsuspected role of alphaIIbbeta3/SERT associations as well as alphaIIbbeta3 activation in control of SERT activity in vivo
- Data show that non-remitters with major depressive disorder have lower serotonin transporter binding than controls in midbrain, amygdala, and anterior cingulate.
- Biologic epistasis between SLC6A4 and BDNF in the human brain by identifying a neural mechanism linking signaling on the neural systems level and having implications for treatment planning in depression.
- Examination of genetic variants at the SLC6A4 locus indicated no association between the selected polymorphisms and childhood-onset mood disorder.
- There is an association between S/12 haplotype of SLC6A4 and low level of harm avoidance in alcohol-dependent patients.
- findings support a differential effect of the 5-HTTLPR gene on primary treatment with antidepressants and treatment augmentation
- These data suggest that the SERT availability values could be considered a biological indicator of OCD disease severity.
- no association of the polymorphic alleles of the 5-HTTLPR with the children of alcoholics was found.
- This study reveals enhanced mRNA expression of trypsinogen IV and SERT and a higher 5-HT content in the small intestine of IBS patients compared to healthy subjects.
- The short allele of the serotonin transporter promoter polymorphism influences relapse in alcohol dependence.
- Role of genes TPH2, 5-HTT, and MAOA regulating the serotonin metabolic pathway in the brain stain in the etiopathogenesis of the sudden infant death syndrome was studied.
- Some ADHD polymorphisms (in genes DAT1, DRD2, DRD3, DBH, 5-HTT) in case-control study.
- heterozygote 5-HTT linked polymorphic region (5-HTT LPR) genotype in boys was found to be associated with symptoms of Conduct Disorder
- Not only do these serotonin transporter alleles have differential effects on gene expression, modulated through changes in messenger RNA stability, but that different commonly occurring SNPs in the human 3' UTR also have similar effects.
- involvement of polymorphisms in repetitive transcranial magnetic stimulation antidepressant response in depression
- No association was found between either of the two markers, 5-HTTLPR and VNTR, and ADHD in our large multisite study or with depression within the sample of ADHD cases.
- No evidence no evidence of association between serotonin transporter gene polymorphisms and major depression following traumatic brain injury
- relationship between variation in SERT gene & activity in left posterior cingulate cortex (PCC), an area activated by visual food stimuli was studied; results show possible genetically driven variation in response of left PCC to visual food presentation
- Polymorphisms in the promoter of the 5-HTT gene may be of importance with regard to SIDS.
- New evidence for the association of SLC6A4 gene haplotypes, threatening life events and depressive phenotype.
- These findings suggest that SLC6A4 gene variation may have only a minor role, if any, in AD or QD.
- Patients with a recent history of acute diverticulitis have a significant attenuation in SERT expression and function, likely secondary to previous inflammation
- Carrying the Short allele of 5-htt may lead to high maladaptive impulsivity due to higher sensitivity to environmental adversity, which is more significantly expressed in girls.
- Women homozygous for the short (s) allele of the 5-HTTLPR were found to choose more disadvantageously than women homozygous for the long allele of the 5-HTTLPR as the IGT progressed.
- Role in depression (Review)
- Functional polymorphism of the SLC6A4 gene may have an influence on treatment outcome in alcohol-dependent patients.
- 792 cigarette smokers from the Patch in Practice trial were genotyped for the tryptophan hydroxylase (TPH1 A779C), serotonin transporter (SLC6A45-HTTLPR), and 5-HT1A (HTR1A C-1019G) polymorphisms.
- Data suggest that M6B regulates serotonin uptake by affecting cellular trafficking of the serotonin transporter.
- The aggressive periodontitis group displayed a significantly higher occurrence of genotype SS and of allele S. It was observed that genotype SS occurred 8 times more frequently in this group.
- When using midbrain [123I] nor-beta-CIT binding as a marker of SERT binding, no differences are detectable between patients with DD and MD. However, low striatum [123I] nor-beta-CIT binding is associated with a longer illness duration in dysthymia.
- Data show that decision-making impairment is related to serotonin transporter promoter polymorphism in a sample of patients with obsessive-compulsive disorder.
- we demonstrate that whereas emotional memory for aversive events per se is not influenced by 5-HTT polymorphism, an emotion-induced retrograde amnesia is expressed solely in the presence of the short allele.
- These studies suggest that a portion of transmembrane helice XI forms part of the entrance to the permeation pathway for substrate translocation in SERT.
- This study aimed to define a single genotype effect of three polymorphic markers in the 5-HTT gene (5-HTTLPR, A/G SNP in 5-HTTLPR and STin2 VNTR) and to check possible association of the 5-HTT haplotypes and personality traits.
