|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for CTNNB1(NM_001098210.1) Search again
Product ID:
HQP054812
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CTNNB, EVR7, MRD19, NEDSDV, armadillo
Gene Description:
catenin beta 1
Target Gene Accession:
NM_001098210.1(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
|
|
| A | B |
|
Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
|
Summary
Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia.
Gene References into function
- Loss of beta-catenin may result in the disruption of the function of the cell-cell adhesion complex, which may cause weak cell-cell adhesion and confer invasive properties on a tumor.
- aardvark gene product
- Abnormal beta-catenin gene expression with invasiveness of primary hepatocellular carcinoma in China.
- Beta-catenin might be related to the occurrence and development of kidney tumor.
- Proof for the regulated phosphorylation of the Ser/Thr residues of beta-catenin by Wnt signaling.
- No germline mutations of CTNNB1 have been identified nor linkage to chromosome 3p21 been demonstrated in 8 subjects with Birt-Hogg-Dube syndrome, suggesting that CTNNB1 should be excluded as a candidate gene for BHD.
- Immunohistochemistry of cyclin D1 and beta-catenin, and mutational analysis of exon 3 of beta-catenin gene in parathyroid adenomas
- Expression and prognostic roles of beta-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival
- The minimal necessary components of the androgen receptor and beta-catenin required for binding nuclear accumulation of beta-catenin nuclear import appears to be the DNA/ligand binding regions and the Armadillo repeats of beta-catenin
- increased expression predicts favorable prognosis in resected nonsmall cell lung carcinoma
- findings indicate that alterations of beta-catenin are frequent in cancer of the uterine cervix and suggest that they may play an important role in the development of these tumors
- mutations rare in ulcerative colitis-related colorectal carcinomas
- CTNNB1 signaling plays a critical role in the development of a significant fraction of prostate cancers.
- One out of 62 melanoma cell lines was found to carry a mutation in exon 3 of the beta-catenin gene indicating that aberration of the Wnt-1/wingless pathway through activation of beta-catenin is a rare event
- results imply that claudin-1 is involved in the beta-catenin-Tcf/LEF signaling pathway
- Activation of AXIN2 expression by beta-catenin-T cell factor
- ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas
- nuclear beta-catenin expression significantly related to ulcerative growth of colorectal cancer
- beta-catenin plays a role in endometrial carcinogenesis, particularly in endometrioid carcinomas
- Arg(96) mutant has a dominant-negative effect on GSK-3beta-dependent phosphorylation of beta-catenin and targeting of beta-catenin for degradation requires prior priming through phosphorylation of Ser(45)
- Protein kinase CK2 dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TRCp and enhances beta-catenin degradation [UBC3B]
- results indicate selection for APC genotypes that are likely to retain some activity in downregulating beta-catenin signaling
- wnt3a-beta catenin signaling regulates LEF-1 gene expression
- targeted inactivation reveals effects of beta-catenin mutation
- Mutation in exon 3 of the beta-catenin gene was found in 2 of the 20 endometrial cancer samples; however, it was not found in the 25 endometrial hyperplasias or the 20 associated hyperplasias.
- Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC.
- Anticancer-drug-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin. beta-Catenin plays a role in promoting Jurkat survival.
- Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin.
- oxidative stress induces tyrosine phosphorylation and cellular redistribution of occludin-ZO-1 and E-cadherin-beta-catenin complexes by a tyrosine-kinase-dependent mechanism
- Nr-CAM is the gene most extensively induced by beta catenin
- data support the notion that upregulation of cyclin D1 and Fra-1 in human colorectal adenocarcinomas is driven by abnormally expressed beta-catenin; however, the regulation of c-myc expression in colorectal tumors appears to be more complex
- Role of Wnt pathway in medulloblastoma oncogenesis: accumulation of beta-catenin in tumor cells was immunohistochemically proven in 5 cases; 2 cases showed positive immunoreactivity for Wnt-1 and another 2 showed mutation of either CTNNB1 or AXIN1
- Restoration of E-cadherin/beta-catenin expression in pancreatic cancer cells inhibits growth by induction of apoptosis.
- Beta catenin induced human melanoma growth requires the downstream target Microphthalmia-associated transcription factor.
- Presenilin couples beta-catenin phosphorylation through two sequential kinase activities independent of the Wnt-regulated Axin/CK1alpha complex.
- beta-catenin, which participates in the Wnt signaling pathway, might play a more important role in the formation of hepatic adenoma than in that of focal nodular hyperplasia.
- found a pattern of beta-catenin immunostaining in typical carcinoid tumors of the appendix that was different from the pattern seen in non-appendiceal carcinoid tumors
- beta-catenin plays an important role in oncogenesis through the crossregulation of NF-kappa B in breast and colonic neoplasms
- abnormal expression of beta-catenin in gastric carcinoma and survival
- The aberrant expression of beta-catenin protein was statistically correlated to the lymph node metastasis in esophageal cancer.
- These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling.
- beta-catenin, p53 and PCNA may play important roles in the carcinogenesis of colorectal adenoma.
- Expression of e-cadherin and beta-catenin in human esophageal squamous cell carcinoma: relationships with prognosis.
- Abnormal E-cadherin and alpha-catenin and beta-catenin in pancreatic carcinoma tissues. Abnormal E-cadherin and alpha-catenin with differentiation, lymph node and liver metastases. Aberrant beta-catenin with lymph node and liver metastases.
- CKI epsilon-dependent phosphorylation of Dvl enhances the formation of a complex of Dvl-1 with Frat-1 and this complex leads to the activation of Wnt-3a-induced accumulation of beta-catenin
- In human pilomatricoma, the frequency of beta-catenin gene mutations was remarkably low (30%),in Exon 3 of the beta-catenin gene .
- matrix metalloproteinase-2 and 9 and membrane-type 1 matrix metalloproteinase mRNA expression in endometriosis was higher than in normal endometrium whereas E-cadherin, alpha- and beta-catenin mRNA expression was not suppressed in endometriosis
- Data show that beta-catenin is overexpressed in Kaposi sarcoma and primary effusion lymphoma, and that this overexpression is regulated by the Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen LANA.
- Mutations of beta-catenin, as well as overexpression of beta-catenin and the Tcf-4 gene, independently activate the Wnt pathway in HCC, with the target gene most likely to be C-myc.
- Data indicate that the rate of nuclear export of adenomatous polyposis coli protein (APC), rather than its nuclear import or steady-state levels, determines the transcriptional activity of beta-catenin.
