|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for F3(NM_001993.4) Search again
Product ID:
HQP054276
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD142, TF, TFA
Gene Description:
coagulation factor III, tissue factor
Target Gene Accession:
NM_001993.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis.
Gene References into function
- The complex between tissue factor and factor VIIa initiates coagulation and intracellular signaling, alters gene expression, and promotes metastasis.
- selective activation of NF-kappaB (p50/p65) during intensive physical exercise does not result in the expression
- TF-FVIIa interaction elicits intracellular signalling events implicated in sepsis, inflammation, angiogenesis, metastasis and atherosclerosis. These include the sequential activation of Src-like kinases, MAP kinases, small GTPases and calcium signalling.
- tissue factor/tissue factor pathway inhibitor imbalance is associated with myocardial infarction at young age in Japanese men.
- TF promotes metastasis by a pathway that does not involve high expression of known PARs by tumor cells. PAR1 enhances the metastatic potential of cells with high TF expression.
- Resveratrol does not inhibit the activation or translocation of NF-kappaB/Rel proteins but inhibits NF-kappaB/Rel-dependent transcription of the gene for TF by impairing the transactivation potential of p65.
- Endothelin-1 enhances TF expression in monocytes from health individuals. No additional stimulation was seen in monocytes from heart failure subjects, who nonetheless have 2.5 times as much TF as controls.
- In children with sepsis-induced multiple organ failure, a cytokine-associated increase in circulating TF and systemic activity was predicted. Increased TF was associated with the development of coagulopathy and tended to be associated with mortality.
- pH dependence of fVIIa amidolytic activity in complex with soluble tissue factor
- differentiation of human monocytes into macrophages in culture enhances their tissue factor expression.
- results suggest involvement of tissue factor in the process of metastasis and progression of colorectal cancer may depend on increased angiogenesis
- Coronary no-reflow is caused by shedding of active tissue factor from dissected atherosclerotic plaque.
- TF-apoprotein selectively binds Hb, most probably via the carbohydrate moieties (alpha-d-glucosyl; alpha-d-mannosyl and N-acetyl-beta-d-glucosaminyl residues) of TF, and enhances its procoagulant activity.
- signaling increased transcription as well as mRNA stabilization leading to up-regulation of interleukin-8 synthesis
- Enhanced monocyte tissue factor expression is implicated in the hemostatic diathesis characterizing hepatosplenic schistosomiasis.
- Fluvastatin upregulated IkappaB alpha in unstimulated as well as in TNFalpha-stimulated HUVEC cells and also impaired the TNFalpha-induced Cdc42 prenylation, indicating that fluvastatin interferes with transcriptional activation of tissue factor gene.
- TF cytoplasmic domain-independent stimulation of protein synthesis via activation of S6 kinase contributes to FVIIa effects in pathophysiology.
- expression of TF and TFPI in human melanoma
- Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells; Plasminogen type 2, containing only one O-linked oligosaccharide chain, did not bind to tissue factor on 1-LN human prostate cancer cells
- Thrombin functions studied during tissue factor-induced blood coagulation
- Tissue factor activity is upregulated in human endothelial cells exposed to oscillatory shear stress.
- expression on monocyte subpopulations during normal pregnancy
- monocyte adhesion and transmigration induce tissue factor expression
- data indicate that endothelial cell surface expression of TF and extrinsic clotting factors are critical in augmenting capillary leak following intravascular tumor necrosis factor administration
- tissue factor expression by LPS-stimulated human monocytes is inhibited by adenosine and involves the adenosine A3 receptor, specifically
- a three-dimensional model of the ternary complex between FVIIa:TF:FIX was built using a full-space search algorithm in combination with computational graphics
- REVIEW:clotting-dependent and -independent mechanisms of TF-induced angiogenesis in cancer
- non-activated and activated platelets contain an inactive form of TF that may develop functional activity following its release
- effect of platelet-derived CD40L on the tissue factor activity of human CD40-positive melanoma cells and monocytes
- levels of tissue factor in placenta and myometrium, over tissue factor in blood plasma may be clinically significant in obstetrics, for instance, in the etiology of DIC in placental abruption
- 15d-PGJ2 down-regulates LPS- and TNFalpha-induced TF activity through inhibition of TF gene transcription.
