|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for TP63(NM_003722.4) Search again
Product ID:
HQP021361
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L
Gene Description:
tumor protein p63
Target Gene Accession:
NM_003722.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
|
|
| A | B |
|
Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
|
Summary
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq].
Gene References into function
- Free p63 core domain did not show specific binding to p53 DNA consensus sites.
- Expression in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders
- TP63 tumor protein 63 kDa with strong homology to p53
- Split-hand/split-foot malformation with paternal missense mutation in the p63 gene
- p63 expression profiles in human normal and tumor tissues.
- Review: Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans
- inhibition by p53 mutants
- p63 and p73 expression may represent an early event in head and neck squamous carcinoma tumorigenesis and may function as oncogenes in the development of these tumors.
- The distribution of mutations over the various p63 protein domains and the structural and functional implications of these mutations establish a clear genotype-phenotype correlation. Review.
- expressed in basal cell carcinoma
- A common role is shown for p63 in classical EEC syndrome, both familial and sporadic, but not in other related or non-syndromic forms of orofacial clefts.
- P63 is a selective nuclear marker, might help to distinguish invasive ductal carcinomas from carcinoma in situ and benign hyperplastic lesions.
- P63 gene mutations and developmental syndromes. Review.
- loss of expression is associated with tumor progression in bladder cancer
- SSRP1 stimulates p63 activity by associating with this activator at the promoter
- prevalence and clinical implications of p63 immunoreactivity (IR) and mRNA expression in laryngeal squamous cell carcinomas
- sequence deletion has a role in abnormal re-epithelialization and lung remodeling in idiopathic pulmonary fibrosis
- identified a novel domain within the C terminus that is necessary and sufficient for transcriptional inhibition and which acts by binding to a region in the N-terminal transactivation domain of p63 homologous to the MDM2 binding site in p53
- Data highlight the modularity of p63, identifying the SAM domain as a dominant transcriptional repression module and indicating that the AEC and EEC frameshift mutants are characterized by a subversion of the p63 transcriptional potential
- p63 staining is at least as sensitive and specific for the identification of basal cells in diagnostic prostate specimens as is high molecular weight cytokeratin staining.
- Seven missense mutations involving codons for arginine residues have been detected in p63 in seven out of 10 non-syndromic split hand/foot malformation patients.
- Delta Np63 alpha phosphoprotein splice variant binds p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity reduced by Hay-Wells syndrome-derived mutations
- P63 is a specific myoepithelial cell marker in normal breast tissue and is expressed in a minority of breast carcinomas, being seen only in grade III ductal carcinomas.
- physical association of p63alpha and ABBP1 led to a specific shift of FGFR-2 alternative splicing toward the K-SAM isoform essential for epithelial differentiation
- This study deominatrates p63 transcriptional regulation of many genes in cancer and development while often demonstrating opposing regulatory functions for TAp63alpha and DeltaNp63alpha.
- ZD1839 downregulates p63 expression at the messenger RNA level, suggesting that p63 is a downstream target of EGFR signaling.
- study supports the hypothesis that in situations where p53 activation is desirable, as with DNA-damaging UVR, DeltaNp63alpha downregulation occurs and may possibly allow for better target gene transcription by p53
- The chemical shifts for backbone resonances of the p63 DNA-binding domain were determined and deposited in BMRB-5700.
- Rapp-Hodgkin syndrome results from mutations of the TP63 gene.
- Our results indicate that both p73 and p63 may be involved in the development of human buccal squamous-cell carcinoma, perhaps in concert with p53.
- DeltaNp63 transactivated the S100A2 promoter, and significantly more fold changes were seen in DeltaNp63-introduced cells than in p53-introduced cells, suggesting that DeltaNp63 may be a novel stimulator of the S100A2 promoter.
- Treatment of keratinocytes with epidermal growth factor results in an increase in Delta Np63 alpha expression at the mRNA level, which is abrogated by inhibition of PI3K but not mitogen-activated protein kinase signaling.
- The expression of p63 gene is associated with poor survival and locoregional failure in cervical squamous cell carcinoma.
- Impaired expression associated with poor prognosis in invasive bladder carcinoma.
- p63 plays critical roles in tumor progression and biochemical terminal differentiation of urothelial neoplasms.
- patients with syndromic ectrodactyly had p63 heterozygous point mutations that affect the DNA binding domain of the protein
- The level of p63 protein was almost the same as that of the control in all types of scars
- This study demonstrated that sclerosing mucoepidermoid carcinomas with eosinophilia (SMECE) stain strongly positive for p63, which is a new marker for UBB/solid cell nests.
- p63 has a role in breast myoepithelial cell differentiation
- The complexity of these p63 expression patterns seen in primary squamous cell carcinoma of the head and neck indicates that p63 has multifaceted roles in tumour biology.
- p63 and p53 play a major role in the carcinogenesis of human esophageal squamous cells and in the growth of the carcinoma
- Emerging evidence in this review discusses a key survival/death checkpoint in both peripheral and central neurons that involves the p53 tumor suppressor and its newly discovered family members, p73 and p63.
- findings suggest that analysis of p63 expression may help in the differential diagnosis of primary vs metastatic cutaneous adenocarcinomas.
- RACK1 physically associated with the p63alpha C-terminal domain through its WD40 domain. However, stratifin binds with phosphorylated DeltaNp63alpha in response to cisplatin.
- We propose the inclusion of p63 as part of the diagnostic workup of challenging spindle cell tumors of the breast as a highly specific marker for metaplastic carcinomas.
- Immunohistochemical staining for p63 could be a useful means of distinguishing adenoid cystic carcinoma from basaloid squamous cell carcinoma.
- These p63alpha mutations also affected the transcriptional regulation of gene targets involved in bone and tooth development (e.g., RUNX2 and MINT) and therefore might contribute to the molecular mechanisms underlying the SHFM phenotype.
- p63 expression is consistently expressed in squamous cell carcinoma in the lung, but is also expressed in a subset of adenocarcinomas and large cell carcinomas.
- maspin tumor suppressor expression is induced by p53 or TAp63gamma
- The findings that DeltaNp63alpha protein levels are regulated by SUMO-1 and that this regulation is altered in natural p63 mutants, suggest that SUMO conjugation to p63 plays a critical role in regulating the biological activity of p63.
- TP63 is amplified in early stage of esophageal squamous cell carcinogenesis but down-regulated in advanced stage of disease.
- studies provide insight to a mechanism for DeltaNp63alpha regulation during normal cell proliferation and, in particular, after stress
- In combination with anticancer drugs, may serve as a new tool in prevention of the toxic side-effects of chemotherapy. (review)
- The ontogeny of p63 in female reproductive organs was essentially identical in mouse and human.
- described an important role for TAp63alpha in the induction of apoptosis and chemosensitivity
- p300 regulates p63-dependent transcription of p21
- The alpha isoform of p63 is necessary for the maintenance of the proliferative potential of limbal stem cells and their ability to migrate over the cornea during regeneration.
- The response elements for p63 binding in the promoter regions of the EVPL and SMARCD3 genes were identified.
- TAp63 protein expression is tightly controlled by its specific DNA-binding and transactivation activities and it is degraded in a proteasome-dependent, MDM2-independent pathway.
- present data indicating that (i) the promyelocytic leukaemia protein (PML) physically interacts with p63, (ii) p63 is localized into the PML nuclear-bodies (PML-NBs) in vivo, and (iii) PML regulates p63 transcriptional activity
- a subset of DLBCL (32% of cases) expressed p63 in the nuclei of neoplastic lymphocytes; p63 expression correlated with high proliferative index, suggesting its involvement in DLBCL tumor progression
- The expression of beta-catenin, p63 and CD34 in the course of androgenetic alopecia is reported.
