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Validated All-in-One™ qPCR Primer for CAV1(NM_001753.4) Search again
Product ID:
HQP054875
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21
Gene Description:
caveolin 1
Target Gene Accession:
NM_001753.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
Gene References into function
- Caveolin-1 expression enhances endothelial capillary tubule formation
- CAV1 was found in liver endothelial cells and in Kupffer cells (liver non-parenchymal cells).
- forms a cholesterol complex and transports it from the endoplasmic reticulum to the cell membrane; activates signal transduction molecules
- over-expression is associated with lymph node metastasis and worse prognosis after surgery in esophageal squamous cell carcinoma
- Neu3 functions as a caveolin-related signaling molecule within caveolin-rich microdomains
- Data show that ER alpha and not ER beta silences caveolin-1/-2 expression in an epigenetic fashion in neuronal cells.
- Some protein tyrosine phosphatases form molecular complexes with caveolin-1 in lipid rafts
- regulation of expression and secretion by a protein kinase c epsilon signaling pathway in human prostate cancer cells
- data show that coexpression of caveolin can markedly inhibit expression of HIV proviral DNA and establish that the inhibition is mediated by the hydrophobic, membrane-associated domain
- Data show that IL-6/raft/STAT3 signaling is a chaperoned pathway that involves caveolin-1 and HSP90 as accessory proteins and suggest a mechanism for the preservation of this signaling during fever.
- both the caveolin-1/EGFR association and EGF-induced tyrosine phosphorylation of caveolin-1 are modulated by ganglioside GM3
- Endostatin associates with integrin alpha5beta1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells.
- data clearly implicate loss of functional Cav-1 in the pathogenesis of mammary epithelial cell hyperplasia
- Caveolin-1 phosphorylation in human squamous cell carcinoma is dependent on ErbB1 expression and Src activation.
- In the cerebral cortex caveolin-1 is expressed by all the cell types that form the vascular wall, endothelial cells, pericytes, and vascular astrocytes in vivo.
- Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation.
- basal and SR-BI-stimulated free cholesterol efflux to HDL and liposomes and SR-BI-mediated selective uptake of HDL cholesteryl ester are not affected by caveolin-1 expression
- Caveolae plays a role in signal-transducing function of cardiac Na+/K+-ATPase.
- caveolin-1 may play a role in lamellar granule assembly, trafficking, and/or function.
- interacts with endothlin b receptor
- ERalpha co-activator caveolin is negatively regulated by the steroid receptor itself
- Caveolin-1 may modify the biosynthetic pathway of sugar chains via the regulation of the intra-Golgi subcompartment localization of N-acetylglucosaminyltransferase III
- caveolin has a role in recovery from cell sensecence
- Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1.
- Caveolin-1 expression is an independent positive prognostic factor for survival in extrahepatic bile duct carcinoma.
- A statistically significant difference in the expression of caveolin-1 between oncocytoma with a mean labeling index of 91.7 and other malignant renal tumors with a lower mean labeling index possibly implicates this peptide in oncocytoma pathogenesis.
- PPARgamma & caveolin-1 may coexist in a complex. PPARgamma participates in the regulation of caveolin gene expression in human carcinoma cells. Caveolin-1 may mediate some of the phenotypic changes induced by PPAR-G in cancer cells.
- Caveolin-1 is an inhibitor of platelet-derived growth factor (PDGF) proliferative responses and might be capable of transforming PDGF-induced proliferative signals into death signals.
- CAV-1 gene can be inactivated through mutations and does not play a role in the development of cervical cancer
- cytoplasmic overexpression of caveolin-1 predicts a poor prognosis in renal cell carcinoma
- Akt activities are largely responsible for cav-1-mediated cell survival
- caveolin-1 has a role in mediating astrocyte responses to MCP-1
- negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis
- caveolin-1 associates with CD147, in a complex distinct from CD147-alpha(3) integrin complexes, thereby diminishing both CD147 clustering and CD147-dependent MMP-1-inducing activity
- inactivation of Caveolin-1 by a mutation or by reduced expression may play a role in the pathogenesis of oral cancer
- overexpression of caveolin-1 in hepatic cells stimulates cholesterol efflux by enhancing transfer of cholesterol to cholesterol-rich domains in the plasma membrane.
- Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase.
- Cav-1 haploinsufficiency in human breast epithelial cells can lead to partial transformation.
- Nitric oxide concentrations could impact on capillary formation via a combination of direct effects on MMP activation and by altering the distribution or abundance of Cav-1 in tumor angiogenesis.