- REVIEW: role of tissue factor-FVIIa complex in pathophysiological processes and effect of the inhibitors of the tissue factor:factor VII pathway
- correlation between tissue factor (TF) expression and hepatic metastasis and prognosis in rectal cancer
- Mice expressing low levels of human TF in an mTF(-/-) background had significantly shorter lifespans than wild-type mice, in part, because of spontaneous fatal hemorrhages. Low-TF mice had a selective heart defect with hemosiderin deposition & fibrosis.
- Tissue factor initiates blood coagulation via circulating microvesicles and platelets.
- the Gla and first epidermal growth factor-like domains of factor X play a role in the prothrombinase and tissue factor-factor VIIa complexes.
- REVIEW: model of the intravascular TF pathway in which adhesive interactions of the TF bearing platelets and microvesicles to neutrophils and monocytes enable blood coagulation
- The influence of several eicosanoids of the lipoxygenase pathway on regulation of LPS-induced tissue factor was examined in whole blood.
- These data support a transcriptional role for both nuclear factor-kappaB and p38 mitogen-activated protein kinase, but not MEK1, in tissue factor gene expression in human dermal microvascular endothelial cells.
- M type 1 and 3 strains of group A streptococci are potent inducers of TF synthesis; findings suggest that a novel interaction between group A streptococci and host cells contributes to the observed coagulopathy in Strep toxic shock syndrome
- review of role of tissue factor in thrombosis
- tissue factor has a role in affecting proliferative ability in meningioma
- TF may influence tumor growth and metastasis by modulating VEGF expression and neoangiogenesis.
- cell surface location-dependent phosphorylation of the TF cytoplasmic domain is regulated at multiple levels
- demonstrate the occurrence of two forms of non-cell-bound TF. One form, which is microparticle-associated, supports thrombin generation via FVII. The other form, which is fluid-phase, does not stimulate thrombin formation
- The ectopic expression of the acute promyelocytic leukemia-specific PML/RARalpha oncoprotein in U-937 cells results in induction of TF mRNA and promoter activity
- The TF and TFPI levels depend significantly on the renal function; elevated TF and TFPI levels may be related to thrombosis and atherosclerosis in chronic renal failure patients on peritoneal dialysis
- In response to endotoxin, there was an increase in IL-6, TF and CD11b expression and a procoagulant shift of clotting onset time, which was normalized by 4 mmol L-1 nicotinamide
- superantigens from S. aureus activate the extrinsic coagulation pathway by inducing expression of TF in monocytes, and that the expression is mainly triggered by superantigen-induced IL-1 beta release
- Tissue factor expression induced by local inflammation is involved in the pathogenesis of thrombosis in patients with nonvalvular atrial fibrillation
- circulating microparticles from platelets, erythrocytes, and granulocytes exposed TF; microparticle-exposed TF antigen levels were higher in cardiac patients compared with healthy individuals.
- model characterizes likely enzyme-binding exosites on FVIIa and Xa that may be involved in the ternary complex (sTF-VIIa-Xa) formation and the membrane binding region of the ternary complex.
- Substitutions on the TF surface that contacts the protease domain of factor VIIa have nearly identical effects on the affinities for both factors VII and VIIa--hence zymogen VII can readily adopt a VIIa-like conformation required for binding to TF.
- The TF-603A/G gene promoter polymorphism significantly influences constitutive TF gene expression in human monocytes but has no major effect on TF gene expression or on whole blood coagulation time in LPS stimulated conditions.
- FVIIa/TF-interaction produces STAT5 phosphorylation, STAT5 nuclear translocation and transactivation of a reporter gene.
- review: role of TF up-regulation in cancer pathogenesis and tumor angiogenesis
- review: role of TF in hypercoagulability and clotting-dependent induction of tumor angiogenesis
- some protease inhibitors might act as stress and induced TF expression with direct phosphorylation of JNK and p38, followed by phosphorylation and activation of AP-1 in monocytic cells
- Review. This review focuses on the roles of TF in hemostasis, thrombosis, and vascular development.
- the transfer of TF to monocytes is not simply an CD62P-mediated adhesion of platelets or platelet-derived microvesicles to monocytes, but may involve other not yet identified mechanisms
- Pancreatic duct cells exert a potent factor VII-dependent procoagulant activity related to their expression of tissue factor.
- EGFR, PYK2, Yes, and SHP-2 are involved in transduction of the TF/FVIIa signal possibly via transactivation of the EGF receptor.
- TF expression in leukocytes plays an important role in various diseases but the expression level does not always correlate with plasma levels of TF antigen
- Data suggest that Rac-dependent activation of the NFkappaB pathway may be a critical element promoting thrombin-induced tissue factor expression and activity, and thus a prothrombotic state in pulmonary hypertension.
- Arg(74) mutant of TF was defective in enhancing both the amidolytic and proteolytic activity of fVIIa, suggesting that this residue may be required for the allosteric activation of the protease.
- polymorphisms in the 5'-UTR of the tissue factor gene are associated with altered expression in human endothelial cells
- membrane cholesterol functions as a positive regulator of TF function by maintaining TF receptors, probably in noncaveolar lipid rafts, in a high-affinity state for VIIa binding
- TF and TFPI mRNA expression, protein levels and activity in trophoblast cells were determined and compared to human umbilical vein endothelial cells
- Tissue factor expression by colorectal cancer cells appears to act as both a regulatory target and an important mediator of oncogene-driven tumor growth and neovascularization.
- Progesterone-dependent up-regulation of tissue fasctor provides a survival advantage to burgeoning breast cancer cells.
- the concentration of physiologically active TF in non-cytokine-stimulated blood from healthy individuals cannot exceed and is probably lower than 20 fM.
- hyperchemotaxis towards PDGFRB is likely to depend in part on phosphorylation of the cytoplasmic domain of TF
- Tissue factor(TF) expression may contribute to the aggressiveness of pancreatic ductal adenocarcinoma by stimulating tumor invasiveness, and that evaluation of the primary tumor for TF expression may identify patients with a poor prognosis.
- dissociation of fVIIai from TF occurred by a two-step mechanism
- TF is enhanced by Shiga toxin and has a role in the coagulopathy observed in hemolytic uremic syndrome
- The higher availability of surface TF antigen on mononuclear leukocytes from high responders and TF-containing microparticles might make these individuals more susceptible to hypercoagulation
- Despite indistinguishable stability under physiological conditions of mutant tissue factor(R200W) and wild-type TF, important clues are revealed regarding misfolding and aggregation propensities of the mutant TF(R200W) to explain why it is lost in vivo.
- FVIIa induces PRIM1 and ensuing cellular proliferation via a TF- and of the PARs entirely PAR-2-dependent pathway, in distinction to that of thrombin which is PAR-1-dependent and TF-independent
- tissue factor-mediated cellular signaling is relevant to cancer angiogenesis
- in a model system, TGF beta-1 released from activated platelets contributes to the hemostatic imbalance at the sinusoidal endothelium in patients with hepatic VOD by increase of endothelial cell PAI-1 production and TF expression.
- CRP regulation of monocyte TF could contribute to the higher than expected atherosclerotic vascular disease seen in patients with inflammatory rheumatic disease
- MCP-1/CCR2 may play a role in Ca2+ influx-dependent TF regulation in the monocyte-endothelial cell interaction in the impairment of nitric oxide synthesis
- human B lymphocytes can express a functional Tissue Factor in response to phorbol myristate acetate
- EGF-mediated upregulation of TF results in its accumulation in caveolae-like membrane fractions and increased coagulative and invasive potential
- Transmembrane glycoprotein involved not only in the onset of the coagulation cascade, but also in cell proliferation and anti-apoptotic processes, may play a role in the development of alloantibody-induced chronic rejection.
