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Validated All-in-One™ qPCR Primer for BDNF(NM_170732.4) Search again
Product ID:
HQP054238
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ANON2, BULN2
Gene Description:
brain derived neurotrophic factor
Target Gene Accession:
NM_170732.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq].
Gene References into function
- Mutation is associated with congenital central hypoventilation syndrome, suggesting the syndrome is genetic.
- Results support the involvement of NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome, implying neuroimmune and adipoimmune pathways in the pathobiology of these cardiovascular disorders.
- Platelets appear to bind, store and release BDNF upon activation at the site of traumatic injury to facilitate the repair of peripheral nerves or other tissues that contain TrkB.
- role in regulating surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons
- a candidate gene in stress and affective disorders
- BDNF as a potential risk allele associated with bipolar disorder
- The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study.
- that the BDNF C-270T polymorphism is a relevant risk factor for AD particularly in patients lacking the ApoE epsilon4 allele in this German sample.
- The gene expression of this protein was studied in the developing human tooth.
- BDNF mRNA levels in prefrontal cortex increase from infancy to adulthood, i.e. they are low during infancy and adolescence, peak during young adulthood, and are stable throughout adulthood and aging.
- BDNF modulates cytokine mRNA expression in immune cells. (BDNF)
- role for BDNF and its val/met polymorphism in human memory and hippocampal function; val/met mutation exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF
- Ovarian levels of this factor are present in follicular fluid from normally cycling women.
- Single base pair (bp) polymorphism at position 240 in non-coding region of BDNF gene and at position 480 within proBDNF sequence analyzed. Frequency of 240T allele found to be significantly increased in partial epilepsy patients.
- This review discusses the importance of BDNF/neurotrophic tyrosine kinase type 2 receptor signaling pathway interactions in memory processes.
- identified a functional cAMP-response element (CRE) in the BDNF gene promoter III and established that it participated in the modulation of BDNF expression in NT2/N neurons via downstream signaling from the D1 class of dopamine receptors.
- Thirty minutes of moderate exercise significantly induced BDNF production in multiple sclerosis patients and controls, but no differential effects are seen.
- mRNA for BDNF is detectable in PBMC. Levels in relapsing-remitting MS are increased by about 60% compared with patients with other neurological diseases or healthy subjects, suggesting a potentially neuroprotective facet of autoimmune inflammation.
- Sequence variants of the brain-derived neurotrophic factor gene are strongly associated with obsessive-compulsive disorder.
- Low BDNF levels may play a pivotal role in the pathophysiology of major depressive disorders and antidepressants may increase BDNF in depressed patients.
- reduction in BDNF in the prefrontal cortex of schizophrenics, and suggests that intrinsic cortical neurons, afferent neurons, and target neurons may receive less trophic support in this disorder.
- the BDNF Met66 variant may be a susceptibility factor to eating disorders, mainly to anorexia nervosa restricted type and low body mass index.
- The relationship of the BDNF val66met genotype and hippocampal activity during episodic memory processing using blood oxygenation level-dependent functional magnetic resonance imaging and a declarative memory task in healthy individuals was studied
- Data suggest that activation of bronchial eosinophils by neurotrophins (nerve growth factor, brain-derived neurotrophic factor, neurotrophins-3 and -4) might play a role in the regulation of eosinophilic inflammation in allergic asthma.
- Messenger RNA levels of BDNF and trk B were significantly reduced, independently and as a ratio to neuron-specific enolase, in both prefrontal cortex and hippocampus in suicide subjects, as compared with those in control subjects.
- Observed immunohistochemical differences in BDNF between schizophrenic and normal cases may indicate the existence of BDNF dysfunction in schizophrenic brain, and this dysfunction may be one of the factors involved in the pathogenesis of schizophrenia.
- We investigated a novel polymorphism of single nucleotide substitution (C270T) of the brain-derived neurotrophic factor (BDNF) gene in schizophrenia patients (n=101) and in controls (n=68).
- These results suggest that genetic variants of the BDNF gene may play a role in specific cognitive functions, but not in overall intelligence.