- Pulse-labeled beta-catenin replaces the beta-catenin bound to the cell surface prebiotinylated E-cadherin immediately after synthesis or arrives at the plasma membrane in a complex with the E-cadherin precursor.
- The MUC1/beta-catenin interaction occurs in primary tumors, & is dramatically increased in metastatic lesions.
- dysregulation of beta-catenin may contribute to pancreatic duct adenocarcinoma progression through distinct mechanisms
- These results indicate that the altered expression of beta-catenin, but not cyclin D1, in hepatocellular carcinoma may play an important role in tumor progression by stimulating tumor cell proliferation.
- Aberrant beta-catenin expression may play an important role in the histologic differentiation and tumor staging of mucoepidermoid carcinoma.
- There is a possible role of progesterone in regulation of beta-catenin expression in endometrial tumors. Nuclear beta-catenin accumulation, like gene abnormalities, is associated with the alteration of tumor morphology due to progesterone.
- Data show that beta-catenin and poly(ADP-ribose) polymerase are cleaved during rhodostomin-induced apoptosis, indicating that cell detachment is a prerequisite for apoptosis.
- CTNNB1 mutations were found in 2/19 adenomas without APC mutation.
- Data show that both UBF1 and UBF2 activate RNA polymerase II-regulated, beta-catenin-responsive promoters.
- beta-catenin is degraded via a retinoid X receptor-mediated pathway
- When colon cancer cells with high beta-catenin levels were treated with beta-catenin antisense ODNs, VEGF-A expression was reduced by more than 50%. There is a close link between beta-catenin signaling & VEGF-A expression regulation in colon cancer.
- CTNNB is ubiquinated at specific lysines by the F-box protein beta-TrCP1.
- types of mutations in sinonasal NK/T cell lymphoma in northeast district of China
- a role for beta-catenin in the control of cell cycle and apoptosis at G2/M
- Mutations of CTNNB1 may not be a factor in tumorigenesis of cervical cancer
- in breast and lung tumor cells, MDA-7 protein expression modulates cell-cell adhesion and intracellular signaling via coordinate regulation of the beta-catenin and PI3K pathways
- model of the interactions between beta-catenin and hedgehog signaling in the epidermis in which SHH promotes proliferation of progenitors of the hair lineages whereas IHH stimulates proliferation of sebocyte precursors
- IpaC interacts with beta-catenin and destabilizes the cadherin-mediated cell adhesion complex.
- provides support that E-cadherin induction by WNT/beta-catenin signaling is an evolutionarily conserved pathway operative in lung cancer cells and that loss of expression may be important in lung cancer development or progression
- Results report a new noncanonical pathway through which Wnt-5a antagonizes the canonical Wnt pathway by promoting the degradation of beta-catenin.
- Overexpression of beta-catenin is associated with hepatocellular carcinoma
- our data indicate that inactivation of beta-catenin by a 3p21.3 homozygous deletion might be a crucial event in the development of the mesothelioma NCI-H28 cells.
- interaction with the co-activator, p300, underlies the trans-repression of beta-catenin signaling by nuclear receptors and their ligands
- Increased expression of beta-catenin is associated with ovarian epithelial cell transformation and in tumour progression
- the beta-catenin pathway is activated by histamine
- Beta-catenin gene mutations are a peculiar feature of skin tumors with matrical differentiation and correlate with a pattern of intense and diffuse beta-catenin nuclear expression.
- We conclude, therefore, that two major components of cell-cell interaction synergistically regulate cell cycle progression in HEK293 cells by regulating p21 expression in a beta-catenin/TCF-dependent manner.
- beta-catenin interferes with transforming growth factor-beta-mediated growth arrest by inducing the expression of BAMBI
- FAM associates with E-cadherin and beta-catenin during trafficking to the plasma membrane
- beta-catenin binds to MUC1 and has a role in T cell receptor signaling
- beta-catenin has a role in progression of colorectal neoplasms
- beta-catenin phosphorylation/degradation is regulated by CDK2
- alpha-catenin and alpha-catulin have distinct activities that downregulate, respectively, beta-catenin and Ras signals converging on the cyclin D1 promoter
- p53-mediated reduction in beta-catenin involves enhanced phosphorylation of beta-catenin on key NH(2)-terminal serines.
- Cyr61 activated the beta-catenin/TCF4 complex, which promoted the expression of c-myc and the latter induced expression of p53
- Wnt signaling pathway associated with beta-catenin regulation in breast cancer tissue
- MUC1 and beta-catenin have a role in progression and invasiveness of colorectal carcinomas
- Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during tumor cell differentiation
- High nuclear expression of beta-catenin is correlated with locally advanced colorectal cancer
- Translocalization of beta-catenin is associated with invasion in gastric cancer
- CTNNB strongly increased activity of the eN/Nt5 promoter and this increase depended on the presence of TCF-1; demonstrated a link between Wnt signaling and the regulation of eN and ADA, which control the metabolism of adenosine
- E-cadherin-mediated cell adhesion is required for keratinocyte-mediated control of melanocytic cells, which can override proliferative activity of beta-catenin.
- beta-catenin/TCF transcriptional activity is blocked by Cdx1 and Cdx2, which then inhibits colon cancer cell proliferation
- LECT2, which encodes a protein with chemotactic properties for human neutrophils, is a direct target gene of Wnt/beta-catenin signaling in the liver.
- beta-catenin nuclear accumulation plays a role in Dukes' D human colorectal cancers
- beta-catenin is downregulated by H2O2 which negatively modulates the Wnt signal pathway
- abnormal immunhistochemical E-cadherin and beta-catenin expression is associated with changes in pit pattern in invasive colorectal neoplasms
- there is cross-talk between Wnt and estrogen signaling pathways via functional interaction between beta-catenin and ERalpha
- In HT29 and HCT116 colorectal cancer cells, beta-catenin/TCF transcriptional activity is inhibited by AP-2alpha due to formation of AP-2alpha/APC/beta-catenin complex.
- terminal tail is responsible for discerning among binding of factors to the armadillo domain
- negative immunoreactivity of beta-catenin in serous carcinomas and the presence of residual tumor seem to be useful markers in selecting patients likely to have an unfavorable course
- Lower levels of nuclear beta-catenin is associated with prostate cancer progression
- beta-catenin is targeted to adhesive or transcriptional complexes, depending on its molecular form
- The beta-catenin, the main system of adherens junction, present in the tight junctions in HepG2 cells.
- IGF-I modulates androgen signaling through beta-catenin
- beta-catenin accumulates in the nucleus of epithelial cells of juvenile polyps
- The interaction and functional cooperation between FHL2, CITED4, and CTNNB were studied.
- identify selective beta-catenin binding hot spots of Tcf4, E-cadherin, and APC
- beta-catenin plays a central role in mesenchymal cells during the healing process, and is an appealing therapeutic target for disorders of wound healing.
- Loss of expression of E-cadherin and beta-catenin may play an important role in the progression of pulmonary adenocarcinoma.
- Induction of the Wnt/beta-catenin pathway by LiCl also elevated PPARgamma levels and induced PPARgamma-dependent reporter and endogenous target genes.
- Alterations in beta-catenin and PTEN genes, as well as MSI, are frequent in low-stage ovarian carcinomas of endometrioid type that have a favorable prognosis.
- Together, we suggest that quercetin is an excellent inhibitor of beta-catenin/Tcf signaling in SW480 cell lines, and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4 proteins.
- Suppression of beta-catenin expression by small interfering RNA decreased the apoptotic response to TGF-beta.
- Here, we generated a fusion in which XWnt8 was fused to the N-terminus of LRP6 and show it synergizes with both Fz4 and Fz5 to potently transactivate beta-catenin-dependent Wnt signaling
- ubiquitin-independent degradation of alpha-catenin regulates beta-catenin signaling and maintenance of the differentiated phenotype of articular chondrocytes
- All 61 meningothelial meningiomas, 10 of 12 invasive meningiomas, and 3 of 5 anaplastic meningiomas were positive for both ECAD and beta-catenin, while these were both negative in all of the fibrous meningiomas.
- Beta-catenin stabilization because of either beta-catenin or AXIN I mutation might be a late event for malignant progression rather than an early genetic event involving the initiation of HCC development.
- LEF-1 expression is regulated through PITX2, LEF-1 and beta-catenin direct physical interactions
- In conclusion, prolonged CPB time entails neutrophil-mediated decrease in MVEC beta-catenin expression, and thus may be an important trigger for BBB disruption.
- Findings suggest that phospho-beta-catenin accumulation in Alzheimer's disease might result from impaired proteasome function.
- crosstalk between the beta-catenin and NF-kappaB signaling pathways is an important regulator of intestinal inflammation
- data indicate that altered expression of beta-catenin may play an important role in oral cancer progression through increased proliferation and invasiveness under epidermal growth factor receptor (EGFR) activation but not mutation or cyclin D1 expression
- TCF4 expression mediated by beta-catenin/p300 may be important for initial steps during trans-differentiation of endometrial carcinoma cells.
- Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin
- The beta-catenin expression in hepatocellular carcinoma cells was heterogeneous among types of hepatitis viral infection
- Lysophosphatidic acid induced colon cancer cell proliferation requires the beta-catenin signaling pathway.
- The regulation of GLCE expression by 2 cis-acting elements of the beta-catenin-TCF4 complex located in the enhancer region of the promoter are reported.
- Tumor sections frmo colorectal cancer patients showed elevated expression levels of AKT1, correlating with enhanced cytoplasmic/nuclear expression of beta-catenin.
- Wnt/beta-catenin signalling pathway is activated in most of gastric cancers, which may play pivotal roles either in gastric cancer formation or in tumour invasion and dissemination
- cyclooxygenase-2/PGE2 may exert pro-oncogenic actions through stimulating the beta-catenin/T cell factor-mediated transcription, which plays critical roles in colorectal carcinogenesis
- results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress
- significantly reduced rates of lymph-node metastases were observed in beta-catenin-positive T1 and T2 squamous cell carcinomas of the mouth floor
- analysis of conformation of the oncogenic protein beta-catenin containing the phosphorylated motif DpSGXXpS bound to the beta-TrCP protein
- ADAM10 has a role in E-cadherin shedding and epithelial cell-cell adhesion, migration, and beta-catenin translocation
- The presence of activated beta-catenin and c-myc in the epidermis of chronic wounds may serve as a molecular marker of impaired healing
- Transendothelial migration is compromised in melanoma cells expressing a dominant-negative form of beta-catenin, thus supporting a regulatory role of beta-catenin signaling in this process.
- beta-Catenin transgenic mice show an in vivo hepatotrophic effect secondary to increased basal hepatocyte proliferation
- Both cell surface reduction and intranuclear accumulation of beta-catenin were detected in intestinal metaplasia
- nuclear beta-catenin is a rare phenomenon in colorectal SRCC, but the involvement of it may indicate a worse prognosis with shorter survival than colorectal SRCC without nuclear beta-catenin expression
- results suggest that the Wnt/beta-catenin signaling pathway plays dual functions in head and neck squamous cell carcinoma (HNSCC) development: promoting both cell survival and invasive growth of HNSCC cells.
- Splice variants of CTNNB1 ands downstream targets were used as markers for neoplastic progression of esophageal cancer.
- Overexpression of Pin1 and beta-catenin may be closely related with the development and/or progression of colorectal carcinoma and further supports that Pin1 overexpression might contribute to the upregulation of beta-catenin.
- cadherins mediate both the association of PS1 and beta-catenin and the effects of PS1 on the cellular levels of beta-catenin
- Altered beta-catenin distribution in gastric cancer may result from the imbalance of E-cadherin production and Wnt expression, which confers on gastric cancer cells more aggressive behaviors.
- The expression of beta-catenin, p63 and CD34 in the course of androgenetic alopecia is reported.
- The cytoplasmic accumulation of beta-catenin is a common characteristic of oral SCC, but is not closely associated with mutational alterations in the APC, beta-catenin and Axin1 genes.
- PKA inhibits the ubiquitination of beta-catenin by phosphorylating beta-catenin, thereby causing beta-catenin to accumulate and the Wnt signaling pathway to be activated.
- TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes
- Data suggest a beta-catenin-dependent, stage-specific role for Notch1 signaling in promoting the progression of primary melanoma.
- Beta-catenin may be an important modulator of angiogenesis and myocyte regeneration
- The positive inter-regulation between beta-cat/Tcf-4 signaling and ET-1 signaling potentiates proliferation and survival of prostate cancer (CaP) cells, thereby representing a novel mechanism that contributes to CaP progression.
- results suggest an established Wnt signaling pathway in most gastric cancers, a close correlation of beta-catenin/TCF4-mediated signaling with tumor dissemination, and the unlikelihood of a direct effect of activated Wnt signaling on CD44 expression
- Results showed that inhibition of PI-3 kinase with wortmannin was accompanied by a considerably reduced expression of beta-catenin.