- the transient, localized expression of TF is sufficient to sustain a TF-independent procoagulant response as long as flow persists
- reports existence of novel TF transcript predominantly expressed in tumor cells; occurs as a result of alternative splicing and insertion of an additional exon
- ability of epithelial cells to interact with the vascular system via expression of the TF gene (and other effectors) is under the control of complex alterations in cellular architecture
- The 5466 AG genotype is a novel predictor of cardiovascular death in acute coronary syndrome and may act through a high TF response
- A marker of endothelial damage/injury in the activation of vascular and coagulation abnormalities in acute coronary syndromes.
- FVIIa/TF interaction on activated monocyte-derived macrophages could be relevant to prepare monocytes/macrophages for extravasation and may represent a novel amplification loop of leukocyte recruitment
- Identified and characterized murine masTF, a soluble splice variant of TF; it is widely and abundantly expressed in adult tissues, in experimentally induced thrombi, and during development.
- TF can promote immune evasion in tumour cells expressing this protein leading to increased survival and therefore metastatic rate in such cells
- review of differential pathways involving activated platelets for the TF-mediated coagulation start in blood.
- protein S, which is well known as the cofactor of activated protein C, specifically inhibits TF activity by promoting the interaction between full-length TF pathway inhibitor (TFPI) and factor Xa (FXa)
- review: tissue factor microparticles are present in a spectrum of cancer patients known to have a high incidence of thromboembolic complications
- hypothesize that granulocytes take-up TF for transport to other locations in order to initiate fibrin formation or to induce pro-inflammatory gene expression upon interaction with factor VIIa
- Among major red wine phenolics, quercetin appears to be the predominant suppressor of TF induction
- structure-based drug design of specific inhibitors for Factor VIIa/Tissue factor.
- TF induction in conjunction with TFPI suppression may be relevant for the increased frequency of myocardial infarction observed in cocaine consumers
- show that increasing the lipid surface area available to each TF:VIIa increases the apparent k(cat) and that it approaches a maximum asymptotically, exhibiting a K(1/2) at a 40 nm lipid radius; the binding parameters of Xa were determined
- Hypertensive individuals with carotid artherosclerosis had a significant increase in monocyte TF mRNA and activity levels compared with hypertensive individuals with no carotid lesions.
- the TF-1208 polymorphism is functional in that it regulates basal TF-mRNA in circulating monocytes and circulating microparticle-associated TF-procoagulant activity in vivo
- This and other proagulants are strongly atherogenic and therefore we suggest a mechanism for the involvement of Chlamydia pneumoniae in the onset and progression of vascular disease.
- Paclitaxel increases endothelial TF expression via its stabilizing effect on microtubules and selective activation of JNK
- Results indicate that proper positioning of the factor VII/VIIa binding site on tissue factor above the membrane surface is important for efficient rates of activation of factor X by this membrane-bound enzyme/cofactor complex.
- FVIIa not only decreased thromboplastin sensitivity to plasma FVII, it surprisingly increased sensitivity to plasma levels of FV, FX and prothrombin.
- formation of TF-FVIIa-FXa complex prevents apoptosis in breast cancer cells by a thrombin-independent pathway
- Induction of macrophage TF expression by VT-1 may play an important role in the acceleration of the coagulation-inflammation-thrombosis circuit during infections by VT-producing E. coli.
- Results suggest that soluble tissue factor might contribute to activation of the coagulation system in pancreatic cancer.
- the inhibiting effect of celecoxib on endothelial TF expression does not extend to vascular smooth muscle cells
- Data demonstrate that tissue factor-factor VIIa-mediated coagulation and cell signaling involve distinct cellular pools of tissue factor.
- Admission coagulation factor VII and tissue factor antigen levels, partially predicted by polymorphisms, are independent predictors of mortality and reinfarction in patients with acute myocardial infarction.
- Platelet-derived tissue factor contributes to the propagation and stabilization of a thrombus.
