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Validated All-in-One™ qPCR Primer for ETV4(NM_001986.2) Search again
Product ID:
HQP053982
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
E1A-F, E1AF, PEA3, PEAS3
Gene Description:
ETS variant transcription factor 4
Target Gene Accession:
NM_001986.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- PEA3 has a central role in tumor progression in ovarian carcinoma
- No association of E1AF levels with HER2/neu mRNA levels, hormone receptor status, histological grade, tumor size, lymph node involvement or prognosis was found.
- role in ovarian and breast malignancies and suggests that it may be target for therapeutic intervention
- PEA3, by its capacity to up-regulate the epithelial marker MUC4 and to down-regulate the ErbB-2 oncogene, appears as a key regulator of the differentiation/proliferation balance in pancreatic cancer cells.
- E1AF has an essential role in the activation of the human GalT I gene in highly metastatic lung cancer cells
- E1AF was modified by ubiquitin through the C-terminal region and ubiquitinated E1AF aggregated in nuclear dots, and the inhibition of proteasome-activated transcription from E1AF target promoters
- important role in the early stage of colorectal carcinogenesis
- E1AF positively regulates transcription from MT1-MMP genes, which plays an important role in invasion and metastasis of squamous cell carcinoma of the tongue by converting pro-MMP-2 into active-MMP-2
- results suggest E1A-F is overexpressed in early stages of human CRC development and may be an important factor in the overexpression of COX-2 and MMP-7
- The ETV4 protein was localised to nuclei of spermatogonia and revealed an intense staining in seminoma cells.
- E1AF is a housekeeping gene, whose expression is controlled in specific tissues.
- Overexpression of ETV4 is identified in 2 of 98 cases of prostate cancer.
- These results provide evidence for the antitumor activity of PEA3 in human breast cancers.
- These data suggest that ETV4 and Myeov may provide novel targets for therapeutic intervention.
- By manipulating LPP levels, we show that it acts to upregulate the transactivation capacity of PEA3.
- PEA3 expression is not correlated with HER-2/neu expression in breast cancer tumor tissues
- PEA3 and c-Jun stimulate synergistically the HER2/neu gene transcription with p300
- PEA3 stabilization due to LKB1 inactivation could lead to epithelial/mesenchymal transition and greater lung cancer invasion potential.
- Overexpression of PEA3 is associated with breast tumour progression
- E1AF increases cell cycle progression via upregulation of Cyclin D3 transcription, which elicits a new mechanism of breast cancer growth and a new mechanism of Cyclin D3 transcription.
- These results suggest that PEA3 is regulated by EGFR and that the elevated PEA3 expression detected in human ovarian cancer may divert cells to a more invasive phenotype by regulating MMP-9 and MMP-14.
- Our results indicate that PIASy negatively regulates E1AF-mediated transcription by both E1AF sumoylation in a dependent and independent fashion.
- This report describes a new mechanism of glioma invasion involving a cooperative effort between E1AF and Sp1 transcription factors.
- E1AF plays a crucial role in the invasion and metastasis of malignant melanoma through up-regulating the MT1-MMP expression
- The two novel ETV4 fusion partners possess as predominant common characteristics androgen-induction and prostate-specific expression.
- Detection of ETS fusion gene by RT-PCR is feasible on formalin-fixed and paraffin-embedded samples.
- E1AF overexpression markedly enhanced mithramycin A-induced Huh-7 cell apoptosis and the expression of pro-apoptotic protein Bax depending on its DNA-binding domain.
- E1AF is correlated significantly with tumor progression of human rectal cancer and may be an important factor in rectal cancer progression.
- SRC-3/AIB1 directly regulates transcription of matrix metalloproteinase (MMP)-2 and MMP-13 through its coactivation of AP-1 and PEA3.
- In 560 human breast tumors, AIB1 expression was found to be positively associated with PEA3, MMP2, and MMP9.
- activation of E1AF provides a means for E2F1 to induce cell apoptosis in response to DNA damage
- A ubiquitously expressed, androgen-insensitive gene, DDX5, fused in frame with ETV4, leading to the expression of a DDX5-ETV4 fusion protein was identified in prostate cancer.