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Validated All-in-One™ qPCR Primer for MMP9(BC006093.1) Search again
Product ID:
HQP054301
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CLG4B, GELB, MANDP2, MMP-9
Gene Description:
matrix metallopeptidase 9
Target Gene Accession:
BC006093.1(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq].
Gene References into function
- involvement of MMPs in microinvasive carcinomas
- 125-kDa urinary gelatinase as being a complex of MMP-9 and NGAL and provides evidence that NGAL modulates MMP-9 activity by protecting it from degradation.
- secretion in primary human monocytes induced by chemokines
- Significant association with poor survival by MMP-9.
- results indicate that two kinds of pro-form and active-form matrix metalloproteinases, MMP-2 and MMP-9, and their degradation products, are present in human seminal plasma
- Multiple signaling pathways involved in activation of matrix metalloproteinase-9 in breast cancer cells
- The CC chemokines CCL2 (MCP-1), CCL3 (MIP-1alpha), and CCL5 (RANTES) stimulated the release of monocyte MMP-9 protein in a bell-shaped dose-dependent manner.
- Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression.
- overexpression of MMP-9 in HTLV-I- infected cells may be in part responsible for the invasiveness of adult T-cell leukemia cells.
- in differentiating trophoblasts Nitric Oxide regulates the induction of MMP-2 and MMP-9 required for invasion during embryo
- shed as membrane vesicle associated components by endothelial cells and this may be a mechanism for regulating focalized proteolytic activity vital to invasive and morphogenic events during angiogenesis
- gelatinolytic activity in situ, in tissue sections of term placenta, is co-localized with gelatinase B
- in pancreatic cancer, invasion into large veins and destroyed type veins could be a risk factor for liver metastasis and that increased expression MMP-2 and MMP-9 were related to such invasion.
- MMP-9 activity is significantly elevated in SLE patients and correlated with disease activity in males but not females. These results suggest that MMP-9 plays a role in the pathogenesis of SLE.
- Respiratory syncytial virus infection of HEp-2 cells induces matrix metalloproteinase-9 expression
- C/C homozygosity at the C-1562T polymorphism of the promoter may be protective against coronary artery disease in Koreans.
- increasing expression and endometrial carcinoma appear closely related
- significantly increased activity seen in plasma of head and neck squamous cell carcinoma patients
- activity significantly higher in lung cancer cells than uninvolved lung parenchyma; may be involved in tumor progression
- The expression of MMP-9 was significantly increased in mesangial proliferative glomeruli and interstitial vascular walls of IgA nephropathy patients.
- expression of MMP-9 in cervical cancer
- The plasma MMP-9 levels in patients with HCC were significantly higher than those in the normal controls
- Results suggest that gastrin increases MMP-9 expression, which is associated with increased invasion, and this is a putative mechanism regulating remodelling of the gastric epithelium.
- Production of matrix metalloproteinase-9 in early stage B-CLL is suppressed by interferons alpha and gamma.
- We have determined the functional significance of a variable number tandem repeat and a single nucleotide polymorphism (SNP) in the MMP-9 gene on promoter activity and their association with preterm premature rupture of membranes (PPROM).
- REVIEW: Role of gelatinase B in leukocytosis and stem cell mobilization.
- novel regulation for the proteolytic activation of MMP-9 in human tissue (tissue-associated chymotrypsin-like proteinase, pM9A).
- Overexpression of MMP-2 and MMP-9 in squamous cell carcinomas of immunosuppressed patients.
- destruction of the surrounding matrix by endometriosis might be caused by various MMPs, which are mainly produced in stromal cells.
- ox-LDL and HDL lipoproteins regulate the production by activated monocytes
- Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor
- FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway.
- signalling pathways involved in MMP-9 regulation at the maternal-fetal interface
- roughly constitutive TIMP-1 expression opposed to an inducible MMP-9 synthesis in Epstein--Barr virus-immortalized B lymphocytes
- The X-ray crystal structure of the proform of human matrix metalloproteinase MMP9 has been solved to 2.5 A resolution
- evaluation of the effect of increased levels of active MMP-9 in the central nervous system
- Expression of MMP9 is elevated during PBSC mobilization by G-CSF.
- Interferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B
- structural basis of the adaptive molecular recognition by MMP9
- No allelic associations have been found between multiple sclerosis and the CA microsatellite marker in the promoter region of the gelatinase B gene in Belgian study populations.
- plasma levels are increased during G-CSF induced hematopoietic stem cell mobilization
- data indicate the involvement of matrix metalloproteinase 2 and matrix metalloproteinase 9 in the cervical ripening
- role of MMP9 in aortic aneurysms
- Fibroblasts promote breast cancer cell invasion by upregulating tumor matrix metalloproteinase-9 production.
- Primary GBMs were significantly more likely than secondary GBMs to contain active MMP-9. Active MMP-9 expression occurred in 83% of the EGFRvIII-immunopositive tumors only.
- Hyaluronan-CD44 interaction inhibits migration of osteoclast-like cells by down-regulating MMP-9.
- MMP9 activation is increased by Eph B4 receptor stimulation in human cells
- mmp-9 production in bronchial epithelial cells is inhibited by S-nitrothiols
- Bombesin-dependent pro-MMP-9 activation in prostatic cancer cells requires beta1 integrin engagement
- MMP-9 level and TIMP-1 levels increased after birth but are not linked to bronchopulmonary dysplasia outcome; low MMP-2 level at birth is associated with the development of BPD
- Block of mmp9 induction via vegfr-1 inhibition could be useful for the prevention of tumor metastasis in lung.
- PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation.
- MMP-9 expression showed a tendency toward an adverse outcome of Hodgkin's lymphoma
- MMP9 expression is regulated by MTA1 via histone-dependent and independent mechanisms in human cells
- ILK activity is aassociated with upregulation of MMP-9 mRNA levels during podocyte stress
- thrombospondin-1 plays a role in the up-regulation of MMP-9 expression in gastric cancer
- data indicate that matrix metalloproteinase-9 is produced by the amnion but not the chorion in response to lipopolysaccharide; tumor necrosis factor-alpha and interleukin-1 beta appear to upregulate its production by the amnion
- The expression of MMP-9 was positively related to the tumor invasiveness and metastasis in gastric cancers
- HBV infection of hepatocytes and HepG2 cells affected the upregulation of MMP-9 expression and MMP-9 activation and, increased the invasion potential by plasmin, this is a report showing that an HBV infection is linked to the upregulation of MMP-9 in HCC
- MMP-9 plays an important role in inflammatory peripheral neuropathy probably as means for inflammatory cell invasion
- The over-expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 may play a key role in invasion and lymph-node metastasis of in squamous carcinoma of the cervix.
- Increase of CD44s, MMP-9, and Ki-67 were involved in the growth and local invasion of osteosarcoma.
- data demonstrated a moderate elevation of matrix metalloproteinases-2 and significant upregulation of matrix metalloproteinases-9 in stable cell lines overexpressing gamma-synuclein
- Details of cleavage of pro-MMP-9 by MMP-26, facilitating the efficient cleavage of fibronectin by MMP-9, and promoting invasiveness of ARCaP cells across fibronectin or type IV collagen
- matrix metalloproteinase-2 and 9 and membrane-type 1 matrix metalloproteinase mRNA expression in endometriosis was higher than in normal endometrium whereas E-cadherin, alpha- and beta-catenin mRNA expression was not suppressed in endometriosis
- MMP-9 may contribute to eosinophil and mast cell migrations into nasal polyp tissue.
- Arfaptin 1 inhibits ADP-ribosylation factor-dependent secretion of this enzyme induced by phorbol ester in fibrosarcoma cells.
- significant increase of MMP-9 and TIMP-1 in the urine of children with acute pyelonephritis.
- In the recurrent implantation failure group, the MMP score and IL-1beta concentration were significantly higher than those in the control group, whereas concentrations of IFN-gamma and IL-10 were significantly lower.
- elevated pro-MMP-9 enzyme during the acute phase of Kawasaki disease may reflect vascular remodeling or an inflammatory response to a microbial agent, suggesting a pathophysiological role for MMP-9 in coronary aneurysm formation.
- triple-helical peptides are highly selective substrates for and are hydrolyzed by human MMP2 and MMP9
- not expressed by intestinal myofibroblasts in inflammatory bowel disease.
- Membrane-bound MMP-9 on PMN may play pathogenetic roles in inflammatory lung diseases
- MMP-9 induction by H. pylori may play an important role in gastric inflammation, ulcer formation, and carcinogenesis.
- The purpose of this study was to evaluate the roles of matrix metalloproteinases (MMPs) and urokinase-type plasminogen activator (uPA) with regard to varicose veins (VVs).
- Chorioamnionitis is associated with increased lung type IV collagenase levels in the ventilated preterm infant. Antenatal lung inflammation with up-regulation of MMP-9 may be important in the pathogenesis of chronic lung disease.
- MMP9 is activated through an oxidative pathway in pneumococcal meningitis
- The interaction between MMP-9 and TIMP-1 in the processes of gastric tumor invasion and metastasis is that MMP-9 mainly promotes tumor invasion and metastasis and TIMP-1 inhibits functions of MMP-9.
- matrix metalloproteinase-9 activation and association with integrin are inhibited by ganglioside GM3
- Data demonstrate that blockade of the ERK pathway suppressed the expression of matrix metalloproteinases 3, 9, and 14, and CD44, and markedly inhibited the invasiveness of tumor cells.
- Polymorphisms of the matrix metalloproteinase-9 gene influences the development of coronary artery disease.
- Requirement for PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells.
- MMP-9 plasma level was significantly higher in patients undergoing thrombolytic therapy whose arteries were not recanalized; MMP-9 may be associated with the formation of a thrombolytics-resistant thrombus
- MMP-9 and LM-R are useful indexes for predicting the metastasis and prognosis of breast cancer.
- MMP9 is activated by SDF1 in bone marrow cells, causing release of soluble Kit-ligand and transfer of hematopoietic stem cells from a quiescent to a proliferative niche
- Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair.
- PBMCs from SLE patients expressed a significantly higher activity of MMP-9 and spontaneously released higher levels of MMP-9, as compared to healthy donors
- NF kappa B plays a in the regulation of MMP-9 expression and the ability of dykellic acid to suppress phorbol myristate acetate induction of MMP-9, with decreased MMP-9 promoter activity and mRNA expression.