- High expression of tissue factor is associated with lymphatic metastasis and gastric cancer with intestinal phenotype
- The differential influence of TF is modified depending on the presence of other coagulation factors and ultimately acts as a deciding factor in the determination of cellular fate for vascular endothelial cells
- The intersubject variability of F3 mRNA production in monocytes and its relation with TLR4 was studied.
- atherosclerotic plaque tissue factor (TF) activity was higher in plaques from dyslipidemic patients than in non dyslipidemic ones.
- local changes in phospholipid bilayer composition modulate the activity of the factor VIIa.tissue factor complex
- review of properties of alternatively spliced tissue factor
- no pro-coagulant activity (FX activation, thrombin generation) of alternatively-spliced human tissue factor was observed on the surface, in lysates, and on microparticles from TF transfected cells.
- down-regulation of urokinase plasminogen activator in female low-tissue factor mice protects them from more severe cardiac fibrosis
- SAA induced TF mRNA in PBMC within 30 min and optimal procoagulant activity within 4 h through activation of NF-kappaB via the ERK1/2 and p38 MAPK pathways. SAA-induced TF was partially inhibited by high-density lipoprotein.
- monocyte-derived human dendritic cells stimulated with a P2X7 receptor (P2X7R) agonist undergo a large release of microparticles containing the membrane-bound form of tissue factor
- These results suggest that both Arg-200 and Lys-201 of TF interact with EGF-1 domain of factor X to facilitate the optimal docking of the substrate into the catalytic groove of the protease in the activation complex.
- The results suggest that estrogens may modulate T F expression and cytokine production by monocytes and may thus be involved, at least in part, in the pathophysiology of acute inflammatory processes associated with high estrogen levels.
- The association between TF and uPA/suPAR system is significantly related to the presence of cardiovascular disease in hemodialysis patients
- human platelets not only assemble the clotting reactions on their membrane, but also supply their own TF for thrombin generation in a timely and spatially circumscribed process
- roles of PAR1 and PAR2 and F7 in tissue factor mobilization and endocytosis
- 1alpha,25-(OH)2DHT(3) blocks TNF-induced monocytic tissue factor expression by inhibition of AP1 and NF-kappa B.
- Semen contains factor VII/tissue factor, reinforcing the concept of an active clotting system in semen.
- An inadequate tissue factor pathway inhibitor (TFPI) concentration as a result of elevated tissue factor (TF):tissue factor pathway inhibitor (TFPI) ratio characterizes patients with clinical manifestations of nephrotic syndrome and mild proteinuria.
- factor VIIa-tissue factor, PAR1 and PAR2 have roles in transcription in tumor cell lines
- The high levels of intravascular TF present in neonates (prior and after LPS-stimulation) might help to explain the clinically observed efficient clotting of cord blood despite low levels of procoagulatory factors.
- identification of TF as an important mediator of C5a-induced oxidative burst in neutrophils in antiphospholipid antibody-induced fetal injury provides a new target for therapy to prevent pregnancy loss
- Nuclear factor of activated T cells and early growth response 1 are required for tissue factor upregulation in response to vascular endothelial growth factor in endothelial cells.
- Leukemia patients showing parallel activation of the studied proteins trended to exhibit higher incidence of fatal outcome.
- Expression of tissue factor (TF) was increased in the pulmonary arterioles and plexiform-like lesions of the rats. TF was also heavily expressed in the vessels and plexiform lesions of humans with pulmonary arterial hypertension.
- review of cellular function of tissue factor: signal transduction, protein interactions
- most abundant n-3 FA, docosahexaenoate, increases the release of TF-exposing microparticles from endothelial cells, accounting for decreased endothelial cell TF surface exposure.
- tissue factor and thrombin signaling have roles in cancer progression [commentary]
- Histone deacetylase inhibitors transcriptionally inhibit agonist-induced tissue factor expression in endothelial cells and monocytes by a TF-kappaB- and HDAC3-dependent mechanism.
- proportion of TF-positive or both TF- and platelet antigen CD41a-positive leukocytes was increased markedly in pericardial blood obtained during CPB.