- caveolin-1 is overexpressed in experimental colon adenocarcinoma by comparison to adjacent normal mucosa, and its expression in human colon cancer cells is directly associated with the growth rate
- Cav-1 has a role in regulating the functional activity of 5-HT(2A) serotonin receptors and Galpha(q)-coupled receptors
- caveolin-1 can inhibit the conversion of LG-CD147 (low glycoform-CD147) to HG-CD147 (high glycoform-CD147)
- Results suggest different roles for CAV1 in SCLC, where CAV1 acts like a tumor suppressor gene, and NSCLC, where it appears required for survival and growth.
- phosphorylation was found in both the acetylated and non-acetylated variants of caveolin-1beta. This variability in modifications is consistent with critical involvement of the N-terminal domain of caveolin in the regulation of caveolae
- review of coordination of caveolin-1 gene expression regulation with that of MDR1 in cancer cells
- In four different groups of marrow samples (20 normal, 56 acute myeloid leukemias (AML) at diagnosis, 48 AMLs at relapse, and 51 regenerating marrows), caveolin-1 and MDR-1 gene expressions were positively correlated
- Our data demonstrate for the first time that the reduction of the plasma membrane cholesterol level induced by overexpressing caveolin-1 may indirectly inhibit P-gp transport activity by increasing plasma membrane fluidity.
- caveolin-1 plays an important role in senescence-associated morphological changes by regulating focal adhesion kinase activity and actin stress fiber formation in the senescent cells.
- Aberrant promoter methylation of the caveolin-1 gene may occur at the precancerous stage, regulated by gender-related factors and is associated with gene silencing of caveolin-1 in the development of colorectal cancer.
- a functional peroxisome proliferator response element in the cav-1 promoter is activated upon rosiglitazone treatment in THP-1 macrophages
- Caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer.
- results suggest that CD26-caveolin-1 interaction plays a role in the up-regulation of CD86 on TT-loaded monocytes and subsequent engagement with CD28 on T cells, leading to antigen-specific T cell activation
- role of aberrant promoter methylation in the regulation of caveolin-1 gene in breast cancer correlated with clinical findings
- caveolin-1 expression was increased upon induction or over-expression of FOXO factors at both mRNA and protein levels
- association of MT1-MMP with phosphorylated caveolin-1 occurs in caveolae membranes and involves the cytoplasmic domain of MT1-MMP
- Caveolin-1 and MAL are located on prostasomes secreted by prostate cancer cells
- Caveolin-1 clusters at cell-cell contacts after assembly of alpha-hemolysin into heptameric oligomers
- facile penetration of alpha-HL's beta-barrel might occur through protein-protein interactions with the surrounding 7 alpha-helices of Caveolin-1
- Overexpression of caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF, two major cytokines in mesangioproliferative nephritis(MN). Caveolin-1 expression vector is potential therapy for MN.
- potential role of caveolin polarity in lamellipod extension and cell migration.
- identiication of KLF11 as a dominant repressor of calveolin-1 gene
- The caveolin 1 was found in the endothelial cells of 10-week-old human placenta.
- Caveolin-1 in human breast cancer cells enhances matrix-independent cell survival that is mediated by upregulation of IGF-I receptor expression and signaling.
- Caveolin-1 inhibits the activation of BMP type IA receptor in preformed hetero-oligomer complexes by binding to BMP type II receptor.
- caveolin-1 (CAV-1) functions as a scaffolding protein for phosphofructokinase (PFK)
- Results demonstrate that a branched signaling pathway involving MEK, ERK, PKCepsilon, PKCalpha, and caveolin-1 regulates collagen expression in normal lung tissue and is perturbed during fibrosis.
- Actin cytoskeleton is involved as part of a caveolar complex in the regulation of myometrial maxi-K channel function.
- The downregulation of caveolin-1 in HCT 116 cells inhibited degradation of the extracellular matrix protein collagen IV and the invasion of these cells through Matrigel.
- When we overexpressed caveolin-1 in young mesenchymal stem cells, not only insulin signaling but also adipogenic differentiation was significantly suppressed with down-regulated PPARgamma2.
- caveolin regulates the inhibition by cell-bound TFPI of the active protease production by the extrinsic pathway of coagulation
- This is the first report providing evidence for CAV-1 being involved in predisposition to aggressive prostate cancer
- unique features of CAV1 phosphorylation on oxidative stress observed implicate an important role of CAV1 in placental endothelial cell biology during pregnancy.