- A strong association between the APOE-epsilon4 polymorphism and late-onset Alzheimer's was observed, but there was no significant association between this BNDF polymorphism and affected patients.
- the current study does not demonstrate any significant difference in Val66Met BDNF genotype or allele frequencies between Alzheimer's disease patients and controls
- BDNF levels were progressively decreased by 1 Hz rTMS in healthy subjects; there was no effect of 1 Hz rTMS on BDNF plasma levels in ALS patients, an effect probably due to the loss of motor cortex pyramidal cells.
- Study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders.
- support for a role for BDNF in the susceptibility to aberrant eating behaviors
- Data indicate the possibility of linkage disequilibrium between the C270T variation and a mutation in coding region of the BDNF gene and suggest that this gene may play a role in the development of familial Parkinson's disease.
- In nigra, increased numbers of BDNF-IR and, less frequently, NT-3-IR ramified glia surrounded fragmented neurons
- Genetic factor other than BDNF is involved in the etiology of febrile seizures.
- The variation in the BDNF gene (val66met)affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.
- This review focuses on the role of BDNF expression and secretion related to the structural and functional changes of hippocampal synapses during late-phase long term potentiation, in the context of long-term memory.
- Monocytes, produce, store and release nerve growth factor, BDNF and neurotrophin 3
- The Brain-derived neurotrophic factor (BDNF) plays an important role in synaptic plasticity and rapidly recruits full-length TrkB (TrkB-FL) receptor into cholesterol-rich lipid rafts from nonraft regions of neuronal plasma membranes.
- This study did not provide evidence supporting an association between BDNF and COMT genes and declarative memory phenotypes.
- The val66met SNP showed significant association for valine with schizophrenia but not bipolar disorder (BP). Haplotype analysis of val/met SNP revealed highly significant underrepresentation of the met or met-1 haplotype in schizophrenia.
- Results did not find a significant association between the three BDNF SNPs studied and Alzheimer's disease when evaluated individually or with haplotype analysis.
- We investigated the involvement of signaling mediated by brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB in producing the altered GABA-related gene expression in schizophrenia.
- MM cells express TrkB, and respond to BDNF by activating MAPK and PI3K/Akt signaling cascades
- Alterations in BDNF gene is associated with anorexia nervosa and bulimia
- Enzyme inhibitors blocked the BDNF-induced effects on the epileptic GABA currents.
- Unstimulated human peripheral blood monocytes, but not lymphocytes, constitutively secrete brain-derived neurotrophic factor (BDNF).
- Val66met, a functional and abundant missense polymorphism in the coding region of the BDNF gene, was associated with variance in the volume of the hippocampal formation in 19 patients with first-episode schizophrenia.
- BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety.
- The BDNF Val66Met polymorphism has a gender specific influence on planning ability in Parkinson's disease.
- human scalp hair follicles are both a source and target of bioregulation by BDNF, which invites to target TrkB-mediated signaling for therapeutic hair growth modulation.
- BDNF essentially increased during the first 2 postnatal weeks in the hippocampus and hypothalamus, with no close correlation to its mRNA levels.
- The distribution of the 240 C/T polymorphism was significantly different between AD patients and controls.
- confirmation that the BDNF gene is the true susceptibility gene for eating disorders could lead to rapid therapeutic progress in treating these disorders--REVIEW
- BDNF polymorphisms are neither robust genetic risk factors nor determinants of BDNF protein levels in Alzheimer's disease
- There are two single nucleotide polymorphisms that are not associated with either anorexia nervosa or schizophrenia.
- No association between BDNF Val66Met polymorphism and genetic risk for schizophrenia in Chinese subjects. Significant relationship between BDNF genotype and logical memory.
- These results demonstrate that the reduction of BDNF occurs early in the course of AD and correlates with loss of cognitive function, suggesting that BDNF plays a role in synaptic loss and cellular dysfunction underlying cognitive impairment in AD.
- BDNF polymorphism is involved in the pathogenesis of attention deficit hyperactivity disorder.
- BDNF variants affect liability to juvenile-onset mood disorders, supported by data from two independent samples.
- In three case control studies Val66Met polymorphism is not associated with late onset Alzheimer's disease.