- loss of p63 or CK5/6 was associated with features of aggressive tumors, and lack of cytokeratin 5/6 was significantly associated with reduced survival in multivariate analysis
- the IGF-IR gene is a novel downstream target for p63/p73 action
- p63 and Dlx play central roles in embryonic patterning and regulation of different developmental processes, and their mutations have been associated with ectodermal dysplasias [review]
- p63 plays an important role in the regulation of cyclin-dependent kinase inhibitor p57Kip2 expression, a type of regulation that is is subverted in ankyloblepharon, ectodermal defects, and cleft lip/palate (AEC) syndrome p63 mutants.
- data suggest that p63, particularly its splice variant DeltaNp73L, is involved in the neoplastic transformation of salivary glands
- The data indicate that p63 has oncogenic properties in SCCHN and is predominantly involved in maintaining cell survival, rather than acting as a directly proliferative factor or as an inhibitor of terminal differentiation.
- P63 should be considered as an additional biomarker that might help pathologists to classify their patients.
- all NH2-terminally deleted p63 isoforms retain a potential in transactivation and growth suppression; an intact DNA-binding domain is required for DeltaNp63 function.
- Q540L substitution impairs the transcriptional activity of TAp63alpha and causes misregulation of genes involved in the control of cell growth and epidermal differentiation
- TAp63alpha may promote thyroid tumour progression by inactivating the tumour suppressor activity of p53.
- Antibodies targeting p63 react specifically in the cytoplasm of breast epithelial cells exhibiting secretory differentiation.
- It is thus likely that both RE1 and RE2 are necessary in rendering p63/p73-specific activation of the WNT4 promoter.
- differential regulation of human telomerase reverse transcriptase and vascular endothelial growth factor in p63-positive breast carcinomas may contribute to the clinically more aggressive behavior of these neoplasms
- transcription factor p63 is a homologue of the tumor suppressor p53. Unlike p53, which is dispensable for normal development, p63 is critical for the development of stratified epithelial tissues such as epidermis, breast, and prostate.
- We tested whether p63 is implicated in transcriptional events related to sustaining cell proliferation by transactivation of antiapoptotic and cell survival target genes such as Adenosine Deaminase (ADA), an important gene involved in cell proliferation.
- DeltaNp63alpha promotes survival in squamous epithelial malignancy by repressing a p73-dependent proapoptotic transcriptional program.
- A different regulation of TAp63 in psoriasis was shown, where the discrepancy between mRNA levels and protein expression indicates a post-transcriptional regulation analogous to that seen in p53.
- some isoforms of p63 serve as a pro-survival factor by up-regulating GPX2 to reduce the p53-dependent oxidative stress-induced apoptotic response
- S100A2 gene, whose transcript and protein are induced during keratinocyte differentiation, is a direct transcriptional target of p73beta and DeltaNp63alpha
- VDR is a direct target of p63 and suggests that p63 may play a role in cancer and differentiation through modulation of the VDR pathway.
- Downregulation of TAp63 mRNA accompanied by protein stabilization in wounds, and the significant upregulation of p63beta in tumors.
- Thus, DeltaNp63 exerts a bidirectional regulation of the DeltaNp63 transcriptional activity in NPC-076 cell.
- p63 expression was closely associated with colorectal villous adenomas and poorly differentiated adenocarcinomas and may represent a marker of poor differentiation in colorectal neoplasms
- An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer.
- The knockdown of DeltaNp63alpha by RNA interference sensitized cells to apoptosis upon genotoxic insult.
- elevated p63 expression counteracts the ability of Notch1 to restrict growth and promote differentiation
- Thus, overexpression of p63 in all histological subtypes may confirm that basaloid progenitor cells are linked tumor-cell lineage and have a role in the tumorigenesis of BCC.
- The three-dimensional solution structure of the p63 sterile alpha-motif (SAM) domain (residues 505-579), a region crucial to explain the human genetic disease ankyloblepharonectodermal dysplasia-clefting syndrome (AEC), was determined by NMR spectroscopy
- Altered expression of P63 was found in head and neck squamous intraepithelial neoplasia.
- In keratinizing carcinomas, p63 was immunodetected peripherally, with loss of expression in central keratinized zones.