- increased expression of caveolins in proliferating bile ductules in primary biliary cirrhosis may be related to the homeostasis of cholesterol transport in regenerating bile ductules in liver
- Cav-1 expression inhibits ras homolog gene family, member C GTPase activation and subsequent activation of the p38 MAPK pathway in primary pancreatic cancer cells thus restricting migration and invasion
- Caveolin-1 is more expressed in cancer tissues than normal colon and related with Akt-1, not with Epidermal Growth Factor Receptor expression in colorectal cancer tissues, which suggests that signaling for caveolin-1 affects Akt-1 activation.
- These results suggest that caveolae could represent an intracellular site that contributes to differentiate IR and IGF-IR activity, and demonstrate the role of caveolin-1 in the eNOS activation by Insulin and IGF-I.
- Overexpression of caveolin-1 is associated with inflammatory breast cancer
- data suggest that caveolin-1 expression indirectly promotes cell-cell adhesion in ovarian carcinoma cells by a mechanism involving inhibition of src-related kinases
- structure activity relationship
- CAV1 is down-regulated and inversely correlated with HER2 and EGFR expression status in DCIS of the breast.
- aberrant methylation and abnormal protein expression of the caveolin-1-gene is involved in the formation of nonurothelial carcinomas of the urinary bladder
- EGF-based signaling cascades phosphorylate Cav1 and have roles in caveolae assembly
- It is therefore concluded that caveolin-1 facilitates the hypotonicity-induced release of Cl(-), taurine, and ATP.
- These novel findings provide insight into possible signaling mechanisms of Nf1 and suggest that together Nf1 and Cav-1 may coordinately regulate cell growth and differentiation.
- Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking
- Two clones of cells expressing caveolin-1 were investigated for their lipoprotein metabolism activity, showing an increase in ldl liprotein degradation and an increase in HDL lipoprotein activity.
- Cell-cell contact is required for BeWo trophoblasts to exhibit plasmalemmal caveolin-1.
- interacts with rotavirus NSP4 and contributes to NSP4 intracellular trafficking from the endoplasmic reticulum to the cell surface.
- CAV1 has a role in both hereditary and sporadic breast cancer
- Expression of caveolin is sufficient to drive the formation of caveolae in cell lines normally lacking caveolin, such as human colon cancer cells (Caco-2).
- The 22285 C-22375-22375 del (Cd) haplotype of CAV1 gene, but not the NOS3-CAV1 interaction, is associated with low levels of blood pressure and protects against metabolic syndrome
- Results suggest that anti-proliferative and pro-apoptotic properties of caveolin-1 may be attributed to reduced survivin expression via a mechanism involving diminished beta-catenin-Tcf/Lef-dependent transcription.
- Homocysteine induced impairment of nitric oxide production through through a modulation of Caveolin-1 expression.
- As such, caveolae and caveolin-1 coordinate PDGF receptor signaling, leading to myocyte proliferation, and inhibit constitutive activity of p42/p44 MAPK to sustain cell quiescence.
- PSMA binds to caveolin-1 and undergoes internalization via a caveolae-dependent mechanism in microvascular endothelial cells
- Cav-1-deficient mammary acini displayed increased ERalpha levels and enhanced sensitivity toward estrogen-stimulated growth, with specific up-regulation of cyclin D1
- important roles for VCAM-1 and Caveolin- 1 in the regulation of metastatic potential of gastric tumor cells
- A ternary complex between NOSTRIN, caveolin-1, and eNOS mediates translocation of eNOS, with important implications for the activity and availability of eNOS in the cell.
- CAV1, either alone or together with eNOS alleles, might modify colorectal cancer heritability.
- Thus, these results demonstrate a crucial role of caveolin-1 scaffolding domain interaction with TRPC1 in regulating Ca2+ influx via SOC.
- Increased immunoexpression of the Cav-1 seems to be associated with the biological aggressiveness of meningiomas, reflecting a worse prognosis.
- Inhibits apoptosis and promotes survival signaling in cancer cells.
- the Sprouty/Caveolin-1 interaction modulates signaling in a growth factor- and Sprouty isoform-specific manner
- Breast cancer patients with higher caveolin-1 expression may benefit from ABI-007 therapy.
- caveolae and caveolins are integral membrane components in basal and ciliated epithelial cellsin rats, mice, and humans, indicating a crucial role in these cell types; in addition to their physiological role, they may be involved in airway infection
- Results describe the expression of caveolin-1 in human fetal tissues during mid and late gestation.
- The interaction of the GLP-1R with caveolin-1 regulates subcellular localization, trafficking, and signaling activity.
- Cav-1 induced the cytoplasmic sequestration of BRCA1.
- transcriptional activation of the IGF-IR gene by Cav-1 requires an intact p53 signaling pathway
- Loss of CAV1 expression inhibited the anchorage-independent growth of EWS cells and markedly reduced the growth of EWS cell-derived tumors in nude mice xenografts, indicating that CAV1 promotes the malignant phenotype in EWS carcinogenesis.
- The role of caveolin-1 as a factor contributing to the severity of the tubulointerstitial process resulting from obstructive nephropathy could be suggested.
- Results indicate a pivotal role for cav-1 in the regulation of extracellular matrix production and suggest a novel therapeutic target for patients with pulmonary fibrosis.
- activated EGF receptor transiently modulates integrin alpha2 cell surface expression and stimulates integrin alpha2 trafficking via caveolae/raft-mediated endocytosis
- CAV1 phosphorylation on Tyr-14 increases the induction of apoptosis by taxanes in breast cancer cells.
- the Cav-1 scaffolding domain bound significantly to the gp41 expressed in mammalian cells
- Caveolin 1 has a role in progression of a subset of basal-like and metaplastic breast carcinomas
- Prolonged stimulation of isolated human thyrocytes by TSH/cAMP/cAMP-dependent protein kinase inhibits caveolin-1 expression.
- overexpression of caveolin-1 overcame the VEGF-mediated inhibition of adhesion and restored ICAM-1 clustering
- Caveolin-1, as a negative regulator of endothelial cell proliferation, may be a potential target for the control of angiogenesis.
- role of caveolin-1 in preventing ischemia-reperfusion injury
- These results suggest that caveolin-1 regulates GD3-mediated malignant signals by altering GD3 distribution and leading edge formation
- Ligation of CD26 by caveolin-1 recruits a complex, including CD26 and CARMA1, which functions in lymphocyte activation.
- Over-expression of Caveolin-1 was associated with established features of prostate cancer and aggressive PSA recurrence.
- This review suggests that caveolin-1 plays an essential role in regulating liver regeneration and that it is implicated in regulation of triglyceride accumulation, an essential process that plays a critical role in the regulation of liver regeneration.
- Aberrant methylation of CAV1 is associated with hepatocellular carcinoma
- These data suggest that in ovarian carcinoma cells cav-1, localized in transcriptionally inactive chromatin, exerts a functional activity mediated, at least in part, by directly binding to sequences of genes involved in proliferation.
- the rotavirus NSP4 binding site was localized to caveolin-1 residues 2-22 and 161-178, at the amino- and carboxyl-termini, respectively
- among astroglial tumors cav-1 expression varies in distribution, pattern & intensity specifically according to tumor types & grades
- These data suggested that loss of caveolin-1 is associated with abnormal re-epithelialization in lung fibrosis.
- glucocorticoids modulate the expression of caveolin-1 and caveolae biogenesis within alveolar epithelial cells via both transcriptional and translational modifications
- Appropriate caveola-membrane organization by caveolin-1 and detection of estrogen receptor beta in the plasma membrane are directly reflected by MAP kinase phosphorylation and consequent vitamin D receptor expression.
- Results indicated that caveolin-1 expression may have potential both as a diagnostic marker in the differential diagnosis of renal tumors and as a therapeutic target, especially for clear-cell renal cell carcinoma.
- EMP2 regulates caveolin-1 transcription and more substantially its protein levels.
- The presence of different caveolin isoforms in many cell types of the human retina, is reported.
- HPV type 31 (HPV31) entry and initiation of early infection events require both caveolin 1 and dynamin 2 and occur independently of clathrin-mediated endocytosis.
- Downregulation of caveolin-1 expression affects bleomycin-induced cell cycle arrest and subsequent cellular senescence that is driven by p53 and p21.
- Positive staining resulted in shorter survival in patients with esophageal squamous cell carcinoma.
- Data suggest that Cav-1 down-modulation might function as a permissive mechanism, which, by unleashing c-Src and Met signaling, enables osteosarcoma cells to invade neighboring tissues.
- These positive correlations provide new evidence for the involvement of prostate cancer cell derived cav-1 in mediating angiogenesis during prostate cancer progression.
- These internalization data were highly suggestive of the predominant use of the clathrin-mediated pathway by NK1-R, even though NK1-R tended to reside constitutively in lipid raft/caveolae microdomains.