- Metabolism of endocannabinoids by the endothelial cell COX-2 coupled to the prostacyclin (PGI(2)) synthase activates the nuclear receptor peroxisomal proliferator-activated receptor delta, which negatively regulates the expression of tissue factor.
- the present data undermine the recently proposed hypothesis that PDI-mediated disulfide exchange plays a role in regulating TF procoagulant and cell signaling functions.
- PAR1 localization in the caveolin-enriched membrane microdomain, bound to caveolin-1, represents a crucial requirement for TF induction in endothelial cells.
- is elevated in patients with cancer
- Postdelivery increase in tissue factor-dependent activation of coagulation is likely to be a natural mechanism to prevent excessive blood loss during and after delivery, and may also increase risk of venous thromboembolism.
- Tissue factor expression contributes to tumor growth/regulating properties of CD133-positive tumor stem cells.
- Low concentrations of tissue factor increased endothelial cell proliferation and higher concentrations reduced cell proliferation/triggered apoptosis.
- A novel monocyte phenotype characterized by high TF/low CD36 presentation could be further developed for use as a marker for detection of individuals prone to developing prothrombotic conditions.
- tumor cell TF-PAR2 signaling is crucial for tumor growth
- TF antisense oligomer suppresses the synthesis of biologically active endothelial TF and antisense oligomers may represent a useful tool in the investigation of endothelial TF function/biology.
- Cisplatin induced the release of endothelial microparticles that showed TF-independent thrombin generation and procoagulant activity.
- Factor VIIa/tissue factor-dependent gene regulation has a role in pro-coagulant activity
- pinpoint monocytes as a major source of TF and provide solid experimental evidence for a direct transfer of TF protein from the monocytes to granulocytes in the blood
- decrease in frequency domains of resting heart rate variability would be associated with elevated plasma levels of interleukin (IL)-6 and soluble tissue factor (sTF)
- the activation of monocytes and blood platelets is accompanied by the elevation of monocytic Tissue Factor expression in advanced liver cirrhosis
- Tissue Factor/Activated Factor VII complex transactivates PDGFRbeta to regulate PDGF-BB-induced chemotaxis of monocytes and fibroblasts
- whole blood tissue factor procoagulant activity and plasma FVIIa in ten patients with type 2 diabetes mellitus and 11 non-diabetic patients at baseline and 6, 12, 24, and 48 hours (h) after presentation for acute stroke
- Replacing the 1st 2 exons of mouse TF with the complete human coding sequence under the control of the mouse promoter mediated normal hemostasis. There may be a threshold TF level for prenatal development & a critical level for maintaining hemostasis.
- 4 models of coagulation including minimally altered whole blood induced to clot by tissue factor (TF)
- alternative spliced TF expression promotes tumor growth, and is associated with increased tumor cell proliferation and angiogenesis in pancreatic cancer
- Na(+)/K(+)-ATPase is required for protein translation of endothelial tissue factor in culture.
- the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa is abolished by simvastatin, which induces apoptosis in human breast cancer cells in a NFkappaB-dependent manner
- data support the role of TF in angiogenesis and disease progression of prostate cancer
- Plasma Tissue Factor (TF) activity and percentage of TF-positive monocytes was signigficantly higher in hyperlipidemic diabetics and those with macrovascular complications
- Found significant differences in frequency at which tissue factor was found in the plasma of patients with coronary artery disease and acute coronary syndromes.
- Prothombinase/factor III induced clotting time was used to monitor heparinization during cardiopulmonary bypass.
- TF may have a role in chemotherapy resistance in human neuroblastoma and its progression, at lest in part, by regulating doxorubicin-induced ap
- Urotensin-induced expression of TF and of VCAM-1/ICAM-1 was mediated through the Rho A-activation of the transcription factor, NF-kappaB
- In acute coronary syndrome patients the greater expression of tissue factor in platelets and platelet-leukocyte aggregates strengthens the link between platelet activation, blood coagulation, and thrombus formation.