- This is the first time that a gender-dependent influence of 5-HTTLPR is reported.
- Hippocampal volumes were found to be associated with polymorphisms in the promotor region of the serotonin transporter (5-HTTLPR) in patients with MD.
- The presence of STin2.10 and absence of STin2.12 allele may be related to a possible genetic endophenotype for characteristic cognitive dysfunctions detected in MDD.
- We replicated the association previously reported between BDNF G196A (Val66Met) polymorphism and BD.
- 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion
- increased symptoms of depression, anxiety, and memory are associated with the 5-HTTLPR(serotonin transporter) polymorphism involving two copies of the short or "s" allele (full mutation) among both males and females
- The neuroticism trait of the personality is also independently associated with the 5-HTTLPR gene.
- We explored associations of gene variants in the dopamine, opioid, and serotonin pathways with smoking reward ('liking') and reinforcement (latency to first puff and total puffs) as a function of negative mood.
- 5-HTTLPR
- Results argue for an involvement of 5-HTTLPR in cognitive processing of threatening stimuli and thus, underpin its general role for individual differences in negative affect.
- A high expression of serotonin transporter induced by LA allele of 5-HTTLPR may be one of the factors implicated with the inhibition of severe diarrhoea in early stages of Swedish familial amyloidotic polyneuropathy
- markers of SLC6A4 that are in linkage disequilibrium may pose a risk towards autism in the Eastern Indian population.
- The antidepressive and anxiolytic effect of sertraline significantly depended on the genetic polymorphism of the serotonin transporter, being more pronounced in patients carrying the "l/l" genetic variant.
- Data show that in two cases of metachromatic leukodystrophy, polymorphisms the serotonin and dopamine transporter genes are related to the symptomatology of schizophrenia and/or depression.
- The association between yearly changes in negative life events and drinking-to-cope motives varied across 5-HTTLPR genotype and gender and was strongest in the positive direction for women with the LA/LA variant
- Sex factor effects are described for SLC6A4 in genetic association with ADHD.
- The effects of 3 variants associated with autism and obsessive-compulsive disorder on the function of SERT are reported.
- This study did not find alterations in measures of 5-HT transporter levels in patients with type II alcoholism.
- No significant effect on negative affect, positive affect, or state anxiety was detected, irrespective of serotonin transporter gene-linked polymorphism.
- No evidence for significant differences in within pair variance between 5HTTLPR genotypic classes and so can provide no support for interaction between these genotypes and the environment.
- The 5-HTTLPR and the STin2 VNTR, but not the rs25531, polymorphisms of SERT are associated with PSD in stroke survivors.
- Offspring at high risk for alcohol dependence showed decreased right/left orbitofrontal cortex volumes; smaller volume in the right hemisphere was significantly associated with variation in the 5-HTT gene.
- Higher SERT occupancy is only associated with more clinical improvement in the L(A)/L(A) genotype.
- Results suggest that prolonged methamphetamine use, combined with high frequency of 5-HTTLPR S-alleles, may lead to reduced 5-HTT levels and 5-HT(1A) receptor-binding potential in the brain, resulting in dysfunction of the serotonergic system.
- Studies on life stress, depression, and polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR).
- A serotonin-related gene polymorphism--5HTTLPR--was associated with adverse cardiac events post CABG, in combination with depressive symptoms.
- serotonin transporter gene polymorphisms is associated with obstructive sleep apnea syndrome.
- Controlling for maternal education, depression and marital discord, 5-HTT genes were significantly associated with maternal sensitivity. Mothers with 5-HTT ss were less sensitive than mothers with 5-HTT sl or ll.
- SLC6A4 single nucleotide polymorphisms are associated with frontotemporal lobar degeneration.
- Hence, our study shows, for the first time, evidence of a link between genetically controlled serotonergic modulation of amygdala activity and placebo-induced anxiety relief.
- Platelet surface P-selectin expression is highly correlated with serotonin transporter density in human subjects.
- The occurrence of psychosis in Alzheimer's disease resulted significantly related to the presence of the 5-HTTLPR L-allele
- Lesser reduction of symptoms after multi-modal therapy in bulimic women who carried low-function alleles of 5-HTTLPR or 5-HT(2A)receptor gene (-1438G/A)promoter
- Serotonin transporter gene long/short promoter polymorphism allelic status determination should not be used to guide clinical decisions about ECT.
- investigation of the influence of the 5HTTLPR gene polymorphism during application of a metacognitive strategy of emotion regulation; short (S) homozygotes showed more negative emotional states than SL individuals in metacognition & control conditions