- Re-expression of E-cadherin in HT29(US) cells restored the ability of caveolin-1 to down-regulate beta-catenin-Tcf/Lef-dependent transcription and survivin expression, as seen in HT29(ATCC) cells.
- The present data suggest that promoter methylation of the 14-3-3 sigma and CAGE-1 genes plays a crucial role during the phenotypical morphogenesis of vesical adenocarcinomas including signet ring cell carcinomas by an epigenetic mechanism.
- PAR1 localization in the caveolin-enriched membrane microdomain, bound to caveolin-1, represents a crucial requirement for TF induction in endothelial cells.
- Our studies indicate that the conformational changes are probably initiated at the Caveolin-1 binding moti.
- COX-2 is localized within caveolae compartment and colocalized with CAV-1 protein in lobular intraepithelial neoplasia of the breast.
- caveolin-1 is a novel Id-1 binding partner that mediates the function of Id-1 in promoting prostate cancer progression through activation of the Akt pathway leading to cancer cell invasion and resistance to anticancer drug-induced apoptosis
- Caveolin-1 was expressed in the sinusoidal endothelial cells and the smooth muscle cells of the unparied arteries of hepatpcellular carcinoma specimens.
- Caveolin-1 inhibits the growth of human laryngeal squamous cell carcinoma HEp2 cell line. CAV1 interacts with EGFR and inhibits phosphorylation of EGFR and Erk1/2.
- PCB77 induces eNOS phosphorylation in endothelial cells through a Src/PI3K/Akt-dependent mechanism, regulated by functional caveolin-1.
- p53 is an indispensable component of cellular signaling system which is regulated by caveolin-1 expression, involving Akt activation and increase in cyclin D1, thereby promoting proliferation of breast cancer cells.
- Caveolin-1, specifically localized in cholesterol-enriched lipid rafts, appears to regulate constitutive and agonist-stimulated cell surface levels of 5-HT7 receptors via a clathrin-independent mechanism.
- results show that there is a close association of AT(1), AT(2), and ERalpha with Cav-1 in human arterial smooth muscle cells in culture
- caveolin-1(CAV1) was observed in most cells in myomas and in only few cells in controls; CAV1 was localized with oxytocin receptor and sex hormone binding globulin in myomas
- caveolin-1 travels to late endosomes and is replaced by newly synthesized caveolin-1 at the plasma membrane
- CBD1 but not CBD2 binds cells and forms large aggregates at the plasma membrane by colocalizing with cytofacial caveolin-1.
- Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae.
- The knockdown of caveolin-1 in endothelial cells decreases caveolin-2 phosphorylation at serine 23 and upregulation of serine 23 phosphorylation depends on caveolin-1-driven targeting to plasma membrane lipid rafts and caveolae.
- The Cx43/Cavs association occurs during exocytic transport, and they clearly indicate that caveolin regulates gap junctional intercellular communication.
- We observed that in the Glu/Asp and Asp/Asp mutant genotypes, the amount of NOS3 associated with Cav-1 was significantly lower.
- low caveolin-1 levels in fibrotic lungs in scleroderma cause their overexpression of collagen, tenascin-C, and alpha actin
- CAV1 as a new Berardinelli-Seip congenital lipodystrophy (BSCL)-related gene and support a critical role for caveolins in human adipocyte function.
- Very rare CAV1 frameshift mutations appear to be associated with atypical lipodystrophy and hypertriglyceridemia.
- AnxA6 interferes with caveolin transport through the inhibition of cPLA(2).
- Interactions of acetylcholinesterase with caveolin-1 and subsequently with cytochrome c appear to be indispensable for apoptosome formation in a colon cancer cell line.
- an association between cav-1 expression and neoangiogenesis in meningiomas
- Alteration of store-operated Ca(2+) entry by caveolin-1 expression changes could be one of the mechanisms contributing to the progression of breast cancer.
- caveolin-1 plays a tumor-promoting role in advanced-stage cancer. (review]
- Caveolin mediates rapid glucocorticoid effects and couples glucocorticoid action to the antiproliferative program.
- Androgen dependent prostate growth in benign prostate hyperplasia may be linked to the interaction of androgen binding protein and oxytocin receptor, associated with caveolin 1
- focal adhesion kinase mediates caveolin-1 up-regulation during epithelial to mesenchymal transition
- Downregulation of CAV1 is associated with primary prostate carcinoma
- Cav-1 increases the basal and TGF-beta1-induced expression of type I procollagen by regulating two opposite signaling pathways: inhibiting TGF-beta1/smad signaling and activating a PI-3 kinase/Akt/mTOR-dependent pathway in human dermal fibroblasts.
