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Validated All-in-One™ qPCR Primer for YY1(NM_003403.4) Search again
Product ID:
HQP018570
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
DELTA, GADEVS, INO80S, NF-E1, UCRBP, YIN-YANG-1
Gene Description:
YY1 transcription factor
Target Gene Accession:
NM_003403.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Validated result:
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| A | B |
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Each All-in-One™ qPCR Primer is experimentally validated to yield a single dissociation curve peak and to generate a single amplification of the correct size for the targeted gene. A cDNA Pool, containing reverse transcript products of 8 different human tissue total RNA(Liver, Testis,Muscle,Thyroid,Brain,Spleen,Stomach,Small Intestine)),was used as the qPCR validation template. qPCR was performed using 0.2 µM primer with 2XAll-in-One™ qPCR Mix (Catalog#: QP001,QP002,QP004,QP005). Reactions were incubated for 10min. at 95°C, followed by 40 cycles of 95°C for 10 sec.; 60°C, 20 sec. and 72°C, 15sec. using Bio-Rad iQ5™ Instrument. At the end of the last cycle, temperature was increased from 72 to 95°C to produce a melting curve. Panel A: Validated Result for Amplification Curve; Panel B: Validated Result for Melting Curve. |
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Summary
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq].
Gene References into function
- Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat.
- Some AML patients showed significantly elevated YY1 transcript levels in bone marrow cells, which together with data presented on mice suggests involvement of abnormal YY1 expression in pathogenesis of human AML
- interaction with E2F provides mechanism for specificity of E2F function
- discovery as regulatory determinant of DEK expression and consistency with the well-documented roles of this factor in cellular proliferation and transformation
- This transcription factor down-regulates expression of CCR5, a major coreceptor for HIV-1.
- YY1-regulated transcription is very likely connected to the pathway of glucose metabolism that culminates in the O-GlcNAcylation on YY1, changing its function in transcription
- YY1 is a negative regulator of alpha-myosin heavy chain gene expression in human heart failure.
- The interaction domains between YY1 and SAP30 were mapped to the C-terminal segment of YY1 (295-414) and the C-terminal 91 amino acid region of SAP30.
- individuals bearing haplotypic variants of the MCP-4 core promoter that avidly bind the transcription factor YY-1 had higher plasma levels of MCP-4 than did individuals with variants with lower binding avidity
- YY1 represses Smad transcriptional activities in a gene-specific manner and thus regulates cell differentiation induced by TGF-beta superfamily pathways
- The ankyrin domain of Notch1 receptor (N1IC) and zinc finger domains of YY1 were essential for the association of N1IC and YY1, which were both present in a large complex of the nucleus to suppress activity transactivated by Notch signaling
- the YY1 factor is translocted to the cytoplasm of vaccinia virus infected macrophages
- transcription factors GATA4 and YY1 are involved in the regulation of FcgammaRIIb expression, and that the expression variants of FcgammaRIIb lead to altered cell signaling, which may contribute to autoimmune pathogenesis in humans.
- YY1 is a negative regulator of p53.
- results designate YY1 as the factor responsible for the intron 1-mediated boost of the HSD3B2 gene basal promoter activity
- YY1 regulates the transcriptional activity, acetylation, ubiquitination, and stability of p53 by inhibiting its interaction with the coactivator p300 and by enhancing its interaction with the negative regulator Mdm2.
- YY1 plays an important role in epidermal differentiation by negatively regulating the human involucrin gene promoter.
- Overexpression of YY1 in lung carcinoma cell line cells can increase HLJ1 expression and reduce cell invasive capability
- CHK down-regulates CXCR4 through the YY1 transcription factor, leading to decreased CXCR4-mediated breast cancer cell motility and migration.
- YY1 is involved in a positive feedback loop during apoptosis.
- YY1 cooperates with AP-2 to stimulate ERBB2 promoter activity through the AP-2 binding sites
- YY1 may play a role in prostate cancer development; however, decreased YY1 may give metastatic cells a survival advantage
- Sp1 and YY1 transactivate human ATP2C1 promoter via cis-enhancing elements and that incomplete upregulation of ATP2C1 transcription contributes to keratinocyte-specific pathogenesis of Hailey-Hailey disease.