- These results indicate that CIP4 is critical for beta-catenin-mediated cell-cell adhesion.
- CoCoA uses different combinations of functional domains in its synergistic coactivator function with beta-catenin or GRIP1
- APC and K-ras, but not CTNNB1 mutations have roles in regulation of expression of hMLH1 in sporadic colorectal carcinomas
- The data suggest a novel role for tyrosine phosphorylation of N-cadherin by Src family kinases in the regulation of beta-catenin association during transendothelial migration of melanoma cells.
- beta-catenin mutation and its nuclear localization are frequent causes of Wnt signaling pathway activation suggesting that beta-catenin activation mutations contribute to tumorigenesis of pilomatricomas
- colon cancer cells retain significant amounts of LEF-1 induced nuclear beta-catenin compared to LEF-1 transfected normal epithelial cells; beta-Catenin binds directly to CRM1 & overexpression of CRM1 reduces nuclear beta-catenin-mediated transactivation
- sulindac sulfone can modulate the APC/beta-catenin pathway in vitro but its efficacy is dependent upon the mutational status of APC and beta-catenin
- In esophageal adenocarcinomas, nuclear translocation of beta-catenin was observed regardless of the expression of APC.
- High Pin1 expression in primary prostate cancer markedly inhibits the beta-catenin interaction with androgen receptor.
- Expressed Bcr is able to bind the transcription factor Tcf1 to disrupt the Tcf1/beta-catenin complex. Phosphorylation of Bcr by the tyrosine kinase pp60(src) can lead to dissociation of the transcriptionally inactive Bcr/Tcf1 complex
- These results unravel a novel pathway in the control of beta-catenin cellular transport and strongly suggest that SYT-SSX2 contributes to tumor development, in part through beta-catenin signaling
- Immunohistological examination of nuclear accumulation of beta-catenin may be useful for diagnosing malignant immunohistological examination of nuclear accumulation of beta-catenin may thus be useful for diagnosing malignant PLTs.
- Phospho-beta-catenin may have a different involvement in invasive breast carcinomas, according to its subcellular distribution.
- analysis of a novel, noncanonical mechanism of modulation of beta-catenin signaling through direct phosphorylation of beta-catenin by PKA, promoting its interaction with CREB-binding protein
- beta-catenin is activated by HBxAg, in part, through the upregulated expression of the HBxAg effector URG11; URG11 stimulates the beta-catenin promoter and hepatocellular growth and survival
- Nuclear localization of beta-catenin, an indirect evidence of deregulated Wnt signaling pathway, was observed in 5 (19%) small intestinal adenocarcinomas and 36 (71%) colorectal adenocarcinomas.
- the cross talk of KLF4 and beta-catenin plays a critical role in homeostasis of the normal intestine as well as in tumorigenesis of colorectal cancers.
- active CKIepsilon generation may induce a negative feedback loop by phosphorylation of sites on LRP5/6 that modulate axin binding and hence beta-catenin degradation
- the MED12 interface within Mediator is a new component in the Wnt/beta-catenin pathway
- PCP-2 may play an important role in the maintenance of epithelial integrity, and a loss of its regulatory function may be an alternative mechanism for activating beta-catenin signaling.
- BMP-2 antagonizes Wnt-3a signaling in osteoblast progenitors by promoting an interaction between Smad1 and Dvl-1 that restricts beta-catenin activation
- The results indicate that estrogen plus overexpressed ERalpha induce LoVo cell apoptosis might mediate through the increase of hTNF-alpha gene expression, which in turn activate caspase-8, -9 and caspase-3 and lead to the DNA fragmentation and apoptosis.
- GR can bind beta-catenin in vitro, suggesting that GC and Wnt signaling pathways are linked directly through their effectors
- variations in beta-catenin protein levels were dependent on post-transcriptional mechanisms involving the Wnt/beta-catenin pathway only in leukemic cells
- Results suggest that alternative splicing and AU-rich elements can act together in regulating beta-catenin mRNA stability and thereby provide a step of controlling the cellular beta-catenin concentration.
- beta-catenin is regulated via epsilon-cleavage of N-cadherin
- STMN2 is required for maintaining the anchorage-independent growth state of beta-catenin/TCF-activated hepatoma cells
- histone deacetylase inhibitor sodium butyrate induces G1/S phase arrest in E1A + Ras-transformed cells through down-regulation of E2F1 activity and stabilization of beta-catenin
- These data indicate that the intracellular amounts of HIC1 protein can modulate the level of the transcriptional stimulation of the genes regulated by canonical Wnt/beta-catenin signaling.
- When beta-catenin is activated in transgenic En1 expressing cells, it induces Dermo1 expression in all cells of the En1 domain and disrupts muscle gene expression.
- the central region of APC is unstructured in the absence of beta-catenin and Axin; beta-catenin may interact with each of the APC 15aa and 20aa repeats independently
- Wnt/beta-catenin activation was observed in 65% of pancreatic adenocarcinomas, independently of beta-catenin gene mutations in most tumors
- beta-catenin level depends on the way and level of Wnt pathway activation
- Splice forms of crucial genes of the Wnt-pathway, beta-Catenin, LRP5, GSK3beta, Axin-1 and CtBP1 are expressed in human colorectal tissue.
- beta-catenin might be involved in the Hh signaling pathway via enhancement of the transcriptional activity of GLI
- APC regulates beta-catenin phosphorylation and ubiquitination by distinct domains and by separate molecular mechanisms
- In conclusion, the canonical Wnt/beta-catenin pathway enhanced monocyte-endothelial cell adhesion without changing expression levels of adhesion molecules.
- Comparative analysis of nuclear and membrane/cytoplasmic beta-catenin can predict local tumor infiltration.
- These data indicate that somatic mutations affecting APC and CTNNB1 do not play a major role in the pathogenesis of sporadic ependymomas.
- Reduced membranous expression of beta-catenin was associated with metastasis in salivary adenoid cystic carcinoma
- in vivo modulation of PRA1 may be involved in TCF/beta-catenin signaling, as well as cellular proliferation and tumorigenesis
- These data indicate that changes in Wnt expression per se are unlikely to be the cause of the observed dysregulation of beta-catenin expression in DD.
- These findings suggest that the participation of beta-catenin in adhesion and signaling may represent a novel mechanism through which gonadotropins may regulate the cellular fate of human ovarian surface epithelial cells.
