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Validated All-in-One™ qPCR Primer for KISS1R(NM_032551.4) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq].
Gene References into function
- Overexpression of hOT7T175 gene was frequently observed and correlated with HCC progression; thus, the possibility that overexpressed hOT7T175 peptides mediate growth signals into cancer cells in HCCs is suggested.
- Mutations in GPR54 cause autosomal recessive idiopathic hypogonadotropic hypogonadism in humans and mice, suggesting that this receptor is essential for normal gonadotropin-releasing hormone physiology and for puberty.
- KiSS-1 and hOT7T175 gene expression have roles in preventing progression of lymph node metastasis in esophageal squamous cell carcinoma
- This review focuses on the role of the kisspeptin-GPR54 system in the activation of GnRH neurons at the time of pubertal awakening of the reproductive axis.
- Recent identification of loss-of-function mutations in GPR54, a receptor for kisspeptin-1, has highlighted a new pathway for the timing of puberty and reproductive control.
- KiSS-1/GPR54 system has been proven as an essential gatekeeper of GnRH neurons, involved in their activation at puberty and their regulation by gonadal steroids.
- role for GPR54 and KP in the cardiovascular system
- Human genetics studies of GPR54.
- One polymorphism in GPR54 gene might be correlated with some cases of central precocious puberty, likely by changes in expression of the receptor
- KiSS1 and its receptor tumoral mRNA levels could be new interesting markers of the tumoral resistance to anti-estrogen treatment.
- Kisspeptin and GPR54 immunoreactivity are significantly associated with favourable prognosis in both disease specific and overall survival.
- 12% of Kallman syndrome males have KAL1 deletions, but intragenic deletions of the FGFR1, GNRH1, GNRHR, GPR54 and NELF genes are uncommon in Idiopathic hypogonadotropic hypogonadism/Kallman syndrome.
- Herein we review the evidence which support the role of KiSS-1/GPR54 system in cancer biology.
- Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function.
- The catalytic subunit of protein phosphatase 2A (PP2A-C) is the protein interacting with GPR54.