- A mechanism to understand the defect associated with variant BDNF and provide a framework two ligands for BDNF and NT-4.
- The BDNF may be a susceptibility gene for MDD and schizophrenia-in particular, in a subgroup of patients with schizophrenia with a lifetime history of depressive symptoms.
- BDNF plays some role in the neurotoxicity of methamphetamine
- The BDNF-Val66Met polymorphism: implications for susceptibility to multiple sclerosis and severity of disease.
- These results suggest that the BDNF GG genotype has a protection effect from AD development in females. The BDNF GG genotype may reduce the effect of APOEepsilon4 on AD risk in females.
- Interaction of the functional Val66Met polymorphism of the BDNF gene with DR# ser9gly polymorphism influencinf age at onset in schizophrenia.
- Genetic polymorphism (Val66Met) may contribute to substance abuse vulnerability.
- Results do not in favour an implication of BDNF in unipolar affective disorder.
- BDNF Val66Met allele increases risk for bipolar I disorder in patients of European descent.
- The significant association of BDNF variants with nicotine dependence (ND) implies that this gene plays a role in the etiology of ND in European-Americans and that the involvement of BDNF is gender specific
- BDNF plays role as anorexigenic factor in dorsal vagal complex. BDNF may constitute common downstream effector of leptin and CCK, possibly involved in their synergistic action.
- Tissue levels of BDNF have an important role in atherogenesis and plaque instability via the activation of NAD(P)H oxidase.
- The val allele of BDNF may be associated with predisposition to bipolar illness but in bipolar patients gives better performance on complex cognitive tests.
- Genetic polymorphism is not associated with obsessive-compulsive disorder.
- The BDNF valine66methionine (Val66Met) polymorphism is a relevant risk factor for geriatric depression.
- Homozygosity for a rare allele of the functional BDNF variant was associated with a 5.3-year older onset age for Parkinson disease, suggesting that BDNF may influence PD onset age.
- The Val66Met polymorphism of bdnf may impact on age-related changes of the brain, and genotype effects of the BDNF gene on brain morphology might differ in female from in male.
- Finding suggests that the investigated BDNF polymorphism plays an important role in the phenotype of schizophrenia, but not in the performance of tests of prefrontal cognitive functions analyzed in these patients.
- Human bronchial smooth muscle cells can express NGF, BDNF and NT-3. Expression may be differently regulated by inflammatory cytokines. Might have potential role in airway inflammation.
- The presence of the met-BDNF allele was found associated with a reduced volume of the hippocampal formation in healthy volunteers.
- This study provide in vivo evidence for a functional interaction between Mecp2 and Bdnf and demonstrate the physiological significance of altered BDNF expression/signaling in RTT disease progression.
- BDNF genotype was significantly associated with later life Raven scores, controlling for sex, age 11 MHT score and cohort. BDNF genotype was significantly associated with age 79 MHT score, controlling for sex and age 11 MHT score.
- There was a significant three-way interaction between BDNF(variant val66met) genotype, 5-HTTLPR, and maltreatment history in predicting depression.
- This study investigates the relationship between Val66Met polymorphisms of the BDNF gene and prefrontal cognitive function in 129 patients with schizophrenia and 111 patients with bipolar mood disorder.
- Our investigation indicates that the BDNF gene Val66Met polymorphism is related to the onset age of schizophrenia and the levels of clinical symptoms that remain after long-term antipsychotic treatment.
- Brain-derived neurotrophic factor Val66Met polymorphism might not greatly contribute to the efficacy of lithium in bipolar disorder.
- obsessive-compulsive disorder and Tourette syndromemay have distinct genetic risk factors related to BDNF polymorphism.
- The BDNF-linked complex polymorphic region is a functional variation that confers susceptibility to bipolar disorder and affects transcriptional activity of the BDNF gene.
- Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
- Results revealed the expression of BDNF mainly in oocytes and, in a minority of samples, also in the granulosa cells (GCs).
- These novel data demonstrate that neurotrophins influence ASM [Ca(2+)](i) and force regulation and suggest a potential role for neurotrophins in airway diseases.
- There was a nominally higher frequency of the G-712A G-allele and the G/G genotype in subjects with substance dependence than in controls.