- Data suggest that intact 654 and 670 tyrosine residues in beta-catenin are crucial in HGF-mediated Met-beta-catenin dissociation, beta-catenin translocation, activation and mitogenesis.
- A functional crosstalk between hepatocyte growth factor receptor (MET) and beta-catenin signaling sustains and increases colorectal carcinoma cell invasive properties.
- vascular endothelial growth factor expression is induced through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells
- Data show that P68 RNA helicase mediates platelet-derived growth factor-induced epithelial mesenchymal transition by displacing Axin from beta-catenin.
- Exposure of colon cancer cells to nitric oxide unraveled a so-far-unidentified mechanism of beta-catenin regulation.
- These data reveal a potentially important role for transcriptionally active beta-catenin in the regulation of Rad6B gene expression, and link aberrant beta-catenin signaling with transcriptional deregulation of Rad6B and breast cancer development.
- crystallographic analysis of how beta-catenin, BCL9, BCL9-2 and Tcf4 interact
- Alterations in adenomatous polyposis coli/beta-catenin pathway and cyclin D1 dysregulation may contribute to pathogenesis of pleuropulmonary desmoid tumors and solitary fibrous tumors.
- Beta-catenin relieves I-mfa-mediated suppression of LEF-1 in mammalian cells.
- Wnt/beta-catenin signaling may contribute to colorectal carcinogenesis by reducing the level of the E2F4 cell cycle repressor via an antisense mechanism
- COX-2 and beta-Catenin may have roles in regulating intracellular Survivin levels in mouse and human colon cancer
- Wnt/beta-catenin signaling has a role in neurodevelopment as well as in neurodegenerative diseases [review]
- beta-catenin may have a role in progression of colorectal neoplasms to metastatic liver lesions
- CTNNB1 mutation is a later event in Wilms tumourigenesis. CTNNB1 mutations might be associated with rhabdomyogenesis
- accumulation of beta-catenin in colorectal cancer is related to chromosomal instability
- mutations in the CTNNB1 gene most frequently coexisted with mutations in the PTEN gene (7/9, 77.8%).
- N-cadherin and beta-catenin play role in cell migration via PDGF-Rbeta-mediated signaling through the scaffolding molecule NHERF2
- Up-regulates prolactin expression using the distal promoter.
- GSK3beta-dependent protein degradation was switched between Hath1 and beta-catenin by Wnt signaling, leading to the dramatic alteration of cell status between proliferation and differentiation in colon cancer
- the recruitment of PI3K to the E-cadherin/beta-catenin/p120-catenin complex via beta-catenin at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and, ultimately, keratinocyte differentiation
- PS/gamma-secretase-mediated cleavage of LAR controls LAR-beta-catenin interaction, suggesting an essential role for PS/gamma-secretase in the regulation of LAR signaling
- No evidence of mutations in parathyroid adenomas.
- Glis2 functions as a negative modulator of beta-catenin/TCF-mediated transcription.
- Decreased beta-catenin expression is associated with advanced gallbladder cancers
- CTNNB1 was expressed strongly on the cuboidal cell membranes and cytoplasm in both tumor types, but to a lesser extent in the polygonal cells, localizing mainly in the cytoplasm.
- CTNNB1 protein mutation/expression in hepatocellualr carcinoma and their significance are reported.
- Interaction of MUCI with CTNNB modulates cyclin D1 in H. pylori-induced stomach neoplasms.
- Data show that E-cadherin/beta-catenin-based adherens junctions are dispensable for tight junction formation and apical lumen biogenesis but not for apical lumen remodeling.
- racial factor may not be related to the occurrence of mismatch repair defects and CTNNB1 mutations in our multi-racial patient cohort.
- inhibition of beta-catenin and in effect c-myc expression through activation of PPARgamma may help prostate cancer cells to restore several characteristics of normal prostate cells phenotype
- Loss of beta-catenin expression is a strong and independent predictor of an unfavorable outcome in patients with endometrial carcinoma.
- Nuclear beta-catenin expression was significantly greater in Multiple colorectal adenoma patients' tumours than in sporadic adenomas.
- Characterization of endogenous CDHE-CTNNB complexes with ELISA represents a dramatic improvement over other assays.
- findings show that WTX, a protein encoded by a gene mutated in Wilms tumors, forms a complex with beta-catenin, AXIN1, beta-TrCP2 and APC; data provide a possible mechanistic explanation for the tumor suppressor activity of WTX
- hepatocellular carcinomas (HCC) with extensive methylation harbor frequent beta-catenin mutations; HCCs with high levels of chromosomal instability are associated with p53 mutations, suggesting presence of two independent pathways for pathogenesis of HCC
- OxPAPC promoted novel interactions between focal adhesion and adherens junction complexes via paxillin and beta-catenin association, which was critically dependent on Rac and Cdc42 activities.
- 3,3'-diindolylmethane -induced cell growth inhibition and apoptosis induction are partly mediated through the regulation of Akt/FOXO3a/GSK-3beta/beta-catenin/AR signaling
- methylation may play important role in progression and metastasis of small bowel carcinoid tumors
- Bilateral Wilms tumours showed loss of the wild type WT1 allele (loss of heterozygosity (LOH)) and a tumour specific mutation in catenin beta1 (CTNNB1).
- there are somatic mutations of APC & beta-catenin genes in desmoid-type fibromatosis & abnormalities in Wnt signal pathway; these abnormalities may result in aberrant cell proliferation & apoptosis, which may be important in tumorigenesis & progression
- we explored the implication of three proteins (E-cadherin, a- and b-catenins) that form the cadherin-catenin complex, a receptorial structure strictly involved in tumoral vascular invasion and embolization in this biologic event
- Transgenic mice express stabilized beta-catenin, which augments IL-7 receptor signaling in thymocytes during positive selection and promotes development of single-positive CD8 antigen-expressing thymocytes.
- Specification of enteroendocrine but not Paneth cells occurs independently of Wnt signals by conditional deletion of beta-catenin transgene in immature cells expressing the transcription factor, neurogenin 3.
- Blockade of Wnt3a stimulation of IP(5) generation blocks beta-catenin accumulation
- TGF-beta is a modulator of beta-Catenin levels in tumoral fibroblasts and non-tumoral fibroblasts, despite the oncogenic mutations already present in this gene in tumoral fibroblasts of desmoid tumors.
- Ajuba promoted GSK-3beta-mediated phosphorylation of beta-catenin by reinforcing the association between beta-catenin and GSK-3beta.