- Altogether, these findings reveal that NO inhibits YY1 DNA-binding activity through S-nitrosation and consequently results in upregulation of Fas expression and tumor cell sensitization to Fas-induced apoptosis.
- HCV core can recruit B23 and p300 to relieve the repression effect of YY1 on B23 promoter activity
- the novel factor YY2 antagonizes the negative actions exerted by YY1
- Actin polymerization controls subcellular YY1 localization, which contributes to vascular smooth muscle proliferation and differentiation in normal pulmonary artery development.
- YY1 accelerates the binding of SNAP(c) to the proximal sequence element, its target within snRNA promoters.
- Depletion of E2F1 prevented prohibitin from repressing the YY1 promoter.
- We discuss here the capacity of YY1 to either repress (through histone deacetylase recruitment) or activate (through CBP recruitment) IFN-beta gene expression according to the occupancy of either only its -90 site or both its -122 and -90 sites.
- YY1 represses homeo box A11-dependent transcription via interactions with the homeo box proteins and Histone Deacetylase recruitment
- Schizophrenia-associated SNP in the Syt11 5'UTR region, where the potent transcription factor YY1 can bind, affects the transcriptional activity of Syt11.
- Results report that Yin Yang 1 protein can be sumoylated both in vivo and in vitro by PIASy, a SUMO E3 ligase.
- Transcription factor Ying Yang 1 (YY1) indirectly regulates the C promoter-binding factor 1 (CBF1)-dependent Notch1 signaling via direct interaction with the Notch1 receptor.
- Our findings provide for the first time evidence for the implication of YY1 in uterine cervix carcinogenesis.
- a new role for YY1 as both an inducer of p53 instability in smooth muscle cells, and an indirect repressor of p21WAF1/Cip1 transcription, p21WAF1/Cip1-cdk4-cyclin D1 assembly and intimal thickening.
- Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters
- the transcription factor YY1 binds to and recruits HDAC3 to the lanosterol synthase promoter.
- These results suggest that YY1 might be a negative regulator of PPARdelta gene expression through its direct interaction with the PPARdelta promoter.
- study identified the major CD30 gene promoter microsatellite binding activity as the transcription factor Yin Yang 1
- YY1 and E2F1 have synergistic effect on p73 promoter activity
- the cooperative interaction of Sp1 and YY1 transcription factors is the critical event triggering the initiation of transcription of the MOR gene in lymphocytes
- YY1 and VEGF/CXCR4 seem to intervene in the pathogenesis of the malignant phenotype of osteosarcoma by acting on cell invasiveness and metastasis growth.
- Transcription factor YY1 participates in activation transcription of the human ribosomal protein L11 gene
- acute loss of p53 in normal HKc induces EGFR expression by a mechanism that involves YY1 and Sp1 and does not require p53 binding to the EGFR promoter
- YY-1 expression was higher in airway biopsy specimens from asthmatic compared with control subjects
- proteasome inhibitor NPI-0052 inhibits the transcription repressor Yin Yang 1 (YY1) which regulates TRAIL resistance and negatively regulates DR5 transcription.
- These results reveal that HDAg interacts with cellular transcription factor YY1 and its associated acetyltransferases CBP and p300 in a large nuclear complex, which in turn modulates the replication of HDV RNA.
- This review focuses on the function of YY1 in the nervous system including its role in neural development, neuronal function, developmental myelination, and neurological disease.
- Silencing of YY1 downregulates RIZ1 promoter in human osteosarcoma.
- C-terminal region of p300 provides corepressor function and facilitates the recruitment of p300 and HDAC3 to the YY1-binding site and represses the c-Myc promoter.
- YY1, HDAC3 and HDAC4 restrained cell senescence by repressing p16(INK4a) expression through an epigenetic modification of histones
- YY1 physically interacts with SUZ12 and can act as a mediator to recruit the polycomb group proteins and DNA methyltransferases to participate in the CEBPD gene silencing process
- The DNA-binding sites of YY1 are longer than the known motif of YY1.
- a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas