|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for CAT(NM_001752.3) Search again
Product ID:
HQP020946
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
-
Gene Description:
catalase
Target Gene Accession:
NM_001752.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
|
|
| A | B |
|
Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
|
Gene References into function
- expression of catalase either in the cytosol or mitochondrial compartments was able to abolish the loss of mitochondrial membrane potential or damage to mitochondria observed in HepG2 cells overexpressing CYP2E1
- results suggest that IGF-1/PI-3 kinase inhibited C2-ceramide-induced apoptosis due to relieving oxidative damage, which resulted from the inhibition of catalase by activated caspase-3
- catalase in livers enhances drug oxidation activities catalyzed by P450 in human liver microsomes.
- The results confirm the involvement of antioxidant enzymes, including catalase, in the pathogenesis of psoriasis.
- Abnormal expression of catalase in the eutopic and ectopic endometrium strongly suggests pathologic involvement of free radicals in endometriosis and adenomyosis
- Malignant lung tumors (squamous cell carcinoma and adenocarcinoma) had significantly decreased levels of this enzyme.
- the level of catalase may play a critical role in cell-induced resistance to the effects of anti-cancer drugs which up-regulate p53
- cell signaling molecules regulate catalase to control cell mitogenesis
- activities of catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and superoxide dismutase (SOD) were decreased during intense physical exercise
- conclude that sun exposure results in a disturbed catalase to superoxide dismutase ratio in the stratum corneum
- results suggest that high glucose flux through aldose reductase inhibits the expression of catalase, CuZn superoxide-dismutase and glutathione peroxidase
- data indicate that catalase plays a direct role in generating oxidants in response to UVB light
- Catalase activity in pulmonary diseases was suppressed by 38-45%.
- findings indicate that, in addition to stimulating catalase activity, c-Abl and Arg promote catalase degradation in the oxidative stress response
- effect of IGFBP-2 overexpression on the activity of catalas in two malignant cell lines
- High catalase activity in human alveolar macrophages limits the effectiveness of H2O2 to act as a mediator of inflammatory gene expression.
- findings support evidence of a new putative type 1 diabetes susceptibility locus for the catalase gene on chromosome 11p13
- catalase (447)Tyr-Val-Asn-Val binds Grb2 upon phosphorylation in tumor cells when stimulated with serum or ligands for integrin receptors
- catalase and hepatocyte growth factor have roles in ceramide-induced apoptosis
- overexpression of human catalase in DF-1 cells endowed cells resistant to the oxidative stress by antimycin A treatment
- SHP2 binds CAT and acquires a hydrogen peroxide-resistant phosphatase activity via integrin-signaling.
- catalase activates the growth of HL60 cells through dismutation of H(2)O(2), leading to activation of the ERK1/2 pathway; H(2)O(2) is an important regulator of growth in HL60 cells
- Genetic variations in the promoter region of catalase gene influence the susceptibility to essential hypertension.
- The novel G-->A mutation in exon 9 changes the essential amino acid Arg 354 to Cys 354 and may be responsible for the decreased catalase activity causing diabetes mellitus.
- Adenovirus-mediated gene transfer of superoxide dismutase and catalase reduced oxidative stress, restenosis, collagen accumulation, and inflammation and improved endothelial function after angioplasty.
- Genetic polymorphisms of CAT and PPARy2 do not play a significant role in the development of SLE in a Korean population.
- genetic polymorphisms of CAT do not play a significant role in the susceptibility to RA in Koreans
- catalase activities in healthy persons
- the accumulation of reactive oxygen species due to catalase attenuation may be a critical aspect of the MAP kinase signaling changes that may lead to skin aging and photoaging in human skin in vivo
- The high-activity catalase CC genotype was associated with an overall 17% reduction in risk of breast cancer compared with having at least one variant T allele.
- catalase has a critical role in CSF-independent survival of human macrophages via regulation of the expression of BCL-2 and BCL-XL
- Cells were exposed to 250 microM hydrogen peroxide and and cell survival, mitochondria transfection with catalase function, were examined.
- No evidence for a major effect of C1167T or C(-262)T sinsgle nucleotide polymorphism on type 1 diabetes mellitus susceptibility in two large sample collections.
- Catalase activity may correlate with the concentration of hypoxanthine in the graft renal vein and other mediators of oxidative stress.
- protective role of the -262T allele of the CAT gene against the rapid development of diabetic nepheropathy.
- Catalase in human enzyme transfected mice rescues insulin-resistance-induced cardiac dysfunction related to ROS production and protein oxidation but probably does not improve insulin sensitivity.
- overexpression of Cu, Zn-SOD and/or catalase in smooth muscle cells attenuates the cell proliferation caused by oxLDL stimulation
- catalase overexpression has a protective role against Ultraviolet B irradiation by preventing DNA damage mediated by the late reactive oxygen species increase.
- The C/T genotype was significantly over-represented in the vitiligo patient group compared with the control cohort.
- A statistically significant higher malondialdehyde concentration in erythrocytes and blood plasma and a higher activity of SOD or CAT in erythrocytes was shown in patients with a brain tumour.
- Mean relative levels of catalase & its mRNA were significantly decreased in women > or =38 years, which may account for granulosa-cell changes associated with reproductive aging.
- Systemic activity of the enzymatic antioxidants (CuZn/SOD, MnSOD, GSH-Px, and CAT) as well as level of lipid peroxidation determined by MDA may not be increased in the course of immune-inflammatory processes associated with chronic idiopathic urticaria.
- findings show that the +22348CT polymorphism and HT4 haplotype of the CAT gene were associated with bone mineral density and bone turnover markers in postmenopausal Korean women
- The muscle of patients undergoing haemodialysis undergoes some adaptive responses in total glutathione content, heat shock protein content and catalase activity that are potentially related to chronic oxidative stress.
- Polymorphisms in catalase is associated with precancerous changes in the gastric mucosa
- analysis of superoxide dismutase and catalase polymorphisms in smokers with COPD
- Catalase is a Noise-induced hearing loss susceptibility gene, but that the effect of CAT polymorphisms can only be detected when noise exposure levels are taken into account.
- C111T polymorphism may implicate a very weak effect on blood catalase activity in different types of diabetes mellitus.
- Significant positive correlations were found between CAT(catalase) and MDA (malondialdehyde) and between CAT and C-reactive protein in children in the active stage of Henoch-Schonlein purpura; CAT levels were lower in patients
- We have developed a novel AAV vector to enhance catalase expression. Lack of apparent toxicity in normal muscle strongly supports further exploration of this vector to reduce oxidative stress-induced muscle damage.
- study shows the well-documented CAT exon 9 T/C & GPX 1 codon 200 polymorphisms may not be associated with Gujarat vitiligo patients; results suggest presence of novel SNPs in Gujarat vitiligo population
- TNF-alpha mediated downregulation of catalase expression and accordingly sufficient H(2)O(2) is required for appropriate function of the NF-kappaB dependent survival pathway.
- Functional promoter variants in CAT and HMOX-1 showed ethnicity-specific associations with new-onset asthma.
- catalase, CK2, and ARC constitute an anti-hypertrophic pathway in the heart.
- This data do not support a role of two gene polymorphisms of the CAT rs1001179 as a possible susceptibility factors for sporadic AD.
- the CAT -330CC genotype may contribute to some clinical manifestations in patients with systemic lupus erythematosus
- The primary factor causing the oxidative stress observed in rheumatoid arthritis and systemic lupus erythematosus is excessive free radical production rather than impaired catalase or superoxide dismutase activity due to autoantibody inhibition.
- Among the SNPs studied, the G-844A, A-89T and C-20T catalase mutant alleles were associated with a lower efficiency of renutrition in malnourished elderly subjects.
- CAT genotype modifies the effect of HRT use on breast cancer risk and HRT may affect risk by affecting oxidative stress.
- Sirt1 overexpression rescued H(2)O(2)-induced apoptosis through the upregulation of catalase.
- An oxidatively modified catalase could be one of the reasons for lower enzymatic activity among SLE subjects, which in turn could favor the accumulation of deleterious hydrogen peroxide
- By chronically reducing catalase activity to approximately 38% of normal, cells respond in a dramatic manner, displaying a cascade of accelerated aging reactions.
- SOD2, SOD3, and CAT genes may influence brain tumor risk.
- Increased catalase expression is associated with multiple sclerosis lesions.
- In AML and APL cell lines, but not primary patient samples, basal catalase levels matched sensitivity to As2O3.
- Enhanced expression of the antioxidant enzyme catalase in human T cells can protect them against reactive oxygen species.