- results strongly support that sTNF up-regulates in an autocrine manner PAI-1 and MMP-9 syntheses during promyelocyte to monocyte differentiation; in more advanced differentiated stages, released sTNF is not a major determinant of PAI-1 and MMP-9 synthese
- a negatively charged peptide motif within the catalytic domain of MMP9 mediates binding to leukocyte beta 2 integrins
- 2.2 kb of the promoter region and all 13 exons (3.3 kb) of MMP9 genomic DNA were scanned for polymorphisms. There is a possible role for the (CA)n repeat in renal disease.
- proMMP-9 has a novel role in providing a cellular switch between stationary and migratory cell phases
- vascular endothelial growth factor and matrix metalloproteinase-9 expression in osteolytic lesions of bone co-relates well with the extent of bone destruction and local recurrence
- MMP-9 released from neutrophils may be involved in the pathogenesis of bronchial asthma and COPD.
- HGF, SDF-1, and MMP-9 have roles in stress-induced human CD34+ stem cell recruitment to the liver
- high levels of plasma MMP-9 activity is associated with evidence of recurrence in breast cancer
- integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells
- Ultraviolet A downregulates MMP-9 in keratinocytes.
- MMP-9 may not only play a role in the pathogenesis of COPD, but also relate to FEV(1.0)% of prediction and RV/TLC%.
- GDNF upregulates expression and enzymatic activity of MMP-9 through different signaling pathways. GDNF modulates MMP-9 expression and activation, and this may promote pancreatic cancer invasion.
- Upregulation of mmp-9 ia assiciated with neoplasm invasiveness in Hereditary nonpolyposis colorectal cancers
- The present results indicate that MMP-2 can be helpful in diagnosing Takayasu arteritis [TA] and that MMP-3 and MMP-9 can be used as activity markers for TA
- oxidative stress-dependent MMP-9 induction in brain capillary endothelial cells was accompanied by a significant increase in the NF-kappaB localized in the nuclei
- monocyte matrix metalloproteinase-1 and -9 are differentially regulated by interferon gamma through tumor necrosis factor-alpha and caspase 8
- Data show that tissue plasminogen activator upregulates matrix metalloproteinase-9 in cell culture and in vivo, and that this is mediated by the low-density lipoprotein receptor-related protein.
- Both active gelatinases were detected in tears of severe corneal ulcer or severe ocular burn cases. The active form of gelatinase expression may be related to the severity of ulceration.
- palpable tumours demonstrated significantly more MMP-2 and significantly less MMP-9 expression than nonpalpable tumours
- MMP9 plays a role in the release of biologically active VEGF and consequently in the formation of ascites in ovarian cancer.
- Increased plasma MMP-9 is associated with colorectal cancer
- gelatinase B and neutrophil collagenase cleave MIG and IP-10
- specific up-regulation of MMP-9 in the erythema migrans skin lesions of patients with acute Lyme disease; may play a role in the dissemination of B. burgdorferi.
- an overview of mmp-9 gene expression in different cell types, from the triggering of cell-surface receptors, to the activation of cytoplasmic mediators and transcription factors responsible for the activation of MMP-9 promoter--REVIEW
- Induction of MMP-9 secretion is related to the inflammation including apoptosis of keratinocytes resulting from UVB irradiation.
- Although MMP-9 level predicts parenchymal brain hemorrhages after tPA treatment, no relationship exists with the C-1562T polymorphism, probably because this mutation is not functional in response to cerebral ischemia in vivo
- MMP-9 within tuberculous granuloma is associated with tissue destruction; monocytic cells packed together at the center of tuberculous granuloma exhibit strong cytoplasmic staining for MMP-9, but not TIMP-1.
- first report to show that cultured HUVE constitutively express MMP9 and that this secretion is restricted to very early-passage cells
- Plasma MMP-9 concentrations decrease aafter insulin infusion.
- RhoA induced the expression of MMP-9; clustering of MMP-9 was observed in advancing lamellipodia at the forefront of endothelial cells, where this proteinase colocalized with RhoA and CD44
- MMP-9 inhibition activity of resveratrol and its inhibition of JNK and PKC-delta may have a therapeutic potential in cancer.
- effect of titanium, zirconia and alumina ceramics on activity and secretion in human osteoblasts
- in wounded keratinocytes, upregulation of matrix metalloproteinase-9 depends on two distinct pathways: Rac1 and/or Cdc42 that control the activation of p38[MAPK] and RhoA activation that is required for stimulation of JNK.
- Data show that matrix metalloproteinase-9 expression in human lung parenchyma is associated with cigarette smoking and with obstruction of airflow, suggesting that MMP-9 may play a role in the pathogenesis of COPD.
- The analysis of MMP-9 in synovial fluid samples can reveal the inflammatory condition of the knee joints with gouty arthritis
- Serum MMP-9 does not relate to the late phase of hepatic ischmeic reperfusion injury after human orthotopic liver transplantation.
- stimulated expression of MMP-1 and MMP-9 may contribute to the invasive activity and the bone and cartilage loss in pigmented villonodular synovitis
- The presence of MMP-9 was found in endometrial cancer, correlating with estrogen receptor alpha and uteroglobin levels.
- MMP-26 was colocalized with MMP-9, TIMP-2, and TIMP-4 in breast cancer cells.
- MMP-9 release from eosinophils is regulated by signaling through p38 MAP kinase
- The -1562C-->T polymorphism of matrix metalloproteinase-9 was associated with bone mineral density in Japanese men
- MMP and TIMP may be involved in the feto-neonatal development and may contribute to the pathogenesis of bronchopulmonary dysplasia and/or intraventricular hemorrhage in critically ill preterm neonates
- Various growth factors induce migration of human non-small cell lung cancer cells in the presence of extracellular matrix (ECM) components MMP-2 and MMP-9.
- polymorphism in the promoter region may not have a relationship with implant loss
- MMP-9 seems to be involved in ischemia/reperfusion injury during human liver transplantation
- downregulated by Cytomegalovirus IL-10 activity in uterine microvascular endothelial cells and differentiating-invading cytotrophoblasts
- the coordinated modulation of MMP-9 transcription via the TRE and the KRE-M9 elements is important in epidermal and mesenchymal tissues.
- MMP-2 and MMP-9 expressions are prognostic factors predicting the recurrence of meningioma, independent of proliferative potential.
- Elevated serum MMP-9 in systemic lupus erythematosus may reflect neuropsychiatric involvement, particularly cognitive dysfunction. Serum MMP-9 concentration may be associated with small-vessel cerebral vasculopathy and risk of cerebral ischemia.
- MMP3, MMP9, and TGFbeta1 are important for the modulation, composition, and maintenance of the ECM in oral squamous cell carcinoma
- MMP-9 may have a role in the higher migrational capacity of CB CD34(+) cells, which may be beneficial to homing of these cells to the BM environment.
- Nitric oxide concentrations could impact on capillary formation via a combination of direct effects on MMP activation and by altering the distribution or abundance of Cav-1 in tumor angiogenesis.
- MMP-2 or MMP-9 mediated tumor cell invasion requires integrin cytoplasmic-tail motif EKQKVDLSTDC
- cleave IGFBP-1 at (145)Lys/Lys(146), resulting in a small (9-kDa) C-terminal peptide of IGFBP-1 in first trimester decidua
- membrane location can influence MMP9 activity in vitro and in vivo, and confirmation of the relevance of stromal-associated, but not tumor-bound MMP9 in mediating tumor-induced angiogenesis
- sICAM-1 was processed distal to Arg441, indicating that MMP-9, docking to ICAM-1, contributes to sICAM-1 shedding and attenuation of the shear stress-induced upregulation of ICAM-1.
- Endometriosis-associated increase in proteolysis and imbalance between of MMP-9 and of TIMP-1 in culture medium of endometrial tissue may reflect in vivo enhanced capacity of this tissue to break down the extracellular matrix in host tissues.
- MMP-9 was increased regionally in the infarct-related coronary artery, at 11.8 ng/ml vs 8.2 ng/ml in the ascending aorta (p<0.001).
- RNAi inhibits MMP9 gene expression in a glioblastoma cell line.
- Results define molecular details for several interactions mediated by the different MMP-9 domains, using specific MMP-9 peptide inhibitors.
- Data suggest that MMP-9 has a role in tumor progression of head and neck carcinomas, as well as in estimation of the prognosis of these diseases.
- HBx contributed to MMP-9 transcriptional regulation through the ERKs & PI-3K-AKT/PKB pathway. Enhanced expression of MMP-9 by activation of these signals is eventually associated with the invasive potential of cells.
- Helicobacter pylori infection results in substantially increased in the gastric mucosa, probably contributed to in large part by tissue-resident macrophages
- coordination of cell signaling, chromatin remodeling, histone modifications, and stepwise recruitment of transcription regulators is critical to precisely regulate MMP-9 gene transcription in a temporally and spatially dependent manner
- The MMP-9 C-1562T promoter polymorphism genotype is associated with large artery stiffening and aortic MMP-9 gene & protein expression, increasing susceptibility to myocardial ischemia.
- Active involvement of MMP-2 and -9 in end-stage liver disease and orthotopic liver transplantation.
- results present proMMP-9 as a novel early indicator of acute host-response in pleural space that complements traditional proinflammatory markers and might be useful in monitoring pleural inflammatory processes
- Pro-MMP-9 is a specific macrophage product and is activated by osteoarthritic chondrocytes via MMP-3 or a MT1-MMP/MMP-13 cascade.
- RAGE and MMP-9 are expressed concordant with metastatic ability of human pancreatic cancer cells.
- results suggest that matrix metalloproteinase-9 and matrix metalloproteinase-2 contribute to caspase-mediated brain endothelial cell death after hypoxia-reoxygenation by disrupting cell-matrix interactions and homeostatic integrin signaling
- MMP-9 expression is inhibited by CIITA by binding to and sequestering CREB-binding protein
- marked difference in MMPs and their inhibitors in the in vitro fertilized women and normally ovulating women
- EGFR, c-erbB-2, VEGF and MMP-2 and MMP-9 play an important role in tumor growth, invasion and metastasis in squamous cell carcinoma of the head and neck
- An intense expression of VEGF and MMP-9 in carotid plaques is related to plaque instability, high degree of stenosis and presence of symptomatic carotid occlusive disease.