- p63 is a key regulator of cellular adhesion and survival in basal cells of the mammary gland and other stratified epithelial tissues
- A heterozygous mutation within the p63 gene is associated with non-syndromic cleft lip.
- In uterine cervix, the expression of DeltaNp63 was increased with progression of CIN, and positive in all SCCs, transitional cell carcinomas, and adenoid basal carcinoma, but negative in all adenocarcinomas.
- Data show that the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73.
- p63 positivity was found in 8/14 (57%) of uterine serous papillary carcinomas and 9/12 (75%) of associated endometrial intraepithelial carcinomas
- Strong p63 staining was observed within cytotrophoblasts of choriocarcinoma (1/1), whereas focal positivity was detected in embryonal carcinomas (4/10) and yolk sac tumors (2/5). Seminomas and intratubular germ cell neoplasia were p63-negative.
- Squamous cell cancer cells are uniquely dependent on DeltaNp63alpha for survival, unlike normal p63-expressing epithelial cells, and that dependence is mediated through tumor-specific up-regulation of the related protein p73.
- The results presented in this study implicate p63 in the regulation of the Shh signaling pathway.
- CK2-site phosphorylation of p53 is induced in DeltaNp63 expressing basal stem cells in UVB irradiated human skin
- These studies provide a potential mechanism by which deltaNp63 directly governs the expression of K14 in a keratinocyte-specific manner.
- Both activated and repressed genes in human keratinocytes via gene expression profiling of p63-depleted cells, were identified.
- We identify approximately 5800 target sites for p63, a p53 homolog essential for stratified epithelial development. p63 targets are enriched for genes involved in cell adhesion, proliferation, death, and signaling pathways; many evolutionarily conserved.
- All thymomas were positive for p63 regardless of type.
- These data lend support to the hypothesis that p63 is involved in growth and differentation of ectoderm-derived oral tissues.
- p53, rather than its homologues p63 and p73, may contribute to control of the first metaphase/anaphase transition of mammalian meiosis by downregulation of Cks2 expression
- Results suggest that p53 family members have different functions in extrahepatic bile duct (EBD) carcinomas, and that interactions between p63 and p73 play an important role in tumorigenesis of EBD carcinoma.
- deltaNp63alpha and TAp63alpha can negatively regulate keratinocyte survival.
- Taken together, our results indicate that hOGG1 is a direct target of TAp63gamma, suggesting a role for TAp63gamma in oxidative damage and repair.
- Can function as a repressor of select p53 target genes involved in growth arrest, DNA repair, and apoptosis.
- Survival factor in a subset of breast cancers.
- Data suggest that the p63-jag1 pathway may be up-regulated at an early phase of epithelial abnormalities in IPF, which can be overcome by NAC even in the TGF beta1-rich milieu.
- initially p53-negative tumors and initially p63-positive tumors that retain this labeling pattern may follow less aggressive biological courses and present better prognoses
- Cloning of DeltaNp63-ChIP-derived DNA fragments identified more than 60 DeltaNp63 target loci. We show that the expression of many of these target genes is altered when DeltaNp63 levels are reduced by siRNA, confirming that these are bona fide targets.
- The combination of p63 and calponin is recommended for analysis of breast papillary lesions.
- after induction of apoptosis, the TI domain of the p63alpha isoforms is cleaved by activated caspases, which results in production of a TAp63 protein with enhanced transcriptional activity
- In the present study, using new high-density microarrays containing more than 22,000 human cDNA sequences, study identified a novel p63 pathway among E2-activated genes and 38 new mitotic genes repressed by E2.
- Overexpression of p63 is associated with Merkel cell carcinoma
- Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain
- Certain TP63 mutations yield typical clinical features of Rapp-Hodgkin syndrome, but also ophthalmic anomalies such as corneal dystrophy and premature menopause.
- results show that components of gastric refluxes activate a pathway that destabilizes p63, providing a plausible mechanism for reprogramming of squamous esophageal stem cells into intestinal-type cells during early steps of Barrett's esophagus formation
- A novel insight into understanding the molecular mechanisms behind TAp63alpha-mediated keratinocyte differentiation.