- These observations unravel the interplay between beta-catenin and Rac1 that is initiated by T-Ag and results in stabilization of beta-catenin and its presence in cell membrane ruffles.
- Fascin is a novel target of beta-catenin-TCF signaling and is expressed at the invasive front of human colon cancer
- Elevated expression of cell-cycle regulators p16(INK4A), p21(CIP1), and cytoplasmic/nuclear beta-catenin correlated with increased colorectal cancers risk, as did elevated expression of survivin and human telomerase reverse transcriptase.
- E-cadherin and beta-catenin have roles in progression of Epstein-Barr virus-associated gastric carcinoma
- We show that a fraction of N-cadherin in a complex with catenins is associated with cholesterol/sphingolipid-rich membrane microdomains in aggressive melanoma cells in vitro and experimental melanomas in vivo.
- Beta-catenin transgene signaling plays a role in the proliferation of neural progenitor cells in the subventricular zone of adult mouse brain.
- Beta-catenin may have an important role in the development of malignancy and in the determination of biological features of keratoacanthoma and squamous cell carcinoma of the skin.
- study found that Wnt/beta-catenin pathway is involved in the genesis of pulmonary sclerosing haemangioma (PSH), but mutation of exon 3 of the beta-catenin gene rarely contributes to the activation of the Wnt/beta-catenin pathway in PSH
- Cytoplasmic beta-catenin is associated with COX-2 overexpression, supporting the role of cytoplasmic beta-catenin in stabilizing PTGS2 (COX-2) mRNA.
- Mutation-specific restriction enzyme digestion was used to detect CTNNB1 mutations in desmoid-type fibromatosis.
- Deregulated beta-catenin signaling may occur in high-risk neuroblastomas without MYCN amplification resulting in transactivation of MYC and other target genes to induce an aggressive phenotype.
- MUC1 may affect cancer cell migration by increasing E-cadherin/beta-catenin complex formation and restoring E-cadherin membrane localization
- Re-expression of E-cadherin in HT29(US) cells restored the ability of caveolin-1 to down-regulate beta-catenin-Tcf/Lef-dependent transcription and survivin expression, as seen in HT29(ATCC) cells.
- FLT3 activation induces beta-catenin tyrosine phosphorylation and nuclear localization.
- Beta-Catenin was co-immunoprecipitated with ERalpha, indicating that these two proteins form a new signaling complex and transcription factor.
- REVIEW of studies pointing to molecular mechanisms that govern the integration between cell-cell adhesion and gene expression, as reflected in the switches between these two functions of beta-catenin in colon cancer cells
- Data indicate that Sox4 and 17 can act as both antagonists and agonists of beta-catenin/TCF activity, and this mechanism may regulate Wnt signaling responses in many developmental and disease contexts.
- immunohistochemistry for b-catenin may be a powerful tool for detecting those adenomas with an increased risk for malinancy.
- This paper focuses on changes in E-cadherin (CDH1), adenomatous polyposis coli (APC), and beta-catenin (CTNNB1) in 50 tumors of the central nervous system
- HER-2/neu transcriptionally activates Jab1 expression via the AKT/beta-catenin pathway in breast cancer cells.
- Endogenous KIT and beta-catenin were found to associate in mast cell leukemia cells, and in vitro kinase assay demonstrated that active KIT phosphorylates tyrosine residues of beta-catenin directly.
- The reciprocal crosstalk between beta-catenin/Tcf pathway and NF-kappaB signaling in hMSCs is mediated through the regulation of lzts2 expression.
- Sporadic desmoids are usually associated with somatic mutations in codons 41 or 45 of exon 3 of beta-catenin (CTNNB1).
- Suggest beta-catenin deregulation is involved in sporadic hepatoblastoma and also suggests that mismatch repair defects and p53 mutations contribute to this rare liver cancer.
- Beta-catenin activation through mutation does not occur in CML.
- functional significance of combined dysregulation of PKD1 and E-cadherin in prostate cancer; their effect on cell growth is mediated by beta-catenin.
- removal of N-glycans on E-cadherin resulted in elevated tyrosine phosphorylation level of beta-catenin and reduced beta- and alpha-catenins at adherens junctions
- analysis of Epstein-Barr virus, beta-catenin, and E-cadherin in gastric carcinomas
- These data show activation of the Wnt/beta-catenin-signalling pathway in uveal melanoma and suggest that components of this pathway might be useful prognostic markers as well as attractive therapeutic targets to treat this disease.
- Results describe a specific intracellular pathway involving the activation of PP1cgamma to mediate the effects of confluence-induced beta-catenin dephosphorylation.
- EpCAM is a Wnt-beta-catenin signaling target gene
- KCC3 down-regulates E-cadherin/beta-catenin complex formation by inhibiting transcription of E-cadherin gene and accelerating proteosome-dependent degradation of beta-catenin protein
- membranous overexpression of E-cadherin and beta-catenin are associated with the metastatic prostate cancer cells in bone and the high frequency of expression suggests their involvement in the intercellular adhesion of the metastatic cells in bone
- an internally truncated LRP5 receptor is strongly implicated in deregulated activation of the WNT/beta-catenin signaling pathway in hyperparathyroid tumors
- Wnt/beta-catenin pathyway is activated by epigenetic inactivation of Dkk3, thereby promoting the growth of lung cancer cells
- betaenin can be involved in polyphenol mediated down regulation of AKT1.
- These observations assign to the tumor suppressor Fhit an unexpected role in the regulation of beta-catenin-mediated gene transcription.
- Beta-catenin mutations do not contribute to cardiac fibroma pathogenesis.
- beta-catenin as a component of the intercentrosomal linker and define a new function for beta-catenin as a key regulator of mitotic centrosome separation.
- shRNAs targeted against beta-catenin could have a gene silencing effect and block the WNT signaling pathway. They could inhibit cell growth, increase apoptosis, and induce cell cycle arrest in human colon cancer cell lines.
- FGF9 mutant tumors showed normal membranous beta-catenin expression and the absence of mutation in the beta-catenin gene
- Wnt signalling induced the interaction between beta-catenin and TBL1-TBLR1, as well as their binding to Wnt target genes. Importantly, the recruitment of TBL1-TBLR1 and beta-catenin to Wnt target-gene promoters was mutually dependent on each other.
- data indicate that beta-catenin signaling is an intrinsic molecular pathway restricting HIV replication in PBMCs
- the importance of beta-catenin in the immortalization process of HPCs, from its dispensable role in their maintenance.