- a mechanism for ROS function in Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell MMP2 and MMP9 during VCAM-1-dependent lymphocyte migration
- Streptococcus pyogenes SpeB activates proMMP-9 with subsequent release of proapoptotic TNF-alpha and sFasL leading to apoptosis, tissue damage and streptococcal invasion in the host.
- Plasma levels are increased in type 2 diabetic patients.
- collagen type II immunodominant epitopes remain intact after cleavage by gelatinase B and may become available, processed as antigens and presented in MHC-II molecules
- HBV affects the malignance of hepatocellular cancer by elevating MMP-9 activity.
- Different regulatory mechanisms of MMP-9 production and/or activity between primary progressive/transitional progressive and relapsing-remitting multiple sclerosis.
- RECK/MMP-9-balance is an informative prognostic indicator for colorectal cancer.
- Overexpression of matrix metalloproteinase 9 is associated with prostate cancer
- Circulating pretreatment MMP-9 and TIMP-1 levels were significantly higher in patients with hypertension
- Both MMP-9 and TIMP-1 levels were higher in the hypertensive group
- In patients with recurrent ovarian cancer the activated forms of MMP-9 were significantly higher compared to ovarian cancers without recurrence.
- Fusobacterium nucleatum subsp. nucleatum increases its tissue-invasive potential by acquiring cell-associated human matrix metalloproteinase 9 (MMP-9) activity
- Increased gelatinase in culture medium of toxic epidermal necrolysis or Stevens-Johnson syndrome skin maintained in organ culture and in blister fluid indicates that these gelatinases may be responsible for detachment of epidermis in these diseases.
- length alteration of the d(CA) repeat in the MMP-9 promoter may cause phenotypic differences among HTLV-I infected infiltrating cells and may thereby be in part responsible for the development of HTLV-1 associated myelopathy (HAM/TSP).
- CDK9 mediates TNF-alpha-induced MMP-9 transcription
- Acrolein, a constitutent of cigarette smoke, increases expression of MMP9 in airway epithelial cells
- Arsenic trioxide directly downregulates radiation-induced MMP-9 mRNA expression by inhibiting nuclear factor kappaB activity in human cervical cancer cells.
- Endometrial MMP-9 activity is overall controlled by the ovarian steroids and locally adjusted through a network of modulators, including LEFTY-A.
- The Matrix Metalloproteinase-9 was expressed of cultured human uveal melanocytes, and analysis revealed the Matrix Metalloproteinase-9 mRNA.
- may be involved in the process of arterial stiffening and development of isolated systolic hypertension
- The expression of MMP-9, TIMP-1 and TIMP-2 was lower in the benign and low malignancy ovarian tumors compared with the malignant ones.
- Our results indicate that the T allele in the MMP-9 promoter is associated with the invasive phenotype of gastric cancer.
- Expression of MMP-2 and MMP-9 in breast cancer seems to be partly related to expression of AP-2 and HER2
- MMP9 is expressed in the unstable coronary atherosclerotic plaque, as are its transcriptional and posttranscriptional regulators
- MIF and MMP-9 are markedly upregulated in vulnerable atheromatous plaques. The ability of MIF to induce MMP-9 expression in VSMCs and macrophages suggests that MIF may play a role in the destabilization of human atherosclerotic plaques.
- In melanoma cells microtubule-dependent traffic of MMP2/mmp9-containing vesicles and exocytosis are critical steps for invasive behavior.
- breast cancer phenotype and outcome can be influenced by common functional polymorphisms in MMP genes.
- secreted pro-MMP-2 and pro-MMP-9 are downregulated by farnesyltransferase inhibitors in carcinoma cells
- Expression in colorectal carcinomas relating to size and invasiveness of the tumor.
- Enhanced production of MMP-9 may contribute to fibrogenic remodeling during the progression of skin sclerosis in systemic sclerosis.
- Increase of pro-MMP-9 circulating in the blood of amyotrophic lateral sclerosis (ALS) patients may link to a primary pathogenetic mechanism, while elevated pro-MMP-9 levels may also rise as a consequence of secondary nerve and muscle damage in ALS.
- MMP-9 was only expressed when lung fibroblasts were grown on collagen type IV and increased with serum concentration, and by hypoxia
- Over expression of MMP-9 is associated with nonsmall cell lung carcinoma progression
- Overexpressing functional TIMP-1- enhanced migration of HepG2-TIMP-1 cells depends on enhanced MMP-activity, especially MMP-9.
- vascular MMP-9 expression may play a role in the pathogenesis of spontaneous intracerebral hemorrhage--REVIEW
- Treatment of THP-1 cells with recombinant TL1A in combination with IFN-gamma also caused induction of MMP-9 and interleukin-8
- altered MMP/TIMP ratios in maternal blood during gestational hypertension
- This is the first demonstration that Akt is involved in the signaling pathway leading to the production of monocyte MMP-9
- serum amyloid A plays a role in the modulation of inflammatory and immune responses via formyl peptide receptor like 1, by inducing MMP-9 upregulation
- Hypoxia induces an increased invasive capacity via gelatinase up-regulation without loss of cell viability in adenocarcinomas
- the particular combination of MMP3 and MMP9 genotypes present at susceptibility loci may contribute to heterogeneity in the presentation of atherosclerosis.
- uPAR and MMP-9 have roles in inhibiting cell proliferation and can reduce the levels of phosphorylated forms of MAPK, ERK, and AKT signaling pathway
- MMP-9 is increased in tuberculous pleural effusions compared with transudates and malignant pleural effusions of lung cancer and is produced predominantly by epithelioid cells in the granulomas of tuberculous pleural tissues.
- indicate that there is a positive correlation between n-3 docosapentaenoic acid and MMP-9
- IL-8-induced MMP-9 release from neutrophils is mediated through CXCR2 and involves two distinct pathways, one involving PKC and ERK1/2 and the other involving Src-family kinases
- NF-kappaB-dependent MMP-9 plays a key role in Platelet-activating factor-induced angiogenesis
- MMP-9 levels in tumor fibroblasts are regulated by a complex tumor-stroma cross-talk.
- MMP-9 activity is inhibited by ascochlorin through suppression of AP-1-dependent induction of MMP-9 gene expression
- expression up-regulated in Helicobacter species-infected colon and bile duct epithelial cells and hepatocytes.
- Migration of CD4+ T cells is dependent on MMP9 expression; T-helper type 2 (Th2) cells secrete lower levels of MMP9 and have less migratory capacity in comparison to Th1 cells.
- Significantly elevated metalloproteinase 9 in broncho-alveolar lavage fluid is associated with Bronchiolitis obliterans
- MMP-9/tissue inhibitor of metalloproteinase 1 system and beta-chemokines could cooperate in conditions of elevated oxidative stress, which ultimately predisposes hemodialysis patients to accelerated atherosclerosis
- expression of CD147 is upregulated during the differentiation of monocyte THP-1 cells to macrophage cells, and CD147 induces the secretion and activation of MMP-2 and MMP-9 and enhances the invasive ability of THP-1 cells
- HIF-1alpha and CA IX, but not VEGF or MMP-9, may have a role in progression of surgically resected non-small cell lung cancer
- MMP-9 and MMP-13 are involved in stroke progression and the neuroinflammatory response
- Findings suggest that the genetic polymorphism in MMP-9 promoter (C-1562-T) is associated with the susceptibility to acute coronary syndrome in the Han population of China.
- MMP-9 gene polymorphisms account for some of the variability in the progression of HCV-related chronic liver diseases.
- relaxin-induced MMP-9 expression in THP-1 cells involves NF-kappaB activation
- MMP-9 but not MMP-2 was associated with internal elastic lamina degeneration, intimal hyperplasia, and luminal narrowing in giant cell arteritis
- MMP9 levels are not significantly associated with age, duration of diabetes, blood pressure, or serum lipid concentrations.
- hemoglobin stimulates the secretion of uPA, MMP-2 and MMP-9 by synovial tissues; possible role of hemoglobin in joint damage after intra-articular bleeding
- MMP-9 might not be a major gene for branchial asthma
- MMP-9/TMIP-1 ratio may be viewed as a reliable marker and may be predictive of MRI activity in relapsing recurring multiple sclerosis in Avonex treatment.
- These data suggest that elevated leukocyte matrix metalloproteinase-9 may contribute to the pathogenesis of type I diabetes and its associated complications.
- NGAL may play an important role in breast cancer in vivo by protecting MMP-9 from degradation, thereby enhancing its enzymatic activity and facilitating angiogenesis and tumor growth
- the potentially functional polymorphisms MMP-9 P574R and R279Q, may have a role in occurrence and metastasis of primary lung cancer
- The most invasive cell line secreted the highest amounts of MMP-2 and MMP-9.
- Although MMP9 may potentially promote tumor growth and metastasis, production of MMP-dependent anti-angiogenic factors seems to override these effects and protects the host from NSCL growth and progression
- MMP9 immunoreactivity was present in polymyositis, dermatomyositis and focal myositis
- Therefore, the inhibition of MMP-9 expression by curcumin might have therapeutic potential for controlling the growth and invasiveness of brain tumor.
- exogenous CXCL12 induced MMP-9 expression in prostate cancer and bone metastasis.
- Polymorphism of MMP-9 (C-1562T) was associated with upper lung dominant emphysema in patients with COPD.
- High MMP-9 expression is associated with recurrent liver or lung tumors of colorectal cancer
- MMP9 in human blood originating from neutrophils is increased by S. aureus peptidoglycan
- Our results demonstrate that SM-7368 is a synthetic compound that inhibits TNF-alpha-induced MMP-9 expression, and thus SM-7368 should be useful for the development of chemotherapies targeting TNF-alpha-mediated tumor invasion and metastasis.
- findings indicate differences in early matrix metalloproteinase 9 (MMP-9) bronchoalveolar lavage fluid levels between resolving respiratory distress syndrome and developing chronic lung disease of prematurity
- The expression of MMP9 is consistently significantly higher in neoplastic brain tissue compared to normal brain tissue, and may be involved in the process of metastasis of breast cancer to the brain.
- the high number of CA repeats in MMP-9 promoter is positively correlated with faster intima media thickening and constrictive remodeling of atherosclerosis
- Runx2-regulated MMP9 levels are functionally related to the invasion properties of cancer cells
- Expression and secretion of the matrix metalloproteinase 9 (MMP-9) in macrophages is induced by lipomannans through a toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism.
- Suppression of MMP-9 by dinoprostone in peritoneal macrophages is associated with severity of endometriosis.
- Enhanced expression and potentially increased activity of LV myocardial MMP-9 triggers the signal cascade instigating cardiac remodeling.
- Although MMP-1 is not detected in patients with persistent ovarian cysts, MMP-9 is expressed in all of the cysts
- With tumor progression and development of heterogeneity, the abnormal expressions of MMP-9, TIMP-2, and E-cadherin or DNA aneuploid rate or high SPF gradually increases, suggesting that they play a crucial role in gastric carcinoma progression
- utility of expression cloning in identifying specific regulators of MMP-9 expression (review)
- FAK regulates integrin-dependent MMP-2 and MMP-9 expression and release by T lymphoid cells through src kinase
- Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-9 is associated with breast cancer
- trophozoite-parasitized RBCs/hemozoin-fed adherent human displayed increased MMP-9 activity and protein/mRNA expression
- Homozygous familial hypercholesterolemia patients exhibited significantly elevated level of active MMP-9.
- Platelet-activating factor-induced MMP-9 expression, in a NF-kappaB-dependent manner, is regulated by Ca(2+), PI3K and ERK signaling pathways.
- The proteolytic activation of pro-MMP-9 in skin inflammatory diseases likely occurs via a pathway including IL-1alpha.
- Results suggest that MMP-9 might contribute in the pathogenesis of chronic kidney disease.
- activation of MMP-13 as well as MMP-9 induced by H-Ras is involved in angiogenesis and with farnesyl transferase inhibitors, in part, exerts their anticancer effects
- Obese women with polycystic ovary syndrome have elevated serum concentrations of MMP-9.
- variations in EMMPRIN glycosylation forms are associated with either MMP-2 or MMP-9 activity
- The active MMP-1 and MMP-9 plasma levels were found to vary in the menstrual cycle.
- During exacerbation, increased inflammatory burden coincides with an imbalance of the proteinase MMP-9 and its cognate inhibitor TIMP-1
- One polymorphism was associated with chronic obstructive pulmonary disease in a cohort of veterans.
- MMP-9 and MMP-2 are mediators of inflammation in chronic otitis media with effusion
- peripheral blood MMP-9 levels might serve as surrogate biomarkers of retinopathy in type 1 diabetic patients free of other vascular complications
- MMP-9 is an important member of the matrix metalloproteinase (MMP) family that participates in remodeling of extracellular matrix during tooth development. Data suggested that MMP-9 gene promoter polymorphism was not associated with hypodontia.
- A localized increase in MMP-8 and -9, mediated by native mesenchymal cells, presents a potential pathway for collagen breakdown and abdominal aortic aneurysm rupture.
- MMP-9 plays an important role in the vascular destruction of Henoch-Schonlein purpura, and circulating white blood cells may be a source of the MMP-9 secreted into the circulation.may be a source of the MMP-9 secreted into the circulation.
- p70S6K activation induces expression of MMP-9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells
- MMP-9 was increased in anterior wall of thoracic aortic aneurysms.
- it is reported here that ECM1 interacts with MMP9 and that such interactions diminish the proteolytic activity of MMP9
- a novel role for P2X(7) as a pro-inflammatory receptor involved in rapid MMP-9 release and leukocyte recruitment.
- We conclude that IL-6 triggers VEGF-induced angiogenic activity through increasing VEGF release, up-regulates KDR expression and phosphorylation through activating ERK1/2 signaling, and stimulates MMP-9 overexpression.
- study indicates that the expression of MMP-9 is up-regulated in a stepwise fashion, with two main steps, the first one, when a laryngeal dysplastic lesion evolves and the next one, when the dysplasia progresses to invasive laryngeal carcinoma
- Overexpression of stromal MMP-9 is independently associated with shorter disease-specific survival in epithelial ovarian cancer.
- Number of repeats (> or =22 CA) in microsatellite of MMP-9 promoter, but not MMP-9 plasma levels, is associated to carotid atherosclerosis and particularly to plaques with thin fibrous cap.
- potential role of VEGF-A, MMP-2 and MMP-9, and TNF-alpha in the mechanism of idiopathic excessive uterine bleeding; active form of MMP-9 was reduced in women with menorrhagia
- Increased matrix metalloproteinases 9 level is associated with high-grade and advanced-stage bladder tumors
- protein expression levels of pro- & active MMP-9 were higher in colorectal tumor tissues than in the corresponding normal tissues.
- Higher MMP9 activity is associated with breast cancer
- first demonstration that Cited2 functions as a Smad3/p300-interacting transcriptional co-activator in modulating the expression of MMP9, which could affect tumor cell invasion mediated by TGF-beta
- 17 polymorphisms associated with the risk of childhood atopic asthma were identified in MMP-9.
- A coding SNP (Q279R in exon 6) within the MMP9 gene to be associated with a lowered risk of trachomatous scarring and trichiasis.
- REVIEW. MMP-9 plays either a primary or secondary role in autoimmune diseases by its up or down-regulation.
- A model of costimulation of chemokine receptor signaling in interferon-alpha dendritic cells is proposed for MMP-9 and its cell surface receptors CD11b and CD44 which enhances migration across the extracellular matrix.
- O-glycosylated and hemopexin domains down-regulate the bioavailability of active MMP-9 and the interactions with the cargo receptors are proposed to be the original function of hemopexin domains in MMPs
- Matrix metalloproteinases (MMPs) may have a role in the pathogenesis of endometrioma.
- MMP9 -8202A/G polymorphism plays a role in the pathogenesis of thoracic aortic aneurysms and thoracic aortic dissections in a white population.
- Higher levels of MMP-9 in human brain tissue after ischemic and hemorrhagic stroke, suggesting a contribution of MMP-9 to ischemic brain injury and perihematoma edema.
- The association between pro-MMP-9 activity in plasma and both blood Pb and plasma Pb concentrations suggests a mechanism through which low lead exposure may increase the susceptibility to cardiovascular and neoplastic diseases.
- Basal secretion levels of active matrix metalloproteinase-9 respond to various extracellular matrix proteins, cytokines, and growth factors in normal human melanocyte cells and melanoma cell lines from different stages of neoplastic progression.
- two inhibitors of p38 MAPK and protein tyrosine kinase pathways could be used as combined targets for inhibiting MMP-9 expression in inflamed tissues
- Up-regulation of MMP-9 expression was observed in atypical and anaplastic meningiomas.
- sublethal dose of radiation could enhance hepatocellular carcinoma cell invasiveness by MMP-9 expression through the PI3K/Akt/NF-kappaB signal transduction pathway
- MMP-9 was also present at the rim of the lesions of secondary progressive multiple sclerosis.
- results suggest that both MMP-9 and TIMP-1 contribute to tissue remodeling in asthma
- Decrease in serum levels eight days after IVIG treatment in neuromuscular disease.
- In artery samples in diabetic patients relative to nondiabetic patients, capillary density was reduced to 30%, VEGF expression was reduced by 48%; the expression and the gelatinolytic activity of MMP-2 and -9 were upregulated.
- an increased ratio of MMP-9 to TIMP-1 might be associated with the formation of microcysts and peritumoral edema in microcystic meningioma
- MMP-2 could be associated with aggressive behavior, but MMP-9 expression diminishes in high-grade tumors.
- These results indicate a temporal relationship between MMP-9 production by endothelial cells and the onset of angiogenic event.
- We suggest that the increase of MMP-9 levels and activity may be used as a new marker to diagnose the development of heart failure in patients with post MI, and provide the therapeutic implications in the future.
- plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal extracellular matrix metabolism
- MMP-9 is physiologically regulated by alpha4beta1 integrin and CXCL12 and plays a key role in cell invasion and transendothelial migration in b-cell chronic lymphocytic leukemia.
- Significantly higher mRNA expression of MMP-9 was found in brain-seeking 231-breast cancer clones in comparison to bone-seeking and parental cells.
- metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 may have roles in development of systemic lupus erythomatosus
- These findings make plausible the involvement of MMP-9/TIMP-1 imbalance in the invasiveness of the endometrial tissue of patients with endometriosis and the ectopic development of the disease.
- Endothelial progenitor cell (EPC) colony levels are significantly lower in individuals with low HDL, and HDL increases eNOS and decreases pro-MMP-9 in EPCs.
- Invasion of human cord blood mast cells through Matrigel is mediated by MMP-9 and not by C5a receptor upregulation.
- Results demonstrated higher expression of MMP-9 protein in meningiomas with subsequent recurrences compared with meningiomas from patients who had no recurrences.
- gelatinase is constantly upregulated by sunlight in the facial epidermis of most women during their daily lives, and may be an etiological factor in photoaging, e.g., by promoting wrinkle formation
- Potential relevance of all-trans retinoic acid as a pharmacological tool to attenuate matrix metalloproteinase-9 secretion in pathological situations.
- adenosine inhibits MMP-9 secretion by neutrophils; this effect involves the A2a receptor and is mediated through the cAMP/PKA/Ca(2+) pathway
- Loss of MMP-2, MMP-3 and FN in lichen planus may be associated with the destruction of the epidermal basal layer and these MMPs may be involved in the pathogenesis of interface dermatitis.
- Genetic polymorphism in MMP9 may have a pathogenic effect in human pulmonary emphysema.
- roles for eicosanoids in monocyte migration induced by urokinase plasminogen activator and MMP9.
- promoter gene polymorphism seems to be associated with severe generalized chronic periodontitis
- Elevated plasma MMP-9 levels correlated with lower left ventricular(LV) ejection fraction and higher end-systolic volume. Increasing MMP-9 levels are associated with aconcurrent deterioration of LV function.
- Monocytes can express MMP-9 in response to stromal factors and that this response may be significantly decreased in myelodysplastic-syndrome-derived monocytes.
- These results demonstrate that NOS2-derived nitric oxide contributes to airway epithelial repair by both PKG-dependent and -independent mechanisms, and involves NO-dependent expression and activation of MMP-9.
- The results of this study suggest that expression of a splice variant of CD99 contributes to the invasive ability of human breast cancer cells by up-regulating AP-1-mediated gene expression through the Akt-dependent ERK and JNK signaling pathways.
- MMP-9 is strongly expressed in medial smooth muscle cells of atherosclerotic Circle of Willis arteries as well as in atherosclerotic aneurysms.
- These data demonstrate that the S100A4 gene controls the invasive potential of human CaP cells through regulation of MMP-9 and that this association may contribute to metastasis of CaP cells.
- TIMP-1 may serve as a useful laboratory marker to predict the clinical outcome of patients presenting with severe sepsis.
- Human labor is associated with increased expression of matrix metallopeptidase 9 (MMP-9) in the myometrium
- MMP9 production in small-cell lung cancer cells is suppressed by CD9 and increased by its absence.
- High matrix metalloproteinase 9 is associated with high-grade gliomas
- MMP9 sequence variation was significantly associated with variation in leukoaraiosis volume in both African-Americans and Whites.
- Data show that MMP9 may be relevant with carcinogenesis, development and metastasis of adenoid cystic carcinoma, and different metastasis potential may result from different subtype of MMPs gene family.
- Elevated levels of MMP-9 iin carotid stenosis were associated with a 2-fold risk of ipsilateral stroke or cardiovascular death. MMP-9 may play an important role in the destabilization of atherosclerotic carotid plaques.
- We observed a moderatedly increased risk for breast cancer in the TT homozygotes of the MMP9-1562 C/T SNP (OR 1.88, 95% CI 0.97-3.63)
- Lycopene decreases the invasive ability of hepatoma cells by inhibiting MMP-9 expression and suppressing the binding actiity of nf-kappab.
- results suggest that wogonin effectively suppresses TNF-alpha-induced HASMC migration through the selective inhibition of MMP-9.
- Astrocytes surrounding amyloid plaques show enhanced expression of MMP-9 in aged amyloid precursor protein (APP)/presenilin 1 transgenic mice.
- MMP9 was abundant in ovary, but its levels did not change significiantly during the ovulatory process, though levels in the early ovulatory phase were non-significantly higher.
- polymorphisms are not associated with the susceptibility to chronic periodontitis in the Czech population; however, the promoter variant may influence the severity of the disease in men
- Our findings suggest a role for MMP-9 in soft tissue sarcoma (STS) progression and expand the role of p53 in molecular control of STS growth and metastasis.
- We conclude that ischemic colitis induces increased activity and expression of MMP-9 and MMP-2 in the involved colonic mucosa.
- The effect of chitooligosaccharides (COS) on activity and expression of MMP-9 in HT1080 cells is reported.
- High levels of MMP-1 in tumour and mucosa as well as MMP-2 in plasma may be correlated to risk of developing distant metastases.
- SNP rs2664538, which is located at the MMP9 gene, is likely to be associated with acute primary angle closure glaucoma.
- These results identify an unexpectedly broad involvement for p8 in key cellular events linked to cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloproteases production, both of which occur in heart failure.
- The relation of nocturnal melatonin levels to serum MMP9 concentrations was studied in patients with myocardial infarction.
- in cultured human vascular smooth muscle cells (VSMC), aggregated LDL (agLDL) -internalization down-regulates MMP-9 activity ina a time -and dose- dependent manner
- The MMP9-1562T allele is associated with a reduced risk of preeclampsia.
- A definitiion of part of the catalytic domain of gelatinase B/MMP-9, but not the zinc-binding or fibronectin domains, as target for the development of selective inhibitors.
- DPC4 regulates MMP9 and may inhibit the proliferation of colon cancer cell by restraining growth and inducing apoptosis
- elevated MMP-9 is strongly associated with the increased incidence of in-hospital mortality and cardiogenic shock observed in type 2 diabetes
- matrix metalloproteinase 9 (MMP-9)levels are increased in complicated atherosclerotic plaques and in plasma level of patients with carotid atherosclerosis
- MMP9 -1562 C/T polymorphism in this particular study do not provide evidence for a major role for this gene in nonsyndromic cleft lip and palate.
- Our findings demonstrated that the shear stress-induced MMP-9 expression involved integrins-p38 MAPK or ERK1/2-NF-kappaB signaling pathways.
- MMP9 polymorphism is associated with prostate cancer development and aggressiveness
- MMP-9 glycoforms secreted by tumor cells are unlikely to be tethered at the site of secretion, thus promoting more extensive cleavage of the extracellular matrix and providing a rationale for the contribution that MMP-9 makes to cancer cell metastasis.
- Induction of MMP-9 gene expression is regulated by oscillatory/cumulative activation of NFkappaB in a colon cancer cell line.
- increases invasion in human pituitary adenoma cell line
- Plasma concentrations of MMP-2, MMP-9, TIMP-1, and TGF-beta1 significantly differed between the various histopathological types of primary glomerulonephritis.
- These results suggest that silibinin represents a potential anti-metastatic agent suppressing PMA-induced cancer cell invasion through the specific inhibition of AP-1-dependent MMP-9 gene expression.
- In co-cultures endothelin-1 produced by endothelial cells results in neutrophil activation/degranulation and proMMp-9 release.
- NF-kappaB is a key mediator of the invasive phenotypic changes induced by RRM2 overexpression.
- We therefore found no evidence that MMP-9 is a marker of susceptibility for AAA.
- targeting constitutive expression of AP-2alpha in AP-2-positive KM12C colon cancer cells with small interfering RNA resulted in an increase in their invasive potential, downregulation of E-cadherin and increased expression of MMP-9
- The aim of the present study was to investigate the effect of P. gingivalis on the expression and production of MMP-2, MMP-9, TIMP-1, and TIMP-2 by oral fibroblasts and epithelial cells.
- Parotid saliva of Infantile chronic recurrent parotitis patients showed an increased protein concentration, altered mode of protein diffusion, a higher frequency of polypeptide bands .
- Infliximab treatment decreases MMP-9 in serum of patients with CD, the latter also in the intestine, which extends and confirms our previous ex vivo explants observations.
- No significant differences in the genetic distribution and allelic frequency of -1562C/T MMP-9 SNP between myocardial infarction patients and centenarians.
- Manganese and activators of the ERK pathway cooperated in HT29-D4 cell adhesion to fibrinogen.
- Loss of GST and gain of MMP-9 in Barrett with dysplasia compared to non-dysplastic metaplasia indicate that these alterations may be early events in carcinogenesis
- MMP9 may have a possible role in the determination of arterial function; has potential implications for involvement in the pathophysiology of cardiovascular diseases.
- Purified MMP9 was able to cleave the soluble, monomeric forms of native collagen types I and III at 37C and 25C, respectively.
- Upregulation of matrix metalloproteinase-9 (MMP-9) expression during early development of knee osteoarthritis (OA) occurs via MAPK ERK, JNK, and p38 signaling pathways and the PI3K signaling pathway in cultured cells debrided from OA knees.
- Siatistically significant value in assocation with survival or event-free survival in head and neck squamous cell carcinoma.
- the transcription factor NF-kappaB, p42/p44 MAPK, p38 MAPK, and JNK are involved in MMP-9 expression in tracheal smooth muscle cells exposed to IL-1beta
- This study demonstrated that proteinase expression, particularly of MMP-9, is modulated by pemphigus vulgaris (PV) serum and associated with PV acantholysis.
- Plasma levels are increaed diabetic patients which may reflect abnormal extracellular matrix metabolism.
- MMP and TIMP plasma levels in premature coronary artery disease are linked to clinical presentation and markers of inflammation and metabolic disorders rather than to genetic polymorphisms
- MMP9 induction promotes E-cadherin posttranslational modification involved in metastatic dissemination.
- "protein kinase Calpha-NF- kappaB"-dependent cascade is involved in the signaling leading to phorbol myristate acetate-induced MMP-9 expression in the lung epithelium
- This study does not provide strong evidence for further investigation into the role of the MMP-9 SNPs in melanoma progression
- mRNA contents of MMP-2 and MMP-9 were not associated with any patient characteristics
- MMP9 levels were significantly higher in diabetic patients with the acute coronary disease syndrome than in nondiabetics.
- We conclude that fetal MMP2 -1306 single nucleotide polymorphism (SNP) is associated with an increased risk for IUGR, but not MMP9 -1562 SNP nor MMP9 microsatellite.
- Cystic fibrosis samples possessed increased levels of active MMP-9, as well as decreased amounts of tissue inhibitor of metalloprotease-1 (TIMP-1), a natural inhibitor of MMP-9.
- expression of FLNa regulates constitutive activation of the Ras/ERK pathway partly through a Ras-GRF1 mechanism to modulate the production of MMP-9.
- The aim of the study was to determine the pattern of immunohistochemical expression of transforming growth factor beta1 (TGFbeta1), metalloproteinase 9 (MMP-9), and Ki-67 in colorectal cancer and adenomatous polyps.
- role FAK plays in promoting cell invasion through the activation of distinct signaling pathways induced by EGF with protein MMP-9 transcription and secretion in follicular thyroid carcinoma cells
- matrix metalloproteinase-9 may have a role in fibrinolysis in human blood
- distinct deficits in NO production and elevations in MMP-8 and -9 expression in diabetic human skin fibroblasts compared to normal
- Expression of active MMP-9 was increased in 9L/F344 rat brain during the growth of malignant gliomas at different time intervals, which indicate that 9L/F344 animal model may be a prospective animal model to test new MMPs inhibitors.
- gene polymorphisms for MMP-9 did not show any association with the G-AgP in Chinese subjects with generalized aggressive periodontitis
- apoptotic keratinocytes impair the extracellular domain of cell surface desmoglein 3 by MMP-9 activity
- Combining staging by endoscopic ultrasonography and MMP-9 improves the accuracy in deciding the invasion and metastasis in the patients with gastric carcinoma.
- These results suggest that PEA3 is regulated by EGFR and that the elevated PEA3 expression detected in human ovarian cancer may divert cells to a more invasive phenotype by regulating MMP-9 and MMP-14.
- The secreted MCP-1 may affect the production of MMP-9 in fibroblasts and/or macrophages.
- AT1R is involved in the progression of gastric cancer and may promote the angiogenesis of gastric cancer cell line (MKN-28), and these effects may be associated with the upregulation of MMP9.
- Il-6 and matrix metalloproteinase-9 provide a link between inflammation, matrix degradation and the development/progresion of acute coronary syndrome.
- CD147 enhanced the activity of MMP9 secreted by systemic lupus erythematosus mononuclear leukocytes.
- a novel 82 kDa species of proMMP-9 was purified from the plasma membrane of THP-1 leukaemic cells, which has substantial differences from the secreted 94 kDa proMMP-9
- Activated MMP-2 and MMP-9 were detected in eight out of nine cases of floppy valves.
- Frequent osteopontin expression is typical of, but not specific for malignant pleural mesothelioma, whereas it appears to select pulmonary adenocarcinoma cases with p65 and MMP-9 expression, suggesting a link with EGFR signalling pathways.
- Results of this study suggest that Systemic sclerosis patients with anticentromere antibodies positivity, after a primary fibrogenetic noxa, react with a more abundant release of MMP/TIMP, whereas patients with anti-Scl70 antibody show a normal response.
- MMP_9 polymorphism of the T allele has an increased risk for developing oral cancer only in initial stages,not in advanced stages.This may be due to the role of MMP-9 in the inhibition of angiogenesis by generating angiostatin from plasminogen.
- MMP-9 polymorphisms may not be independent factors to influence susceptibility to adult astrocytoma
- MMP-9 in plasma is asscociated with radical production during carotid endarterectomy.
- C-reactive protein induces matrix metalloproteinase-9 production in human mononuclear cells
- proMMP-2 and proMMP-9 secretion are decreased in THP-1 cells infected with Toxoplasma gondii
- Bcl-2 induces the expression of MMP9 in rernal cell tumors grown in the orthotopic sites, though no appreciable effects were observed in vitro.
- no significant differences were observed in distribution of the MMP-2-790T/G, -955A/C, and MMP-9-1562 C/T polymorphisms or haplotype of MMP-2 SNPs between patients and controls
- Hypoxia induces epidermal keratinocyte MMP9 secretion via the protein kinase C pathway.
- describes the site-specific distribution and activities of MMPs and therefore might help in elucidating the molecular mechanisms in pathologies such as premature rupture of membranes
- Expression of MMP9 was evaluated in hepatocellular carcinoma and surrounding non-tumor tissue.
- incidental clear cell renal cell carcinomas strongly expressing MMP-9 and TIMP-2 have a higher nulclear grade(worse prognosis).
- The activation of MMP-9 promoter is dependent upon interactions of Fra-1/c-Jun with Stat3.
- showed reduction in MMP-9 levels in the abdominal aortic aneurysm wall in patients randomised to simvastatin.
- These data reveal a new mechanism by which host- and pathogen-derived factors act together in Mycobacterium infection to drive MAPK-dependent MMP-9 secretion from respiratory epithelial cells.
- Matrix metalloproteinase-9 polymorphism contributes to blood pressure and arterial stiffness in essential hypertension.
- Study found that an HIV-1-dependent increase in matrix metalloproteinase 9 production from donor cells significantly contributed to the cell-to-cell transmission of the viral products.
- In macrophages, raloxifene significantly reduced MMP-9 secretion in a concentration-dependent manner, without affecting MMP-9 activation.
- release of active MMP-9 by IL-13-stimulated KCs may play a crucial role in skin inflammation by facilitating migration of leukocytes into the epidermis.
- These novel structural details should facilitate the design of more selective MMP-9 inhibitors
- During acute phases after stroke, resveratrol preconditioning suppresses matrix metalloprotease-9 activity to ameliorate blood-brain barrier disruption, edema formation and neuronal cell death.
- MMP-9 was present in 59% of cancer patients and the lytic activity was enhanced in pleurisy and absent in cirrhosis.
- Functional MMP-9 -1562 C>T polymorphism is associated with oral squamous cell carcinoma risk only in younger areca chewers.
- COX-2, MMP-2 and MMP-9 were expressed in a high percentage of primary endometrial carcinomas and their expressions may be associated closely with parameters of tumor aggressiveness.
- MMP-2, MMP-9, and vascular endothelial growth factor C were expressed to similar degrees at all time points in cells exposed to lymphatic flow.
- Cholesterol inhibits MMP9 expression in epidermal keratinocytes and HaCaT cells.
- The significant decrease in T allele carriership (p = 0.01), was found in female MS patients in Serbia.
- simultaneous downregulation of urokinase plasminogen activator receptor and MMP-9 using RNAi technology may provide an effective tool for breast cancer therapy
- TIMP-1 and its inhibitory domain, N-TIMP-1, are weak inhibitors of MMP9.
- multivariate analysis confirmed that enhanced MMP-9 expression was an independent and significant factor for prediction of a poor prognosis in colorectal cancer.
- VEGF, MMP2, 7 and 9, and COX-2 expression is related to progression of advanced uterine cervical cancer in young women
- The -1562C>T polymorphism in the MMP-9 promoter is strongly associated with acute myocardial infarction.
- Matrix metalloproteinase-9 is increased in plaques causing coronary artery syndrome.
- MMPs also cleave a variety of non-ECM proteins, including cytokines, chemokines, and growth factors, activating or inactivating them, or generating other products that have biological consequences.
- NGAL in complex with activated MMP-9 is present in AAA wall and thrombus.
- Multidrug resistant breast cancer cells with p-glycoprotein substrates could affect outcome through modulating the production of CD147.
- MMP-9-1562C>T polymorphism affects lymph node metastasis of colorectal cancer in northeast Chinese population.
- Elevated MMP-9 levels in H. pylori-infected gastric mucosa are reversible by eradication of the infection.
- results indicate that Abeta peptide increases MMP-9 secretion through integrins; MMP-9 then directly processes cell surface APP695 with an alpha-secretase like activity, substantially reducing the levels of secreted Abeta peptide
- Multinucleated giant cells (MGCs) in tuberculous lymph-node biopsy samples express high MMP-9 levels adjacent to areas of necrosis, and may contribute to inflammatory tissue damage in human tuberculosis.
- Increased mmp-9 is assopciated with squamous cell laryngeal carcinoma
- Nicorandil suppresses the increases in MMP2 and MMP9 levels and activities and prevents the development of ventricular remodeling in acute myocardial infarct
- Expression of c-fos in the human endometrium may be regulated by 17beta-E(2), and c-fos may be involved in development of endometriosis by promoting MMP-9 gene expression and subsequently the invasive potential of endometrial explants.
- S. enterica serovar Typhimurium activates proMMP-9 (gelatinase B) secreted by human primary macrophages
- Correlation between MMP-2 expression levels and the collagen fraction in the pathological hearts indicated a putative role of MMP-2 in the fibrosis that takes place in congestive heart failure.
- MMP-9 is involved in B-cell chronic lymphocytic leukemia nodal infiltration
- The CC homozygote genotype of the peroxisome proliferator-activated receptor gamma (PPAR gamma) gene had increased matrix metalloproteinase 9 (MMP-9) levels compared with T allele carriers.
- Elevated serum matrix metalloproteinase 9 concentration is associated with colorectal neoplasia
- Increased expression of matrix metalloproteinase 9 is associated with pulmonary sclerosing hemangioma
- MMP-9 expression increased by SDF-1alpha enhances lung cancer invasiveness through the CXCR4/ERK/NF-kappaB signal transduction pathway
- role of the HPV gene E2 and transcription factor NF-kappaB in the induction of MMP-9 expression in squamous cell carcinoma of human uterine cervix.
- SDF-1-CXCR4 interaction activated MMP-9 at the both transcription and protein levels and MMP-2 only at the post-translation level.
- imbalance of serum MMP-9 and tissue inhibitors of metalloproteinases 1 levels in patients with acute encephalopathy following prolonged febrile seizures may be associated with severe neurological sequelae
- the structural model of full-length pro-MMP-9 and, in particular, the molecular character of its unique proline-rich and heavily O-glycosylated (OG) domain.
- serum MMP-9 levels are strongly associated with vasculo-Behcet's disease, particularly aneurysmatic involvement, suggesting their pathogenetic roles in vasculo-Behcet's disease complicated with aneurysm formation
- Mmp9 gelatinase activity in pulmonary epithelial cells were attenuated in the Cd8-deficient mice.
- Chymase-induced MMP-9 activation may play an important role in the progression of abdominal aortic aneurysm
- Low molecular weight heparin treatment of abdominal aortic aneurysms was associated with decreased plasma MMP-9 activity.
- The present study failed to demonstrate any association between serum levels of MMPs, VEGF and CA 15.3 and well-known clinicopathological characteristics of breast carcinoma
- MMP-2/9 production is regulated by sPLA2-IB acting as a receptor ligand to activate cPLA2
- One single irradiation of UVB increases the immunohistochemical expression of gelatinases in almost all evaluated cell lines, with the exception of MMP-9 in keratinocytes
- These results indicate that MMP-9 inhibition induces apoptosis due to altered beta1-integrin expression in medulloblastoma and ERK activation plays an active role and functions upstream of NF-kappaB activation to initiate the apoptotic signal.
- Patients with low- and high-grade CIN were found to have significantly different plasma MMP-9 levels but not MMP-2 levels.
- Acrolein increased pro-hMMP9 cleavage and activity in concentrations (100-300 nM) found in sputum from chronic obstructive pulmonary disease COPD subjects.
- No difference exists in gene expression of MMPs in ascending aorta and AV between patients with BAV and TAV.
- Genotype frequency of MMP-3, but not MMP-1 and MMP-9 in idiopathic dilated cardiomyopathy patients, was significantly different from that in healthy controls.
- a major role for host-derived MMP-9 in angiogenesis and in the growth of human pancreatic cancer in the pancreas of nude mice.
- polymorphisms in MMP1, MMP2, MMP3, MMP9, or MMP10 weren't associated with acute MI compared with angina or with coronary disease. Circulating levels of MMP9 are independently associated with development of an acute MI rather than stable angina.
- MMP-2, MMP-9, TIMP-1 and TIMP-2 play an important role in the pathogenesis of non-melanoma skin cancer. The immunoexpression of these proteins may be useful indicators of cutaneous cancer invasion and progression.
- MMP2, MMP14, and MMP9 might be used as prognostic markers in patients with sinonasal and oral malignant melanoma.
- results suggest that thrombin induces expression and association of beta1-integrin with MMP-9 and that the cell surface localization of the protease by the integrin promotes tumor cell invasion
- Coincubation of platelets with monocytes induced EMMPRIN-mediated nuclear factor kappaB activation in monocytes with increased MMP-9, interleukin-6, and tumor necrosis factor-alpha secretion by monocytes
- serum level significantly and positively correlated with carotid-femoral pulse wave velocity in hypertensive patients
- MMP-9 (type IV collagenase) was also found in synovial fluid from patients with rheumatoid arthritis.
- 1562 gene T allele might be associated with a decreased risk for generalized aggressive periodontitis in the Turkish population.
- Col-IV regulates the secretion of MMP-9 via a Src and FAK dependent pathway in MCF-7 cells
- Co-localization of trypsin-2 and MMP-9 resulted in intracellular proMMP-9 processing that represented fully or partially activated MMP-9.
- In early human stroke we found evidence of increased oxidative stress and a relationship with MMP-9 expression.
- Baseline serum MMP-9 level predicted the prognosis after coronary revascularizations, suggesting its potential role in risk stratification before revascularization strategies for stable coronary artery disease.
- The aim of this study was to analyse the influence of recombinant IFN beta-1a (identical with natural IFN-beta) on MMP-2 and MMP-9 activities
- Therefore, the strong inhibition of MMP-9 expression by irisolidone might be a potential therapeutic modality for controlling the growth and invasiveness of gliomas.
- role of C(-1562)T promoter polymorphism in myocardial ischemia
- the findings of this study provide mechanistic reasons for the unique proangiogenic function of neutrophil-derived MMP-9.
- MMP-9 abnormal expression may play a role in the increased vessel density notoriously found in bone marrow of acute myeloid leukemia (AML) patients at diagnosis and thus it may be involved in the leukemogenic process and in myelodysplastic syndrome.
- Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways to stimulate angiogenesis.
- No significant positive correlation was observed between the MMP-9 levels and the number of CD34+ cells. Hence, we found no significant role for MMPs during the mobilization of peripheral blood stem cells stimulated by G-CSF.
- results suggest the usefulness of MMP-9 as a tumor marker in diagnosis, but not in prognosis of esophageal cancer
- data suggest that MMP-2 -735C/T, MMP-9 -1562C/T and MMP-12 357Asn/Ser polymorphisms are not associated with susceptibility to severe CP in Turkish population. T allele of MMP-9 -1562 gene might be associated with decreased susceptibility to severe CP.
- Investigation of cellular responses to experimental phonation may provide insight into how matrix metalloproteinases and other extracellular matrices contribute to maintenance of the vocal fold and development of pathology.
- High concentrations of MMP-9 found in patients with carotid stenosis and cerebral lesions suggest that MMP-9 assay could be useful in the evaluation of all carotid lesions to help identify those at highest risk of a neurologic event.
- down-regulation of matrix metalloproteinase (MMP)-9 protein levels in prostate cancer.
- our results demonstrate associations of MMP-9 genotypes with different stages of carotid atherosclerosis.
- Proinflammatory effects of VIP are associated with stimulation of exocytosis of secretory vesicles as well as tertiary (gelatinase) granules with up-regulation of MMP9.
- MPO and pro-MMP-9 activity may contribute to the development of fat meal induced endothelial damage.
- MMP-9 was not associated with the clinical course of melanoma.
- The K23 motifs of RECK protein can inhibit MMP-9 secretion and activity and attenuate metastasis of lung cancer cells.
- IR/visible light spectrum of sunlight significantly increased skin MMP-9 expression.
- Data show that increased expression of MMP9 was associated significantly with low histological differentiation of the tumor, deeper tumor invasion, and was more often observed in tumors of colorectal cancer patients with unfavorable prognosis.
- Enzyme immunoassays showed the levels of metalloproteinase 9 were virtually the same in colorectal cancer and mucosa.
- The results herein provide initial evidence that the inhibitory effect of hypoxia on MMP-9 by mature dendritic cells requires the activation of A(2b) in a cAMP/PKA-dependent pathway.
- MMP-2, TIMP-1 and TIMP-2 levels are significantly higher and MMP-9 lower in children with chronic hepatitis B
- Taken together, we demonstrate that EPA inhibits TNF-alpha-induced MMP-9 expression through inhibition of p38 and Akt activation.
- These data suggest that MMP-9 and MMP-14 overexpression may have an important role in gllbladder tumorigenesis.
- These data show that Snail functions as a molecular mediator of TGF-beta1-regulated MMP-9 expression by increasing Ets-1 and thereby contributing to oral cancer progression.
- results suggest that relaxin may promote the invasive potential of early placental EVTs through up-regulating MMP-2, -9 mRNAs and down-regulating TIMP-1 mRNA in EVTs.
- The cleavage catalyzed by beta-hematin coincides with the first cleavage by matrix metalloproteinase-3, and preincubation of matrix metalloproteinase-9 with beta-hematin enhances the activation rate by matrix metalloproteinase-3 at least 6-fold.
- The matrix metalloproteinase 9 C-1562T polymorphism significantly influenced matrix metalloproteinase 9 mRNA expression in alveolar macrophages.
- found significantly higher immunohistochemical MMP9 levels in decidual cells and adjacent interstitial trophoblasts in placental sections of preeclamptic versus gestational age-matched control women
- MMP-2, MMP-9 and claudin-4 expression may be phenotypic features, distinguishing intestinal-type and diffuse-type gastric cancer.
- Data suggest that Fra-1 enhances lung cancer epithelial cell motility and invasion by inducing the activity of matrix metalloproteinases, in particular MMP-2 and MMP-9, and EGFR-activated signaling.
- HCG increases the secretion of MMP-2 and -9 in cytotrophoblasts in a dose-dependent manner.
- The dysregulated MMP9 expression is associated with infertility and early pregnancy loss.
- Increased MMP-2 and -9 and altered beta-catenin may play a role in the pathogenesis of endometriosis.
- These results may suggest that the expression of matrix metalloproteinase-9 (MMP-9) and cathepsin B is correlated with lymph node metastasis in advanced gastric carcinoma, but not with patients' postoperative survival.
- MMP-9, but not MMP-2, may have a role in mechanisms for stimulation of cell division and matrix biosynthesis, which cause matrix remodeling in the umbilical cord of preeclamptic newborns
- ESE-1 negatively regulates the invasion of oral squamous cell carcinoma via transcriptional suppression of MMP-9.
- TGF-beta1-induced HaCaT cell migration is mediated by MMP-14, which regulates MMP-9 expression via JNK signaling
- Microvessel and inflammatory MMP-9 response are associated with hemorrhagic complications after stroke
- B-CLL cells attached to and bound proMMP-9 and active MMP-9, and this was inhibited by blocking the expression or function of alpha4beta1 or CD44.
- results suggest that in A549 cells, phosphorylation of p42/p44 MAPK, JNK, and transactivation of NF-kappaB are essential for TNF-alpha-induced MMP-9 gene expression
- Specific knockdown of MMP-9 revealed a close correlation between invasion-dependent events and liver tumor cell-derived MMP-9 expression.
- coordination of ERK signaling and NF-kappaB and Brg-1 activation are indispensable to regulation of Axl-dependent MMP-9 gene transcription
- study demonstrates a significantly higher expression of MMP-9 in adenoma with high grade dysplasia-colorectal cancer sequence as compared to normal tissue; over-expression of MMP-9 strongly suggests its association with colorectal carcinogenesis
- uPA-mediated direct activation of MMP-9 may promote glioblastoma cell invasion.
- Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), MIF, and matrix metalloproteinase-9 (MMP-9), decreased significantly after weight loss.
- the role of MAP kinase signaling pathways in Activation of matrix metalloproteinase-9 by TNF-alpha in human urinary bladder cancer HT1376 cells.
- pro-matrix metalloproteinase-9/proteoglycan heteromer interacts with gelatin and collagen
- NGAL and MMP-9/NGAL complex suppression might have a protective role in women with PCOS.
- Megakaryocytic progenitors expressed matrix metalloproteinase-9 (MMP-9) and membrane-type (MT) 1-MMP, and transmigrated across the reconstituted basement membrane Matrigel.
- Overexpression of Gelatinase B is associated with advanced rectal carcinoma
- Stromal expression of MMP-9 (matrix metalloproteinase-9) was significantly higher in premenopausal endometrial polyps compared to postmenopausal polyps
- These data suggest that neutrophils are good candidates to be the main source of MMP-9 following t-PA stroke treatment and in consequence, partially responsible for thrombolysis-related brain bleedings.
- The absolute concentration of TIMP-1 in the airway, rather than its molar ratio with MMP-9, was associated with persistent wheezing.
- Our findings suggest that the MMP-9 level in CSF is an indicator of inflammatory damage to the brain in SSPE (subacute sclerosing panence).
- The members of caspases, MEK1/2, PKC, and NF-kappaB are involved in TRAIL-induced expression of uPA, IL-8, MMP-7 and MMP-9.
- Alpha-1-antichymotrypsin is a pathophysiologic inhibitor that controls MMP-9 activation in skin tissue.
- results establish a central role for MMP-9 in the pathogenesis of COPD by demonstrating that expression of this protease in macrophages can alter the extracellular matrix and induce progressive air space enlargement in mice.
- members of the Hh pathway, especially Gli1, play an important role in the invasiveness of pancreatic cancer cells through the regulation of MMP-9 expression.
- c-FLIPL promotes the motility of HeLa cells by activating FAK and ERK, and increasing MMP-9 expression.
- Cell-surface MMP-9 regulates the invasive capacity of leukemia blast cells with monocytic features.
- in colorectal neoplasms, MMP-2 expression correlates with the depth of invasion, venous invasion and liver metastasis; MMP-9 and RECK expression correlate with venous invasion
- Unlike MMP-1 and MMP-9 genotypes, MMP-3 5A allele, with higher transcriptional activity, may be a risk factor for the poor prognosis of hepatocellular carcinoma
- Zymography, Western blotting, and immunofluorometric analysis of diabetic nephropathy urine showed a significant association especially between activation of MMP-9 as well as PMN-type MMP-8 and TRY-2
- Surgical wound-produced host Pro-MMP-9 and tumor cell VEGF might be important mediators leading to metastasis of residual breast cancer after surgery.
- These results suggest an important role for MMP-2 and MMP-9 in the induction of T. cruzi-induced acute myocarditis.
- Overexpression of MMP-9 results in increased generation of antiangiogenic fragments, decreased angiogenesis, and therapeutic effects of established breast cancer.
- study has shown significant associations between the two nonsynonymous MMP-9 polymorphisms with lymph node metastasis in gastric cancer, especially with the diffuse type
- NO is incapable of directly activating proMMP-9 and S-nitrosylation of MMP-9 propeptide by NO-donors is unrelated to their ability to regulate MMP-9 activity
- regulation of intervertebral disc ECM metabolism by the THBS2-MMP system plays an essential role in the etiology and pathogenesis of LDH.
- These results describe a novel mechanism for the potentiation of TGF-beta1 signaling to induce MMP-9 expression via Smad and MLCK.
- Berberine induced down-regulation of MMP9 in gastric neoplastic cells in vitro.
- Atorvastatin does not alter interferon Beta-induced changes of serum matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in patients with multiple sclerosis
- MMP-9 plays a role in the pathophysiology of gestational hypertension.
- Various drugs with a triptan-like chemical structure interact with cellular components of the innate immune system, resulting in an apparent indirect inhibition of NKC activity and direct inhibition of neutrophils pMMP-9 secretion.
- Activator protein-4 expression was associated with the expression of matrix metalloproteinase-9 and vascular endothelial growth factor in the advanced colorectal cancer.
- Rap1GAP inhibits tumor growth but induces MMP2- and MMP9-mediated SCC invasion and tumor progression, suggesting a role for this protein as a biomarker for early N-stage, aggressive SCCs
- suppression of expression of matrix metalloproteinase-9 in breast cancer cells
- MMP-2 stimulates keratinocyte survival whereas MMP-9 promotes terminal differentiation.
- MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not.
- the G allele of MMP-9(matrix metalloproteinase 9) polymorphism rs2250889 is overrepresented in patients with histologically confirmed giant cell arteritis
- MMP-9 is a poor clinical biomarker of remodeling and outcome in patients with systolic heart failure
- arsenic in the airway can alter the airway epithelial barrier by restricting proper wound repair in part through the upregulation of MMP-9 by lung epithelial cells.
- Histamine upregulates keratinocyte MMP-9 production via the histamine H1 receptor
- This study did not find an association between the rs2664538 polymorphism within the MMP-9 gene and PACG (primary angle-closure glaucoma) in this sample of Chinese subjects.
- Neither MMP-2 SNPs nor MMP-9 SNPs revealed significant association with proliferative diabetic retinopathy in single-locus comparisons.
- A possible involvement of MMP-9 inmandibuloacral dysplasia type A disease.
- Overexpression of MMP-9 is associated with ovarian carcinoma
- MMP-9-induced IGFBP2 proteolysis may be regarded as an important post-translational event involved in astrocytoma aggressiveness. These new findings support drug targeting of MMP-9 as an interesting approach in the treatment of astrocytoma.
- genetic polymorphisms of the MMP-9 promoter regions are not associated with the development of systemic lupus erythematosus in Korea
- The expression of MMP-2 and -9 in tissue samples from keloids was investigated by immunohistochemistry.
- identification of a series of proteins whose levels are affected by MMP-9, some of which are clearly direct substrates for MMP-9 and become candidates for involvement in metastasis
- The expression of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and inducible nitric oxide synthase (iNOS) in a verrucous proliferative leukoplakia sample, was investigated.
- ) expression of MMP9 increased after surgical manipulation of vein grafts in all patients
- Expression of gelatinases or their inhibitors did not have any significant correlations with prognosis, although MMP-9 predicted a good response to first-line chemotherapy.
- KLF5 causes cartilage matrix degradation through transcriptional induction of MMP9, providing the first evidence that transcriptional regulation of a proteinase contributes to endochondral ossification and skeletal development.
- The Matrix Metalloproteinase (MMP-2, MMP-9) to E-cadherin (M/E ratio) characterizes an important aspect of the molecular phenotype associated with the histologic progression of prostate cancer among African American prostate cancer patients.
- the increased expression of MMP9 gene caused by genetic polymorphism in the gene promoter is important in the early development of serious complications of chronic obstructive pulmonary disease
- MMP9 release representing ongoing aortic degradation after endografting can be inhibited by doxycycline therapy to increase aortic stability and improve the results of endografting.
- estrogen receptor 1, vitamin C receptors SLC23A1 and SLC23A2, and matrix metalloproteinase MMP3 and MMP9 are associated with susceptibility to lymphoma
- In 560 human breast tumors, AIB1 expression was found to be positively associated with PEA3, MMP2, and MMP9.
- While the TLR-2 +2258 (G>A) and MMP-9 -1562 (C>T) SNPs failed to present any significant association with pre-eclampsia, there was a marked trend for an association between the IL-4 -590 (C>T) SNP and pre-eclampsia (chi(2)= 5.87, P = 0.055)
- Data suggest that RECK protein is inversely correlated with tissue damage and MMP-9 secretion in systemic lupus erythematosus.
- Activation of the adenosine-A3 receptor stimulates matrix metalloproteinase-9 secretion by macrophages.
- Plasma levels of MMP-2 and MMP-9 are increased in obese patients which may reflect abnormal extracellular matrix metabolism.
- human coronary smooth muscle cells and dimethyl sulfoxide-differentiated HL60 cells upregulate ProMMP9 activity and promote mobility-modulation by reactive oxygen species
- MMP9 transcription activity is significantly upregulated along with neuron and glial cell apoptosis following spinal cord injury in transgenic mice.
- MMP-9 gene P574R polymorphism is associated with esophageal squamous cell carcinoma.
- In patients with high-risk bacteria, MMP-8-, MMP-9- and TIMP-1-concentrations were higher than in patients with low-risk bacteria.
- MMP-9, DJ-1 and A1BG proteins are overexpressed in pancreatic juice from pancreatic ductal adenocarcinoma
- Alterations of MMP-2 and -9 expression may play a role in eosinophilic chronic rhinosinusitis, but the association with IL-5 and IL-13 remains unclear
- the cleavage sites in the extracellular juxtamembrane region of Ptprz by tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase 9.
- MMP7 and MMP9-mediated cleavage of EphB2 is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses
- MMP-9 in cortical plaques in multiple sclerosis patient is associated with loss of perineuronal nets
- the genetic tendency to higher levels of circulating MMP-9 was not associated with AAA.
- TNF-alpha-induced MMP-9 expressions are involved with migrations of smooth muscle cells
- These studies demonstrate a new level of transcriptional regulation of MMP-9 expression by the cooperative action of co-activators.
- no significant association between the MMP9 polymorphic alleles or genotype and memory was detected in 449 Han Chinese participants
- These results suggest that TGase 2 inhibits MMP-9 via downregulation of MMP-9 transcription activity by blocking the binding of the Jun-fos complex to an AP-1 site.
- the simultaneous downregulation of uPAR and MMP-9 induces apoptosome-mediated apoptosis through FADD-associated protein RIP and caspase 9
- high basal MMP-9 activity is associated with tumoral syndrome in childhood acute lymphoblastic leukemia
- A significant decrease of the -1562T allele carriers in MS patients compared to controls (Pa=0.01, Pacorr=0.05) in -1562C/T MMP-9 gene polymorphism was found.
- Vanillin inhibits MMP9 expression through down-regulation of NF-kappaB signaling pathway in human hepatocellular carcinoma cells.
- Significantly higher matrix metallopeptidase 9 expression is associated with prostate cancer.
- MMP-9-PEX inhibits angiogenic features of endothelial cells and retards intracranial glioblastoma growth
- HCMV infection specifically alters the MMP-9/TIMP-1 balance in human macrophages, which in turn reduces MMP-9 activity in infected cells.
- Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression.
- A diagnostic tool incorporating the values of matrix metalloproteinase 9, brain natriuretic factor, d-dimer, and S-100beta into a composite score was sensitive for acute cerebral ischemia.
- In this review, the complex regulation of MMP9 within the uterus is highlighted, and the potential novel role of microRNAs in the regulation of this protease is discussed.
- ADAM10 and MMP9 to be involved in RAGE shedding.
- MMP9 is downregulated in lobular carcinoma in situ compated with normal breast epithelium and stroma.
- The structural changes in the venous wall in addition to the increased expression of MMP-2, MMP-9 and MMP-13 in venous aneurysms suggests a possible causal role for these MMPs in their pathogenesis.
- Non-surgical periodontal treatment was effective in reducing the levels of MMP9 in gingival crevicular fluid from diabetic patients with chronic periodontitis.
- matrix metalloproteinase-9 is induced in keratinocytes by histamine
- Increased level of MMP-3, MMP-9, and IL-6 may be responsible for ectasia formation in patients with coronary artery ectasia.
- a significant increase in osteopontin and MMP-9 levels and activity in patients with prostate cancer
- Cervicovaginal MMP-9 correlated with cervical ripening before labor at term.
- glioma cells enhance EPC angiogenesis via VEGFR-2, not VEGFR-1, mediated by the MMP-9, Akt and ERK signal pathways
- Serous and mucinous ovarian tumors express different profiles of MMP-9.
- that p38 MAPK and Akt signaling pathways are crucial for the ErbB2-induced MMP-9 up-regulation, invasion and migration of MCF10A cells
- The MMP9 Arg668Gln polymorphism was significantly associated with a decreased risk of skin SCC.
- MMP-9 gene silence by lentivirus mediated RNA interference can inhibit invasion and growth of laryngeal squamous cell carcinoma.
- MMP-2 and MMP-9, beside their roles in liver injury with tissue remodeling and fibrosis can be markers of acute rejection after liver transplantation.
- Matrix metalloproteinase 2 and 9 as the factor of head and neck tumor metastasis
- On the basis of linked-function analysis, we demonstrated that collagen binding domain of MMP2 tuned the cleavage of collagen IV by MMP9, presumably by inducing a ligand-linked structural change on the type IV collagen.
- Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells.
- Results suggest that nitric oxide attenuates 12-O-tetradecanoylphorbol 13-acetate-triggered matrix metalloproteinase-9 mainly through a direct inhibition of protein kinase Cdelta.
- The results revealed that mononuclear cells were highly immunoreactive for TIMP-1, TIMP-2 and MMP-9 during viral meningitis and that the expression of TIMPs in polymorphonuclear cells was even higher during bacterial meningitis.
- This is the first study comparing the expression of metalloproteinase-9 in cancer and inflamatory infiltrate cells in different histopatological types of esophageal cancer.
- MMP-9 were identified at higher levels in lung secretions of pediatric ALI patients compared with controls.
- Data strongly suggest that LRP1 promotes glioblastoma cell migration and invasion by regulating the expression and function of MMP2 and MMP9 perhaps via an ERK-dependent signaling pathway.
- RECK is a glycosylphosphatidylinositol-anchored glycoprotein that inhibits the enzymatic activities of MMP-9, thereby suppressing fibrosarcoma metastasis.
- TNF-alpha induces the activation of COX-2 by the up-regulation of MMP-9 via PGE2 receptors in cholangiocarcinoma.