- The trans-activator (TA) isoforms of p63 activate MFGE8 transcription though a p53/p63 motif at -370, which was confirmed by a chromatin immunoprecipitation experiment.
- We report the differential expression and the cellular localization of the DeltaNp63 isoform in fibroblasts isolated from human keloids and hypertrophic scars. DeltaNp63 has nuclear localization and is overexpressed only in keloid fibroblasts
- VDR is regulated by p63 and p73 and the induction of VDR expression upon DNA damage is p73-dependent
- Expression of p63 protein is apparently cell lineage specific and in ovarian neoplasms is confined to benign and borderline Brenner tumours.
- Reciprocal regulation of p63 by C/EBP delta in human keratinocytes
- The expression of the p63 gene studied was significantly deregulated, with decreasing levels in early bladder cancer versus normal tissue.
- The mutation is in exon 8 of p63, 1046G --> A, which predicts an amino acid substitution G310E. SSCP analysis of the segregation pattern of the mutation strongly suggests a causal relationship to the SHFM phenotype in p63.
- p63 may be a useful adjunct in the diagnosis of skin carcinomas; however, expression of p63 does not rule out the metastatic origin of a cutaneous carcinoma.
- Study reveals that SCF(betaTrCP1) is an E3 ligase that activates p63 through ubiquitylation.
- global repair may be regulated at multiple levels and suggest a novel role for p63 in modulating repair of DNA damage in human keratinocytes
- DeltaNp63 levels increased 77-fold in stage III ovarian cancer patients, independently of the p53 status. Patients with high deltaNp63 expression had the worst overall survival
- Its transcriptional activity can be regulated by modification(s) of, or protein interactions with, the p63 proline-rich domain.
- p63 exhibits several transcriptional and stress-response properties similar to those of p53
- In pleural malignant effusion, malignant mesothelioma can be identified with positive staining for WT-1 and negative staining for p63.
- The results indicate that the overexpression of p63 in oral precancerous lesions and squamous cell carcinoma in betel-quid chewers in Sri Lanka may be a useful marker for oral precancerous lesions.
- Disrupting endogenous p63 expression downregulated TRAF4 mRNA & protein in SCCHN cells. Endogenous p63 bound the TRAF4 promoter in vivo. TAp63 is the most active transactivator of TRAF4.
- p63 can be used as a diagnostic marker to aid the clinical diagnosis of GCTOB.
- findings indicate a contribution by p63 in cell invasion and migration, supporting an oncogenic role for p63 in squamous cell carcinoma of the head and neck
- autoregulation of DeltaNp63 gene transcription is mediated through activation of STAT3 and its subsequent binding to the STAT3RE.
- P-cadherin is a newly defined transcriptional target gene of p63, with a crucial role in hair follicle morphogenesis as well as the apical ectodermal ridge during limb bud outgrowth in humans.
- a good correlation exists between histological grade and p63 protein expression in meningiomas
- Tprg gene is predominantly expressed in skin, is physically associated with the p63 gene during evolution, and directly regulated by p63 through a long-distance enhancer located within the Tprg locus.
- Ki-67- and p53-immunostained cells were mainly located in the suprabasal layers. p63-positive cells were found throughout the lining cystic epithelium.
- p63 may be a useful biomarker to differentiate giant cell tumor of bone from central giant cell granuloma and other giant cell-rich tumors
- Immunohistochemically, reserve cell-like cells were positive for p63, cytokeratins 34BE12 and CK17 and were very weakly positive or negative for CAM5.2.
- DeltaNp63/BMP-7 signaling pathway modulates wound healing process through the regulation of matrilin-2.
- 4 Rapp-Hodgkin/Hay-Wells-like syndromes patients with mutation in the N-terminal part of the p63 protein showed premature translation termination.
- TAp63gamma by IKKbeta stabilizes the TAp63gamma protein by blocking ubiquitylation-dependent degradation of this protein.