- These findings suggest a possible relationship between Val66Met polymorphism and BMI in healthy adults.
- BDNF is likely to play roles not only in early growth but also in maintenance of neurons throughout life.
- A significant interaction effect between 'MS-status' and the BDNF genotype was found for GM volumes, with the result that patients carrying the BDNF Met-allele showed a higher risk of developing global GM atrophy than the homozygous Val/Val.
- BDNF gene variation may influence brain morphology.
- Results are consistent with previous studies pointing to a role for BDNF in susceptibility to mood disorders.
- Light and electron microscopy immunohistochemistry showed that tonsillar samples were positive for BDNF.
- levels of BDNF and beta-TG in blood of Alzheimers patients is decreased; BDNF and beta-TG are associated with degree of platelet activation
- Several strategies to decrease central BDNF activity that have potential use in the treatment of drug addiction are proposed. [REVIEW]
- BDNF V166M polymorphism is not associated with variation in working memory in healthy adolescents.
- In the human BDNF gene, resulting in a valine to methionine substitution in the prodomain (Val66Met), has been shown to lead to memory impairment and susceptibility to neuropsychiatric disorders.
- results support an association between the BDNF Val66Met polymorphism and sense of coherence such that study participants who were Met carriers were found to have an increased likelihood of a weaker sense of coherence
- No correlations between BDNF levels and clinical variables in autistic patients, but serum levels are lower in autistic patients compared with a control group.
- BDNF is a stress-responsive intercellular messenger modifying hypothalamic-pituitary-adrenocortical axis activity
- It is proposed that p11 may act through the tPA/plasminogen/BDNF pathway to achieve its antidepressant effect.
- These results suggest that the 196G/A SNP of the human BDNF gene does not contribute to the genetic susceptibility to BN and BED, but may predispose those patients to a more severe binge eating behavior.
- After correction for the predominant effect of the CAG expansion, no multiple regression model provided evidence of association between the BDNF Val66Met genotype and variation in HD age-at-onset.
- Zinc sulfate could be potential agent for the treatment of Rett syndrome through increasing central BDNF levels.
- The Val66Met BDNF polymorphism is associated with citalopram efficacy, with M-allele carriers responding better to citalopram treatment. Moreover, the Val66Met polymorphism was correlated with improvements in core, activity, and psychic anxiety symptoms.
- The role of BDNF in depression is discussed.
- In contrast to short duration aerobic exercise immediately after a following short duration high-intensity exercise to exhaustion, there is a transient augmentation of serum BDNF.
- role of two common BDNF variants (Val66Met, C270T) in two samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212)
- BDNF G196A polymorphism in part determines the antidepressant effect of both milnacipran and fluvoxamine.
- neither sequence variations in nor near the BDNF gene contribute significantly to the variance of age at onset in Huntington disease
- A de novo chromosomal inversion, 46,XX,inv(11)(p13p15.3) caused hyperphagia and severe obesity, impaired cognitive function, and hyperactivity in a young girl
- Decreased BDNF may be a pathogenetic factor involved not only in dementia and depression, but also in type 2 diabetes.
- Serum BDNF may be a useful marker of disease activity in atopic dermatitis. Both activated T helper type 2 (Th2) cells and eosinophils are major cellular sources of serum BDNF.
- Single nucleotide polymorphisms are not associated with aggression in childhood and adolescence.
- The sexual abuse scale were negatively associated with memory performance. Furthermore, the low-activity Met allele of the brain-derived neurotrophic factor (BDNF) gene interacted with sexual abuse scores to result in reduced memory test performance.
- Two exons within BDNF represent potential functional variants that may be causing the observed associations of this protein with attention deficit with hyperactivity.
- The study confirms the association of Val66Met to substance-related disorders, eating disorders, and schizophrenia.
- We did not find support for an involvement of the Val66 allele of the Val66Met polymorphism of BDNF in the pathogenesis of ADHD
- The BDNF val66met polymorphism may modify the association between stroke and depression.
- In conclusion, our results do not provide statistically significant evidence that common genetic variability in BDNF would associate with the risk for PD in the Caucasian populations studied here.