- phosphorylation of TF at Ser258 and to a lesser extent Ser253, plays an essential role in the protective influence of TF on immune evasion by tumour cells
- Leptin induced functional TF and increased TF mRNA and protein expression in both neutrophils and mononuclear leukocytes
- Levels of intra-alveolar TFPI in adult respiratory distress syndrome are not sufficient to block intra-alveolar TF procoagulant activity due to truncation and inactivation of intra-alveolar TFPI
- ASF/SF2 and SRp55 appear to interact with the variable TF exon 5 through exonic splicing enhancers at bases 39 and 87-117. Weakening of the above ESE modulates splicing of TF exon 5.
- Membrane-bound prothrombin fragment 1 is required to promote optimum Fva cofactor activity which in turn is translated by efficient initial cleavage of prothrombin by prothrombinase at Arg(320).
- P-selectin-PSGL-1-induces TF and IL8 expression through Lyn phosphorylation, and part of the inhibitory effect of IL10 depends on reduced phosphorylation
- Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects.
- results confirm that the procoagulant properties of bronchoalveolar lavage fluid (BALF) from Acute Respiratory Distress Syndrome patients are the result of TF induction & indicate that BALF neutrophils are a main source of TF in intra-alveolar fluid
- Viral myocarditis is a hypercoagulative state which is associated with increased myocardial TF expression and activity. Upregulation of TF contributes to a systemic activation of the coagulation cascade.
- Studies suggest that TF-FVIIa-FXa-mediated signaling modulates mTOR pathway activation, which regulates in part breast cancer cell migration.
- recombinant activated protein C-mediated up-regulation of IL-10 reduces TF in circulating monocytes
- in blood cells from patients with PV or ET, the presence of JAK2V617F mutation translates into activation of hemostasis, with increased expression of platelet-associated TF microparticles & formation of increased platelet/neutrophil aggregates.[review]
- Certain levels of TF are required for the maintained viability and growth of endothelium and TF-expressing tumor cells.
- no evidence for TF expression in high-purity preparations of immunologically isolated eosinophils
- Elevated levels of TF and TFPI in patients with peripheral arterial occlusive disease can be independent risk factor for atherosclerotic complications.
- Eosinophils are the cellular source of TF in chronic urticaria skin lesions.
- Case Report: Pulmonary tumor thrombotic microangiopathy caused by an ovarian cancer expressing tissue factor and vascular endothelial growth factor.
- identify ROS originating in mitochondria as key mediators of the signaling pathways triggered by PAR1 and PAR2 engagement in endothelial cells; mechanisms downstream from PAR1 and PAR2 activation, different for the two receptors, also induced TF
- Thrombin up-regulates TF activity in pleural mesothelial cells through the transcriptional activation of TF, whereas plasmin increases TF activity by inactivating the cell-associated TFPI by a limited proteolysis.
- Insulin inhibits TF expression in monocytes and monocyte-derived microparticles through interference with G(i)alpha(2)-mediated cAMP suppression, which attenuates Ca(2+)-mediated TF synthesis.
- heme induces TF expression by directly activating endothelial cells; the time-course of heme-mediated TF antigen expression paralleled the induction of procoagulant activity
- Report increased tissue factor-bearing leukocytes after off-pump coronary artery bypass surgery.
- Activation of clotting with less than 5 pmol/l of TF facilitates thrombin and fibrin generation at low, but not at supraphysiological rVIIa concentrations
- PPROM is associated with specific changes in the hemostatic/coagulation system.
- Maternal plasma concentrations of tissue factor were higher in pre-eclampsia than in normal pregnancy, but lower in those who delivered a small for gestational age neonate.
- Modulation of endothelial cell tissue factor and tissue factor pathway inhibitor-1 by neutrophil proteases.
- Data suggest that melagatran decreases tissue factor expression in platelet/monocyte heterotypic complexes.
- study shows binding uninhibited Factor VIIa affects segmental motions in sTF; decrease in Pro(79)-Pro(92)loop motions indicates loop entropy has a role in the thermodynamics of protein-protein interactions involved in allosteric control of VIIa activatio