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Validated All-in-One™ qPCR Primer for SERPINB2(NM_001143818.1) Search again
Product ID:
HQP055083
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HsT1201, PAI, PAI-2, PAI2, PLANH2
Gene Description:
serpin family B member 2
Target Gene Accession:
NM_001143818.1(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Gene References into function
- regulator of monocyte proliferation and differentiation
- plasminogen activator inhibitor type 2: potential prognostic factor for endometrial carcinomas
- Identification of plasminogen activator inhibitor-2 as a gastrin-regulated gene
- post-transcriptional regulation of the PAI-2 gene is modulated by tristetrapolin
- Data suggest that the CD-loop functions as a redox-sensitive switch that converts plasminogen activator inhibitor type 2 (PAI-2) between an active stable monomeric and a polymerogenic conformation.
- These results indicate that PAI-2 may enhance Rb's tumor suppressor activity and suggest a potential therapeutic role for PAI-2 against HPV-transformed lesions.
- evidence that a polymorphism of the PAI-2 gene is associated with an increased risk of myocardial infarction
- PAI-2 has a role in scleroderma, as seen by its expression in fibroblasts
- PAI-2 expression has a potent suppressive effect on human papillomavirus type 18 oncogene transcription mediated by Rb and LIP, a finding with potential implications for prognosis and treatment of human papillomavirus-transformed lesions.
- PAI2 is present in normal conjunctiva.
- Elevated plasma levels in, and therefore a marker for cancers.
- investigated the unique mousetrap inhibition mechanism of serpins through saturation mutagenesis of the P8 residue for PAI-2
- the urokinase/PAI-2 complex is a new high affinity ligand for the endocytosis receptor low density lipoprotein receptor-related protein
- SerpinB2 is a potentially important inducible host factor that significantly promotes HIV-1 replication
- in patients with complex congenital malformations amniotic fluid levels of plasminogen activator inhibitor type 2(PAI2)
- Data indicate that this family did not follow the Mendelian inheritance pattern; the Ser(413)/Ser genotype in 60% of the affected members might increase the risk for autoimmune syndromes such as anti-phospholipid syndrome or systemic lupus erythematosus.
- PAI-2 is able to inhibit and clear urokinase plasminogen activator activity without initiating mitogenic signalling events through the very-low-density-lipoprotein receptor (VLDLr).
- Type 2 diabetes in this study seems not to increase gingival crevicular fluid levels of the evaluated inflammatory mediators PAI2.
- SerpinB2 is a cell survival factor that modulates Rb repression of proapoptotic signal transduction
- PAI-2 can inhibit cell-bound tPA activity in vitro and thus prevent plasmin formation
- Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1.