- The better functioning val66val allele of BDNF appears to be associated with an increased risk for bipolar disorder and perhaps early onset or rapid cycling. [REVIEW]
- results do not support a significant role for the BDNF Val66Met polymorphism in the development of schizophrenia in Asian populations (Review; Meta-analysis)
- SNPs in BDNF gene showed no statistical significance in bipolar disorder.
- population-based study and meta-analysis demonstrate that the BDNF C-270T and Val66Met polymorphisms do not play major roles in the susceptibility to schizophrenia in either Caucasian or Asian populations
- Two SNPs are found between exons VI and VII, while the Val66Met polymorphism is located in the coding exon VIII; the total distance for the three SNPs is 14308 base pairs in Alzheimer disease.
- Results suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system.
- our data provide no support for association in this large OCD patient sample and point toward the need to examine other genes as candidates for risk determinants in OCD.
- Altered BDNF levels modulated by BDNF gene variability are associated with the susceptibility to eating disorders, providing physiological evidence that BDNF plays a role in the development of anorexia nervosa and bulemia nervosa.
- The results of this study support the notion that allelic variation at the BDNF locus--in interaction with other gene variants--influences anxiety- and depression-related personality traits.
- The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.
- findings suggest that Met-BDNF allele carriers may be at risk of developing smaller hippocampal volumes and might be susceptible to developing major depression
- A weak evidence of association between C270T polymorphism and schizophrenia whereas there was no evidence of association for G196A polymorphism.
- No association between the Val66Met polymorphism and schizophrenia or bipolar disorder, according to a meta-analysis.
- BDNF-mediated induction of tissue-type plasminogen activator (t-PA) transcription relies on conserved modular promoter elements, including a novel upstream BDNF-responsive domain as well as the proximal t-PA gene promoter.
- This study examines whether BDNF V66M (c.196 G --> A) or NR4A2 IVS6 +18insG polymorphism is associated with the risk of Taiwanese Parkinson's disease and the age of onset using a case-control study.
- These results in vivo confirm that the huntingtin mutation causes BDNF production to decline and show that the BDNF deficiency is detectable in Huntington's disease patients' sera.
- BDNF -270 C/T polymorphism may influence the personality trait associated with higher risk of anorexia nervosa.
- Significant interactions of SLEs with both 5-HTTLPR and BDNF genotypes were observed on risk of depression after adjustment for age, gender, education, and disability. A significant three-way interaction between 5-HTTLPR, BDNF, and SLEs was also found.
- BDNF genetic polymorphisms were not associated with mood disorders, but did influence antidepressant treatment outcome.
- Polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in major depressive patients
- Relationship between histone H4 modification, epigenetic regulation of BDNF gene expression, and long-term memory for extinction of conditioned fear.
- brain derived neurotrophic factor Met allele(s) moderated the effect of early adversity on depressive symptoms (two-way interaction)
- a relationship between the BDNF gene and asthma and male gender of asthmatic children.
- Our data, though indirectly, suggest that there is no significant increase in endogenous extracellular BDNF after a stroke in humans.
- Molecular genetic analysis of COMT, PRODH and BDNF genes showed no significant effects of any variants on schizotypal components or factors of SPQ after correction for multiple testing.
- This article presents findings of higher NGF and BDNF levels correlated to increased glutamate levels in the CSF of both chronic migraine and fibromyalgia patients.
- Transgenic overexpression of BDNF accelerates the laminar refinement of ganglion cell dendrites.
- Valine/methionine amino acid substitution may be involged in the susceptibility to anorexia nervosa in Polish Caucasians.
- meta-analysis of case-control association studies between the C270T polymorphism of BDNF and schizophrenia; the results of the meta-analysis indicated that the allele may not confer susceptibility to schizophrenia
- BDNF and antiBDNF transcripts form dsRNA duplexes in the brain in vivo, suggesting an important role for antiBDNF in regulating BDNF expression in human
- Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans.
- Single nucleotide polymorphism of brain-derived neurotrophic factor had no significant associations in multiple sclerosis
- Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population.
- The C270T polymorophism of the BDNF may not be involved in susceptibility to schizophrenia in Chinese Han population.
