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Validated All-in-One™ qPCR Primer for MTA1(NM_004689.3) Search again
Product ID:
HQP022096
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
-
Gene Description:
metastasis associated 1
Target Gene Accession:
NM_004689.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues.
Gene References into function
- expression is closely related to invasiveness and metastasis in non-small-cell lung carcinoma
- metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes
- naturally occurring short form that contains a previously unknown sequence of 33 amino acids with an ER-binding motif, Leu-Arg-Ile-Leu-Leu (LRILL); MTA1s localizes in the cytoplasm, sequesters ER in the cytoplasm, and enhances non-genomic responses of ER
- MTA1 binds to the MMP-9 promoter, thereby repressing expression of this type IV collagenase via histone-dependent and independent mechanisms
- interaction with MAT1 and regulation of estrogen receptor transactivation functions
- The results suggest that the MTA1 protein may serve multiple functions in cellular signaling, chromosome remodeling and transcription processes that are important in the progression, invasion and growth of metastatic epithelial cells.
- High expression of the MTA1 gene is associated with hepatocellular carcinoma
- MTA1 and MTA2 repress transcription specifically, are located in the nucleus, and contain associated histone deacetylase activity; MTA1 associates with a different set of transcription factors from MTA2
- enhanced expression of MTA1 promotes the acquisition of an invasive, metastatic phenotype, and thus enhances the malignancy of pancreatic adenocarcinoma cells by modulation of the cytoskeleton
- This study identified an association of MTA1 expression and prostate cancer progression.
- MTA1s interacts with CKI-gamma2 in vitro and in vivo and colocalizes in the cytoplasm
- overexpression of MTA1 protein and acetylation level of histone H4 protein are closely related
- Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator
- MTA1 is one of the first downstream targets of c-MYC function that are essential for the transformation potential of c-MYC.
- MTA1 overexpression is associated with high recurrence of breast cancer
- role for MTA1-BCAS3 pathway in promoting cancerous phenotypes in breast tumor cells
- structure and antiestrogenic activity of the unique C-terminal, NR-box motif-containing region of MTA1
- These studies demonstrate that MTA1 is expressed in both benign and malignant neoplasms. While its expression is associated with tissue invasion it may not be sufficient for the progression of neoplasms to metastatic stages.
- BCAS3 overexpression in hormone receptor-positive premenopausal breast cancer seemed to be associated with impaired responses to tamoxifen
- MTA1 enhances angiogenesis by stabilization of the HIF-1alpha protein, which is closely related to the increased metastatic potential of cancer cells with high MTA1 expression
- role for the MTA1 as an upstream modifier of Six3 and indicate that Six3 is a direct stimulator of rhodopsin expression.
- Results suggest that MTA1 promotes the metastatic ability of B16F10 cancer cells.
- These findings strongly implicate MTA1 in the transcriptional repression of BRCA1 leading to abnormal centrosome number and chromosomal instability.
- study shows HSF1 binds to MTA1 in vitro & in breast carcinoma; repression of estrogen-dependent transcription may contribute to role of HSF1 in cancer
- MTA1 expression was significantly higher in noninvasive breast cancer cell lines than in invasive ones.
- MTA1 is closely associated with microvascular invasion, frequent postoperative recurrence, and poor survival of HCC patients, especially in those with HBV-associated HCC.
- HIF-1alpha expression may be regulated through HDAC1/MTA1, which is associated with a poor prognosis for pancreatic carcinoma
- Histologically, MTA1 protein production was strongly associated with cancer cell invasion, and clinically there was a correlation between lymph node metastasis and MTA1 protein production.
- MTA1 is up-regulated in advanced ovarian cancer, represses ERbeta, and enhances expression of GRO.
- This study was undertaken to explore the potential role of MTA1 in mouse liver.