- Over-expression of beta-catenin was sufficient to suppress the differentiation and mineralization of DPSCs.
- GSK-3beta enters the nucleus, forms a complex with beta-catenin and lowers the levels of beta-catenin/TCF-dependent transcription in a mechanism that involves GSK-3beta-Axin binding
- the pathway including S100A7/psoriasin and beta-catenin signaling has a role in tumor progression of squamous cell carcinoma of oral cavity
- These data indicate that the differential crosstalk between beta-catenin/Tcf and NF-kappaB pathway in various cancer cells resulted from the differences in the regulation of NF-kappaB-induced lzts2 expression.
- Vpu leads to the depression of both total and beta-catenin-associated E-cadherin levels through beta-TrCP-dependent stabilization of the transcriptional repressor Snail.
- PTPRK influences transactivating activity of beta-catenin in non-tumoral and neoplastic cells by regulating the balance between signaling and adhesive beta-catenin, thus providing biochemical basis for the hypothesis of PTPRK as a tumor suppressor gene.
- Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma.
- Mutations in CTNNB1, APC, AXIN1, and AXIN2 are not implicated in nuclear accumulation of beta-catenin, and the expression of cyclin D1 is accelerated independently of beta-catenin in ameloblastomas.
- beta-catenin and/or CDX2 immunolabeling may have diagnostic usefulness in the evaluation of serrated polyps
- Data suggest the Wnt/beta-catenin signaling pathway may be associated with ethanol-induced osteonecrosis.
- Increased MMP-2 and -9 and altered beta-catenin may play a role in the pathogenesis of endometriosis.
- Overexpression of Myc stimulated sebocyte differentiation, whereas overexpression of beta-catenin stimulated involucrin and cornifin expression.
- The results indicated that HBx induction in the CCL13-HBx stable cell line downregulated Wnt-3/beta-catenin expression and suppressed cell growth by repressing cell proliferation or triggering cell apoptosis.
- WT1 and WTX mutations occur with similar frequency, that they partially overlap in Wilms tumors, and that mutations in WT1, WTX, and CTNNB1 underlie the genetic basis of about one-third of Wilms tumors
- study examined the presence of mutations in TP53 at codon 249 (Ser-249, considered as a hallmark of mutagenesis by aflatoxin) and in CTNNB1 in circulating free DNA of patients with hepatocellular carcinoma or chronic liver disease from Alexandria, Egypt
- levels in colon carcinomas were not statistically different from levels in adjacent normal mucosa and were not correlated with tumor, nodes, and metastases stage
- a beta-catenin-RET kinase pathway is a critical contributor to the development and metastasis of thyroid carcinoma
- Nuclear beta-catenin expression correlating with the grade of IEN in polyps and carcinomas supports its role in colorectal carcinogenesis.
- Mutations of CTNNB1 were observed in cases of gastric cancer.
- Crystal structure of a full-length beta-catenin.
- the expression manner of PTEN, beta-catenin, and p53 immunocytochemistry was observed in the normal endometrium (proliferative, secretory, and atrophic, and endometrial glandular and stromal breakdown[beta-catenin]
- nuclear beta-catenin immunostaining can serve as a sensitive immunohistochemical marker for the diagnosis of endometrial stromal tumors
- CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes
- a frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling
- Mutations in CTNNB1 are associated with melanoma
- beta-catenin signalling is essential in sustaining the cancer stem cell phenotype
- Peroxisome proliferator-activated receptor gamma suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor pathway.
- study of correlation between mutations & expression of E-cadherin, beta-catenin, occludin & claudin & complexity of colon carcinoma growth; perturbed expression & distribution of these proteins was found, but could not be linked to complexity of growth
- These results support a functional role for beta-catenin during proliferation of human islet-derived precursor cells (hIPCs) and suggest that activated beta-catenin signalling may also be important during hIPC derivation from islets.
- Determination of role nuclear pore complex in regulating TCF4/beta cateninin mediated Wnt signaling.
- study showed that the beta-catenin signal transduction pathway was upregulated by chronic alcohol abuse
- There is a functional role for the long cytoplasmic domain of CEACAM1 in regulation of beta-catenin activity.
- Combined increased p53 and reduced membranous beta-catenin protein expression indicated a very poor prognosis in patients with esophageal squamous cell carcinoma.
- SOX2 and beta-catenin act in synergy in the transcription regulation of CCND1 in breast cancer cells
- A loss of nuclear beta-catenin is the most consistent feature in prostate cancer rather than absolute levels of expression
- Beta-catenin induced through the Wnt receptor complex was significantly more competent transcriptionally than overexpressed beta-catenin, both in cultured cells and in early Xenopus embryos.
- three WT1 subtypes were correlated with WT1, IGF2, and CTNNB1 genetics
- In focal nodular hyperplasia, increased activation of the beta-catenin pathway was found restricted to enlarged perivenous areas
- Our study proved that beta-catenin protein levels are negatively associated with myeloma cells' sensitivity to Bortezomib.
- Report nuclear targeting of beta-catenin and p120ctn during thrombin-induced endothelial barrier dysfunction.
- These experiments suggest that in breast cancer cells, the expression of ZBP1 and the expression of beta-catenin are coordinately regulated.
- These results indicate that localized decrease of beta-catenin contributes to the spatial pattern of differentiation in hESC colonies.
- Epigenetic repression of DACT3 leads to aberrant Wnt-beta-catenin signaling in colorectal cancer cells.
- Aberrant accumulation of beta-catenin is very common in parathyroid tumors, and is caused by stabilizing homozygous mutation in 7.3% of Swedish patients.
- findings suggest that hepatitis B virus X protein (HBx) negatively regulated proliferation of CCL13-HBx-stable cells via the GSK-3beta/beta-catenin cascade
- Wnt/beta-catenin signaling mediates the differentiation of osteochondral progenitor cells during fracture repair.
- CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors
- This study reveals for the first time that alpha-catenin is a key regulator of beta-catenin transcriptional activity and that the status of alpha-catenin expression in tumor tissues might have prognostic value for Src targeted therapy
- 14-3-3epsilon and 14-3-3zeta are identified as Cby-binding partners.
- We define a novel modification of beta-catenin that regulates its nuclear localization and transcriptional function.
- MCC is a nuclear, beta-catenin-interacting protein that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt/beta-catenin signal transduction.