- Mutated p53R248W and Delta Np63 alpha, as well as other unknown proteins involved in proteosome-dependent degradation, convey a protective effect on HPV20E6 under these conditions.
- Our current study provides an insight onto the regulation of DeltaNp63alpha protein levels in response to cisplatin and also suggests that UFD2a might play an important role in the regulation of cisplatin mediated cell death mediated by p63.
- rarity of p63 expression supports a nonbronchial histogenesis of bronchioloalveolar carcinoma, well-differentiated adenocarcinoma of lung, adenomatous hyperplasia and atypical adenomatous hyperplasia
- By targeting deltaNp63, miR-203 acts as a switch between keratinocyte proliferation and differentiation.
- High levels of DeltaNp63alpha interact with activated c-Rel in keratinocytes and squamous cell cancer, thereby promoting uncontrolled proliferation, a key alteration in the pathogenesis of cancers.
- the R298Q mutation of p63 gene in autosomal dominant ectodermal dysplasia is associated with arrhythmogenic right ventricular cardiomyopathy
- beta-catenin acts together with Lef-1 to influence DeltaNp63 promoter activity and protein expression
- p63 mutants exhibit differential effects on p63 and p53/p63 specific target genes and on the induction of apoptosis.
- IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias
- senescence of primary NHP cells expressing progenitor cell markers CD44, alpha2beta1, p63, hTERT, and CK5/CK18, involves loss of telomerase expression, up-regulation of p16, and activation of p53.
- Sequencing of the TP63L (p63) gene, residing at 3q27, remained normal in the presented patient.
- These results implicate specific kinases, and target phosphorylation sites in the degradation of Delta Np63 alpha following DNA damage.
- Split hand foot malformation with whorl-like pigmentary pattern: phenotypic expression of somatic mosaicism for the CKAP4 mutation is reported.
- p63 is absent in Paget cells in primary vulvar Paget's disease and is therefore useful in differentiating primary VPD from VPD secondary to urothelial carcinoma.
- WWP1 may have a context-dependent role in regulating cell survival through targeting different p63 proteins for degradation.
- performing stains for p63 when it occurs can help prevent underdiagnosing prostatic carcinoma.
- TGFbeta and retinoic acid downregulated the expression of p63 in immortalized nasopharyngeal epithelial cells and may play a role in regulating differentiation in squamous epithelial cells
- The purpose of this study was to test the feasibility of immunocytochemically detecting markers that may be affected by therapy or are predictive of therapeutic responsiveness, including phosphohistone H1, XIAP and p63.
- Coexistence of strong CK19 positivity and p63-positive cells can enhance the cytologic diagnosis of PTC.
- TP63 protein fine-tunes the Procaspase-8-FADD-Like Apoptosis Regulating Protein pro- and antiapoptotic pathway in keratinocytes.
- Np63 may play an oncogenic role in transitional cell carcinoma of the bladder progression through promoting cell survival and proliferation
- Oncocytic mucoepidermoid carcinoma behaves as a low-grade tumor, and is diffusely positive for p63, which may aid in its differential diagnosis.
- Immunohistochemistry with anti-AMACR/TP63 is useful for detecting prostate cancer in the full range of prostate specimens encountered in needle biopsies.
- Results indicate that DeltaNp63 plays important roles in the regulation of NPC-076 cell-cycle progression, and may play a role in the maintenance of NPC-076 tumor cell phenotype.
- expression of S100P, GATA3, and p63 by a majority of ovarian Brenner tumors underscores the similarity between these neoplasms and urothelial proliferations of bladder origin
- AIRE and p63 are involved in the regulation of HLA class II; defects in the AIRE-p63 interaction may lead to malfunction of HLA-based selection of self-reactive helper CD4(+) T cells in the thymus.
- TP63 mRNA expression in normal prostate tissue is retained in reduced amounts in prostate cancer, and a functional TP63 mutation was identified in one prostate tumor. If TP63 is a prostate cancer gene it likely functions as a tumor suppressor.