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Validated All-in-One™ qPCR Primer for ETS1(NM_001143820.1) Search again
Product ID:
HQP054427
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ETS-1, EWSR2, c-ets-1, p54
Gene Description:
ETS proto-oncogene 1, transcription factor
Target Gene Accession:
NM_001143820.1(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
ETS transcriptions factors, such as ETS1, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM].
Gene References into function
- Hepatocyte growth factor induces collagenase (matrix metalloproteinase-1) via the transcription factor Ets-1 in human hepatic stellate cell line.
- c-Ets1 expression in epithelial ovarian cancer correlates to the malignant potential of the tumor.
- Sp100 interacts with ETS-1 and stimulates its transcriptional activity.
- Ets-1 and Sp1 have a role in regulating FasL expression in human vascular smooth muscle cells
- Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium
- cooperatively binds to the palindromic head to head ETS-binding sites of the stromelysin-1 promoter by counteracting autoinhibition
- Coexpression of P-glycoprotein, Ets-1, and p53 in oral carcinoma is associated with poor prognosis
- results showed a significant correlation between microvessel counts and ets-1 gene expression levels in uterine cervical cancers;localization of ETS-1 was similar to that of vascular endothelial cells
- results showed a significant correlation between microvessel count and ets-1 gene expression levels in uterine endometrial cancers; localization of ETS-1 was similar to that of vascular endothelial cells
- HIF-2alpha and Ets-1 binding is required for transcriptional activation of Flk-1 in endothelial cells
- Its expression is an independent prognostic marker for relapse-free survival in breast cancer
- ETS1 phosphorylation by CAMKII is regulated in a pathway with calcium and GM-CSF
- ETS1 may be regulated by PKCalpha in invasive breast cancer cells
- a splicing variant of Ets1 is downregulated in invasive Ets1-expressing breast cancer cells
- interacts with EAPII and modulates its transcriptional function
- AP-2alpha gene expression in the placenta is enhanced by a cis-acting element at nucleotides -1279 to -1139 that contains a critical Ets1-binding site.
- findings suggest a potential mechanism by which PTHrP transcription may be regulated by Ets-1 as a consequence of events that promote tumorigenic behavior in breast epithelial cells
- Ets-1 expression may be an important pathogenic mechanism and predictor of aggressive biologic behavior of cutaneous melanoma
- ets-1 together with microvessel density determined by CD105 may have prognostic value in the multistep event of carcinogenesis.
- Upregulation of Ets 1 transcription factor ia assiciated with neoplasm invasiveness in Hereditary nonpolyposis colorectal cancers
- overexpression of ETS-1 is associated with angiogenesis and ovarian cancer progression
- binding of ETS transcription factors to the ETS binding sites in the human LIF promoter is critical for its inducibility in response to T cell activators and play an important functional role within the endocrine-immune network.
- p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1.
- Ets-1 is involved in transcriptional regulation of factors involved in invasion of melanoma cells.
- Ets-1 expression is increased in asthma and contributes to enhanced expression of TNF-alpha-induced matrix metalloproteinase-9 and tenascin in bronchial fibroblasts activated ex vivo.
- a novel, functional binding element in the proximal region of the TN-C promoter mediating responsiveness to TGF-beta involving Smad3/4, Sp1, Ets1, and CBP/p300
- Data suggest that glycogen synthase kinase-3beta-phosphorylated Ets1 is a target of Runx1-recruited calcineurin phosphatase at the granulocyte macrophage colony-stimulating factor promoter.
- Ets-1 regulated angiogenesis through the induction of angiogenic growth factors (VEGF and HGF).
- SP100 modulates ETS1-dependent biological processes
- ETS-1 in ovarian endometriomas is significantly positively correlated with microvessel counts.
- Protein kinase C is a potential regulator of Ets1 activity in breast cancer cells.
- proximal 5'-flanking region of the IKKalpha gene contains a functional promoter reciprocally regulated by p53 and ETS-1
- Ets1 serves as an effector for protein kinase C alpha to fulfil certain functions in cancer ce
- Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells
- Ras/mitogen-activated protein kinase signaling activates ETS-1 by CBPp300 recruitment.
- Ets-1 has a role in breast tumor growth and spread [review]
- Associated with tumour growth and histological differentiation of breast carcinomas.
- Genes that are negatively regulated by ETS1 and upregulated by SP100 have antimigratory or antiangiogenic properties.
- Results suggest that Ets-1 might play an important role in carcinogenesis and/or the progression of human prostatic carcinomas.
- Ets1 is activated in human adrenocortical cells expressing a mutated K-ras gene.
- Modification of local protooncogene Ets-1 level is likely being involved in the regulation of melanoma growth
- Ets-1 expression increases the transformed phenotype of HeLa cells, by promoting cell migration, invasion and anchorage-independent growth, while Ets-1 downregulation reduces cell attachment.
- STAT1 and Nmi are downstream targets of Ets-1 in MCF-7 human breast cancer cells
- Peroxide-inducible ETS1 mediates platelet-derived growth factor receptor-alpha gene transcription in vascular smooth muscle cells.
