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Validated All-in-One™ qPCR Primer for RAB11A(NM_004663.4) Search again
Product ID:
HQP021523
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
YL8
Gene Description:
RAB11A, member RAS oncogene family
Target Gene Accession:
NM_004663.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. [provided by RefSeq].
Gene References into function
- mutation impairs a specific subset of Rab11 interactions, possibly those involved in cytoskeleton-based movements driving the slow recycling pathway
- Rab11a, RPL7, and RPL28 showed moderate levels of differential expression in esophageal squamous cell carcinoma
- there is a pivotal role for rab11 in regulating the traffic of a G protein-coupled receptor at the level of the recycling endosome
- an interaction between Rab11 and TPbeta directs TPbeta recycling
- Data suggest that polarization of hepatocytes requires recruitment of rab11a and myosin Vb to intracellular membranes that contain apical ABC transporters and transcytotic markers.
- We conclude that the glutamine residue of Rab11a at position 70 is not strictly essential for GTPase activity of this protein in contrast to Ras and other Rab proteins.
- Results describe the distinct C-terminal binding regions of FIP3 and FIP4 for Rab11 and ARF5/ARF6, and the crystal structure of Rab11 in complex with the Rab11-binding domain (RBD) of FIP3.
- Rab 11 and Arf6 function synergistically in the switch from furrowing to abscission, as well as in the terminal stage of abscission
- CaR is constitutively endocytosed and recycled to the plasma membrane by a Rab11a-dependent mechanism.
- myosin Vb is required for CFTR recycling in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells
- Rab11 plays a role in the intracellular trafficking of various types of LG-molecule from the TGN to the cell surface
- These results show that Rab11A and Langerin are required for BG biogenesis, and they illustrate the role played by a Rab GTPase in the formation of a specialized subcompartment within the endocytic-recycling system.
- These data therefore show that (i) Rab11a regulates cell surface abundance of both GLUT4 and FAT/CD36.
- Both phosphorylated and nonphosphorylated MOR internalize via Rab5-dependent pathway after agonist stimulation, and the phosphorylated and nonphosphorylated MORs recycle through distinct vesicular trafficking pathways mediated by Rab4 and Rab11.
- endosomal activation of the PI3K/AKT signaling pathway in response to Gbetagamma trafficking, via its interaction with Rab11, is a relevant step in the mechanism controlling cell survival and proliferation
- Rab11a was expressed in umbrella cells (but not Rab11b or Rab25) and was associated with discoidal/fusiform vesicles, which were dependent on the activity of the Rab11a GTPase for exocytosis.
- Both rab11a and HSP90 appear to be involved in the process of exocytosis of internalized extracellular alpha-synuclein.