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Validated All-in-One™ qPCR Primer for IQGAP1(NM_003870.3) Search again
Product ID:
HQP021588
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HUMORFA01, SAR1, p195
Gene Description:
IQ motif containing GTPase activating protein 1
Target Gene Accession:
NM_003870.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.
Gene References into function
- IQGAP1 enhances the function of beta-catenin in the nucleus and that calmodulin regulates this stimulation
- The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium/calmodulin
- IQGAP1 has a crucial role in transducing Cdc42 signaling to the cytoskeleton
- IQGAP1 is a potential target protein of S100B during processes of dynamic rearrangement of cell membrane morphology
- interaction of calmodulin with IQ motifs
- Identification and characterization of the Cdc42-binding site of IQGAP1.
- IQGAP1 has a fundamental role in cell motility and invasion
- Data suggest that cyclic AMP/protein kinase A may be coupled with calcium/calmodulin and guanosine triphosphatases through an IQGAP1/AKAP79 complex.
- Rac1 enhances the accumulation of actin filaments, E-cadherin, and beta-catenin by acting on IQGAP1.
- IQGAP1 binds ERK2 and modulates its activity
- IQGAP1 functions as a VEGFR2-associated scaffold protein to organize ROS-dependent VEGF signaling, thus promoting EC migration & proliferation, which may contribute to repair & maintenance of the functional integrity of established blood vessels.
- differential requirement for efficient GTP hydrolysis by the Sar1p GTPase in export of cargo from the endoplasmic reticulum
- IQGAP1 might serve as an effector or sequester nucleotide-free Cdc42 to prevent signaling
- We therefore propose that PP2A, especially PP2A-A, functions to maintain F-actin assembly to which beta1 integrin is anchored by recruitment of IQGAP1 to Rac-beta1 integrin.
- IQGAP1 is expressed in podocytes at significant levels, and could be found at the immediate vicinity of the slit diaphragm
- Data show that IQGAP1 is phosphorylated at multiple sites in intact cells and that phosphorylation of IQGAP1 will alter its ability to regulate the cytoskeleton of neuronal cells.
- a specific sequence of IQGAP1 is necessary for its oligomerization; self-association is required for the normal cellular function of IQGAP1
- IQGAP1 interacts directly with MEK1 and MEK2 kinases.
- IQGAP1 may function to link Nox2 to actin at the leading edge, thereby facilitating reactive oxygen species production at the site of injury, which may contribute to endothelial cell migration
- GluR4 may regulate its synaptic targeting through phosphorylation-dependent interactions with alpha-Actinin-1 and IQGAP1
- We therefore propose that PP2A plays a crucial role in the maintenance of cell-cell adhesion through recruitment of IQGAP1 to the Rac-bound E-cadherin-catenins complex.
- PTPmu may regulate Rho-GTPase-dependent functions of IQGAP1
- Findings suggest the involvement of IQGAP1 in the progression and spread of ovarian adenocarcinomas.
- IQGAP1 represents a potential target for the design of new organ preservation strategies and prevention of Ischemia-reperfusion injury to improve transplantation outcome.
- signal-induced relief of the autoinhibited fold of IQGAP1 allows activation of N-WASP to stimulate Arp2/3-dependent actin assembly
- in motile cells beta-catenin is recruited by IQGAP1 and N-cadherin to active membrane ruffles, wherein beta-catenin mediates the internalization and possible recycling of the membrane-associated proteins N-cadherin and APC
- IQGAP1 may link the calmodulin and Rap1 signaling pathways
- These data suggest that IQGAP1 serves as a junction to integrate multiple signalling molecules to facilitate cell migration.
- IQGAP1 modulates activation of B-Raf.
- DIA1 and IQGAP1 interact in cell migration and phagocytic cup formation.
- IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1, and Cdc42
- that ALIX and TSG101/ESCRT-I also bind a series of proteins involved in cytokinesis, including CEP55, CD2AP, ROCK1, and IQGAP1.
- IQGAP1 enhances mammary tumorigenesis, suggesting that it may be a target for therapeutic intervention.
- The exocyst subunits Sec3 and Sec8 interact with the polarity protein IQGAP1 and that this interaction is triggered by active Cdc42 and RhoA, which are essential for matrix degradation.
- the scaffold protein IQGAP1 couples Ca(2+) and calmodulin signaling to B-Raf function
- IQGAP1 promotes cell proliferation and phosphorylation of IQGAP1 is involved in the process of wound closure in bronchial epithelial cells.
- Only the first IQ motif interacts with Mlc1sa. The first and second IQ motifs interact with S100B in the presence of calcium ions.
- IQGAP1, Ca(2+), and calmodulin are a novel signaling complex regulating actin pedestal formation by EPEC
- IQGAP1 expression level seemed to be closely associated with the enhanced invasion and migration in ovarian cancer cell lines.
- Data suggest that ARF6-mediated Rac1 activation is essential for glioma cell invasion via a signaling pathway that requires IQGAP1.