- caveolin-1 may play an important role in the progression of transitional cell carcinoma of the upper urinary tract
- This is the first evidence of increased nuclear and cytoplasmic localization of caveolin 1 during establishment of H(2)O(2)-induced premature senescence.
- Wild-type APC regulates CAV1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc.
- Human breast cancer-associated fibroblasts show CAV1 down-regulation and RB tumor suppressor functional inactivation.
- Concluded that IL-6/sIL-6R enhances cathepsin B and L production via IL-6/sIL-6R-mediated Cav-1-JNK-AP-1 pathway in human gingival fibroblasts.
- the relationships between Cav-1 abundance, atherosclerotic plaque characteristics and clinical manisfestations of atherosclerotic disease.
- These data indicate that caveolin-1 specifies filamin A as a novel target for Akt-mediated filamin A Ser-2152 phosphorylation thus mediating the effects of caveolin-1 on IGF-I-induced cancer cell migration.
- These findings suggest that FASN and Cav-1 physically and functionally interact in PCa cells.
- Caveolin-1-dependent infectious entry of human papillomavirus type 31 in human keratinocytes proceeds to the endosomal pathway for pH-dependent uncoating
- Caveolin-1 may provide an effective target to protect against human immunodeficiency virus-1 (HIV-1) protein Tat-induced brain microvascular endothelial cell dysfunction and disruption of the blood-brain barrier in HIV-1-infected patients.
- There is a role for caveolin-1 in degenerative rather than age-induced changes in the nucleus pulposus. A positive correlation was identified between gene expression of caveolin-1 and p16INK4a (biomarker of cellular senescence).
- A new subtype of congenital generalized lipodystrophy is not associated with the CAV1 gene.
- irradiation triggered caveolin-1 dependent Receptor, Epidermal Growth Factor internalization into caveolae.
- Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma.
- variations of caveolin-1 expression may have an important role in the progression of human breast lobular cancer
- a feedback loop between Rho/ROCK, Src, and phosphorylated Cav1 in tumor cell protrusions, identifying a novel function for Cav1 in tumor metastasis that may contribute to the poor prognosis of some Cav1-expressing tumors.
- Data indicate that HERG channels interact with caveolin-1 and are negatively regulated by this interaction.
- Absence of significant correlations between cav-1 expression and other pathological parameters, such as the stage of disease or the patients overall survival, indicates that the role of cav-1 in GC is neither stage-specific nor related to prognosis.
- Findings suggest that hOAT4 and caveolin-1 share a cellular expression in the plasma membrane and caveolin-1 up-regulates the organic anionic compound uptake by hOAT4 under the normal physiological condition.
- These results reveal a new mechanism by which caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells.
- In head and neck squamous cell carcinoma, cav-1 may play an inhibitory role in tumorigenesis and lung metastasis through regulating integrin beta1- and Src-mediated cell-cell and cell-matrix interactions.
- Caveolin-1 was upregulated and beta-catenin was recruited to the plasma membrane when xCT was deficient, which were followed by the inhibition of beta-catenin transcriptional activity.
- Caveolin-1 expression is a distinct feature of chronic rejection-induced transplant capillaropathy.
- hepaCAM is partially localized in the lipid rafts/caveolae and interacts with Cav-1 through its first immunoglobulin domain.
- The data suggested that autophagy played a key role in Cd2+ induced endothelial dysfunction; integrin beta4, caveolin-1 and PC-PLC might be the targets of Cd2+ in vascular endothelial cells.
- GTPCH I is targeted to caveolae microdomains in vascular endothelial cells, and tetrahydrobiopterin production occurs in proximity to endothelial NO synthase. The regulation of GTPCH I activity involves the caveolar coat protein, caveolin-1.
- In prostate cancer cells in culture, delta-catenin was co-localized with caveolin-1 and CD59, suggesting its potential excretion into extracellular milieu through exosome/prostasome associated pathways.
- These data suggest that flotillin-1 regulates caveolin-1 level by preventing its lysosomal degradation in intestinal epithelial cells.
- caveolin-1 is essential in the down-regulation of MT1-MMP activity by promoting internalization from the cell surface
- CAV1 deficient mammary stromal fiboblasts are able to undergo endothelial-like transdifferentiation, and are predictive of poor outcome in breast cancer.