- Genetically influenced variation in BDNF function plays a role in recovery from subarachnoid hemorrhage
- In the autism cases, mean BDNF levels were lower in children 0-9 years old compared to teenagers or adults, or to age-matched healthy controls, indicating a delayed BDNF increase with development.
- We present novel data that BDNF is downregulated in lesional mast cells in atopic dermatitis.
- IL-7 is an important factor in the development of GVHD, presumably by supporting the survival, proliferation, and possibly activation of alloreactive donor-derived T cells in the recipients.
- Men with Val allele in the BDNF gene have an increased risk for smoking in the Han Chinese population with schizophrenia.
- Maline-66-methionine substitution may modulate the effect of childhood sexual abuse on the violence of suicide behavior in adulthood.
- We used a linkage disequilibrium (LD)-mapping approach to investigate the role that BDNF and its specific receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) may play in increasing susceptibility to OCD.
- bipolar disorder met-carriers of BDNF have abnormal energy metabolism in the left dorsolateral prefrontal cortex
- the BDNF/TrkB signaling pathway could be involved, at least in part, in multiple myeloma-induced angiogenesis
- a relationship between the BDNF Val66Met genotype and the ages of first psychiatric hospitalization and first schizophrenia symptoms
- Temporal grey matter reductions in bipolar disorder are associated with the BDNF Val66Met polymorphism.
- Met66 allele carriers have almost double the odds of having geriatric depression than do Val66 allele homozygotes
- Brain-derived neurotropic factor gene polymorphism is not associated with attention deficit hyperactivity disorder
- the genetic risk of developing depression does not translate directly into whole blood BDNF levels; in females who are genetically disposed for depression and subjected to recent stressful life events whole blood BDNF levels are lower
- Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression.
- in the mothers with adult-onset depression the Val/Met genotype was associated with more depressive symptoms, and rumination again mediated the relationship between genotype and depression.
- Our results support initial findings that the BDNF Met allele is associated with reduced cognitive functioning.
- variation in the BDNF gene may be a risk factor for weight gain in male patients with schizophrenia on long-term antipsychotic treatment, and decreased BDNF levels may be associated with weight gain in females.
- BDNF plays a prominent role in memory subprocesses thought to engage the medial temporal lobe
- Multiple variants of BDNF gene not influence age-at-onset of schizophrenia.
- BDNF(Met) variant may be one of several factors affecting progressive brain volume changes in schizophrenia.
- Ttis review focuses on recent advances in the understanding of the regulation of the glutamatergic synapse by BDNF, and its implications in synaptic plasticity--REVIEW
- C270T and G196A BDNF polymorphisms may affect susceptibility to and onset of multiple sclerosis.
- results suggest that BDNF G196A gene polymorphism is associated with a susceptibility to a suicide history in schizophrenia patients in the Taiwanese population
- Results showed a short-term, significant increase in serum BDNF levels after exercise. This supports the need for larger sample size in studies on BDNF changes in psychiatric disorders or psychiatric drug effects.
- neurotrophins (NT)and high affinity NT receptor proteins were more abundantly expressed in idiopatic pulmonary fibrosis/usual interstitial pneumoniae than non specific pneumonia and respiratory bronchiolitis-associated interstitial lung disease patients
- NTRK2 gene that encodes the BDNF receptor, TRKB, was overexpressed in MeCP2 deficient human and mouse brains either directly or as an attempt to compensate for BDNF deficiency
- involvement of BDNF is a factor to be taken into account in the response to methadone maintenance in opioid addiction
- N-terminal Vps10p domain of sortilin, which is responsible for the interaction with the neurotrophins, adopts a beta-propeller fold, and that the N-terminal regions of sortilin, pro-NGF and pro-BDNF are mainly intrinsically disordered regions
- BDNF genotype does not exert a major influence on the development of depression.
- The study demonstrates that the BDNF C-270T and Val66Met polymorphisms are unlikely to contribute to the genetic predisposition to BPD and Val66Met may be associated with susceptibility to the early age of onset subset of the disorder.
- The functional genetic variant of BDNF (BDNF-G196A) played no significant role in normal cognitive ageing.