- Overexpression of a beta-catenin mutant and depletion of SFRP1 using siRNA synergistically upregulated TCF/LEF transcriptional activity.
- rather than being translocated to the nucleus for regulating the target gene transcription, Smad7-stabilized-beta-catenin is shunted to the E-cadherin complex to modulate cell-cell adhesion.
- HIF-1alpha was found to inactivate the Wnt signaling by binding to hARD1 or beta-catenin, which may contribute to the hypoxia-induced growth arrest of tumor cells.
- WNT3 and DKK1 regulate distinct internalization pathways of LRP6 to tune the activation of beta catenin signaling.
- Nuclear beta-catenin expression provides additional information in predicting patient outcome in advanced colorectal cancer.
- Slit-2-overexpressing breast cancer cells exhibit tumor suppressor capabilities through the novel mechanism of beta-catenin modulation.
- beta-catenin acts together with Lef-1 to influence DeltaNp63 promoter activity and protein expression
- The Wnt/beta-catenin signaling pathway may have a role in megakaryocytopoiesis in polycythemia vera and essential thrombocythemia.
- SMRT and NCoR have important roles in the regulation of beta-catenin-TCF4-mediated gene transcription
- Polycystin-1 C-terminal tail co-localizes with and binds to beta-catenin in the nucleus.
- close proximity between cPLA(2)alpha and PPARdelta provides advantage for their efficient functional coupling in the nucleus, where AA produced by cPLA(2)alpha becomes immediately available for PPARdelta binding and subsequent beta-catenin activation.
- The occurrence as an additional hit of a CTNNB1 somatic mutation is associated with larger or more aggressive adrenocortical tumors.
- FHL2-beta-catenin interaction potentiates beta-catenin nuclear translocation and TCF/LEF transcription, resulting in increased Runx2 and alkaline phosphatase expression, which was inhibited by the Wnt inhibitor DKK1.
- Decreased immunoexpression of beta-catenin and E-cadherin in serous ovarian tumors may be helpful in identifying the cases of higher metastatic potential and infiltration ability.
- erbin acts as a negative regulator of beta-catenin/T-cell-factor-dependent gene expression. An erbin mutant with a deletion of the N-terminal leucine-rich repeat allows the PDZ domain of erbin to increase beta-catenin/T-cell-factor-dependent transcriptio
- the Wnt/beta-catenin pathway contributes to carcinogenesis and cancer cell survival by driving expression of OPG
- 33 (52%) of 64 mantle cell lymphoma tumors showed nuclear localization of beta-catenin, which significantly correlated with the expression of the phosphorylated/inactive form of GSK3beta
- Snail and Slug promote formation of beta-catenin-T-cell factor (TCF)-4 transcription complexes that bind to the promoter of the TGF-beta3 gene to increase its transcription.
- The pVHL tumour suppressor and the Wnt tumorigenesis pathway are therefore directly linked through Jade-1.
- No mutations were detected in adenomatous polyposis coli protein or beta-catenin in pulmonary artery sarcoma.
- Activated Akt seems to characterize well-differentiated invasive squamous laryngeal carcinomas, loss of E-cadherin and activation of beta-catenin correlated with high grade carcinomas.
- CTNNB1 mutations are highly common in desmoid tumors.
- In hepatocellular carcinoma (HCC), there is a negative correlation between the positive expression of p130Cas and the normal expression of E-cadherin/beta-catenin. p130Cas plays important roles in the invasion, metastasis and prognosis of HCC.
- There is no predictive value of nuclear beta-catenin in colorectal cancer outcomes.
- the combined pattern of positive KL-6 expression and decreased membranous beta-catenin expression by colorectal carcinoma is a useful biomarker for distinguishing a subgroup of patients with a worse prognosis.
- Beta-catenin overexpression in Dupuytren's disease is unrelated to disease recurrence.
- No mutations were found in the GSK-3beta phosphorylation sites on exon 3 of beta-catenin gene in this group of patients with the MRKH syndrome.
- No mutations are observed in the CTNNB1 gene in any of of sporadic colorectal tumors in this study.
- Dkk3 is a negative regulator of beta-catenin and its downregulation contributes to an activation of the beta-catenin signaling pathway
- novel role of beta-catenin in endoplasmic reticulum (ER) stress-mediated growth inhibition and a new proapoptotic mechanism triggered by beta-catenin on inhibition of PKC isoforms
- nuclear translocation of beta-catenin was found in 1 of 4 cases of adult Wilms' tumor; none had a beta-catenin gene mutation; nuclear translocation of beta-catenin & mutation of beta-catenin gene were found in 53% & 15.8% of pediatric Wilms' tumors
- Consequences of modulation of PAR1 and PAR2 expression and function on cytotrophoblast invasion and beta-catenin stabilization, were examined.
- The SCF(beta-TrCP) binding site created by phosphorylation of beta-catenin is highly vulnerable to protein phosphatase 2A (PP2A) and must be protected by the adenomatous polyposis coli (APC) tumor suppressor protein.
- analysis of Wnt/beta-catenin and Myc signaling in liver cancer
- alterations in beta-catenin/E-cadherin complex play a critical role in spindle and/or corded (SPICO) cells' features
- Data describe alterations of myocardial intercellular and cell-matrix contacts in hypertrophic tissue, and show intracellular translocation of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 in both an animal model and in LVH patients.
- Data suggest that integrin alpha3beta1 is a critical coordinator of epithelial-mesenchyme transition signaling pathways involving beta-catenin and pSmad2.
- Ret/ptc1 cross talks with Met at transcriptional and signaling levels and promotes beta-catenin transcriptional activity to drive thyrocyte neoplastic transformation.
- BCL-W may function as a downstream effector of inappropriate WNT/beta-catenin signalling.
- Enforced expression of stabilized beta-catenin transgene by pre-T cell receptor (TCR) signals downstream of the pre-TCR is sufficient to mediate TCR beta-selection including sustained expression of early growth response (Egr) genes in developing T-cells.
- The main role for transgenic beta-catenin during T cell maturation is at the initial stages, and not the terminal stages, of T cell receptor beta-chain selection, when CD4+CD8+ double-positive cells are normally being generated.
- Mutations in CTNNB1 gene is associated with Wilms tumor.
- There was increased expression of E-cadherin and beta-catenin in the eutopic and ectopic endometrium in adenomyosis.
- These findings suggest that WNT3A can mediate transcriptional changes in melanoma cells in a manner reminiscent of the known role of Wnt/beta-catenin signaling in normal melanocyte development.