- ets-1 is transcriptionally up-regulated by H2O2 via an antioxidant response element in tumor cell lines
- c-Myb and c-Ets family members (Ets-1/2, PU.1, and Spi-B) control hGR 1A promoter regulation in T- and B-lymphoblast cells
- overexpression of SphK1 up-regulated MMP1 protein, MMP1 mRNA, and MMP1 promoter activity, and this action of SphK1 required activation of the ERK1/2-Ets1 and NF-kappaB pathways
- Overexpression of Ets-1 in human hematopoietic progenitor cells blocks erythroid and promotes megakaryocytic differentiation.
- matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs
- Ets-1 plays an important role in the growth and differentiation of gastrointestinal stromal tumors, leiomyomas and schwannomas.
- Taken together, these results suggest that AP-2epsilon and Ets-1 are involved in the regulation of integrin alpha10 transcription in chondrocytes.
- Up-regulation of Ets-1 expression was observed in atypical and anaplastic meningiomas.
- Results found that basal Ets-1 levels are necessary not only for a fast induction of MMPs but also for maintenance of the bFGF-induced expression of TIMPs.
- Fli1 and Ets1 have roles in the pathological extracellular matrix regulation during fibrosis and cancer
- CD226 promoters P1 and P2 are regulated by Ets-1 and AP-1
- Results demonstrated higher expression of Ets-1 protein in meningiomas with subsequent recurrences compared with meningiomas from patients who had no recurrences.
- delineation of the details of the molecular recognition of Ets-1 by ERK2, the binding of various mutants and truncations of Ets-1 were analyzed by fluorescence anisotropy
- the interaction between ETS1 and GFI1 facilitates their binding to specific sites on the Bax promoter and represses Bax expression
- KSHV activated the Ang-2 promoter via AP-1 and Ets1 transcriptional factors, which were mediated by ERK, JNK, and p38 mitogen-activated protein kinase (MAPK) pathways.
- Coexpression of Etsl and CBP induced a synergistic activation of the parathyroid hormone-related protein P3 promoter only in the tumorigenic cell line.
- The results suggest that multiple cellular signaling pathways can reactivate the virus in a genetically homogeneous cell population. Further analysis revealed that the Raf/MEK/ERK/Ets-1 pathway mediates Ras-induced reactivation.
- PIASy controls Ets-1 function, at least in part, by inhibiting Ets-1 protein turnover via the ubiquitin-proteasome system.
- Ets-1 enhances expression of the beta-1,4-GalT V gene through activation of the Sp1 gene in cancer cells
- ETS transcription regulatory networks have a role in breast cancer progression [review]
- Identification of distinct classes of ETS gene rearrangements demonstrates that dormant oncogenes can be activated in prostate cancer by juxtaposition to tissue-specific or ubiquitously active genomic loci.
- Binding sequences for the avian erythroblastosis virus E26 homologue (ETS) transcription factor family were also highly enriched, and an interaction between the AR and ETS1 at a subset of AR promoter targets, was uncovered.
- Transactivation by Ets1 increased luciferase expression 15-fold, in the absence of stimulation. Synergistic interactions were demonstrated between Ets1, GATA-3 and AP-1.
- Expression of Ets-1 must be down-regulated before plasmacytic differentiation can occur.
- MDMX basal promoter activity requires c-Ets-1 and Elk-1. c-Ets-1 and Elk-1 control MDMX transcription and contribute to the suppression of p53 activity.
- A proximal Ets-1 site and an upstream potential vitamin D response element are critical for the inducible expression of chemokine (C-C motif) receptor 10 (CCR10) by 1,25-dihydroxyvitamin D3 in terminally differentiating B cells.
- The downregulation of ETS1 expression with small interfering RNA (siRNA) is involved in regulating hypoxia-inducible genes.
- Suggest functional role for SPINK1 in ETS rearrangement-negative prostate cancers.
- Study presents the structure of Ets-1 on the stromelysin-1 promoter element, revealing a ternary complex in which protein homo-dimerization is mediated by the specific arrangement of the two ETS-binding sites.
- an angiogenic signal-ETS1/HIF-2alpha axis regulates the VEGFR1 chromatin domain to induce VEGFR1 transcription in endothelial cells and in differentiating embryonic stem cells
- MUC5AC gene expression are mediated by a complex regulatory cascade controlling interactions between CREB and c-Ets1 that bind to a promoter element in the MUC5AC gene enhancing MUC5AC gene transcription.
- Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.
- This study confirms that Ets-1 is a downstream effector of oncogenic HER2, associated with MMP-1.
- Ets-1 binds to the human epiregulin promoter and regulates epiregulin expression.
- Binding elements for ETS and transcription factor AP-2 (TFAP2) were significantly enriched in Smad2/3 binding sites, and knockdown of either ETS1 or TFAP2A resulted in overall alteration of TGF-beta-induced transcription.
- Ets-1 binds cooperatively to the EBS palindrome of the hp53 promoter.
- Ets-1 can induce aberrant Pim-3 expression and subsequently prevent apoptosis in human pancreatic cancer cells.