- Mania is probably associated with hypoactivity of central BDNF.
- Review provides future perspective on BDNF/TrkB signaling as a novel molecular target to correct the pathogenesis of schizophrenia and improve its long-term clinical outcome by treatments with conventional and adjunctive drugs.
- The BDNF Met66 allele is associated with greater white matter hyperintensity volumes in older individuals which may correlate with late-life depression.
- Allelic and haplotype association was found between both BDNF and adult ADHD, and LIN-7 and adult ADHD.
- Plasmin (but not related proteases) is a specific and efficient activator of pro-BDNF.
- BDNF mRNA expression in microdissections of non-preganglionic Edinger-Westphal nucleus was 3.36 times lower in male suicide victims, but 5.27 times higher in female victims, compared with controls.
- Biologic epistasis between SLC6A4 and BDNF in the human brain by identifying a neural mechanism linking signaling on the neural systems level and having implications for treatment planning in depression.
- BDNF levels correlated with risk factors for metabolic syndrome and were elevated in individuals with high metabolic risk
- the Met66 allele was associated with lower levels of subjective social support and a trend for fewer social interactions
- In the female type 2 diabetic patients, BDNF is positively related to immunoreactive insulin.
- findings suggest that BDNF plays an important role in the susceptibility to schizophrenia and that the (GT)n repeat polymorphism of the BDNF gene may be an independent contributor to the chlorpromazine treatment-sensitive form of schizophrenia
- Early onset of seizures is linked to the combined MECP2 and BDNF genotypes. The BDNF Met66 allele may protect against seizures, whereas missense mutations in the MBD of MECP2 are more frequently associated with early seizures.
- p35 and Bcl2 up-regulation contribute to BDNF-stimulated neural differentiation and to the survival of differentiated cells.
- Amyloid precursor protein-overexpressing mice show a genotype-dependent increase of cortical BDNF that is highly correlated with amyloid concentrations, which may reflect an amyloid-related glia-derived secretion or altered axonal transport.
- involvement of polymorphisms in repetitive transcranimal magentic stimulation antidepressant response in depression
- The combination of the A1 allele with a Met BDNF allele was associated with lower scores of voluntary attention and higher scores of involuntary attention.
- The effect of gene-gene interaction between the DRD3 and BDNF variations on brain morphology in midline and medial temporal lobe structures, but do not support its specific role in the pathogenesis of schizophrenia.
- In a case-control study approach, the functional Val66MET polymorphism (rs6265) of the BDNF gene was investigated in 265 migraine patients and 153 controls. Genotype and allele frequencies did not differ between healthy subjects and migraineurs
- Relevant BDNF gene variation(s) may act as risk factors for bipolar disorder susceptibility[REVIEW]
- Altered BDNF signalling may contribute to intermediate phenotypes associated with schizophrenia.[RERVIEW]
- mRNA encodes brain derived neurotrophic factor (BDNF), plays a critical role in learning and memory, and which displays abnormal levels in several neuropsychiatric disorders.[REVIEW]
- A genetic variant BDNF may play a key role in genetic predispositions to anxiety and depressive disorders. [REVIEW]
- fMRI measurements revealed a significantly negative correlation between the dose of Met-BDNF allele and encoding related brain activity in the bilateral hippocampi and right parahippocampal gyrus.
- Semantic verbal fluency has been associated with the BDNF Val66Met polymorphism in schizophrenia
- Data show that the confounding variables as cortical grey matter volume are associated a functional polymorphism in the targeting region of BDNF gene.
- Data show that the patients who are BDNF met/met x COMT L carriers have more delusional symptoms and poorer cognitive flexibility.
- Depressed patients who carried the BDNF Val66Met polymorphism variant (GA + AA) appeared to show a significantly increased risk of suicidal behaviour.
- A link between smoking and the brain derived neurotrophic factor Val66Met polymorphism could not be found
- BDNF polymorphism does not play a major role in the susceptibility to tardive dyskinesia in schizophrenic patients
- These data do not support a role for genomic imprinting as a modifier of the contribution of BDNF gene to risk of susceptibility to BD.
- stress and altered BDNF may represent a major vulnerability factor in teenage suicidal behaviour
- Effect of BDNF val66met polymorphism on age-related amygdala volume changes in healthy subjects.
- Polymorphisms in the BDNF gene may be associated with variation in frontal lobe morphology.
- MiR-30 family are involved in the BDNF gene expression during late maturation and aging of human prefrontal cortex.
- The presence of brain-derived neurotrophic factor (BDNF) and its receptor in the human intervertebral disc is shown at the translational level in cultured human annulus cells.
- Met-allele carriers of the BDNF (val66met) polymorphism had smaller hippocampal volumes in both patients and healthy controls when compared with homozygous val-allele carriers.
- These results suggest that BDNF G196A as well as 5HTT-LPR polymorphisms confer risk for SB in BD, but we did not observe any evidence for an interaction between them.
- We determined the gene expression of BDNF in lymphocytes obtained from 26 PBD subjects during a drug-free baseline period and during the eighth week of treatment (n = 19) and from 21 medication-free normal control subjects.
- The val66Met polymorphism of BDNF is associated with the obesity in a Belgian cohort study of 532 obese women.
- This study did not show a significant correlation between the BDNF Val66Met polymorphism and age of onset, risk factors, duration or recurrence of TGA.
- study found that hippocampus volumes were significantly smaller in bipolar disorder (BD) compared to healthy subjects, and presence of the BDNF met allele was associated with smaller hippocampus volume in both groups
- Plasma BDNF is a biomarker of impaired memory and general cognitive function in ageing women
- in mature B cell lines, an autocrine BDNF production is up-regulated by stress culture conditions and exerts a modulation of apoptosis through the sortilin pathway
- Both the annulus fibrosus and nucleus pulposus cells of the intervertebral disc (IVD) express the neurotrophins NGF and BDNF, factors that may influence and enhance innervation and pain in the degenerate IVD.
- BDNF levels are associated with clinical changes in depression
- Among persons with the WAGR syndrome, BDNF haploinsufficiency is associated with lower levels of serum BDNF and with childhood-onset obesity; thus, BDNF may be important for energy homeostasis in humans.
- BDNF (brain-derived neurotrophic factor) was stored in chromogranin A-containing secretory granules of neuroendocrine cells of the nasal mucose, and was secreted in a polarised manner
- support the concept of rhythmic variation in plasma BDNF regulation that seems to be sex-related
- The results suggest that BDNF gene variation participates in regulation of norepinephrine turnover rates in the central nervous system of human subjects.
- results do not support an association between BDNF Val66Met and anxiety, depression, or neuroticisim
- Nerve-growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels are potential biomarkers for lymphocyte activation in primary Sjogren's syndrome patients.
- The BDNF Val66Met polymorphism modulates human motor cortical plasticity and the response to repetitive transcranial magnetic stimulation.
- Association between the Val66Met polymorphism of brain-derived neurotrophic factor gene and schizophrenia in Russians
- BDNF gene influences time to onset of levodopa-induced dyskinesia in Parkinson disease.
- NT-4/5, as well as BDNF and NGF, is suggested to play a role in the regulation of function of periodontal ligament cells.
- Offspring at high risk for alcohol dependence showed decreased right/left orbitofrontal cortex volumes; smaller volume in the right hemisphere was significantly associated with variation in the BDNF gene.
- link between BDNF Val66Met polymorphism and CAD
- exploratory analysis was performed to test for an association of the SNPs in BDNF and the phenotypes of rapid cycling and episode frequency
- The Val66Met polymorphism has been associated with a predisposition to mood disorders and schizophrenia and with therapeutic response to mood stabilizers, antidepressants and antipsychotics(review).
- Data show that three isoforms of BDNF, alternatively spliced and located in the second exon cluster, are essential for neuroblastoma cell survival under cytotoxic stress.
- study confirms increased level of peripheral BDNF in Relapsing-Remitting Multiple Sclerosis (RRMS), even during the inactive phase of the disease; it also underscores the potential role of the Val66Met polymorphism on peripheral BDNF expression in RRMS
- neuroprotective role of BDNF in psychiatric disorders which are characterized with prominent neuronal cell death [review]